iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003893

Ensembl Protein ID

ENSAPLP00000008700.1

UniProt Accession

U3IN77; U3IN77_ANAPL

Genbank Protein ID

ENSAPLP00000008700

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01097669

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000008925.1	ENSAPLT00000009384.1	ENSAPLP00000008700.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-136	454.3	607	938

Active Site

Position(s)	Description	Evidence
908	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 607  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLLDG 695
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 696  FFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 779
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 780  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 868
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP Y+s e l+ekLl+A+e+++gFe
   Q: 869  TGTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPLYESFEDLREKLLMAVENAQGFE 938
           *********************************************************************8 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

KCDLFFCSDP YVKLSLYVAD ENRELALVQT KTIKKTLNPK WNEEFYFRVN PTNHRLLFEV 60
FDENRLTRDD FLGQVDVPLS HLPTEDPTME RPYTFKDFLL RPRSHKSRVK GFLRLKMAYM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGTGACC TCTTCTTTTG CAGTGACCCC TACGTGAAAC TTTCCTTGTA TGTAGCAGAT 60
GAGAACAGAG AACTTGCCCT GGTGCAGACA AAAACTATTA AAAAGGTATG TATATACTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	92.36	0.00e+00	1633.00
IUUC-Aca-004744	Anolis carolinensis	91.51	0.00e+00	1664.00
IUUC-Acl-008273	Aspergillus clavatus	48.69	2.00e-161	563.00
IUUC-Afl-008713	Aspergillus flavus	48.51	1.00e-158	553.00
IUUC-Afu-009103	Aspergillus fumigatus	48.85	1.00e-161	563.00
IUUC-Ani-009259	Aspergillus nidulans	48.37	3.00e-160	558.00
IUUC-Ang-009738	Aspergillus niger	48.83	1.00e-159	556.00
IUUC-Aor-010053	Aspergillus oryzae	57.38	8.00e-100	356.00
IUUC-Ate-010529	Aspergillus terreus	48.93	7.00e-161	560.00
IUUC-Ame-010810	Astyanax mexicanus	72.14	0.00e+00	1241.00
IUUC-Bgr-012148	Blumeria graminis	47.42	1.00e-151	530.00
IUUC-Bta-012679	Bos taurus	94.19	0.00e+00	1547.00
IUUC-Bci-013785	Botrytis cinerea	46.91	6.00e-154	537.00
IUUC-Cja-018732	Callithrix jacchus	94.28	0.00e+00	1711.00
IUUC-Cfa-021226	Canis familiaris	93.95	0.00e+00	1691.00
IUUC-Cpo-021671	Cavia porcellus	92.36	0.00e+00	1643.00
IUUC-Csa-023344	Chlorocebus sabaeus	92.50	0.00e+00	1698.00
IUUC-Cho-024832	Choloepus hoffmanni	98.30	0.00e+00	733.00
IUUC-Csv-026098	Ciona savignyi	58.70	0.00e+00	655.00
IUUC-Cne-026849	Cryptococcus neoformans	47.70	5.00e-159	554.00
IUUC-Dre-027770	Danio rerio	78.29	0.00e+00	1391.00
IUUC-Dno-029466	Dasypus novemcinctus	94.16	0.00e+00	1711.00
IUUC-Dor-030138	Dipodomys ordii	88.76	0.00e+00	1570.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	1.00e-157	550.00
IUUC-Ete-033145	Echinops telfairi	85.83	0.00e+00	1239.00
IUUC-Eca-033445	Equus caballus	94.52	0.00e+00	1535.00
IUUC-Eeu-035247	Erinaceus europaeus	92.29	0.00e+00	1351.00
IUUC-Fca-035489	Felis catus	91.29	0.00e+00	1482.00
IUUC-Fal-037604	Ficedula albicollis	94.90	0.00e+00	1729.00
IUUC-Fox-037774	Fusarium oxysporum	48.43	5.00e-157	548.00
IUUC-Gmo-039674	Gadus morhua	77.52	0.00e+00	1352.00
IUUC-Gga-040703	Gallus gallus	97.66	0.00e+00	1763.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.02	0.00e+00	1384.00
IUUC-Ggo-045332	Gorilla gorilla	92.95	0.00e+00	1672.00
IUUC-Hsa-045968	Homo sapiens	94.37	0.00e+00	1710.00
IUUC-Lch-050443	Latimeria chalumnae	87.05	0.00e+00	1446.00
IUUC-Loc-052662	Lepisosteus oculatus	80.97	0.00e+00	1414.00
IUUC-Laf-053850	Loxodonta africana	92.89	0.00e+00	1684.00
IUUC-Mcc-055821	Macaca mulatta	94.27	0.00e+00	1708.00
IUUC-Meu-056712	Macropus eugenii	80.35	0.00e+00	760.00
IUUC-Mga-059264	Meleagris gallopavo	76.86	0.00e+00	1110.00
IUUC-Mvi-060395	Microbotryum violaceum	53.91	1.00e-149	523.00
IUUC-Mmr-060798	Microcebus murinus	89.63	0.00e+00	1585.00
IUUC-Mdo-062173	Monodelphis domestica	92.61	0.00e+00	1711.00
IUUC-Mmu-064136	Mus musculus	93.53	0.00e+00	1675.00
IUUC-Mpu-066765	Mustela putorius furo	93.95	0.00e+00	1680.00
IUUC-Mlu-067565	Myotis lucifugus	92.38	0.00e+00	1527.00
IUUC-Nfi-068427	Neosartorya fischeri	48.85	5.00e-162	564.00
IUUC-Ncr-068918	Neurospora crassa	47.49	8.00e-155	540.00
IUUC-Nle-069070	Nomascus leucogenys	90.66	0.00e+00	1619.00
IUUC-Opr-071044	Ochotona princeps	93.33	0.00e+00	1167.00
IUUC-Ont-072044	Oreochromis niloticus	77.88	0.00e+00	1425.00
IUUC-Oan-073032	Ornithorhynchus anatinus	91.09	0.00e+00	1415.00
IUUC-Ocu-074160	Oryctolagus cuniculus	91.52	0.00e+00	1628.00
IUUC-Olo-080326	Oryza longistaminata	44.08	2.00e-88	322.00
IUUC-Opu-083428	Oryza punctata	44.56	5.00e-90	327.00
IUUC-Ola-087467	Oryzias latipes	79.41	0.00e+00	1407.00
IUUC-Oga-088460	Otolemur garnettii	90.19	0.00e+00	1518.00
IUUC-Oar-090198	Ovis aries	93.95	0.00e+00	1671.00
IUUC-Ptr-090939	Pan troglodytes	94.37	0.00e+00	1710.00
IUUC-Pan-092284	Papio anubis	94.27	0.00e+00	1707.00
IUUC-Psi-093645	Pelodiscus sinensis	95.01	0.00e+00	1711.00
IUUC-Pma-094364	Petromyzon marinus	82.47	0.00e+00	859.00
IUUC-Pfo-096768	Poecilia formosa	91.34	0.00e+00	961.00
IUUC-Pab-098088	Pongo abelii	94.16	0.00e+00	1706.00
IUUC-Pca-100714	Procavia capensis	74.63	0.00e+00	1264.00
IUUC-Pva-102354	Pteropus vampyrus	92.51	0.00e+00	1630.00
IUUC-Ptt-103806	Puccinia triticina	53.38	2.00e-122	432.00
IUUC-Rno-105318	Rattus norvegicus	93.43	0.00e+00	1672.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.08	1.00e-162	566.00
IUUC-Sha-107482	Sarcophilus harrisii	94.32	0.00e+00	1579.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.25	3.00e-155	542.00
IUUC-Stu-112582	Solanum tuberosum	36.09	1.00e-54	207.00
IUUC-Sbi-113794	Sorghum bicolor	45.00	2.00e-92	335.00
IUUC-Ssc-115950	Sus scrofa	68.58	0.00e+00	1145.00
IUUC-Tgu-117130	Taeniopygia guttata	97.77	0.00e+00	1763.00
IUUC-Tru-118610	Takifugu rubripes	80.19	0.00e+00	1432.00
IUUC-Tsy-119492	Tarsius syrichta	89.21	0.00e+00	1580.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.21	0.00e+00	1360.00
IUUC-Tre-122203	Trichoderma reesei	44.86	4.00e-153	535.00
IUUC-Tvi-122595	Trichoderma virens	46.69	5.00e-153	534.00
IUUC-Tbe-127441	Tupaia belangeri	85.41	0.00e+00	743.00
IUUC-Ttr-128235	Tursiops truncatus	85.64	0.00e+00	1464.00
IUUC-Xtr-132859	Xenopus tropicalis	88.87	0.00e+00	1614.00
IUUC-Xma-133797	Xiphophorus maculatus	81.09	0.00e+00	1417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence