iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068805

Ensembl Protein ID

EAA27168

UniProt Accession

Q7RXA6; PPIL2_NEUCR

Genbank Protein ID

EAA27168.1

Protein Name

Peptidyl-prolyl cis-trans isomerase-like 2; Cyclophilin-60; Cyclophilin-like protein Cyp-60; RING-type E3 ubiquitin transferase isomerase-like 2; Rotamase

Genbank Nucleotide ID

CM002238

Gene Name

ppi-2; cyp6; NCU00181

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU00181	EAA27168	EAA27168

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.40e-11	43.4	47	102

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrr 63
            C+ sl+++++Pv++p+G  +d + I  wl++ ++ +Pvt++pl+ +dl+  ++ r+
   Q: 47   FCAASLQPFKNPVCTPDGTIFDVEVIGSWLEKHKT-NPVTGEPLSAKDLIKLNFARN 102
           5999*************************877766.**************9988886 PP

Organism

Neurospora crassa

Functional Description
(View)

May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.

Protein Sequence
(Fasta)

MGKGTDKLYI THSEWSSSDA YGASTGANAG ARAQRRGASF KKLPFNFCAA SLQPFKNPVC 60
TPDGTIFDVE VIGSWLEKHK TNPVTGEPLS AKDLIKLNFA RNGDTTDSDE NKGDLIDPVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGTCGCA AAACACCACC ATCACCAACC CGCCGGCTCG ACAAGATGGG CAAAGGAACG 60
GATAAACTAT ACATCACCCA CTCCGAGTGG TCGTCCTCGG ATGCGTACGG CGCCAGTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX

Pfam

PF00160--Pro_isomerase
PF04564--U-box

PRINTS

PR00153--CSAPPISMRASE

SMART

SM00504--Ubox

Gene Ontology

GO:0005634--C:nucleus
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006457--P:protein folding

KEGG

ncr:NCU00181

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000982	Aegilops tauschii	46.70	8.00e-38	150.00
IUUC-Aml-002351	Ailuropoda melanoleuca	52.63	1.00e-55	209.00
IUUC-Atr-002724	Amborella trichopoda	49.30	2.00e-47	181.00
IUUC-Apl-003515	Anas platyrhynchos	50.00	2.00e-44	171.00
IUUC-Aca-004802	Anolis carolinensis	41.70	3.00e-93	333.00
IUUC-Aly-005928	Arabidopsis lyrata	51.74	2.00e-44	172.00
IUUC-Ath-007574	Arabidopsis thaliana	55.29	7.00e-41	160.00
IUUC-Acl-008183	Aspergillus clavatus	54.10	5.00e-142	496.00
IUUC-Afl-008382	Aspergillus flavus	55.38	3.00e-141	493.00
IUUC-Afu-008952	Aspergillus fumigatus	54.95	2.00e-138	484.00
IUUC-Ani-009146	Aspergillus nidulans	53.27	7.00e-138	482.00
IUUC-Ang-009743	Aspergillus niger	55.15	2.00e-142	497.00
IUUC-Aor-010027	Aspergillus oryzae	54.64	7.00e-139	485.00
IUUC-Ate-010569	Aspergillus terreus	50.00	2.00e-133	467.00
IUUC-Ame-010783	Astyanax mexicanus	40.08	4.00e-90	323.00
IUUC-Bgr-012172	Blumeria graminis	50.98	6.00e-133	465.00
IUUC-Bta-012459	Bos taurus	52.88	2.00e-52	198.00
IUUC-Bci-013693	Botrytis cinerea	61.39	0.00e+00	635.00
IUUC-Bdi-014623	Brachypodium distachyon	36.45	2.00e-70	258.00
IUUC-Bol-015781	Brassica oleracea	51.24	6.00e-47	180.00
IUUC-Bra-016624	Brassica rapa	51.24	3.00e-47	181.00
IUUC-Cel-018328	Caenorhabditis elegans	40.12	2.00e-85	307.00
IUUC-Cja-019427	Callithrix jacchus	42.14	2.00e-92	330.00
IUUC-Cfa-020829	Canis familiaris	40.81	1.00e-87	315.00
IUUC-Cpo-022189	Cavia porcellus	41.90	1.00e-91	328.00
IUUC-Cre-022723	Chlamydomonas reinhardtii	48.02	1.00e-45	176.00
IUUC-Csa-024212	Chlorocebus sabaeus	41.61	3.00e-90	323.00
IUUC-Cin-025720	Ciona intestinalis	48.08	9.00e-53	199.00
IUUC-Csv-026137	Ciona savignyi	39.84	3.00e-86	310.00
IUUC-Cgl-026532	Colletotrichum gloeosporioides	66.11	0.00e+00	684.00
IUUC-Cne-026830	Cryptococcus neoformans	38.83	4.00e-95	340.00
IUUC-Dre-028561	Danio rerio	40.16	2.00e-89	321.00
IUUC-Dno-029029	Dasypus novemcinctus	52.88	2.00e-50	191.00
IUUC-Dor-030683	Dipodomys ordii	56.82	3.00e-33	134.00
IUUC-Dse-031506	Dothistroma septosporum	54.07	2.00e-148	517.00
IUUC-Dme-032058	Drosophila melanogaster	42.34	4.00e-99	353.00
IUUC-Ete-033157	Echinops telfairi	42.58	5.00e-38	150.00
IUUC-Eeu-034470	Erinaceus europaeus	54.11	4.00e-32	130.00
IUUC-Fca-036571	Felis catus	40.43	3.00e-86	310.00
IUUC-Fal-037613	Ficedula albicollis	50.96	2.00e-50	191.00
IUUC-Fox-037795	Fusarium oxysporum	66.00	0.00e+00	678.00
IUUC-Fso-038213	Fusarium solani	63.68	0.00e+00	639.00
IUUC-Gmo-039609	Gadus morhua	40.78	5.00e-83	300.00
IUUC-Ggr-039825	Gaeumannomyces graminis	65.35	0.00e+00	639.00
IUUC-Gga-041191	Gallus gallus	51.42	6.00e-51	193.00
IUUC-Gac-041524	Gasterosteus aculeatus	40.44	1.00e-89	321.00
IUUC-Gma-042936	Glycine max	50.23	2.00e-44	172.00
IUUC-Ggo-045352	Gorilla gorilla	41.50	1.00e-91	328.00
IUUC-Hsa-045709	Homo sapiens	41.50	2.00e-91	327.00
IUUC-Hvu-047058	Hordeum vulgare	47.39	6.00e-43	167.00
IUUC-Itr-048483	Ictidomys tridecemlineatus	42.11	1.00e-90	325.00
IUUC-Lch-049681	Latimeria chalumnae	41.84	2.00e-84	304.00
IUUC-Lpe-050799	Leersia perrieri	48.83	6.00e-45	173.00
IUUC-Loc-052566	Lepisosteus oculatus	37.55	2.00e-79	288.00
IUUC-Lma-053028	Leptosphaeria maculans	58.32	1.00e-148	517.00
IUUC-Laf-054547	Loxodonta africana	53.85	3.00e-51	194.00
IUUC-Mcc-054753	Macaca mulatta	53.37	2.00e-50	191.00
IUUC-Meu-056855	Macropus eugenii	36.99	2.00e-33	134.00
IUUC-Mor-056941	Magnaporthe oryzae	62.46	7.00e-175	605.00
IUUC-Mpo-057306	Magnaporthe poae	62.37	0.00e+00	652.00
IUUC-Mtr-058349	Medicago truncatula	51.16	4.00e-45	174.00
IUUC-Mla-058842	Melampsora laricipopulina	46.95	2.00e-46	177.00
IUUC-Mga-060099	Meleagris gallopavo	51.42	9.00e-51	192.00
IUUC-Mvi-060413	Microbotryum violaceum	38.12	2.00e-90	324.00
IUUC-Mmr-061530	Microcebus murinus	42.66	2.00e-92	331.00
IUUC-Mdo-062668	Monodelphis domestica	51.44	5.00e-50	190.00
IUUC-Mmu-063871	Mus musculus	42.03	1.00e-93	335.00
IUUC-Mac-064559	Musa acuminata	47.91	4.00e-46	177.00
IUUC-Mpu-065919	Mustela putorius furo	38.68	2.00e-80	291.00
IUUC-Mlu-067846	Myotis lucifugus	45.19	8.00e-41	159.00
IUUC-Nfi-068507	Neosartorya fischeri	53.00	2.00e-135	474.00
IUUC-Nle-070125	Nomascus leucogenys	39.24	1.00e-79	288.00
IUUC-Opr-070486	Ochotona princeps	42.29	3.00e-67	246.00
IUUC-Ont-071597	Oreochromis niloticus	42.02	4.00e-94	337.00
IUUC-Ocu-074411	Oryctolagus cuniculus	42.42	1.00e-92	331.00
IUUC-Oba-075040	Oryza barthii	48.83	5.00e-45	173.00
IUUC-Obr-076727	Oryza brachyantha	48.83	4.00e-45	174.00
IUUC-Ogl-077605	Oryza glaberrima	48.83	5.00e-45	173.00
IUUC-Ogu-078177	Oryza glumaepatula	48.83	5.00e-45	173.00
IUUC-Oin-079549	Oryza indica	37.72	9.00e-40	156.00
IUUC-Olo-081090	Oryza longistaminata	48.83	5.00e-45	173.00
IUUC-Ome-081979	Oryza meridionalis	48.83	6.00e-45	173.00
IUUC-Oni-082819	Oryza nivara	48.83	5.00e-45	173.00
IUUC-Opu-083212	Oryza punctata	48.36	2.00e-44	172.00
IUUC-Oru-084412	Oryza rufipogon	48.83	5.00e-45	173.00
IUUC-Osa-085431	Oryza sativa	39.86	8.00e-26	107.00
IUUC-Ola-086602	Oryzias latipes	43.33	9.00e-89	318.00
IUUC-Olu-087682	Ostreococcus lucimarinus	38.22	5.00e-77	280.00
IUUC-Oga-088999	Otolemur garnettii	40.00	2.00e-80	291.00
IUUC-Oar-089338	Ovis aries	37.20	4.00e-70	256.00
IUUC-Ptr-091185	Pan troglodytes	41.50	1.00e-91	328.00
IUUC-Pan-092321	Papio anubis	41.70	3.00e-92	330.00
IUUC-Psi-094018	Pelodiscus sinensis	50.94	7.00e-51	192.00
IUUC-Pma-094111	Petromyzon marinus	37.82	8.00e-65	238.00
IUUC-Pno-094782	Phaeosphaeria nodorum	54.74	9.00e-159	551.00
IUUC-Ppa-095335	Physcomitrella patens	49.75	5.00e-47	180.00
IUUC-Pfo-097393	Poecilia formosa	41.98	4.00e-92	330.00
IUUC-Pab-098263	Pongo abelii	39.07	7.00e-79	286.00
IUUC-Pop-099316	Populus trichocarpa	47.22	7.00e-41	159.00
IUUC-Pca-100387	Procavia capensis	41.92	4.00e-30	124.00
IUUC-Ppe-101275	Prunus persica	48.37	6.00e-44	170.00
IUUC-Pva-102150	Pteropus vampyrus	36.42	2.00e-68	251.00
IUUC-Pgr-103378	Puccinia graminis	42.54	6.00e-97	346.00
IUUC-Ptt-103908	Puccinia triticina	38.20	7.00e-84	302.00
IUUC-Pte-104248	Pyrenophora teres	55.07	9.00e-159	551.00
IUUC-Pyt-104645	Pyrenophora triticirepentis	54.91	2.00e-158	550.00
IUUC-Rno-105162	Rattus norvegicus	52.88	6.00e-51	193.00
IUUC-Sha-107123	Sarcophilus harrisii	54.82	2.00e-43	168.00
IUUC-Sja-107828	Schizosaccharomyces japonicus	41.32	4.00e-108	383.00
IUUC-Spo-108368	Schizosaccharomyces pombe	42.10	1.00e-115	407.00
IUUC-Smo-109102	Selaginella moellendorffii	47.76	3.00e-44	171.00
IUUC-Sit-110821	Setaria italica	48.83	2.00e-44	171.00
IUUC-Sly-111803	Solanum lycopersicum	36.04	1.00e-77	281.00
IUUC-Stu-112730	Solanum tuberosum	35.85	1.00e-73	268.00
IUUC-Sar-113618	Sorex araneus	42.95	8.00e-88	315.00
IUUC-Sbi-114487	Sorghum bicolor	49.07	4.00e-44	171.00
IUUC-Sre-115009	Sporisorium reilianum	42.39	1.00e-53	202.00
IUUC-Ssc-115984	Sus scrofa	41.73	2.00e-90	324.00
IUUC-Tgu-117410	Taeniopygia guttata	50.47	3.00e-50	191.00
IUUC-Tru-118537	Takifugu rubripes	40.88	2.00e-86	311.00
IUUC-Tni-120514	Tetraodon nigroviridis	40.16	2.00e-62	231.00
IUUC-Tca-121620	Theobroma cacao	49.30	9.00e-43	166.00
IUUC-Tre-121904	Trichoderma reesei	62.98	4.00e-166	576.00
IUUC-Tvi-122585	Trichoderma virens	61.86	2.00e-169	586.00
IUUC-Tae-125342	Triticum aestivum	46.92	1.00e-42	166.00
IUUC-Tme-126960	Tuber melanosporum	54.47	2.00e-146	509.00
IUUC-Tbe-127839	Tupaia belangeri	48.00	3.00e-26	110.00
IUUC-Ttr-129173	Tursiops truncatus	32.73	3.00e-58	217.00
IUUC-Uma-129595	Ustilago maydis	48.95	2.00e-48	184.00
IUUC-Vda-130012	Verticillium dahliae	64.56	0.00e+00	686.00
IUUC-Vvi-131156	Vitis vinifera	47.91	3.00e-46	177.00
IUUC-Xtr-132807	Xenopus tropicalis	40.63	3.00e-87	313.00
IUUC-Yli-134361	Yarrowia lipolytica	47.46	1.00e-34	139.00
IUUC-Zma-135759	Zea mays	49.75	3.00e-43	167.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence