iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106444

UUCD1 version

UUC-SaC-00251

Ensembl Protein ID

YDR054C

UniProt Accession

P14682; D6VS40; UBC3_YEAST

Genbank Protein ID

AAA35188.1; CAA58970.1; CAA98872.1; CAA89083.1; DAA11900.1

Protein Name

Ubiquitin-conjugating enzyme E2-34 kDa; Cell division control protein 34; E2 ubiquitin-conjugating enzyme 3; E3 ubiquitin ligase complex SCF subunit CDC34; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

M21877; X84162; Z74350; Z49209; BK006938

Gene Name

CDC34; DNA6; UBC3; YDR054C; D4211; YD9609.08C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YDR054C	YDR054C	YDR054C

Annotation

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20663873; 18676617; 19112177; 16687735; 12388757

Classification

Family	E-value	Score	Start	End
E2/UBC	3.10e-45	151.8	16	161

Active Site

Position(s)	Description	Evidence
95	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 3    kkelkelekdppegisakpvdesdltewevlilG.pedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk..........eeekWs 93
           ++el++  k+  ++++++++d+s++++w++ ++  +ed++Y+gg+Fk++++fped+Pf+PP+++f+  i+hPnvy++G++C+sil+          ++e+Ws
   Q: 16   YRELTD-PKKAIPSFHIELEDDSNIFTWNIGVMVlNEDSIYHGGFFKAQMRFPEDFPFSPPQFRFTPAIYHPNVYRDGRLCISILHqsgdpmtdepDAETWS 116
           566666.477889*****************9998799************************************************889999999999***** PP
   S: 94   palsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           p+++vesvl+si+sll++pn++sp+n++aa  ++kn+e+yk++v+
   Q: 117  PVQTVESVLISIVSLLEDPNINSPANVDAAVDYRKNPEQYKQRVK 161
           *******************************************97 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MSSRKSTASS LLLRQYRELT DPKKAIPSFH IELEDDSNIF TWNIGVMVLN EDSIYHGGFF 60
KAQMRFPEDF PFSPPQFRFT PAIYHPNVYR DGRLCISILH QSGDPMTDEP DAETWSPVQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTAGTC GCAAAAGCAC CGCTTCTAGC TTACTGTTAC GGCAATATAG AGAACTTACT 60
GATCCTAAGA AAGCTATTCC CTCATTTCAT ATAGAACTAG AGGATGATTC AAATATTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0235--DNA replication
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0006260--P:DNA replication
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

sce:YDR054C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007877	Ashbya gossypii	88.29	5.00e-96	341.00
IUUC-Acl-008052	Aspergillus clavatus	54.24	2.00e-47	180.00
IUUC-Afl-008620	Aspergillus flavus	51.90	2.00e-52	196.00
IUUC-Afu-009004	Aspergillus fumigatus	55.56	2.00e-46	177.00
IUUC-Ani-009262	Aspergillus nidulans	51.43	7.00e-51	191.00
IUUC-Ang-009716	Aspergillus niger	60.67	3.00e-43	166.00
IUUC-Aor-009930	Aspergillus oryzae	51.90	2.00e-52	196.00
IUUC-Ate-010563	Aspergillus terreus	51.90	2.00e-51	193.00
IUUC-Bgr-012246	Blumeria graminis	46.02	9.00e-42	160.00
IUUC-Bci-013915	Botrytis cinerea	45.50	3.00e-44	169.00
IUUC-Cpo-022139	Cavia porcellus	36.16	2.00e-37	146.00
IUUC-Cin-025257	Ciona intestinalis	38.03	1.00e-41	160.00
IUUC-Csv-025954	Ciona savignyi	38.73	1.00e-41	161.00
IUUC-Cgl-026751	Colletotrichum gloeosporioides	48.62	1.00e-39	154.00
IUUC-Dno-029368	Dasypus novemcinctus	38.73	1.00e-35	140.00
IUUC-Dse-031160	Dothistroma septosporum	51.61	4.00e-45	172.00
IUUC-Fal-037135	Ficedula albicollis	38.73	2.00e-35	140.00
IUUC-Fox-037794	Fusarium oxysporum	52.80	5.00e-39	151.00
IUUC-Fso-038169	Fusarium solani	52.17	4.00e-37	145.00
IUUC-Ggr-040103	Gaeumannomyces graminis	56.13	1.00e-43	167.00
IUUC-Gga-040694	Gallus gallus	36.32	2.00e-36	143.00
IUUC-Kpa-049316	Komagataella pastoris	78.95	3.00e-79	285.00
IUUC-Lma-052988	Leptosphaeria maculans	47.89	1.00e-51	193.00
IUUC-Mor-056910	Magnaporthe oryzae	45.45	5.00e-39	152.00
IUUC-Mpo-057346	Magnaporthe poae	56.77	2.00e-43	166.00
IUUC-Mga-060075	Meleagris gallopavo	37.24	2.00e-36	143.00
IUUC-Mlu-067163	Myotis lucifugus	36.18	2.00e-36	143.00
IUUC-Nfi-068322	Neosartorya fischeri	51.52	7.00e-48	181.00
IUUC-Ncr-068676	Neurospora crassa	46.19	2.00e-41	160.00
IUUC-Opr-070826	Ochotona princeps	37.84	3.00e-34	136.00
IUUC-Ocu-074902	Oryctolagus cuniculus	37.91	1.00e-35	141.00
IUUC-Oga-088845	Otolemur garnettii	36.82	1.00e-36	144.00
IUUC-Pno-094950	Phaeosphaeria nodorum	53.63	1.00e-53	200.00
IUUC-Pab-098200	Pongo abelii	37.91	9.00e-36	140.00
IUUC-Pte-104143	Pyrenophora teres	48.57	7.00e-53	197.00
IUUC-Pyt-104604	Pyrenophora triticirepentis	48.57	8.00e-53	197.00
IUUC-Ssl-108409	Sclerotinia sclerotiorum	46.86	3.00e-48	182.00
IUUC-Sar-112992	Sorex araneus	36.73	2.00e-34	136.00
IUUC-Sre-114933	Sporisorium reilianum	43.35	6.00e-31	124.00
IUUC-Tre-122036	Trichoderma reesei	52.38	8.00e-37	144.00
IUUC-Tvi-122621	Trichoderma virens	51.70	6.00e-39	151.00
IUUC-Tme-127042	Tuber melanosporum	41.40	2.00e-38	150.00
IUUC-Ttr-129037	Tursiops truncatus	38.07	1.00e-35	140.00
IUUC-Vda-130006	Verticillium dahliae	52.70	3.00e-38	149.00
IUUC-Yli-134354	Yarrowia lipolytica	64.71	3.00e-65	239.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence