iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072936

UUCD1 version

UUC-OrA-00035

Ensembl Protein ID

ENSOANP00000008405.4

UniProt Accession

F6Q3K4; F6Q3K4_ORNAN

Protein Name

Uncharacterized protein

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000005283.4	ENSOANT00000008407.4	ENSOANP00000008405.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-60	198.1	696	729
UBD/Beta-Prp	6.40e-96	321.3	447	729

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 696  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 729
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 447  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 531
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 532  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 614
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 615  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 699
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 700  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 729
           *************************98776 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSESMCGCGC SILSSLMKRL GRSTCCSDLL SCSHTTDQLP RLSVECPRQP KNVKTFASSD 60
SLAKVQEVAS WLLEMNQELL SVGSKRRRTG GSLRGNASSS QVDEEQMNRV VEEEQQLRQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAATAGTA GAGTCATAAA AGGTCGGCAC CTCTGATTGG TAAATTAAAG GAGCGTCCAG 60
TAATCTGCTC TCTCCGTTGT AGCTCTAAGC AATGCAGCAG CAGTTCTTTT CCAGGTATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	99.46	0.00e+00	1140.00
IUUC-Apl-003489	Anas platyrhynchos	90.82	0.00e+00	1186.00
IUUC-Aca-005318	Anolis carolinensis	97.82	0.00e+00	1098.00
IUUC-Ago-007794	Ashbya gossypii	31.07	5.00e-62	231.00
IUUC-Acl-008123	Aspergillus clavatus	32.40	3.00e-75	275.00
IUUC-Afl-008730	Aspergillus flavus	31.38	3.00e-74	272.00
IUUC-Afu-009014	Aspergillus fumigatus	32.53	1.00e-75	276.00
IUUC-Ani-009332	Aspergillus nidulans	33.47	1.00e-80	293.00
IUUC-Ang-009790	Aspergillus niger	31.32	4.00e-76	278.00
IUUC-Aor-010215	Aspergillus oryzae	30.71	5.00e-75	274.00
IUUC-Ate-010535	Aspergillus terreus	32.09	1.00e-76	280.00
IUUC-Ame-010898	Astyanax mexicanus	94.16	0.00e+00	1048.00
IUUC-Bgr-012075	Blumeria graminis	33.40	1.00e-79	290.00
IUUC-Bta-012391	Bos taurus	98.55	0.00e+00	1107.00
IUUC-Bci-013725	Botrytis cinerea	33.20	2.00e-78	286.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	1.00e-131	462.00
IUUC-Cja-018902	Callithrix jacchus	99.82	0.00e+00	1139.00
IUUC-Cfa-020237	Canis familiaris	99.82	0.00e+00	1142.00
IUUC-Cpo-022234	Cavia porcellus	98.55	0.00e+00	1110.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.54	3.00e-49	188.00
IUUC-Csa-023532	Chlorocebus sabaeus	99.64	0.00e+00	1139.00
IUUC-Cho-025026	Choloepus hoffmanni	83.83	0.00e+00	771.00
IUUC-Cin-025516	Ciona intestinalis	70.34	3.00e-141	493.00
IUUC-Csv-026312	Ciona savignyi	75.47	0.00e+00	755.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	4.00e-85	308.00
IUUC-Cne-027018	Cryptococcus neoformans	33.08	3.00e-73	270.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.11	4.00e-31	129.00
IUUC-Dre-028303	Danio rerio	94.09	0.00e+00	1050.00
IUUC-Dno-029576	Dasypus novemcinctus	97.85	0.00e+00	1122.00
IUUC-Dor-030196	Dipodomys ordii	90.13	0.00e+00	1194.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	1.00e-70	260.00
IUUC-Dme-031702	Drosophila melanogaster	76.61	0.00e+00	803.00
IUUC-Ete-032791	Echinops telfairi	90.74	0.00e+00	1003.00
IUUC-Eca-033424	Equus caballus	98.55	0.00e+00	1108.00
IUUC-Eeu-034996	Erinaceus europaeus	96.41	0.00e+00	1097.00
IUUC-Fca-036422	Felis catus	99.82	0.00e+00	1143.00
IUUC-Fal-037267	Ficedula albicollis	98.18	0.00e+00	1095.00
IUUC-Fox-037800	Fusarium oxysporum	34.07	1.00e-84	306.00
IUUC-Fso-038258	Fusarium solani	34.21	2.00e-83	303.00
IUUC-Gmo-039119	Gadus morhua	83.73	0.00e+00	901.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.66	2.00e-85	309.00
IUUC-Gga-040667	Gallus gallus	91.36	0.00e+00	1186.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.63	0.00e+00	803.00
IUUC-Ggo-044422	Gorilla gorilla	99.82	0.00e+00	1142.00
IUUC-Hsa-045898	Homo sapiens	99.64	0.00e+00	1142.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.79	0.00e+00	976.00
IUUC-Kpa-049097	Komagataella pastoris	32.06	2.00e-76	280.00
IUUC-Lch-050414	Latimeria chalumnae	95.87	0.00e+00	1085.00
IUUC-Loc-052348	Lepisosteus oculatus	96.34	0.00e+00	1071.00
IUUC-Lma-053185	Leptosphaeria maculans	32.40	2.00e-72	266.00
IUUC-Laf-054054	Loxodonta africana	99.46	0.00e+00	1139.00
IUUC-Mcc-055056	Macaca mulatta	99.64	0.00e+00	1139.00
IUUC-Meu-056778	Macropus eugenii	90.93	0.00e+00	729.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	4.00e-74	272.00
IUUC-Mpo-057542	Magnaporthe poae	39.13	2.00e-74	273.00
IUUC-Mla-059081	Melampsora laricipopulina	32.57	9.00e-77	280.00
IUUC-Mga-059255	Meleagris gallopavo	91.38	0.00e+00	1174.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	2.00e-67	251.00
IUUC-Mmr-061292	Microcebus murinus	99.82	0.00e+00	1138.00
IUUC-Mdo-062304	Monodelphis domestica	90.49	0.00e+00	1224.00
IUUC-Mmu-063610	Mus musculus	92.54	0.00e+00	1238.00
IUUC-Mpu-065931	Mustela putorius furo	99.64	0.00e+00	1140.00
IUUC-Mlu-066976	Myotis lucifugus	92.81	0.00e+00	1224.00
IUUC-Nfi-068428	Neosartorya fischeri	31.93	2.00e-75	276.00
IUUC-Ncr-068688	Neurospora crassa	35.97	1.00e-87	317.00
IUUC-Nle-070174	Nomascus leucogenys	99.64	0.00e+00	1142.00
IUUC-Opr-070851	Ochotona princeps	86.32	0.00e+00	651.00
IUUC-Ont-071997	Oreochromis niloticus	93.97	0.00e+00	1075.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.64	0.00e+00	1137.00
IUUC-Obr-076806	Oryza brachyantha	31.52	5.00e-30	126.00
IUUC-Oin-079809	Oryza indica	31.52	5.00e-30	126.00
IUUC-Ola-087098	Oryzias latipes	94.27	0.00e+00	1063.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	3.00e-38	151.00
IUUC-Oga-088884	Otolemur garnettii	100.00	0.00e+00	788.00
IUUC-Oar-090220	Ovis aries	98.58	0.00e+00	1132.00
IUUC-Ptr-090492	Pan troglodytes	99.64	0.00e+00	1142.00
IUUC-Pan-091770	Papio anubis	99.64	0.00e+00	1139.00
IUUC-Psi-093207	Pelodiscus sinensis	98.55	0.00e+00	1108.00
IUUC-Pma-094749	Petromyzon marinus	83.49	0.00e+00	942.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	4.00e-71	262.00
IUUC-Pfo-096493	Poecilia formosa	94.56	0.00e+00	1063.00
IUUC-Pab-098141	Pongo abelii	98.55	0.00e+00	1108.00
IUUC-Pca-100571	Procavia capensis	99.00	0.00e+00	809.00
IUUC-Pva-102988	Pteropus vampyrus	93.80	0.00e+00	1206.00
IUUC-Pgr-103612	Puccinia graminis	35.41	3.00e-62	233.00
IUUC-Ptt-103698	Puccinia triticina	35.55	1.00e-41	164.00
IUUC-Pte-104275	Pyrenophora teres	32.36	1.00e-73	271.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	39.09	2.00e-70	259.00
IUUC-Rno-105706	Rattus norvegicus	98.75	0.00e+00	1136.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.39	6.00e-61	228.00
IUUC-Sha-107653	Sarcophilus harrisii	94.22	0.00e+00	1248.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	2.00e-79	289.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.14	1.00e-62	233.00
IUUC-Sar-113600	Sorex araneus	93.36	0.00e+00	1044.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	8.00e-68	251.00
IUUC-Ssc-115787	Sus scrofa	98.03	0.00e+00	1111.00
IUUC-Tgu-117510	Taeniopygia guttata	91.24	0.00e+00	1174.00
IUUC-Tru-117819	Takifugu rubripes	94.15	0.00e+00	1084.00
IUUC-Tsy-118828	Tarsius syrichta	93.65	0.00e+00	1209.00
IUUC-Tni-120468	Tetraodon nigroviridis	94.33	0.00e+00	1075.00
IUUC-Tre-122193	Trichoderma reesei	36.25	2.00e-85	309.00
IUUC-Tvi-122615	Trichoderma virens	35.03	7.00e-84	304.00
IUUC-Tme-127021	Tuber melanosporum	34.55	5.00e-84	304.00
IUUC-Tbe-127925	Tupaia belangeri	99.81	0.00e+00	1103.00
IUUC-Ttr-128899	Tursiops truncatus	99.46	0.00e+00	1137.00
IUUC-Uma-129449	Ustilago maydis	46.89	5.00e-67	249.00
IUUC-Vda-129802	Verticillium dahliae	36.20	1.00e-87	317.00
IUUC-Vpa-130082	Vicugna pacos	99.79	0.00e+00	959.00
IUUC-Xtr-132213	Xenopus tropicalis	88.03	0.00e+00	1161.00
IUUC-Xma-133646	Xiphophorus maculatus	94.89	0.00e+00	1056.00
IUUC-Yli-134429	Yarrowia lipolytica	34.27	6.00e-87	314.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence