iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118610

UUCD1 version

UUC-TaR-00636

Ensembl Protein ID

ENSTRUP00000030141.1

UniProt Accession

H2TZN2; H2TZN2_TAKRU

Protein Name

Uncharacterized protein

Gene Name

nedd4l

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000011917.1	ENSTRUT00000030256.1	ENSTRUP00000030139.1
ENSTRUG00000011917.1	ENSTRUT00000030257.1	ENSTRUP00000030140.1
ENSTRUG00000011917.1	ENSTRUT00000030258.1	ENSTRUP00000030141.1
ENSTRUG00000011917.1	ENSTRUT00000030259.1	ENSTRUP00000030142.1
ENSTRUG00000011917.1	ENSTRUT00000030260.1	ENSTRUP00000030143.1
ENSTRUG00000011917.1	ENSTRUT00000030261.1	ENSTRUP00000030144.1
ENSTRUG00000011917.1	ENSTRUT00000030262.1	ENSTRUP00000030145.1
ENSTRUG00000011917.1	ENSTRUT00000030263.1	ENSTRUP00000030146.1
ENSTRUG00000011917.1	ENSTRUT00000030264.1	ENSTRUP00000030147.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-134	449.3	651	980

Active Site

Position(s)	Description	Evidence
950	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 651  ILKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVFHGKLLDGFF 739
           6899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++lgk++sl+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++e+++g+t++++Lkp+G+++ VtneNk+eY++lv+++r
   Q: 740  IRPFYKMMLGKQISLKDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNENKNEYIDLVIQWR 823
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af eGf+e+i ++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+v+  +++e+r ++LqFvTg
   Q: 824  FVNRVQKQMNAFLEGFTELILIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKVVLLMDAEKRIRLLQFVTG 912
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP+Y+s e l+ekLl+A+e+++gFe
   Q: 913  TSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPTYESFEDLREKLLMAVENAQGFE 980
           *******************************************************************8 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

FMAATYEPIY GLSEDEHETR VLRVKVIAGI DLAKKDIIGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFFF RVCPQNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCACGGCAG AGAAAGGAAA GTGGGACTTT ATTGTTCAAG GCTAGCTCGC TAGCTTTGCC 60
AACTGGCTTG TTTTTGTGTG CAAAGTGTGG ACCACAGGCT TTATGGCTGC GACGTACGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	78.83	0.00e+00	1400.00
IUUC-Apl-003893	Anas platyrhynchos	80.08	0.00e+00	1444.00
IUUC-Aca-004744	Anolis carolinensis	77.00	0.00e+00	1394.00
IUUC-Ago-007742	Ashbya gossypii	48.82	8.00e-159	554.00
IUUC-Acl-008273	Aspergillus clavatus	49.67	1.00e-161	563.00
IUUC-Afl-008713	Aspergillus flavus	49.67	3.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.83	2.00e-162	565.00
IUUC-Ani-009259	Aspergillus nidulans	48.85	3.00e-161	561.00
IUUC-Ang-009738	Aspergillus niger	54.32	1.00e-152	533.00
IUUC-Aor-010053	Aspergillus oryzae	57.72	1.00e-100	359.00
IUUC-Ate-010529	Aspergillus terreus	49.67	2.00e-162	566.00
IUUC-Ame-010810	Astyanax mexicanus	90.35	0.00e+00	1076.00
IUUC-Bta-012679	Bos taurus	79.17	0.00e+00	1302.00
IUUC-Bci-013785	Botrytis cinerea	48.07	1.00e-154	540.00
IUUC-Cja-018732	Callithrix jacchus	80.22	0.00e+00	1491.00
IUUC-Cfa-021226	Canis familiaris	80.41	0.00e+00	1474.00
IUUC-Cpo-021671	Cavia porcellus	79.38	0.00e+00	1441.00
IUUC-Csa-023344	Chlorocebus sabaeus	78.68	0.00e+00	1472.00
IUUC-Cho-024832	Choloepus hoffmanni	94.32	0.00e+00	712.00
IUUC-Dre-027770	Danio rerio	84.68	0.00e+00	1541.00
IUUC-Dno-029466	Dasypus novemcinctus	80.53	0.00e+00	1489.00
IUUC-Dor-030138	Dipodomys ordii	76.37	0.00e+00	1352.00
IUUC-Ete-033145	Echinops telfairi	73.25	0.00e+00	1056.00
IUUC-Eca-033445	Equus caballus	79.39	0.00e+00	1294.00
IUUC-Eeu-035247	Erinaceus europaeus	77.89	0.00e+00	1170.00
IUUC-Fca-035489	Felis catus	76.96	0.00e+00	1242.00
IUUC-Fal-037604	Ficedula albicollis	77.73	0.00e+00	1465.00
IUUC-Fox-037774	Fusarium oxysporum	47.67	7.00e-154	537.00
IUUC-Fso-038393	Fusarium solani	46.82	2.00e-152	532.00
IUUC-Gmo-039674	Gadus morhua	86.50	0.00e+00	1580.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.66	1.00e-153	537.00
IUUC-Gga-040703	Gallus gallus	79.98	0.00e+00	1496.00
IUUC-Gac-042020	Gasterosteus aculeatus	92.06	0.00e+00	1671.00
IUUC-Ggo-045332	Gorilla gorilla	79.14	0.00e+00	1418.00
IUUC-Hsa-045968	Homo sapiens	80.22	0.00e+00	1485.00
IUUC-Lch-050443	Latimeria chalumnae	80.16	0.00e+00	1315.00
IUUC-Loc-052662	Lepisosteus oculatus	83.43	0.00e+00	1503.00
IUUC-Laf-053850	Loxodonta africana	79.28	0.00e+00	1457.00
IUUC-Mcc-055821	Macaca mulatta	80.00	0.00e+00	1462.00
IUUC-Meu-056712	Macropus eugenii	62.20	3.00e-163	569.00
IUUC-Mor-057097	Magnaporthe oryzae	44.53	2.00e-156	546.00
IUUC-Mpo-057442	Magnaporthe poae	51.32	1.00e-144	507.00
IUUC-Mvi-060395	Microbotryum violaceum	54.53	1.00e-151	530.00
IUUC-Mmr-060798	Microcebus murinus	76.77	0.00e+00	1370.00
IUUC-Mdo-062173	Monodelphis domestica	78.80	0.00e+00	1491.00
IUUC-Mmu-064136	Mus musculus	79.71	0.00e+00	1469.00
IUUC-Mpu-066765	Mustela putorius furo	80.41	0.00e+00	1456.00
IUUC-Mlu-067565	Myotis lucifugus	78.92	0.00e+00	1300.00
IUUC-Nfi-068427	Neosartorya fischeri	50.00	2.00e-162	565.00
IUUC-Ncr-068918	Neurospora crassa	47.91	5.00e-153	535.00
IUUC-Nle-069070	Nomascus leucogenys	77.39	0.00e+00	1422.00
IUUC-Opr-071044	Ochotona princeps	83.98	0.00e+00	1075.00
IUUC-Ont-072044	Oreochromis niloticus	89.54	0.00e+00	1722.00
IUUC-Oan-073032	Ornithorhynchus anatinus	75.41	0.00e+00	1180.00
IUUC-Ocu-074160	Oryctolagus cuniculus	78.99	0.00e+00	1437.00
IUUC-Ola-087467	Oryzias latipes	91.38	0.00e+00	1670.00
IUUC-Oga-088460	Otolemur garnettii	77.89	0.00e+00	1285.00
IUUC-Oar-090198	Ovis aries	80.10	0.00e+00	1451.00
IUUC-Ptr-090939	Pan troglodytes	80.22	0.00e+00	1485.00
IUUC-Pan-092284	Papio anubis	80.33	0.00e+00	1486.00
IUUC-Psi-093645	Pelodiscus sinensis	79.88	0.00e+00	1493.00
IUUC-Pma-094364	Petromyzon marinus	82.44	0.00e+00	837.00
IUUC-Pfo-096768	Poecilia formosa	97.42	0.00e+00	1009.00
IUUC-Pab-098088	Pongo abelii	80.23	0.00e+00	1472.00
IUUC-Pca-100714	Procavia capensis	70.22	0.00e+00	966.00
IUUC-Pva-102354	Pteropus vampyrus	78.75	0.00e+00	1398.00
IUUC-Pgr-103620	Puccinia graminis	53.32	1.00e-147	516.00
IUUC-Ptt-103806	Puccinia triticina	53.86	3.00e-124	439.00
IUUC-Rno-105318	Rattus norvegicus	79.07	0.00e+00	1436.00
IUUC-Sha-107482	Sarcophilus harrisii	79.22	0.00e+00	1340.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.24	7.00e-155	541.00
IUUC-Ssc-115950	Sus scrofa	63.38	0.00e+00	1040.00
IUUC-Tgu-117130	Taeniopygia guttata	79.94	0.00e+00	1478.00
IUUC-Tsy-119492	Tarsius syrichta	75.87	0.00e+00	1327.00
IUUC-Tni-120113	Tetraodon nigroviridis	90.27	0.00e+00	1637.00
IUUC-Tvi-122595	Trichoderma virens	47.10	9.00e-153	534.00
IUUC-Ttr-128235	Tursiops truncatus	90.39	0.00e+00	988.00
IUUC-Uma-129332	Ustilago maydis	52.48	8.00e-141	494.00
IUUC-Xtr-132859	Xenopus tropicalis	79.30	0.00e+00	1463.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence