iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023344

Ensembl Protein ID

ENSCSAP00000014174.1

UniProt Accession

A0A0D9RZY5; A0A0D9RZY5_CHLSB

Genbank Protein ID

ENSCSAP00000014174

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01127778

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000018158.1	ENSCSAT00000016254.1	ENSCSAP00000014174.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-135	450.8	659	990

Active Site

Position(s)	Description	Evidence
960	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 659  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 747
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 748  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 831
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 832  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 920
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 921  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 990
           *********************************************************************8 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MATGLGEPVY GLSEDEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAAGCGGC GCCGGCAGCG GCCGGGGCGA GCGCTCGGGC ACCCTCACCT GCCGGCGCCC 60
GGCCGGTTCC CCGGCAGGGC GTCCGCAGGG CAGGGTGCGG GACCGGGGGG ACCTGGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	93.85	0.00e+00	1688.00
IUUC-Apl-003893	Anas platyrhynchos	92.50	0.00e+00	1704.00
IUUC-Aca-004744	Anolis carolinensis	89.13	0.00e+00	1658.00
IUUC-Acl-008273	Aspergillus clavatus	47.67	5.00e-160	558.00
IUUC-Afl-008713	Aspergillus flavus	47.44	2.00e-157	550.00
IUUC-Afu-009103	Aspergillus fumigatus	47.45	3.00e-160	558.00
IUUC-Ani-009259	Aspergillus nidulans	46.98	3.00e-158	552.00
IUUC-Ang-009738	Aspergillus niger	47.73	2.00e-158	553.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	361.00
IUUC-Ate-010529	Aspergillus terreus	47.83	1.00e-160	560.00
IUUC-Ame-010810	Astyanax mexicanus	70.46	0.00e+00	1239.00
IUUC-Bta-012679	Bos taurus	95.65	0.00e+00	1592.00
IUUC-Bci-013785	Botrytis cinerea	46.43	2.00e-152	533.00
IUUC-Cja-018732	Callithrix jacchus	97.49	0.00e+00	1846.00
IUUC-Cfa-021226	Canis familiaris	95.91	0.00e+00	1791.00
IUUC-Cpo-021671	Cavia porcellus	94.48	0.00e+00	1744.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	744.00
IUUC-Csv-026098	Ciona savignyi	57.22	0.00e+00	645.00
IUUC-Dre-027770	Danio rerio	77.15	0.00e+00	1432.00
IUUC-Dno-029466	Dasypus novemcinctus	96.37	0.00e+00	1834.00
IUUC-Dor-030138	Dipodomys ordii	90.55	0.00e+00	1629.00
IUUC-Dse-031241	Dothistroma septosporum	46.17	2.00e-156	546.00
IUUC-Ete-033145	Echinops telfairi	86.95	0.00e+00	1279.00
IUUC-Eca-033445	Equus caballus	96.31	0.00e+00	1585.00
IUUC-Eeu-035247	Erinaceus europaeus	87.23	0.00e+00	1484.00
IUUC-Fca-035489	Felis catus	93.13	0.00e+00	1533.00
IUUC-Fal-037604	Ficedula albicollis	92.80	0.00e+00	1759.00
IUUC-Fox-037774	Fusarium oxysporum	47.19	5.00e-155	541.00
IUUC-Gmo-039674	Gadus morhua	75.60	0.00e+00	1391.00
IUUC-Gga-040703	Gallus gallus	91.74	0.00e+00	1759.00
IUUC-Gac-042020	Gasterosteus aculeatus	78.76	0.00e+00	1430.00
IUUC-Ggo-045332	Gorilla gorilla	95.60	0.00e+00	1741.00
IUUC-Hsa-045968	Homo sapiens	97.89	0.00e+00	1843.00
IUUC-Lch-050443	Latimeria chalumnae	84.86	0.00e+00	1432.00
IUUC-Loc-052662	Lepisosteus oculatus	79.10	0.00e+00	1449.00
IUUC-Laf-053850	Loxodonta africana	94.89	0.00e+00	1783.00
IUUC-Mcc-055821	Macaca mulatta	97.85	0.00e+00	1808.00
IUUC-Meu-056712	Macropus eugenii	79.59	0.00e+00	775.00
IUUC-Mmr-060798	Microcebus murinus	92.76	0.00e+00	1672.00
IUUC-Mdo-062173	Monodelphis domestica	97.28	0.00e+00	1884.00
IUUC-Mmu-064136	Mus musculus	95.47	0.00e+00	1792.00
IUUC-Mpu-066765	Mustela putorius furo	96.42	0.00e+00	1771.00
IUUC-Mlu-067565	Myotis lucifugus	93.42	0.00e+00	1563.00
IUUC-Nfi-068427	Neosartorya fischeri	47.45	2.00e-160	559.00
IUUC-Nle-069070	Nomascus leucogenys	93.96	0.00e+00	1747.00
IUUC-Opr-071044	Ochotona princeps	93.36	0.00e+00	1186.00
IUUC-Ont-072044	Oreochromis niloticus	77.00	0.00e+00	1466.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.93	0.00e+00	1434.00
IUUC-Ocu-074160	Oryctolagus cuniculus	93.26	0.00e+00	1723.00
IUUC-Ola-087467	Oryzias latipes	78.52	0.00e+00	1451.00
IUUC-Oga-088460	Otolemur garnettii	91.40	0.00e+00	1564.00
IUUC-Oar-090198	Ovis aries	95.60	0.00e+00	1754.00
IUUC-Ptr-090939	Pan troglodytes	97.89	0.00e+00	1843.00
IUUC-Pan-092284	Papio anubis	97.99	0.00e+00	1843.00
IUUC-Psi-093645	Pelodiscus sinensis	92.45	0.00e+00	1754.00
IUUC-Pma-094364	Petromyzon marinus	79.62	0.00e+00	851.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.73	4.00e-160	558.00
IUUC-Pab-098088	Pongo abelii	97.45	0.00e+00	1815.00
IUUC-Pca-100714	Procavia capensis	74.46	0.00e+00	1308.00
IUUC-Pva-102354	Pteropus vampyrus	93.91	0.00e+00	1681.00
IUUC-Rno-105318	Rattus norvegicus	94.69	0.00e+00	1746.00
IUUC-Sha-107482	Sarcophilus harrisii	94.77	0.00e+00	1622.00
IUUC-Ssc-115950	Sus scrofa	68.76	0.00e+00	1167.00
IUUC-Tgu-117130	Taeniopygia guttata	92.62	0.00e+00	1739.00
IUUC-Tru-118610	Takifugu rubripes	78.78	0.00e+00	1475.00
IUUC-Tsy-119492	Tarsius syrichta	90.43	0.00e+00	1640.00
IUUC-Tni-120113	Tetraodon nigroviridis	73.52	0.00e+00	1350.00
IUUC-Tbe-127441	Tupaia belangeri	87.20	0.00e+00	782.00
IUUC-Ttr-128235	Tursiops truncatus	85.94	0.00e+00	1503.00
IUUC-Xtr-132859	Xenopus tropicalis	87.77	0.00e+00	1651.00
IUUC-Xma-133797	Xiphophorus maculatus	79.76	0.00e+00	1470.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence