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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063788
Ensembl Protein ID ENSMUSP00000099388.1
UniProt Accession P97432; Q9JIH9; NBR1_MOUSE
Genbank Protein ID AAC53025.1; AAF74118.1
Protein Name Next to BRCA1 gene 1 protein; Membrane component chromosome 17 surface marker 2 homolog; Neighbor of BRCA1 gene 1 protein
Genbank Nucleotide ID U73039; AF227188
Gene Name Nbr1; M17s2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000017119.19 ENSMUST00000103099.7 ENSMUSP00000099388.1
ENSMUSG00000017119.19 ENSMUST00000107213.7 ENSMUSP00000102831.1
ENSMUSG00000017119.19 ENSMUST00000123558.7 ENSMUSP00000133619.1
ENSMUSG00000017119.19 ENSMUST00000107208.7 ENSMUSP00000102826.1
ENSMUSG00000017119.19 ENSMUST00000107212.7 ENSMUSP00000102830.1
ENSMUSG00000017119.19 ENSMUST00000136185.1 ENSMUSP00000134500.1
ENSMUSG00000017119.19 ENSMUST00000149019.1 ENSMUSP00000119900.1
ENSMUSG00000017119.19 ENSMUST00000071537.12 ENSMUSP00000071467.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 19427866; 20814249
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.00014 23.0 941 977
ULD/UDP/UFD/PB1 6.00e-18 65.9 4 85
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAveyLl 39
            +++ l eMGF dr+++l+ Lr + +n l++++e+L 
   Q: 941  ALMAHLFEMGFcDRQLNLRLLRKHnYNILQVVTELLQ 977
           5788999*****************9999999999985 PP
   

   ULD/UDP/UFD/PB1
   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla.skksllrlliqk 83
           +v+++v++k+e++sf ++ +++++++d++++v+   +++ +++++kY De+++ ++++s+ ++++a+++++ ++ ++l++++++
   Q: 4    QVTLNVTFKNETQSFLVSDPENTTWADVEAMVKV--SFDLNTIQIKYLDEENEEISINSQGEYEEALKMANiKQGNQLQMQVHE 85
           6899******************************..**********************************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
 Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
Protein Sequence
(Fasta)
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD EENEEISINS 60
QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE NQAAARTGKK PLAHYSSLVR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063788|UBD,UBA;ULD,PB1|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGTCACAGTA GTTCTGTACA AAGGGTGGGA ATCGCTCCCT GAGGCCGGAA TATGAGCGCA 60
AGGTAGTGCC CAAAGCAGTT GCAAAACGAG GTCTCATCCC TCCCTCAGCC TTCCTGCCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063788|UBD,UBA;ULD,PB1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032350--N_BRCA1_central
IPR033513--NBR1
IPR000270--PB1_dom
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ
PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF16158--N_BRCA1_IG
PF00564--PB1
PF00569--ZZ
SMART

SM00666--PB1
SM00291--ZnF_ZZ
Gene Ontology

GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0031430--C:M band
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0000407--C:pre-autophagosomal structure
GO:0051019--F:mitogen-activated protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0016236--P:macroautophagy
GO:0045668--P:negative regulation of osteoblast differentiation
GO:0051259--P:protein oligomerization
GO:0030500--P:regulation of bone mineralization
GO:0032872--P:regulation of stress-activated MAPK cascade
KEGG mmu:17966
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002028 Ailuropoda melanoleuca 78.29 0.00e+00 1431.00
IUUC-Atr-003106 Amborella trichopoda 36.64 2.00e-14 75.10
IUUC-Apl-003851 Anas platyrhynchos 56.92 0.00e+00 932.00
IUUC-Aca-005281 Anolis carolinensis 52.84 0.00e+00 846.00
IUUC-Acl-008033 Aspergillus clavatus 26.28 1.00e-15 79.00
IUUC-Afl-008503 Aspergillus flavus 25.68 2.00e-14 75.10
IUUC-Afu-008992 Aspergillus fumigatus 26.91 6.00e-16 79.70
IUUC-Ani-009220 Aspergillus nidulans 23.73 7.00e-15 76.30
IUUC-Aor-010141 Aspergillus oryzae 25.34 2.00e-14 75.10
IUUC-Ate-010391 Aspergillus terreus 26.88 6.00e-15 77.00
IUUC-Ame-010904 Astyanax mexicanus 43.21 1.00e-134 474.00
IUUC-Bgr-011970 Blumeria graminis 30.08 6.00e-09 56.60
IUUC-Bta-013030 Bos taurus 82.56 0.00e+00 1566.00
IUUC-Bol-015840 Brassica oleracea 33.80 1.00e-14 75.10
IUUC-Bra-017383 Brassica rapa 38.26 9.00e-15 75.50
IUUC-Cja-019576 Callithrix jacchus 78.30 0.00e+00 1505.00
IUUC-Cfa-021030 Canis familiaris 78.85 0.00e+00 1482.00
IUUC-Cpo-021386 Cavia porcellus 62.48 0.00e+00 1045.00
IUUC-Cre-022856 Chlamydomonas reinhardtii 30.91 1.00e-02 37.70
IUUC-Csa-023265 Chlorocebus sabaeus 83.25 0.00e+00 1551.00
IUUC-Cho-024901 Choloepus hoffmanni 64.09 5.00e-161 560.00
IUUC-Cne-027045 Cryptococcus neoformans 43.94 1.00e-10 62.80
IUUC-Dre-028204 Danio rerio 41.91 4.00e-135 476.00
IUUC-Dno-028885 Dasypus novemcinctus 78.56 0.00e+00 1506.00
IUUC-Dse-031315 Dothistroma septosporum 27.48 9.00e-11 62.80
IUUC-Eca-033409 Equus caballus 82.64 0.00e+00 1580.00
IUUC-Fca-035407 Felis catus 78.41 0.00e+00 1501.00
IUUC-Fal-037400 Ficedula albicollis 55.68 0.00e+00 946.00
IUUC-Gmo-039454 Gadus morhua 37.69 1.00e-100 361.00
IUUC-Gga-040430 Gallus gallus 61.64 0.00e+00 795.00
IUUC-Gac-042114 Gasterosteus aculeatus 41.58 6.00e-179 621.00
IUUC-Gma-044280 Glycine max 36.84 8.00e-17 82.80
IUUC-Ggo-045643 Gorilla gorilla 86.88 0.00e+00 1212.00
IUUC-Hsa-045869 Homo sapiens 81.64 0.00e+00 1543.00
IUUC-Itr-048172 Ictidomys tridecemlineatus 84.73 0.00e+00 1588.00
IUUC-Lch-050238 Latimeria chalumnae 53.64 0.00e+00 933.00
IUUC-Loc-052860 Lepisosteus oculatus 47.87 2.00e-117 417.00
IUUC-Lma-053158 Leptosphaeria maculans 28.24 1.00e-11 65.10
IUUC-Laf-054460 Loxodonta africana 80.73 0.00e+00 1561.00
IUUC-Mcc-055768 Macaca mulatta 83.22 0.00e+00 1549.00
IUUC-Meu-056136 Macropus eugenii 65.34 0.00e+00 751.00
IUUC-Mor-057101 Magnaporthe oryzae 24.24 2.00e-15 78.20
IUUC-Mtr-058592 Medicago truncatula 39.66 1.00e-14 75.10
IUUC-Mga-059507 Meleagris gallopavo 62.37 0.00e+00 806.00
IUUC-Mvi-060452 Microbotryum violaceum 37.07 7.00e-14 73.20
IUUC-Mmr-060796 Microcebus murinus 82.88 0.00e+00 1430.00
IUUC-Mdo-062214 Monodelphis domestica 70.70 0.00e+00 1362.00
IUUC-Mpu-066809 Mustela putorius furo 79.22 0.00e+00 1468.00
IUUC-Mlu-067887 Myotis lucifugus 82.68 0.00e+00 1543.00
IUUC-Nfi-068336 Neosartorya fischeri 26.91 3.00e-17 84.00
IUUC-Nle-069230 Nomascus leucogenys 82.35 0.00e+00 1543.00
IUUC-Opr-070848 Ochotona princeps 84.28 0.00e+00 719.00
IUUC-Ont-071913 Oreochromis niloticus 43.34 0.00e+00 676.00
IUUC-Oan-073479 Ornithorhynchus anatinus 47.23 6.00e-176 611.00
IUUC-Ocu-074112 Oryctolagus cuniculus 82.32 0.00e+00 1582.00
IUUC-Ola-087486 Oryzias latipes 38.85 5.00e-146 511.00
IUUC-Oga-088832 Otolemur garnettii 82.83 0.00e+00 1517.00
IUUC-Oar-090088 Ovis aries 82.28 0.00e+00 1548.00
IUUC-Ptr-090790 Pan troglodytes 82.11 0.00e+00 1546.00
IUUC-Pan-092523 Papio anubis 83.15 0.00e+00 1548.00
IUUC-Psi-093398 Pelodiscus sinensis 56.96 0.00e+00 992.00
IUUC-Pno-095009 Phaeosphaeria nodorum 25.45 5.00e-15 77.00
IUUC-Pfo-097491 Poecilia formosa 40.18 4.00e-143 502.00
IUUC-Pab-098775 Pongo abelii 82.23 0.00e+00 1509.00
IUUC-Pca-100690 Procavia capensis 81.84 0.00e+00 775.00
IUUC-Ppe-101351 Prunus persica 40.00 1.00e-16 81.60
IUUC-Pva-102582 Pteropus vampyrus 84.34 0.00e+00 825.00
IUUC-Pgr-103390 Puccinia graminis 40.00 6.00e-11 63.90
IUUC-Ptt-103754 Puccinia triticina 38.68 7.00e-14 72.80
IUUC-Pte-104190 Pyrenophora teres 25.36 3.00e-15 77.40
IUUC-Pyt-104763 Pyrenophora triticirepentis 25.36 3.00e-16 80.90
IUUC-Rno-105543 Rattus norvegicus 91.30 0.00e+00 1680.00
IUUC-Sha-106861 Sarcophilus harrisii 70.41 0.00e+00 1357.00
IUUC-Sly-111749 Solanum lycopersicum 38.21 1.00e-16 81.60
IUUC-Stu-111924 Solanum tuberosum 40.16 8.00e-18 85.90
IUUC-Sar-113740 Sorex araneus 73.61 0.00e+00 1286.00
IUUC-Ssc-116108 Sus scrofa 83.55 0.00e+00 1588.00
IUUC-Tgu-117185 Taeniopygia guttata 55.50 0.00e+00 941.00
IUUC-Tru-117624 Takifugu rubripes 43.58 0.00e+00 654.00
IUUC-Tsy-119265 Tarsius syrichta 86.64 0.00e+00 819.00
IUUC-Tni-120728 Tetraodon nigroviridis 44.51 9.00e-142 498.00
IUUC-Tca-120994 Theobroma cacao 33.86 6.00e-15 76.60
IUUC-Tre-122001 Trichoderma reesei 23.33 6.00e-14 73.20
IUUC-Tme-127010 Tuber melanosporum 26.79 2.00e-09 58.50
IUUC-Tbe-127236 Tupaia belangeri 82.41 0.00e+00 1553.00
IUUC-Ttr-128229 Tursiops truncatus 88.73 0.00e+00 838.00
IUUC-Vpa-130650 Vicugna pacos 81.53 6.00e-124 437.00
IUUC-Vvi-131325 Vitis vinifera 38.94 7.00e-18 86.30
IUUC-Xtr-132375 Xenopus tropicalis 48.10 0.00e+00 813.00
IUUC-Xma-134007 Xiphophorus maculatus 39.72 2.00e-140 493.00
IUUC-Zma-134921 Zea mays 38.40 5.00e-17 83.20
Created Date 25-Jun-2017

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