iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108120

Ensembl Protein ID

SPCC622.16c.1:pep

UniProt Accession

O94603; JHD1_SCHPO

Genbank Protein ID

CAA21872.1

Protein Name

Putative JmjC domain-containing histone demethylation protein 1; Heterochromatin-destabilizing protein epe1; [Histone-H3]-lysine-36 demethylase 1

Genbank Nucleotide ID

CU329672

Gene Name

epe1; jhd1; SPCC622.16c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC622.16c	SPCC622.16c.1	SPCC622.16c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	32.48	3.00e-50	197.00	IUUC-Dme-032039

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Represses transcriptional silencing by negatively affecting heterochromatin stability.

Protein Sequence
(Fasta)

MDSWLEYDDI INQDIDIPSN DLSGSGTLCV GVHSSLLENS LNSIDSFISS KEEISWCGNQ 60
STPIATKSHL SCINPQYVNP FDTSPVSVDT EFQDTYLLDA PSFAQPHFSE RQSVDKTRSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAACATTT AATTACTATT CAAAAATTCT GGGTAGTTTG TAACTCAACT CTACGGAAGC 60
TTTAGAATTG GCTCATCTTT CCAAAGCTGC ACAATAGAAG TGCGCTTGTG CTAAATCGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR003347--JmjC_dom

PROSITE

PS51184--JMJC

Pfam

PF02373--JmjC

SMART

SM00558--JmjC

Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0044732--C:mitotic spindle pole body
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0006338--P:chromatin remodeling
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0033696--P:negative regulation of extent of heterochromatin assembly
GO:0001672--P:regulation of chromatin assembly or disassembly
GO:0090052--P:regulation of chromatin silencing at centromere
GO:0090054--P:regulation of chromatin silencing at silent mating-type cassette
GO:0031454--P:regulation of extent of heterochromatin assembly
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPCC622.16c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002052	Ailuropoda melanoleuca	34.24	1.00e-47	183.00
IUUC-Apl-003192	Anas platyrhynchos	35.34	7.00e-49	187.00
IUUC-Aca-004247	Anolis carolinensis	32.26	5.00e-53	201.00
IUUC-Ago-007912	Ashbya gossypii	33.33	3.00e-39	154.00
IUUC-Acl-008303	Aspergillus clavatus	33.58	2.00e-58	219.00
IUUC-Afl-008579	Aspergillus flavus	43.70	1.00e-24	106.00
IUUC-Afu-008903	Aspergillus fumigatus	32.42	3.00e-57	215.00
IUUC-Ani-009279	Aspergillus nidulans	31.98	2.00e-53	202.00
IUUC-Ang-009645	Aspergillus niger	33.42	1.00e-55	209.00
IUUC-Aor-010233	Aspergillus oryzae	33.51	4.00e-58	218.00
IUUC-Ate-010345	Aspergillus terreus	33.51	8.00e-58	217.00
IUUC-Ame-011753	Astyanax mexicanus	34.19	2.00e-53	202.00
IUUC-Bta-013531	Bos taurus	30.50	2.00e-48	186.00
IUUC-Cel-018303	Caenorhabditis elegans	32.31	5.00e-42	164.00
IUUC-Cja-019030	Callithrix jacchus	34.24	2.00e-47	182.00
IUUC-Cfa-020644	Canis familiaris	34.24	1.00e-47	183.00
IUUC-Cpo-022055	Cavia porcellus	34.13	5.00e-47	181.00
IUUC-Csa-023379	Chlorocebus sabaeus	34.24	2.00e-47	182.00
IUUC-Cho-024541	Choloepus hoffmanni	30.10	1.00e-31	129.00
IUUC-Cin-025140	Ciona intestinalis	35.97	3.00e-43	168.00
IUUC-Csv-025861	Ciona savignyi	31.80	5.00e-44	171.00
IUUC-Cne-026797	Cryptococcus neoformans	25.81	1.00e-31	129.00
IUUC-Cme-027118	Cyanidioschyzon merolae	27.83	2.00e-33	135.00
IUUC-Dre-028182	Danio rerio	33.66	2.00e-51	196.00
IUUC-Dno-029268	Dasypus novemcinctus	34.24	1.00e-47	183.00
IUUC-Dor-030736	Dipodomys ordii	31.65	7.00e-47	181.00
IUUC-Dse-031402	Dothistroma septosporum	37.14	9.00e-56	211.00
IUUC-Dme-032039	Drosophila melanogaster	32.48	7.00e-52	197.00
IUUC-Ete-032467	Echinops telfairi	34.24	3.00e-49	188.00
IUUC-Eca-033526	Equus caballus	34.24	2.00e-47	182.00
IUUC-Eeu-035273	Erinaceus europaeus	39.53	4.00e-35	141.00
IUUC-Fca-035532	Felis catus	34.24	1.00e-47	182.00
IUUC-Fal-037017	Ficedula albicollis	31.96	3.00e-50	191.00
IUUC-Gmo-038932	Gadus morhua	34.90	9.00e-51	193.00
IUUC-Gga-040290	Gallus gallus	34.90	1.00e-49	189.00
IUUC-Gac-041674	Gasterosteus aculeatus	33.33	2.00e-50	192.00
IUUC-Ggo-044712	Gorilla gorilla	41.10	2.00e-48	186.00
IUUC-Hsa-046760	Homo sapiens	35.57	4.00e-50	191.00
IUUC-Kpa-049384	Komagataella pastoris	35.36	9.00e-45	172.00
IUUC-Lch-049793	Latimeria chalumnae	36.59	3.00e-48	185.00
IUUC-Loc-051972	Lepisosteus oculatus	33.45	1.00e-48	186.00
IUUC-Lma-053190	Leptosphaeria maculans	34.41	4.00e-52	198.00
IUUC-Laf-053939	Loxodonta africana	34.24	2.00e-47	182.00
IUUC-Mcc-054600	Macaca mulatta	34.24	2.00e-47	182.00
IUUC-Meu-056259	Macropus eugenii	31.67	2.00e-47	182.00
IUUC-Mla-058890	Melampsora laricipopulina	35.12	5.00e-47	179.00
IUUC-Mga-059549	Meleagris gallopavo	35.34	7.00e-49	187.00
IUUC-Mvi-060481	Microbotryum violaceum	32.25	2.00e-53	202.00
IUUC-Mmr-061132	Microcebus murinus	35.57	5.00e-50	191.00
IUUC-Mdo-062567	Monodelphis domestica	34.24	8.00e-48	184.00
IUUC-Mmu-063458	Mus musculus	35.91	7.00e-51	194.00
IUUC-Mpu-066055	Mustela putorius furo	34.24	1.00e-47	183.00
IUUC-Mlu-067228	Myotis lucifugus	34.24	1.00e-47	183.00
IUUC-Nfi-068537	Neosartorya fischeri	33.08	1.00e-57	217.00
IUUC-Nle-069668	Nomascus leucogenys	34.24	2.00e-47	182.00
IUUC-Opr-070225	Ochotona princeps	34.24	2.00e-47	182.00
IUUC-Ont-072151	Oreochromis niloticus	35.31	6.00e-53	201.00
IUUC-Oan-073654	Ornithorhynchus anatinus	36.23	9.00e-48	183.00
IUUC-Ocu-074710	Oryctolagus cuniculus	34.24	2.00e-47	182.00
IUUC-Ola-087410	Oryzias latipes	34.90	2.00e-51	196.00
IUUC-Oga-088644	Otolemur garnettii	34.60	7.00e-47	180.00
IUUC-Oar-089193	Ovis aries	34.60	1.00e-47	183.00
IUUC-Ptr-091328	Pan troglodytes	35.57	1.00e-49	189.00
IUUC-Pan-092415	Papio anubis	34.24	2.00e-47	182.00
IUUC-Psi-093382	Pelodiscus sinensis	34.45	4.00e-50	191.00
IUUC-Pma-094621	Petromyzon marinus	35.44	3.00e-48	184.00
IUUC-Pno-094984	Phaeosphaeria nodorum	29.86	7.00e-54	204.00
IUUC-Ppa-095609	Physcomitrella patens	34.69	1.00e-39	154.00
IUUC-Pfo-096512	Poecilia formosa	33.33	1.00e-50	193.00
IUUC-Pab-097907	Pongo abelii	30.79	7.00e-49	187.00
IUUC-Pca-100628	Procavia capensis	36.07	1.00e-35	143.00
IUUC-Pva-102416	Pteropus vampyrus	34.24	2.00e-47	182.00
IUUC-Pgr-103554	Puccinia graminis	35.49	9.00e-52	196.00
IUUC-Ptt-103859	Puccinia triticina	34.50	4.00e-53	201.00
IUUC-Pte-104241	Pyrenophora teres	35.50	1.00e-49	190.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	35.18	5.00e-49	187.00
IUUC-Rno-105814	Rattus norvegicus	33.90	5.00e-47	181.00
IUUC-Sce-106445	Saccharomyces cerevisiae	31.34	2.00e-35	141.00
IUUC-Sha-106693	Sarcophilus harrisii	34.24	1.00e-47	183.00
IUUC-Sja-107763	Schizosaccharomyces japonicus	54.81	9.00e-140	488.00
IUUC-Smo-109024	Selaginella moellendorffii	34.80	2.00e-38	152.00
IUUC-Sit-109892	Setaria italica	29.17	7.30e-01	27.30
IUUC-Sar-113568	Sorex araneus	33.90	9.00e-46	177.00
IUUC-Sre-115112	Sporisorium reilianum	31.69	1.00e-42	166.00
IUUC-Ssc-115432	Sus scrofa	35.34	1.00e-47	181.00
IUUC-Tgu-117091	Taeniopygia guttata	32.22	6.00e-51	194.00
IUUC-Tru-118423	Takifugu rubripes	34.98	2.00e-51	195.00
IUUC-Tsy-119214	Tarsius syrichta	36.20	3.00e-48	185.00
IUUC-Tni-120020	Tetraodon nigroviridis	33.55	3.00e-48	185.00
IUUC-Tme-127054	Tuber melanosporum	30.83	8.00e-48	184.00
IUUC-Tbe-128138	Tupaia belangeri	36.23	4.00e-47	181.00
IUUC-Ttr-128194	Tursiops truncatus	34.90	2.00e-49	189.00
IUUC-Uma-129458	Ustilago maydis	32.10	1.00e-43	169.00
IUUC-Vpa-130655	Vicugna pacos	32.62	9.00e-40	157.00
IUUC-Xtr-131839	Xenopus tropicalis	35.34	5.00e-50	190.00
IUUC-Xma-133139	Xiphophorus maculatus	33.33	2.00e-50	192.00
IUUC-Yli-134626	Yarrowia lipolytica	34.28	3.00e-50	190.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence