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Tag Content
UUCD2 ID IUUC-Nle-069225
UUCD1 version UUC-NoL-00349
Ensembl Protein ID ENSNLEP00000008096.1
UniProt Accession G1R4H4; G1R4H4_NOMLE
Genbank Protein ID ENSNLEP00000008096
Protein Name Uncharacterized protein
Genbank Nucleotide ID ADFV01035015
Gene Name NEDD4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000006630.2 ENSNLET00000008483.2 ENSNLEP00000008096.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.40e-135 451.2 987 1316
Active Site
Position(s) Description Evidence
1286 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 987  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1073
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1074 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLV 1155
           ***********************************99...6666..7**************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++
   Q: 1156 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRL 1242
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1243 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1316
           *************************************************************************8 PP
   
Organism Nomascus leucogenys
Protein Sequence
(Fasta)
MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHVCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSAYL QSSNVLADSD DASFTCILKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Nle-069225|E3,HECT|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA CCCTTTGTCA 60
GAAACCTCCG GAGATGACTT GGATAGCCAT GTTCATGTGT GCTTCAAAAG ACCAACACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Nle-069225|E3,HECT|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0044111--P:development involved in symbiotic interaction
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0031175--P:neuron projection development
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001201 Ailuropoda melanoleuca 90.93 0.00e+00 2370.00
IUUC-Apl-003886 Anas platyrhynchos 75.14 0.00e+00 1265.00
IUUC-Afl-008713 Aspergillus flavus 47.62 5.00e-157 548.00
IUUC-Afu-009103 Aspergillus fumigatus 48.30 4.00e-159 555.00
IUUC-Ani-009259 Aspergillus nidulans 47.03 2.00e-157 549.00
IUUC-Ame-011138 Astyanax mexicanus 83.54 0.00e+00 851.00
IUUC-Bgr-012148 Blumeria graminis 45.15 4.00e-153 535.00
IUUC-Bta-012453 Bos taurus 89.24 0.00e+00 2305.00
IUUC-Cel-018564 Caenorhabditis elegans 54.05 0.00e+00 629.00
IUUC-Cja-019034 Callithrix jacchus 96.12 0.00e+00 1441.00
IUUC-Cfa-020258 Canis familiaris 91.46 0.00e+00 2303.00
IUUC-Cpo-021648 Cavia porcellus 90.91 0.00e+00 1481.00
IUUC-Csa-023334 Chlorocebus sabaeus 98.51 0.00e+00 1528.00
IUUC-Cho-024672 Choloepus hoffmanni 83.72 0.00e+00 724.00
IUUC-Cin-025157 Ciona intestinalis 55.83 0.00e+00 879.00
IUUC-Csv-026098 Ciona savignyi 68.76 0.00e+00 647.00
IUUC-Dno-029159 Dasypus novemcinctus 90.08 0.00e+00 1333.00
IUUC-Dor-030729 Dipodomys ordii 79.70 0.00e+00 1041.00
IUUC-Dme-032166 Drosophila melanogaster 67.99 0.00e+00 714.00
IUUC-Ete-032409 Echinops telfairi 86.22 0.00e+00 1196.00
IUUC-Eca-033441 Equus caballus 95.27 0.00e+00 1453.00
IUUC-Eeu-034546 Erinaceus europaeus 74.94 0.00e+00 1189.00
IUUC-Fca-036384 Felis catus 91.25 0.00e+00 2354.00
IUUC-Fal-037547 Ficedula albicollis 80.27 0.00e+00 1303.00
IUUC-Fox-037774 Fusarium oxysporum 47.17 8.00e-155 540.00
IUUC-Gmo-039679 Gadus morhua 67.28 0.00e+00 1092.00
IUUC-Gga-040524 Gallus gallus 81.51 0.00e+00 1307.00
IUUC-Gac-042607 Gasterosteus aculeatus 66.83 0.00e+00 1097.00
IUUC-Hsa-046479 Homo sapiens 98.10 0.00e+00 2506.00
IUUC-Itr-048383 Ictidomys tridecemlineatus 83.67 0.00e+00 1224.00
IUUC-Lch-050445 Latimeria chalumnae 60.29 0.00e+00 1465.00
IUUC-Loc-052645 Lepisosteus oculatus 73.28 0.00e+00 1197.00
IUUC-Lma-052980 Leptosphaeria maculans 44.12 2.00e-88 319.00
IUUC-Laf-053638 Loxodonta africana 85.12 0.00e+00 1367.00
IUUC-Mcc-055585 Macaca mulatta 97.73 0.00e+00 2454.00
IUUC-Meu-056897 Macropus eugenii 95.47 9.00e-172 597.00
IUUC-Mla-058996 Melampsora laricipopulina 52.81 3.00e-149 522.00
IUUC-Mga-059362 Meleagris gallopavo 74.63 0.00e+00 1275.00
IUUC-Mvi-060395 Microbotryum violaceum 53.10 1.00e-149 523.00
IUUC-Mmr-061061 Microcebus murinus 92.95 0.00e+00 2387.00
IUUC-Mmu-063318 Mus musculus 80.07 0.00e+00 1278.00
IUUC-Mpu-066567 Mustela putorius furo 94.80 0.00e+00 1543.00
IUUC-Mlu-068148 Myotis lucifugus 88.52 0.00e+00 2276.00
IUUC-Nfi-068427 Neosartorya fischeri 48.30 5.00e-159 555.00
IUUC-Ncr-068918 Neurospora crassa 47.49 4.00e-156 545.00
IUUC-Oan-073019 Ornithorhynchus anatinus 85.47 0.00e+00 1389.00
IUUC-Ocu-074409 Oryctolagus cuniculus 88.72 0.00e+00 2262.00
IUUC-Oga-088241 Otolemur garnettii 87.44 0.00e+00 2157.00
IUUC-Oar-089797 Ovis aries 95.15 0.00e+00 1521.00
IUUC-Ptr-091629 Pan troglodytes 97.59 0.00e+00 1420.00
IUUC-Psi-093618 Pelodiscus sinensis 67.98 0.00e+00 1628.00
IUUC-Pno-095118 Phaeosphaeria nodorum 48.20 7.00e-162 564.00
IUUC-Pfo-097145 Poecilia formosa 67.07 0.00e+00 1066.00
IUUC-Pab-098394 Pongo abelii 98.88 0.00e+00 1546.00
IUUC-Pca-100568 Procavia capensis 78.58 0.00e+00 1154.00
IUUC-Pva-102303 Pteropus vampyrus 89.11 0.00e+00 1082.00
IUUC-Pgr-103620 Puccinia graminis 52.39 2.00e-147 516.00
IUUC-Ptt-103806 Puccinia triticina 51.57 6.00e-121 428.00
IUUC-Pte-104016 Pyrenophora teres 48.21 4.00e-161 561.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 48.21 4.00e-161 561.00
IUUC-Rno-106095 Rattus norvegicus 80.20 0.00e+00 1286.00
IUUC-Sha-107370 Sarcophilus harrisii 67.47 0.00e+00 1754.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 50.18 2.00e-156 546.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 47.16 1.00e-156 546.00
IUUC-Tgu-117474 Taeniopygia guttata 80.89 0.00e+00 1312.00
IUUC-Tru-117675 Takifugu rubripes 65.12 0.00e+00 1067.00
IUUC-Tni-119993 Tetraodon nigroviridis 64.77 0.00e+00 1059.00
IUUC-Tvi-122595 Trichoderma virens 46.30 1.00e-153 537.00
IUUC-Tbe-127408 Tupaia belangeri 86.68 0.00e+00 1170.00
IUUC-Ttr-128437 Tursiops truncatus 85.10 0.00e+00 1197.00
IUUC-Vpa-130503 Vicugna pacos 88.60 0.00e+00 1306.00
Created Date 25-Jun-2017

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