• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046268
UUCD1 version UUC-HoS-00404
Ensembl Protein ID ENSP00000458143.1
UniProt Accession Q9NYG5; A8MTT2; B7ZW64; Q502X9; Q9BW64; Q9P0R2; APC11_HUMAN
Genbank Protein ID AAF65816.1; AAL95694.1; AAF36134.1; AAH00607.2; AAH66308.1; AAH95454.1; AAI04642.1; AAI71892.1; AAI71898.1; AAI71899.1; AAI71900.1
Protein Name Anaphase-promoting complex subunit 11; Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger protein
Genbank Nucleotide ID AF247565; AF247789; AF151048; AC145207; BC066308; BC095454; BC104641; BC171892; BC171898; BC171899; BC171900
Gene Name ANAPC11; HSPC214
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000141552.17 ENST00000571570.5 ENSP00000458143.1
ENSG00000141552.17 ENST00000582222.5 ENSP00000464403.1
ENSG00000141552.17 ENST00000357385.7 ENSP00000349957.3
ENSG00000141552.17 ENST00000584197.5 ENSP00000464519.1
ENSG00000141552.17 ENST00000585259.1 ENSP00000462527.1
ENSG00000141552.17 ENST00000612413.4 ENSP00000484031.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACmiRWalkRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 19690564; 21107322; 16763193
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0026 19.9 23 77
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+  f            +++++ ++C H+fh +C+ kw    + ++ +++CP Cr
   Q: 23   CGICRMAFngccpdckvpgdDCPLVWGQCSHCFHMHCILKW---LHAQQVQQHCPMCR 77
           9999666688788888888666677799*************...445999999****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
 Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Protein Sequence
(Fasta)
MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI 60
LKWLHAQQVQ QHCPMCRQEW KFKE 84
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046268|E3,APC_C;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGTGCTGCCA CTTGTCGGGA AGTTGTTTTG GCTGAAAAAA AAACCGCAAC AAGAGCAGAT 60
CTGTGAGTCT CAGTCCAGGG CTTTCCTGAC CCTCACGGCT ACTCCGGACC CTTCCTCTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046268|E3,APC_C;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024991--Apc11
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF12861--zf-ANAPC11
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0097602--F:cullin family protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:51529
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002323 Ailuropoda melanoleuca 98.81 5.00e-45 171.00
IUUC-Aly-006393 Arabidopsis lyrata 68.29 5.00e-33 131.00
IUUC-Ath-006698 Arabidopsis thaliana 68.29 5.00e-33 131.00
IUUC-Ago-007824 Ashbya gossypii 42.42 6.00e-19 86.30
IUUC-Acl-008180 Aspergillus clavatus 57.50 6.00e-24 102.00
IUUC-Afl-008622 Aspergillus flavus 57.50 4.00e-24 102.00
IUUC-Afu-008844 Aspergillus fumigatus 56.25 2.00e-23 100.00
IUUC-Ani-009260 Aspergillus nidulans 56.25 1.00e-23 100.00
IUUC-Ang-009794 Aspergillus niger 58.23 2.00e-27 117.00
IUUC-Ame-011274 Astyanax mexicanus 91.67 1.00e-38 150.00
IUUC-Bgr-012017 Blumeria graminis 50.63 1.00e-18 84.00
IUUC-Bta-012644 Bos taurus 97.62 7.00e-45 171.00
IUUC-Bci-013779 Botrytis cinerea 52.94 1.00e-23 100.00
IUUC-Bdi-014975 Brachypodium distachyon 67.47 1.00e-31 127.00
IUUC-Bol-016184 Brassica oleracea 70.13 1.00e-31 127.00
IUUC-Bra-016983 Brassica rapa 65.48 3.00e-33 133.00
IUUC-Cel-018191 Caenorhabditis elegans 48.28 3.00e-18 83.60
IUUC-Cja-019909 Callithrix jacchus 100.00 1.00e-45 173.00
IUUC-Cfa-020306 Canis familiaris 98.81 5.00e-45 171.00
IUUC-Cpo-021773 Cavia porcellus 98.81 5.00e-45 171.00
IUUC-Cre-022961 Chlamydomonas reinhardtii 54.76 5.00e-24 102.00
IUUC-Csa-024274 Chlorocebus sabaeus 100.00 1.00e-45 173.00
IUUC-Cgl-026398 Colletotrichum gloeosporioides 53.57 3.00e-23 99.00
IUUC-Cne-027036 Cryptococcus neoformans 45.19 3.00e-22 96.70
IUUC-Cme-027263 Cyanidioschyzon merolae 55.95 2.00e-26 110.00
IUUC-Dre-027617 Danio rerio 91.67 5.00e-39 151.00
IUUC-Dse-031304 Dothistroma septosporum 58.02 9.00e-24 101.00
IUUC-Dme-031897 Drosophila melanogaster 72.29 4.00e-34 135.00
IUUC-Fca-036297 Felis catus 98.81 7.00e-46 174.00
IUUC-Fal-037228 Ficedula albicollis 88.10 2.00e-42 162.00
IUUC-Fox-037929 Fusarium oxysporum 60.34 1.00e-15 74.30
IUUC-Fso-038194 Fusarium solani 56.96 4.00e-22 95.50
IUUC-Gmo-039638 Gadus morhua 93.62 1.00e-18 84.00
IUUC-Gga-040897 Gallus gallus 91.67 1.00e-43 166.00
IUUC-Gac-041644 Gasterosteus aculeatus 93.62 1.00e-18 84.00
IUUC-Gma-043111 Glycine max 67.07 1.00e-32 131.00
IUUC-Hvu-047356 Hordeum vulgare 66.27 4.00e-31 125.00
IUUC-Itr-048453 Ictidomys tridecemlineatus 98.81 5.00e-45 171.00
IUUC-Kpa-049388 Komagataella pastoris 42.20 2.00e-18 84.30
IUUC-Lch-049838 Latimeria chalumnae 90.48 3.00e-42 162.00
IUUC-Lpe-050878 Leersia perrieri 73.02 1.00e-25 107.00
IUUC-Lma-053166 Leptosphaeria maculans 53.57 5.00e-24 102.00
IUUC-Laf-054221 Loxodonta africana 98.81 5.00e-45 171.00
IUUC-Mor-056930 Magnaporthe oryzae 56.47 2.00e-24 103.00
IUUC-Mtr-058104 Medicago truncatula 71.05 7.00e-32 128.00
IUUC-Mla-059079 Melampsora laricipopulina 47.66 4.00e-24 103.00
IUUC-Mvi-060446 Microbotryum violaceum 65.52 4.00e-22 97.40
IUUC-Mmu-064301 Mus musculus 98.81 5.00e-45 171.00
IUUC-Mac-064936 Musa acuminata 71.08 1.00e-33 134.00
IUUC-Mpu-066041 Mustela putorius furo 98.81 5.00e-45 171.00
IUUC-Mlu-067360 Myotis lucifugus 97.62 7.00e-45 171.00
IUUC-Ncr-068931 Neurospora crassa 56.10 1.00e-23 101.00
IUUC-Ont-072502 Oreochromis niloticus 92.77 7.00e-39 151.00
IUUC-Ocu-074751 Oryctolagus cuniculus 88.10 5.00e-40 155.00
IUUC-Oba-075026 Oryza barthii 69.88 2.00e-32 130.00
IUUC-Obr-076888 Oryza brachyantha 68.67 3.00e-32 130.00
IUUC-Ogl-077846 Oryza glaberrima 69.88 2.00e-32 129.00
IUUC-Ogu-078433 Oryza glumaepatula 68.67 6.00e-33 133.00
IUUC-Oin-079264 Oryza indica 69.88 2.00e-32 129.00
IUUC-Ome-081297 Oryza meridionalis 74.60 3.00e-26 111.00
IUUC-Oni-082739 Oryza nivara 69.88 5.00e-33 133.00
IUUC-Opu-083502 Oryza punctata 74.60 2.00e-25 107.00
IUUC-Oru-084838 Oryza rufipogon 69.88 7.00e-33 132.00
IUUC-Osa-085826 Oryza sativa 69.88 2.00e-32 129.00
IUUC-Ola-087572 Oryzias latipes 92.86 6.00e-39 151.00
IUUC-Olu-087765 Ostreococcus lucimarinus 52.94 1.00e-23 100.00
IUUC-Oga-088853 Otolemur garnettii 98.81 3.00e-45 172.00
IUUC-Oar-089687 Ovis aries 98.81 5.00e-45 171.00
IUUC-Ptr-091674 Pan troglodytes 100.00 1.00e-45 173.00
IUUC-Psi-093124 Pelodiscus sinensis 95.24 6.00e-44 167.00
IUUC-Pno-094852 Phaeosphaeria nodorum 53.57 7.00e-24 102.00
IUUC-Ppa-095866 Physcomitrella patens 65.79 2.00e-29 119.00
IUUC-Pfo-096410 Poecilia formosa 90.48 3.00e-38 149.00
IUUC-Pop-099204 Populus trichocarpa 71.43 1.00e-32 130.00
IUUC-Ppe-101903 Prunus persica 68.67 2.00e-32 129.00
IUUC-Pte-104160 Pyrenophora teres 52.38 6.00e-23 98.60
IUUC-Rno-104979 Rattus norvegicus 98.81 5.00e-45 171.00
IUUC-Sce-106149 Saccharomyces cerevisiae 44.12 4.00e-19 87.40
IUUC-Sja-107930 Schizosaccharomyces japonicus 52.94 5.00e-24 101.00
IUUC-Spo-108296 Schizosaccharomyces pombe 53.09 7.00e-22 94.70
IUUC-Ssl-108464 Sclerotinia sclerotiorum 47.50 5.00e-15 72.00
IUUC-Smo-109289 Selaginella moellendorffii 65.79 1.00e-29 120.00
IUUC-Sit-109777 Setaria italica 67.47 1.00e-31 127.00
IUUC-Sly-111381 Solanum lycopersicum 74.36 5.00e-14 68.90
IUUC-Stu-112287 Solanum tuberosum 70.13 2.00e-32 130.00
IUUC-Sbi-113803 Sorghum bicolor 67.47 1.00e-31 127.00
IUUC-Sre-115018 Sporisorium reilianum 55.81 4.00e-22 95.50
IUUC-Ssc-116403 Sus scrofa 95.18 7.00e-43 164.00
IUUC-Tgu-117375 Taeniopygia guttata 88.10 2.00e-42 162.00
IUUC-Tru-118064 Takifugu rubripes 90.00 8.00e-36 140.00
IUUC-Tni-120387 Tetraodon nigroviridis 90.48 2.00e-38 149.00
IUUC-Tca-121186 Theobroma cacao 71.43 3.00e-22 96.30
IUUC-Tre-122153 Trichoderma reesei 56.25 2.00e-23 100.00
IUUC-Tvi-122412 Trichoderma virens 52.94 2.00e-23 100.00
IUUC-Tae-125184 Triticum aestivum 67.47 1.00e-31 127.00
IUUC-Tur-126516 Triticum urartu 66.27 1.00e-31 127.00
IUUC-Tme-127121 Tuber melanosporum 53.01 2.00e-24 103.00
IUUC-Uma-129529 Ustilago maydis 57.32 2.00e-21 93.60
IUUC-Vvi-131191 Vitis vinifera 71.05 3.00e-32 130.00
IUUC-Xma-133275 Xiphophorus maculatus 89.29 9.00e-38 147.00
IUUC-Yli-134369 Yarrowia lipolytica 60.98 6.00e-26 108.00
IUUC-Zma-134869 Zea mays 67.47 2.00e-31 126.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved