iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000155100.10	ENST00000285420.8	ENSP00000285420.4
ENSG00000155100.10	ENST00000522894.5	ENSP00000428528.2
ENSG00000155100.10	ENST00000615618.1	ENSP00000481196.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	19615732; 21267069

Classification

Family	E-value	Score	Start	End
DUB/OTU	3.90e-29	103.5	178	313

Active Site

Position(s)	Description	Evidence
155	N/A	{ECO:0000250}
158	Nucleophile	ECO:0000250}
277		{ECO:0000250}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek........edekefcqklvepeakgeeihifa 84
            i+++++DG+C+++A++++   ++++d+ l+   v+aLr++t+ey+q++ ++f +f+++         e+++++c+++v+++a+g++++++a
   Q: 178  EIKQIPSDGHCMYKAIEDQ---LKEKDCaLT---VVALRSQTAEYMQSHVEDFLPFLTNPntgdmytpEEFQKYCEDIVNTAAWGGQLELRA 263
           699****************...******555...9********************************************************* PP
   S: 85   LaqiLsrpiivvdvdsleskvggillpllfpeeklkkpivLlY.rsg.....HYdaLva 137
           L++iL++pi+++++ds          p +++ee++kkp++L+Y r++     HY+++++
   Q: 264  LSHILQTPIEIIQADSP---------PIIVGEEYSKKPLILVYmRHAyglgeHYNSVTR 313
           *****************.........89***************663366677****986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEPRVRVEGW KVPTSRCRFL LARVLGYLVV MEAVLTEELD EEEQLLRRHR KEKKELQAKI 60
QGMKNAVPKN DKKRRKQLTE DVAKLEKEME QKHREELEQL KLTTKENKID SVAVNISNLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCACGCGC AGCACCCCAT TTAAGTTTCT CGTCTTTGCA GTGGCTTTGC TTAGATCCGG 60
TGCCGCCTTG AAGGCGGGGC TGGGTCCCAG CCGTAGCCAA TGGAGCCCCG GGTGAGGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity

KEGG

hsa:51633

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000723	Aegilops tauschii	46.11	6.00e-34	137.00
IUUC-Aml-001290	Ailuropoda melanoleuca	88.58	2.00e-132	465.00
IUUC-Atr-002888	Amborella trichopoda	32.32	8.00e-34	137.00
IUUC-Apl-003899	Anas platyrhynchos	75.97	1.00e-97	349.00
IUUC-Aca-004835	Anolis carolinensis	71.38	1.00e-96	345.00
IUUC-Aly-006370	Arabidopsis lyrata	42.11	4.00e-34	138.00
IUUC-Ath-007205	Arabidopsis thaliana	42.86	7.00e-34	137.00
IUUC-Ago-007839	Ashbya gossypii	31.52	9.00e-19	87.40
IUUC-Acl-008062	Aspergillus clavatus	27.98	3.00e-21	95.50
IUUC-Afl-008387	Aspergillus flavus	28.31	5.00e-20	91.70
IUUC-Afu-008806	Aspergillus fumigatus	32.80	2.00e-19	89.70
IUUC-Ani-009345	Aspergillus nidulans	32.43	8.00e-20	91.30
IUUC-Ang-009541	Aspergillus niger	31.09	8.00e-19	87.80
IUUC-Aor-010036	Aspergillus oryzae	33.33	2.00e-14	73.20
IUUC-Ate-010590	Aspergillus terreus	32.28	3.00e-19	89.40
IUUC-Ame-011488	Astyanax mexicanus	63.39	7.00e-61	226.00
IUUC-Bgr-012112	Blumeria graminis	31.15	3.00e-25	108.00
IUUC-Bta-013496	Bos taurus	90.25	2.00e-133	468.00
IUUC-Bci-013804	Botrytis cinerea	29.93	3.00e-24	105.00
IUUC-Bdi-014498	Brachypodium distachyon	44.22	4.00e-27	115.00
IUUC-Bol-016446	Brassica oleracea	40.83	2.00e-32	133.00
IUUC-Bra-017283	Brassica rapa	42.35	8.00e-32	130.00
IUUC-Cel-018541	Caenorhabditis elegans	29.97	1.00e-26	114.00
IUUC-Cja-018882	Callithrix jacchus	95.37	3.00e-158	550.00
IUUC-Cfa-020707	Canis familiaris	85.76	7.00e-130	456.00
IUUC-Cpo-022119	Cavia porcellus	91.33	1.00e-136	479.00
IUUC-Cre-022759	Chlamydomonas reinhardtii	41.06	7.00e-25	108.00
IUUC-Csa-023715	Chlorocebus sabaeus	97.47	1.00e-137	482.00
IUUC-Cho-024435	Choloepus hoffmanni	86.07	5.00e-146	510.00
IUUC-Cin-025653	Ciona intestinalis	42.86	2.00e-53	202.00
IUUC-Csv-026057	Ciona savignyi	44.12	2.00e-52	199.00
IUUC-Cgl-026523	Colletotrichum gloeosporioides	33.33	6.00e-22	98.20
IUUC-Dre-028563	Danio rerio	62.77	3.00e-95	341.00
IUUC-Dno-029138	Dasypus novemcinctus	86.65	6.00e-144	503.00
IUUC-Dor-030988	Dipodomys ordii	83.95	4.00e-137	480.00
IUUC-Dse-031425	Dothistroma septosporum	30.16	1.00e-25	110.00
IUUC-Dme-031629	Drosophila melanogaster	42.11	2.00e-35	142.00
IUUC-Ete-032439	Echinops telfairi	82.94	2.00e-119	421.00
IUUC-Eca-034429	Equus caballus	90.97	2.00e-134	471.00
IUUC-Eeu-035037	Erinaceus europaeus	88.45	6.00e-131	459.00
IUUC-Fca-036027	Felis catus	90.97	7.00e-125	439.00
IUUC-Fal-037520	Ficedula albicollis	74.91	3.00e-93	334.00
IUUC-Fox-037880	Fusarium oxysporum	37.72	4.00e-24	105.00
IUUC-Fso-038257	Fusarium solani	32.55	2.00e-25	109.00
IUUC-Gmo-039015	Gadus morhua	59.43	2.00e-80	291.00
IUUC-Ggr-039742	Gaeumannomyces graminis	29.41	3.00e-13	68.90
IUUC-Gga-040141	Gallus gallus	76.33	1.00e-96	345.00
IUUC-Gac-042173	Gasterosteus aculeatus	62.32	4.00e-84	304.00
IUUC-Gma-043157	Glycine max	34.38	2.00e-29	123.00
IUUC-Ggo-045246	Gorilla gorilla	99.07	8.00e-158	549.00
IUUC-Hvu-047159	Hordeum vulgare	46.43	2.00e-34	139.00
IUUC-Itr-048258	Ictidomys tridecemlineatus	88.93	2.00e-139	488.00
IUUC-Kpa-049163	Komagataella pastoris	31.13	1.00e-27	117.00
IUUC-Lch-049420	Latimeria chalumnae	67.74	2.00e-67	248.00
IUUC-Lpe-051225	Leersia perrieri	44.97	3.00e-30	125.00
IUUC-Loc-052416	Lepisosteus oculatus	67.15	2.00e-103	369.00
IUUC-Lma-053040	Leptosphaeria maculans	31.64	2.00e-16	80.10
IUUC-Laf-054394	Loxodonta africana	88.09	3.00e-120	424.00
IUUC-Mcc-054615	Macaca mulatta	95.29	8.00e-132	462.00
IUUC-Meu-056364	Macropus eugenii	84.19	2.00e-93	335.00
IUUC-Mor-056998	Magnaporthe oryzae	30.16	1.00e-23	103.00
IUUC-Mtr-058093	Medicago truncatula	35.07	4.00e-33	135.00
IUUC-Mla-059177	Melampsora laricipopulina	35.00	6.00e-25	107.00
IUUC-Mga-059453	Meleagris gallopavo	74.91	5.00e-93	334.00
IUUC-Mvi-060416	Microbotryum violaceum	41.84	1.00e-26	114.00
IUUC-Mmr-060981	Microcebus murinus	91.98	5.00e-150	523.00
IUUC-Mdo-062093	Monodelphis domestica	84.27	5.00e-118	417.00
IUUC-Mmu-064380	Mus musculus	85.54	1.00e-137	482.00
IUUC-Mac-065176	Musa acuminata	36.33	9.00e-35	140.00
IUUC-Mpu-065855	Mustela putorius furo	88.89	9.00e-137	479.00
IUUC-Mlu-067838	Myotis lucifugus	86.64	2.00e-136	478.00
IUUC-Nfi-068315	Neosartorya fischeri	32.45	1.00e-19	90.10
IUUC-Ncr-068865	Neurospora crassa	33.33	8.00e-22	97.80
IUUC-Nle-069630	Nomascus leucogenys	98.15	7.00e-164	569.00
IUUC-Opr-071119	Ochotona princeps	75.43	7.00e-101	360.00
IUUC-Ont-071312	Oreochromis niloticus	62.63	4.00e-82	297.00
IUUC-Oan-072983	Ornithorhynchus anatinus	78.57	2.00e-66	244.00
IUUC-Ocu-074722	Oryctolagus cuniculus	89.56	5.00e-132	463.00
IUUC-Oba-075617	Oryza barthii	44.64	2.00e-32	132.00
IUUC-Obr-076339	Oryza brachyantha	37.89	2.00e-32	133.00
IUUC-Ogl-077215	Oryza glaberrima	44.64	2.00e-32	132.00
IUUC-Ogu-078380	Oryza glumaepatula	44.64	2.00e-32	132.00
IUUC-Oin-079517	Oryza indica	44.64	2.00e-32	132.00
IUUC-Olo-081082	Oryza longistaminata	45.24	4.00e-32	132.00
IUUC-Ome-081465	Oryza meridionalis	44.64	6.00e-32	131.00
IUUC-Oni-082627	Oryza nivara	44.64	2.00e-32	132.00
IUUC-Opu-083380	Oryza punctata	38.60	2.00e-34	139.00
IUUC-Oru-084842	Oryza rufipogon	44.64	2.00e-32	132.00
IUUC-Osa-085590	Oryza sativa	44.64	2.00e-32	132.00
IUUC-Ola-086422	Oryzias latipes	60.22	2.00e-83	301.00
IUUC-Olu-087662	Ostreococcus lucimarinus	38.46	3.00e-26	112.00
IUUC-Oga-088876	Otolemur garnettii	93.50	1.00e-139	489.00
IUUC-Oar-089336	Ovis aries	88.59	3.00e-132	464.00
IUUC-Ptr-091496	Pan troglodytes	99.38	1.00e-158	552.00
IUUC-Pan-092768	Papio anubis	95.99	4.00e-150	523.00
IUUC-Psi-093375	Pelodiscus sinensis	79.04	3.00e-109	387.00
IUUC-Pma-094689	Petromyzon marinus	52.33	4.00e-67	248.00
IUUC-Pno-094941	Phaeosphaeria nodorum	30.54	3.00e-17	82.40
IUUC-Ppa-095454	Physcomitrella patens	35.40	2.00e-26	112.00
IUUC-Pfo-096151	Poecilia formosa	63.80	6.00e-89	320.00
IUUC-Pab-097625	Pongo abelii	98.45	2.00e-157	548.00
IUUC-Pop-099071	Populus trichocarpa	34.60	1.00e-32	134.00
IUUC-Pca-100563	Procavia capensis	84.21	7.00e-129	453.00
IUUC-Ppe-101211	Prunus persica	37.40	2.00e-36	146.00
IUUC-Pva-102274	Pteropus vampyrus	85.08	6.00e-129	453.00
IUUC-Pgr-103298	Puccinia graminis	33.15	8.00e-23	101.00
IUUC-Ptt-103989	Puccinia triticina	36.53	4.00e-27	115.00
IUUC-Pte-104218	Pyrenophora teres	28.33	2.00e-16	79.70
IUUC-Pyt-104729	Pyrenophora triticirepentis	30.59	2.00e-18	86.70
IUUC-Rno-105036	Rattus norvegicus	85.03	5.00e-136	477.00
IUUC-Sce-106447	Saccharomyces cerevisiae	34.13	2.00e-28	119.00
IUUC-Sha-107542	Sarcophilus harrisii	83.90	8.00e-118	416.00
IUUC-Sja-107660	Schizosaccharomyces japonicus	42.34	2.00e-22	99.40
IUUC-Ssl-108611	Sclerotinia sclerotiorum	33.53	2.00e-23	103.00
IUUC-Smo-108969	Selaginella moellendorffii	42.59	1.00e-28	120.00
IUUC-Sit-110074	Setaria italica	40.48	6.00e-32	131.00
IUUC-Sly-111078	Solanum lycopersicum	38.73	7.00e-31	127.00
IUUC-Stu-112039	Solanum tuberosum	34.81	2.00e-32	133.00
IUUC-Sar-113115	Sorex araneus	90.36	3.00e-43	168.00
IUUC-Sbi-114416	Sorghum bicolor	35.89	6.00e-34	137.00
IUUC-Sre-115147	Sporisorium reilianum	33.02	6.00e-25	108.00
IUUC-Ssc-116178	Sus scrofa	90.97	6.00e-134	469.00
IUUC-Tgu-116914	Taeniopygia guttata	75.27	4.00e-97	347.00
IUUC-Tru-118639	Takifugu rubripes	60.50	4.00e-80	291.00
IUUC-Tsy-119450	Tarsius syrichta	73.07	4.00e-107	380.00
IUUC-Tni-119783	Tetraodon nigroviridis	59.30	2.00e-78	285.00
IUUC-Tca-121280	Theobroma cacao	36.64	7.00e-32	130.00
IUUC-Tre-122157	Trichoderma reesei	33.89	8.00e-21	94.40
IUUC-Tvi-122520	Trichoderma virens	31.35	8.00e-25	107.00
IUUC-Tae-123145	Triticum aestivum	46.71	2.00e-34	139.00
IUUC-Tur-126310	Triticum urartu	45.51	5.00e-33	135.00
IUUC-Tme-126898	Tuber melanosporum	29.37	3.00e-16	79.00
IUUC-Tbe-127260	Tupaia belangeri	92.78	2.00e-131	461.00
IUUC-Ttr-128495	Tursiops truncatus	87.62	1.00e-132	466.00
IUUC-Vda-129934	Verticillium dahliae	34.32	2.00e-21	96.70
IUUC-Vpa-130030	Vicugna pacos	71.30	9.00e-107	380.00
IUUC-Vvi-130959	Vitis vinifera	34.14	5.00e-34	138.00
IUUC-Xtr-132480	Xenopus tropicalis	68.33	1.00e-94	339.00
IUUC-Xma-133210	Xiphophorus maculatus	64.62	7.00e-84	303.00
IUUC-Yli-134372	Yarrowia lipolytica	34.21	6.00e-22	98.20
IUUC-Zma-135524	Zea mays	35.99	1.00e-33	137.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence