iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064401

Ensembl Protein ID

ENSMUSP00000052563.9

UniProt Accession

P58283; Q3U493; Q3UE56; Q3UGM3; Q68FN0; Q6P1H8; Q6PWY5; Q8BN27; Q8C1U3; RN216_MOUSE

Genbank Protein ID

AAS78930.1; AAS78931.1; BAC40959.1; BAE28184.1; BAE29055.1; BAE32540.1; AAH65066.1; AAH79540.1; AAK51470.1

Protein Name

E3 ubiquitin-protein ligase RNF216; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1

Genbank Nucleotide ID

AY572785; AY572786; AK089775; AK147861; AK149741; AK154368; BC065066; BC079540; AF361000

Gene Name

Rnf216; Triad3; Ubce7ip1; Uip83; Zin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000045078.12	ENSMUST00000053498.12	ENSMUSP00000052563.9
ENSMUSG00000045078.12	ENSMUST00000200607.4	ENSMUSP00000143705.1
ENSMUSG00000045078.12	ENSMUST00000197296.4	ENSMUSP00000143242.1
ENSMUSG00000045078.12	ENSMUST00000200430.4	ENSMUSP00000142355.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RBR	86.95	0.00e+00	1320.00	IUUC-Hsa-046941

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis.

Protein Sequence
(Fasta)

MAEGNNKEEV IHLNNFPCHR GKEWMAVREG PITISDSSDE EGIPMLVTPA TEQQEDDLDD 60
DVILTEDDSE DEYGGFLDLE SGKKEGEAKP GPSSKQTADD IVNPRLEQKV IILGENGLLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGAAGGA ACGCAGTAGC GGCCTCGGTG GCGGCGGCGG CGGTCGCAGC GGCGGCGGTC 60
GCAGCGGGGG AGCTTTTCCA GCGGCTGCTT CTTCAGGTGA ACTTGAGACT GAACTCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR002867--IBR_dom

SMART

SM00647--IBR

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0006915--P:apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0050691--P:regulation of defense response to virus by host
GO:0032648--P:regulation of interferon-beta production

KEGG

mmu:108086

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008315	Aspergillus clavatus	27.69	3.00e-30	127.00
IUUC-Afl-008385	Aspergillus flavus	35.75	3.00e-30	126.00
IUUC-Ani-009166	Aspergillus nidulans	36.92	8.00e-29	122.00
IUUC-Ang-009679	Aspergillus niger	34.39	8.00e-28	119.00
IUUC-Aor-010208	Aspergillus oryzae	36.27	1.00e-23	103.00
IUUC-Ame-011379	Astyanax mexicanus	66.12	7.00e-175	607.00
IUUC-Bta-013550	Bos taurus	84.14	0.00e+00	1286.00
IUUC-Csa-024269	Chlorocebus sabaeus	86.72	0.00e+00	1376.00
IUUC-Cgl-026651	Colletotrichum gloeosporioides	27.23	2.00e-32	134.00
IUUC-Cne-027073	Cryptococcus neoformans	39.58	4.00e-36	145.00
IUUC-Dre-027806	Danio rerio	61.86	5.00e-173	601.00
IUUC-Dse-031551	Dothistroma septosporum	34.58	5.00e-28	119.00
IUUC-Eca-034282	Equus caballus	84.00	0.00e+00	1332.00
IUUC-Fox-037923	Fusarium oxysporum	34.02	1.00e-26	115.00
IUUC-Fso-038201	Fusarium solani	36.05	7.00e-25	108.00
IUUC-Gmo-039065	Gadus morhua	67.93	1.00e-68	253.00
IUUC-Ggr-039902	Gaeumannomyces graminis	35.85	2.00e-26	114.00
IUUC-Gac-041625	Gasterosteus aculeatus	55.79	3.00e-88	318.00
IUUC-Ggo-044824	Gorilla gorilla	93.33	9.00e-12	61.20
IUUC-Hsa-046941	Homo sapiens	85.68	0.00e+00	1358.00
IUUC-Mcc-055112	Macaca mulatta	86.61	0.00e+00	1369.00
IUUC-Mor-057161	Magnaporthe oryzae	34.73	9.00e-25	108.00
IUUC-Mla-059062	Melampsora laricipopulina	34.58	1.00e-34	140.00
IUUC-Mvi-060218	Microbotryum violaceum	35.04	3.00e-30	127.00
IUUC-Ncr-068705	Neurospora crassa	30.57	3.00e-23	103.00
IUUC-Oan-073478	Ornithorhynchus anatinus	73.88	0.00e+00	1132.00
IUUC-Ola-086823	Oryzias latipes	68.12	2.00e-122	432.00
IUUC-Pno-094885	Phaeosphaeria nodorum	32.02	1.00e-24	108.00
IUUC-Ppa-095391	Physcomitrella patens	41.02	1.00e-42	167.00
IUUC-Pab-098076	Pongo abelii	85.68	0.00e+00	1358.00
IUUC-Pca-100450	Procavia capensis	83.68	9.00e-159	554.00
IUUC-Pte-104212	Pyrenophora teres	42.74	1.00e-21	98.20
IUUC-Pyt-104636	Pyrenophora triticirepentis	29.71	3.00e-12	67.40
IUUC-Smo-109322	Selaginella moellendorffii	46.58	4.00e-49	189.00
IUUC-Ssc-115410	Sus scrofa	96.09	0.00e+00	747.00
IUUC-Tre-121991	Trichoderma reesei	39.52	5.00e-23	102.00
IUUC-Tvi-122601	Trichoderma virens	36.49	1.00e-27	116.00
IUUC-Tme-126901	Tuber melanosporum	30.48	5.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence