iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000000851.8	ENSRNOT00000085598.1	ENSRNOP00000074143.1
ENSRNOG00000000851.8	ENSRNOT00000001129.4	ENSRNOP00000001129.3
ENSRNOG00000000851.8	ENSRNOT00000060832.2	ENSRNOP00000057557.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	6.30e-20	71.3	18	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           ++ vktl++++ ++ v  +++v+e+Ke+ia++ ++p e+q+LIy+G++L+Dd++L+++++  g+v+hlv + ++
   Q: 18   EVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQDYNVG-GKVIHLVERAPP 90
           799*********************************************************9.*******99876 PP

Organism

Rattus norvegicus

Functional Description
(View)

May mediate ricin-induced apoptosis.

Protein Sequence
(Fasta)

MEPSDSTSTA MEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI 60
YQGRVLQDDK KLQDYNVGGK VIHLVERAPP QTQLPSGASS GTGSASATHG GGPLPGTRGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCAGGCGC AGTGCGGTCC CCCGGGCGAC GGCGGCGGCG GCGGCTCCTC CGGGTGGTCG 60
GCTCCCTCCC ATCTAGGCCG GCCCCGGCCC GTCTCGCCCC CCAGAAACTC ACTGCTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0391--Immunity
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0744--Spermatogenesis
KW-0813--Transport

Interpro

IPR021925--DUF3538
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF12057--DUF3538
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0071818--C:BAT3 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0043022--F:ribosome binding
GO:0015643--F:toxic substance binding
GO:0007420--P:brain development
GO:0030154--P:cell differentiation
GO:0016569--P:covalent chromatin modification
GO:0009790--P:embryo development
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0002429--P:immune response-activating cell surface receptor signaling pathway
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001822--P:kidney development
GO:0030324--P:lung development
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0030101--P:natural killer cell activation
GO:0043066--P:negative regulation of apoptotic process
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045861--P:negative regulation of proteolysis
GO:1904294--P:positive regulation of ERAD pathway
GO:0050821--P:protein stabilization
GO:0042127--P:regulation of cell proliferation
GO:0007283--P:spermatogenesis
GO:0007130--P:synaptonemal complex assembly
GO:0071816--P:tail-anchored membrane protein insertion into ER membrane
GO:0006810--P:transport
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:94342

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000364	Aegilops tauschii	43.42	6.00e-12	66.60
IUUC-Aml-001312	Ailuropoda melanoleuca	94.33	0.00e+00	752.00
IUUC-Atr-002741	Amborella trichopoda	39.55	7.00e-20	92.80
IUUC-Aca-005226	Anolis carolinensis	64.68	1.00e-165	577.00
IUUC-Aly-005932	Arabidopsis lyrata	41.01	4.00e-18	87.00
IUUC-Ath-006845	Arabidopsis thaliana	36.69	9.00e-16	79.30
IUUC-Acl-008361	Aspergillus clavatus	35.23	2.00e-08	54.30
IUUC-Afl-008403	Aspergillus flavus	39.77	8.00e-10	58.50
IUUC-Afu-009029	Aspergillus fumigatus	32.95	5.00e-08	52.40
IUUC-Ang-009826	Aspergillus niger	39.29	1.00e-10	60.50
IUUC-Aor-010091	Aspergillus oryzae	39.77	8.00e-10	58.50
IUUC-Ate-010419	Aspergillus terreus	38.37	8.00e-09	55.10
IUUC-Ame-011606	Astyanax mexicanus	55.27	2.00e-147	516.00
IUUC-Bta-012561	Bos taurus	91.15	0.00e+00	723.00
IUUC-Bdi-015055	Brachypodium distachyon	41.90	1.00e-13	71.60
IUUC-Bol-015438	Brassica oleracea	44.19	1.00e-14	75.50
IUUC-Bra-017388	Brassica rapa	37.96	3.00e-15	77.40
IUUC-Cja-019188	Callithrix jacchus	86.05	0.00e+00	676.00
IUUC-Cfa-021178	Canis familiaris	93.80	0.00e+00	736.00
IUUC-Cpo-022133	Cavia porcellus	90.36	0.00e+00	718.00
IUUC-Cin-025671	Ciona intestinalis	49.35	2.00e-14	72.40
IUUC-Dre-028559	Danio rerio	55.41	5.00e-156	545.00
IUUC-Dno-029388	Dasypus novemcinctus	96.56	0.00e+00	688.00
IUUC-Dor-030577	Dipodomys ordii	97.05	0.00e+00	692.00
IUUC-Dme-031599	Drosophila melanogaster	42.35	8.00e-17	83.60
IUUC-Ete-032733	Echinops telfairi	95.35	4.00e-156	545.00
IUUC-Eca-033397	Equus caballus	95.65	0.00e+00	740.00
IUUC-Eeu-034638	Erinaceus europaeus	96.31	0.00e+00	692.00
IUUC-Fca-036518	Felis catus	95.66	0.00e+00	768.00
IUUC-Gmo-038892	Gadus morhua	48.41	6.00e-120	425.00
IUUC-Ggr-039961	Gaeumannomyces graminis	36.00	3.00e-07	49.70
IUUC-Gac-041284	Gasterosteus aculeatus	51.57	8.00e-134	471.00
IUUC-Gma-043104	Glycine max	42.55	2.00e-14	75.10
IUUC-Ggo-044420	Gorilla gorilla	96.22	0.00e+00	726.00
IUUC-Hsa-046687	Homo sapiens	96.22	0.00e+00	722.00
IUUC-Itr-048007	Ictidomys tridecemlineatus	92.00	0.00e+00	753.00
IUUC-Lch-049762	Latimeria chalumnae	47.05	1.00e-96	347.00
IUUC-Lpe-051531	Leersia perrieri	40.70	1.00e-11	65.90
IUUC-Laf-053832	Loxodonta africana	96.45	0.00e+00	722.00
IUUC-Mcc-055256	Macaca mulatta	96.22	0.00e+00	730.00
IUUC-Meu-056280	Macropus eugenii	70.40	2.00e-70	260.00
IUUC-Mtr-058642	Medicago truncatula	39.71	5.00e-16	80.10
IUUC-Mmr-061073	Microcebus murinus	91.87	0.00e+00	712.00
IUUC-Mdo-062059	Monodelphis domestica	85.07	0.00e+00	679.00
IUUC-Mmu-063815	Mus musculus	96.04	0.00e+00	785.00
IUUC-Mac-064677	Musa acuminata	30.71	8.00e-06	46.60
IUUC-Mpu-066558	Mustela putorius furo	95.47	0.00e+00	774.00
IUUC-Mlu-067697	Myotis lucifugus	95.27	0.00e+00	715.00
IUUC-Nfi-068487	Neosartorya fischeri	32.95	4.00e-08	52.80
IUUC-Nle-068988	Nomascus leucogenys	95.65	0.00e+00	713.00
IUUC-Opr-071123	Ochotona princeps	95.09	0.00e+00	718.00
IUUC-Ont-072239	Oreochromis niloticus	51.08	4.00e-126	445.00
IUUC-Ocu-073903	Oryctolagus cuniculus	96.03	0.00e+00	715.00
IUUC-Oba-075736	Oryza barthii	42.27	8.00e-13	68.90
IUUC-Obr-076574	Oryza brachyantha	39.82	3.00e-13	70.10
IUUC-Ogl-077678	Oryza glaberrima	42.27	8.00e-13	68.90
IUUC-Ogu-078952	Oryza glumaepatula	42.27	9.00e-13	68.90
IUUC-Oin-079943	Oryza indica	42.27	1.00e-12	68.60
IUUC-Ome-081937	Oryza meridionalis	39.42	3.00e-13	70.50
IUUC-Oni-082471	Oryza nivara	42.27	8.00e-13	68.90
IUUC-Opu-083366	Oryza punctata	42.27	8.00e-13	68.90
IUUC-Oru-085170	Oryza rufipogon	42.27	9.00e-13	68.90
IUUC-Osa-085915	Oryza sativa	42.27	7.00e-13	67.80
IUUC-Ola-087116	Oryzias latipes	48.22	4.00e-116	413.00
IUUC-Oga-088614	Otolemur garnettii	90.83	0.00e+00	732.00
IUUC-Oar-090085	Ovis aries	91.15	0.00e+00	723.00
IUUC-Pan-091999	Papio anubis	96.22	0.00e+00	729.00
IUUC-Ppa-095775	Physcomitrella patens	38.69	1.00e-16	82.40
IUUC-Pfo-097252	Poecilia formosa	49.25	3.00e-127	449.00
IUUC-Pab-098493	Pongo abelii	96.22	0.00e+00	727.00
IUUC-Pop-099480	Populus trichocarpa	48.28	2.00e-16	81.30
IUUC-Ppe-101620	Prunus persica	45.45	8.00e-14	72.80
IUUC-Pva-103214	Pteropus vampyrus	94.52	0.00e+00	708.00
IUUC-Sha-106964	Sarcophilus harrisii	85.88	0.00e+00	651.00
IUUC-Smo-108772	Selaginella moellendorffii	38.79	3.00e-13	70.50
IUUC-Sit-110231	Setaria italica	43.88	5.00e-13	69.70
IUUC-Sly-111457	Solanum lycopersicum	38.35	4.00e-16	80.10
IUUC-Sar-113198	Sorex araneus	96.51	3.00e-163	569.00
IUUC-Sbi-114712	Sorghum bicolor	39.05	9.00e-13	68.90
IUUC-Ssc-116256	Sus scrofa	91.64	0.00e+00	730.00
IUUC-Tru-118440	Takifugu rubripes	52.56	2.00e-111	397.00
IUUC-Tsy-119351	Tarsius syrichta	89.60	0.00e+00	639.00
IUUC-Tca-121577	Theobroma cacao	37.60	5.00e-13	69.70
IUUC-Tbe-127897	Tupaia belangeri	98.29	3.00e-152	532.00
IUUC-Ttr-128389	Tursiops truncatus	96.31	0.00e+00	689.00
IUUC-Vvi-130920	Vitis vinifera	46.67	4.00e-14	73.90
IUUC-Xtr-132680	Xenopus tropicalis	57.73	7.00e-149	521.00
IUUC-Xma-133181	Xiphophorus maculatus	59.04	3.00e-51	196.00
IUUC-Yli-134630	Yarrowia lipolytica	37.66	5.00e-10	58.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence