iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064221

UUCD1 version

UUC-MuM-00546

Ensembl Protein ID

ENSMUSP00000087694.4

UniProt Accession

Q6ZQ89; Q6PCS1; Q80V02; Q80VC7; Q8BJA0; Q8BXX6; MARH6_MOUSE

Genbank Protein ID

BAC31427.1; BAC40971.1; BAC97979.1; AAH37454.1; AAH48816.1; AAH59190.2

Protein Name

E3 ubiquitin-protein ligase MARCH6; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; RING-type E3 ubiquitin transferase MARCH6

Genbank Nucleotide ID

AK042980; AK089827; AK129169; BC037454; BC048816; BC059190

Gene Name

March6; Kiaa0597

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000039100.9	ENSMUST00000090227.4	ENSMUSP00000087694.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.11	0.00e+00	1508.00	IUUC-Hsa-046275
E3 activity/RING/RING	28.79	9.00e-16	80.90	IUUC-Sce-106352

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Protein Sequence
(Fasta)

MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE YCELCKHRFA 60
FTPIYSPDMP SRLPIQDIFA GLVTSIGTAI RYWFHYTLVA FAWLGVVPLT ACRIYKCLFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCTCCC CGGCGCTCGC TTTCTGTCAG TCGCTGTCCC TGTCCCCCTC GCCCGCGACC 60
GGCTTCCTCT CGCACCCGAG CGCACGCACT TGCCCGGCCC GCGTCCTCTT CCTCCTCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0019899--F:enzyme binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0010498--P:proteasomal protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:223455

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000529	Aegilops tauschii	25.46	4.00e-56	213.00
IUUC-Aml-002317	Ailuropoda melanoleuca	97.97	0.00e+00	1494.00
IUUC-Atr-002732	Amborella trichopoda	29.27	6.00e-62	233.00
IUUC-Apl-003346	Anas platyrhynchos	90.55	0.00e+00	1434.00
IUUC-Aca-004674	Anolis carolinensis	91.99	0.00e+00	1409.00
IUUC-Aly-005919	Arabidopsis lyrata	31.42	4.00e-65	243.00
IUUC-Ath-007662	Arabidopsis thaliana	29.58	2.00e-65	244.00
IUUC-Ago-007857	Ashbya gossypii	37.68	1.00e-11	65.90
IUUC-Acl-008114	Aspergillus clavatus	32.76	4.00e-22	100.00
IUUC-Afl-008703	Aspergillus flavus	40.00	7.00e-22	99.80
IUUC-Afu-008872	Aspergillus fumigatus	49.15	1.00e-31	133.00
IUUC-Ani-009237	Aspergillus nidulans	49.57	2.00e-30	129.00
IUUC-Ang-009656	Aspergillus niger	40.00	1.00e-21	99.40
IUUC-Aor-010019	Aspergillus oryzae	48.31	3.00e-31	131.00
IUUC-Ate-010367	Aspergillus terreus	49.15	7.00e-32	133.00
IUUC-Ame-011557	Astyanax mexicanus	88.87	0.00e+00	957.00
IUUC-Bgr-011974	Blumeria graminis	44.35	1.00e-28	123.00
IUUC-Bta-013572	Bos taurus	97.52	0.00e+00	1463.00
IUUC-Bci-013727	Botrytis cinerea	41.53	9.00e-28	120.00
IUUC-Bdi-014478	Brachypodium distachyon	31.19	8.00e-65	242.00
IUUC-Bol-015765	Brassica oleracea	31.61	1.00e-65	244.00
IUUC-Bra-017013	Brassica rapa	30.84	2.00e-63	238.00
IUUC-Cel-018256	Caenorhabditis elegans	43.75	2.00e-115	410.00
IUUC-Cja-019361	Callithrix jacchus	96.42	0.00e+00	1512.00
IUUC-Cfa-021059	Canis familiaris	98.20	0.00e+00	1497.00
IUUC-Cpo-022259	Cavia porcellus	94.38	0.00e+00	1422.00
IUUC-Csa-024132	Chlorocebus sabaeus	97.98	0.00e+00	1490.00
IUUC-Cho-024752	Choloepus hoffmanni	89.95	0.00e+00	934.00
IUUC-Cin-025673	Ciona intestinalis	48.13	0.00e+00	742.00
IUUC-Cgl-026714	Colletotrichum gloeosporioides	38.93	9.00e-23	103.00
IUUC-Cne-026977	Cryptococcus neoformans	45.71	5.00e-20	94.40
IUUC-Cme-027283	Cyanidioschyzon merolae	40.26	4.00e-17	83.60
IUUC-Dre-027968	Danio rerio	88.70	0.00e+00	991.00
IUUC-Dno-029848	Dasypus novemcinctus	97.15	0.00e+00	1549.00
IUUC-Dor-031149	Dipodomys ordii	80.05	0.00e+00	1033.00
IUUC-Dse-031295	Dothistroma septosporum	47.06	2.00e-25	112.00
IUUC-Dme-031749	Drosophila melanogaster	47.50	8.00e-156	544.00
IUUC-Ete-032230	Echinops telfairi	81.94	0.00e+00	962.00
IUUC-Eca-034268	Equus caballus	97.97	0.00e+00	1488.00
IUUC-Eeu-034731	Erinaceus europaeus	78.60	0.00e+00	1098.00
IUUC-Fca-036434	Felis catus	97.68	0.00e+00	1519.00
IUUC-Fal-036963	Ficedula albicollis	92.93	0.00e+00	1449.00
IUUC-Fox-038040	Fusarium oxysporum	57.61	2.00e-29	125.00
IUUC-Fso-038260	Fusarium solani	40.71	1.00e-28	122.00
IUUC-Gmo-038917	Gadus morhua	78.08	0.00e+00	1179.00
IUUC-Ggr-039905	Gaeumannomyces graminis	43.59	2.00e-26	115.00
IUUC-Gga-041150	Gallus gallus	92.65	0.00e+00	1454.00
IUUC-Gac-042399	Gasterosteus aculeatus	82.66	0.00e+00	907.00
IUUC-Gma-042674	Glycine max	30.05	4.00e-69	256.00
IUUC-Ggo-045093	Gorilla gorilla	98.10	0.00e+00	1493.00
IUUC-Hsa-046275	Homo sapiens	98.21	0.00e+00	1493.00
IUUC-Hvu-047562	Hordeum vulgare	32.14	5.00e-22	100.00
IUUC-Itr-048106	Ictidomys tridecemlineatus	97.37	6.00e-141	493.00
IUUC-Kpa-049197	Komagataella pastoris	40.54	2.00e-22	101.00
IUUC-Lch-050358	Latimeria chalumnae	86.19	0.00e+00	1083.00
IUUC-Lpe-051172	Leersia perrieri	27.21	6.00e-87	316.00
IUUC-Loc-051866	Lepisosteus oculatus	91.60	0.00e+00	1033.00
IUUC-Lma-053314	Leptosphaeria maculans	43.22	3.00e-28	121.00
IUUC-Laf-054000	Loxodonta africana	83.02	0.00e+00	1333.00
IUUC-Mcc-055595	Macaca mulatta	97.86	0.00e+00	1476.00
IUUC-Meu-056541	Macropus eugenii	89.78	0.00e+00	748.00
IUUC-Mor-057197	Magnaporthe oryzae	41.03	9.00e-26	113.00
IUUC-Mpo-057582	Magnaporthe poae	41.03	2.00e-24	108.00
IUUC-Mtr-057848	Medicago truncatula	31.28	3.00e-67	250.00
IUUC-Mla-058855	Melampsora laricipopulina	32.26	9.00e-08	52.00
IUUC-Mga-059985	Meleagris gallopavo	91.93	0.00e+00	1405.00
IUUC-Mvi-060425	Microbotryum violaceum	30.67	5.00e-18	87.40
IUUC-Mmr-061236	Microcebus murinus	98.41	0.00e+00	1469.00
IUUC-Mdo-062693	Monodelphis domestica	93.56	0.00e+00	1437.00
IUUC-Mac-064930	Musa acuminata	54.72	9.00e-18	81.60
IUUC-Mpu-066231	Mustela putorius furo	96.18	0.00e+00	1493.00
IUUC-Mlu-067461	Myotis lucifugus	97.63	0.00e+00	1489.00
IUUC-Nfi-068608	Neosartorya fischeri	49.15	1.00e-31	132.00
IUUC-Ncr-068743	Neurospora crassa	42.61	5.00e-27	117.00
IUUC-Nle-069646	Nomascus leucogenys	98.21	0.00e+00	1493.00
IUUC-Opr-070365	Ochotona princeps	80.77	0.00e+00	1180.00
IUUC-Ont-071418	Oreochromis niloticus	84.70	0.00e+00	935.00
IUUC-Oan-073127	Ornithorhynchus anatinus	93.37	0.00e+00	1311.00
IUUC-Ocu-074853	Oryctolagus cuniculus	96.42	0.00e+00	1419.00
IUUC-Oba-075890	Oryza barthii	30.54	5.00e-62	233.00
IUUC-Obr-076659	Oryza brachyantha	31.21	2.00e-64	240.00
IUUC-Ogl-077236	Oryza glaberrima	30.44	1.00e-64	241.00
IUUC-Ogu-078167	Oryza glumaepatula	30.54	2.00e-62	234.00
IUUC-Oin-079695	Oryza indica	28.27	8.00e-46	179.00
IUUC-Olo-080267	Oryza longistaminata	26.06	3.00e-37	151.00
IUUC-Ome-081382	Oryza meridionalis	36.67	3.00e-09	55.10
IUUC-Oni-083058	Oryza nivara	30.54	6.00e-62	233.00
IUUC-Opu-083911	Oryza punctata	31.18	2.00e-65	244.00
IUUC-Oru-084882	Oryza rufipogon	30.54	5.00e-62	233.00
IUUC-Osa-085984	Oryza sativa	30.63	7.00e-65	242.00
IUUC-Ola-087523	Oryzias latipes	84.89	0.00e+00	955.00
IUUC-Olu-087805	Ostreococcus lucimarinus	29.17	9.00e-08	52.00
IUUC-Oga-088607	Otolemur garnettii	96.05	0.00e+00	1373.00
IUUC-Oar-089601	Ovis aries	97.63	0.00e+00	1454.00
IUUC-Ptr-091477	Pan troglodytes	98.21	0.00e+00	1493.00
IUUC-Pan-092525	Papio anubis	98.03	0.00e+00	1253.00
IUUC-Psi-094098	Pelodiscus sinensis	91.69	0.00e+00	1437.00
IUUC-Pma-094706	Petromyzon marinus	84.76	1.00e-53	201.00
IUUC-Pno-094876	Phaeosphaeria nodorum	54.79	2.00e-25	112.00
IUUC-Ppa-095692	Physcomitrella patens	31.60	2.00e-66	248.00
IUUC-Pfo-096116	Poecilia formosa	81.13	0.00e+00	916.00
IUUC-Pab-098038	Pongo abelii	98.21	0.00e+00	1493.00
IUUC-Pop-099523	Populus trichocarpa	29.61	5.00e-69	256.00
IUUC-Pca-101000	Procavia capensis	81.74	0.00e+00	1246.00
IUUC-Ppe-101729	Prunus persica	31.32	9.00e-68	252.00
IUUC-Pva-102450	Pteropus vampyrus	96.75	0.00e+00	1449.00
IUUC-Pgr-103425	Puccinia graminis	43.64	2.00e-23	106.00
IUUC-Ptt-103985	Puccinia triticina	51.28	1.00e-20	96.70
IUUC-Pte-104148	Pyrenophora teres	24.82	5.00e-26	114.00
IUUC-Pyt-104663	Pyrenophora triticirepentis	31.87	7.00e-28	120.00
IUUC-Rno-105989	Rattus norvegicus	99.56	0.00e+00	1550.00
IUUC-Sce-106352	Saccharomyces cerevisiae	28.79	5.00e-16	80.50
IUUC-Sja-107820	Schizosaccharomyces japonicus	34.39	2.00e-30	128.00
IUUC-Spo-108307	Schizosaccharomyces pombe	46.73	1.00e-29	125.00
IUUC-Smo-109022	Selaginella moellendorffii	32.09	9.00e-92	331.00
IUUC-Sit-110338	Setaria italica	30.95	2.00e-61	231.00
IUUC-Sly-111874	Solanum lycopersicum	29.76	3.00e-65	244.00
IUUC-Stu-112495	Solanum tuberosum	29.91	1.00e-65	245.00
IUUC-Sar-113497	Sorex araneus	90.50	3.00e-138	486.00
IUUC-Sbi-114728	Sorghum bicolor	30.77	2.00e-63	237.00
IUUC-Sre-115100	Sporisorium reilianum	45.30	1.00e-25	112.00
IUUC-Ssc-115407	Sus scrofa	97.86	0.00e+00	1493.00
IUUC-Tgu-117016	Taeniopygia guttata	92.93	0.00e+00	1449.00
IUUC-Tru-118345	Takifugu rubripes	86.87	0.00e+00	930.00
IUUC-Tsy-119470	Tarsius syrichta	89.27	0.00e+00	1385.00
IUUC-Tni-119846	Tetraodon nigroviridis	74.45	0.00e+00	1129.00
IUUC-Tca-121135	Theobroma cacao	30.93	3.00e-72	267.00
IUUC-Tre-121940	Trichoderma reesei	60.87	1.00e-25	113.00
IUUC-Tvi-122339	Trichoderma virens	61.33	5.00e-27	117.00
IUUC-Tae-122752	Triticum aestivum	31.08	2.00e-62	234.00
IUUC-Tur-126371	Triticum urartu	25.46	2.00e-56	214.00
IUUC-Tme-127133	Tuber melanosporum	48.60	1.00e-26	116.00
IUUC-Ttr-128802	Tursiops truncatus	90.59	0.00e+00	1351.00
IUUC-Uma-129384	Ustilago maydis	43.59	2.00e-24	108.00
IUUC-Vda-130026	Verticillium dahliae	45.22	8.00e-29	123.00
IUUC-Vpa-130798	Vicugna pacos	95.28	0.00e+00	1263.00
IUUC-Vvi-130911	Vitis vinifera	30.67	8.00e-70	259.00
IUUC-Xtr-132891	Xenopus tropicalis	86.37	0.00e+00	1356.00
IUUC-Xma-133659	Xiphophorus maculatus	86.34	0.00e+00	941.00
IUUC-Yli-134628	Yarrowia lipolytica	44.74	1.00e-26	115.00
IUUC-Zma-135318	Zea mays	31.87	2.00e-61	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence