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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064358
UUCD1 version UUC-MuM-00832
Ensembl Protein ID ENSMUSP00000031072.7
UniProt Accession Q91W96; Q99LR5; Q9CZZ0; APC4_MOUSE
Genbank Protein ID AAH02259.1; AAH16237.1; AAH24870.1; BAB27965.1
Protein Name Anaphase-promoting complex subunit 4; Cyclosome subunit 4
Genbank Nucleotide ID BC002259; BC016237; BC024870; AK011994
Gene Name Anapc4; D5Ertd249e
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029176.13 ENSMUST00000031072.13 ENSMUSP00000031072.7
ENSMUSG00000029176.13 ENSMUST00000144574.7 ENSMUSP00000114475.1
ENSMUSG00000029176.13 ENSMUST00000198207.4 ENSMUSP00000143055.1
ENSMUSG00000029176.13 ENSMUST00000150682.2 ENSMUSP00000143745.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 93.44 0.00e+00 1476.00 IUUC-Hsa-046958
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MLRFPTCFPS FRVVGEKQLP QEIIFLAWSP KRDLIALANT TGEVLLHRLA SFHRVWSFPP 60
NESTGKEVTC LAWRPDGKLL AFALADTKKI ILCDVEKPES LHSFSVEAPV SCMHWTEVTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064358|E3,APC_C|Mus musculus
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Nucleotide Sequence
(Fasta)
TGCGCTCTCC CCGCCCCACC GGCGCGCGGC TGCTGTGCCA CTCACTTCCT CTCGCGAAGA 60
CGTCCCGGCG TCGGCGCCGG AAGCTTTCTC CGAGCGCGGA GGGCGGAGTG AGAGGGCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064358|E3,APC_C|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR024789--APC4
IPR024790--APC4_long_dom
IPR017169--APC4_metazoa
IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
Pfam

PF12896--ANAPC4
PF12894--ANAPC4_WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005634--C:nucleus
GO:0019903--F:protein phosphatase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG mmu:52206
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002338 Ailuropoda melanoleuca 91.85 0.00e+00 1472.00
IUUC-Atr-003115 Amborella trichopoda 24.85 2.00e-34 140.00
IUUC-Apl-003682 Anas platyrhynchos 76.07 0.00e+00 1089.00
IUUC-Aca-005052 Anolis carolinensis 77.03 0.00e+00 1168.00
IUUC-Ath-007407 Arabidopsis thaliana 24.34 9.00e-37 148.00
IUUC-Acl-008322 Aspergillus clavatus 36.78 4.00e-04 40.40
IUUC-Afl-008731 Aspergillus flavus 21.13 5.00e-10 60.10
IUUC-Afu-008986 Aspergillus fumigatus 22.41 2.00e-05 45.10
IUUC-Ani-009236 Aspergillus nidulans 22.39 1.00e-06 48.90
IUUC-Ate-010504 Aspergillus terreus 22.22 4.00e-11 63.50
IUUC-Ame-011676 Astyanax mexicanus 66.04 0.00e+00 964.00
IUUC-Bgr-012272 Blumeria graminis 20.89 2.00e-08 54.70
IUUC-Bta-013421 Bos taurus 91.71 0.00e+00 1473.00
IUUC-Bdi-014507 Brachypodium distachyon 24.23 7.00e-33 135.00
IUUC-Bol-015675 Brassica oleracea 24.17 2.00e-34 140.00
IUUC-Bra-017735 Brassica rapa 23.78 8.00e-35 142.00
IUUC-Cja-019695 Callithrix jacchus 92.25 0.00e+00 1469.00
IUUC-Cfa-020688 Canis familiaris 92.33 0.00e+00 1481.00
IUUC-Cpo-022263 Cavia porcellus 90.88 0.00e+00 1466.00
IUUC-Csa-023068 Chlorocebus sabaeus 93.69 0.00e+00 1512.00
IUUC-Cho-024289 Choloepus hoffmanni 87.16 1.00e-171 597.00
IUUC-Cin-025329 Ciona intestinalis 28.49 3.00e-53 202.00
IUUC-Dre-028148 Danio rerio 65.46 0.00e+00 922.00
IUUC-Dno-028901 Dasypus novemcinctus 90.08 0.00e+00 889.00
IUUC-Dor-030642 Dipodomys ordii 78.07 0.00e+00 1180.00
IUUC-Dse-031568 Dothistroma septosporum 21.64 1.00e-05 45.40
IUUC-Ete-032229 Echinops telfairi 65.60 2.00e-148 520.00
IUUC-Eca-033983 Equus caballus 92.44 0.00e+00 1500.00
IUUC-Eeu-035203 Erinaceus europaeus 85.89 0.00e+00 1357.00
IUUC-Fca-036269 Felis catus 92.06 0.00e+00 1481.00
IUUC-Fal-036650 Ficedula albicollis 78.92 0.00e+00 1198.00
IUUC-Fso-038390 Fusarium solani 20.60 2.00e-10 60.80
IUUC-Gmo-039161 Gadus morhua 67.52 0.00e+00 967.00
IUUC-Gga-041031 Gallus gallus 78.39 2.00e-88 318.00
IUUC-Gac-042424 Gasterosteus aculeatus 66.67 0.00e+00 976.00
IUUC-Gma-043402 Glycine max 25.64 4.00e-39 156.00
IUUC-Ggo-045199 Gorilla gorilla 83.12 0.00e+00 1219.00
IUUC-Hsa-046958 Homo sapiens 92.82 0.00e+00 1481.00
IUUC-Itr-049044 Ictidomys tridecemlineatus 93.19 0.00e+00 1501.00
IUUC-Kpa-049219 Komagataella pastoris 23.95 1.00e-07 51.60
IUUC-Lpe-050838 Leersia perrieri 24.24 5.00e-37 149.00
IUUC-Loc-052502 Lepisosteus oculatus 68.83 0.00e+00 990.00
IUUC-Laf-054361 Loxodonta africana 91.71 0.00e+00 1486.00
IUUC-Mcc-054893 Macaca mulatta 93.43 0.00e+00 1503.00
IUUC-Mor-056950 Magnaporthe oryzae 21.46 6.00e-14 73.20
IUUC-Mpo-057479 Magnaporthe poae 20.09 5.00e-07 50.10
IUUC-Mtr-058751 Medicago truncatula 24.31 5.00e-37 149.00
IUUC-Mga-059591 Meleagris gallopavo 76.21 0.00e+00 1076.00
IUUC-Mvi-060263 Microbotryum violaceum 23.27 3.00e-03 37.70
IUUC-Mmr-060603 Microcebus murinus 92.95 0.00e+00 1495.00
IUUC-Mdo-062137 Monodelphis domestica 80.35 0.00e+00 1207.00
IUUC-Mac-064679 Musa acuminata 24.49 1.00e-20 94.40
IUUC-Mpu-065751 Mustela putorius furo 92.94 0.00e+00 1501.00
IUUC-Mlu-067502 Myotis lucifugus 91.16 0.00e+00 1423.00
IUUC-Nfi-068257 Neosartorya fischeri 19.72 7.00e-10 59.70
IUUC-Ncr-068721 Neurospora crassa 20.73 6.00e-06 46.60
IUUC-Nle-069134 Nomascus leucogenys 93.56 0.00e+00 1507.00
IUUC-Opr-071225 Ochotona princeps 83.46 0.00e+00 1303.00
IUUC-Ont-072232 Oreochromis niloticus 67.60 0.00e+00 983.00
IUUC-Oan-073358 Ornithorhynchus anatinus 78.95 0.00e+00 1190.00
IUUC-Oba-075232 Oryza barthii 23.45 4.00e-34 139.00
IUUC-Oin-079188 Oryza indica 23.33 6.00e-30 125.00
IUUC-Opu-083725 Oryza punctata 24.12 2.00e-36 147.00
IUUC-Osa-086145 Oryza sativa 30.58 7.00e-13 66.20
IUUC-Ola-086672 Oryzias latipes 65.64 0.00e+00 939.00
IUUC-Oga-088691 Otolemur garnettii 92.95 0.00e+00 1470.00
IUUC-Oar-089607 Ovis aries 93.23 0.00e+00 1442.00
IUUC-Ptr-090893 Pan troglodytes 92.82 0.00e+00 1482.00
IUUC-Pan-092793 Papio anubis 93.56 0.00e+00 1503.00
IUUC-Psi-093143 Pelodiscus sinensis 77.33 0.00e+00 1151.00
IUUC-Pma-094645 Petromyzon marinus 56.25 2.00e-153 536.00
IUUC-Pno-094772 Phaeosphaeria nodorum 18.89 7.00e-04 39.30
IUUC-Ppa-095509 Physcomitrella patens 25.38 1.00e-28 122.00
IUUC-Pfo-096716 Poecilia formosa 64.96 0.00e+00 923.00
IUUC-Pab-098772 Pongo abelii 95.58 0.00e+00 1228.00
IUUC-Pop-099247 Populus trichocarpa 25.81 3.00e-39 157.00
IUUC-Pca-101083 Procavia capensis 87.68 0.00e+00 1120.00
IUUC-Ppe-101619 Prunus persica 24.64 2.00e-22 101.00
IUUC-Pva-103168 Pteropus vampyrus 91.30 0.00e+00 1345.00
IUUC-Rno-105693 Rattus norvegicus 97.40 0.00e+00 1527.00
IUUC-Sha-106567 Sarcophilus harrisii 79.81 0.00e+00 1189.00
IUUC-Sja-107773 Schizosaccharomyces japonicus 21.68 4.00e-10 60.10
IUUC-Spo-108176 Schizosaccharomyces pombe 22.71 1.00e-05 45.40
IUUC-Ssl-108414 Sclerotinia sclerotiorum 32.79 4.00e-10 60.50
IUUC-Smo-108903 Selaginella moellendorffii 31.33 3.00e-10 59.70
IUUC-Sit-110467 Setaria italica 23.09 5.00e-30 126.00
IUUC-Sly-111734 Solanum lycopersicum 26.62 1.00e-38 154.00
IUUC-Sar-112993 Sorex araneus 73.53 0.00e+00 844.00
IUUC-Sbi-114693 Sorghum bicolor 24.11 3.00e-36 147.00
IUUC-Ssc-115237 Sus scrofa 92.19 0.00e+00 1461.00
IUUC-Tgu-116897 Taeniopygia guttata 78.55 0.00e+00 1199.00
IUUC-Tru-117802 Takifugu rubripes 63.82 0.00e+00 914.00
IUUC-Tsy-119583 Tarsius syrichta 88.63 0.00e+00 1335.00
IUUC-Tni-120268 Tetraodon nigroviridis 77.30 4.00e-135 474.00
IUUC-Tca-121296 Theobroma cacao 25.68 4.00e-37 149.00
IUUC-Tae-123786 Triticum aestivum 24.28 1.00e-33 138.00
IUUC-Tbe-127711 Tupaia belangeri 85.36 0.00e+00 1232.00
IUUC-Ttr-128537 Tursiops truncatus 89.60 0.00e+00 1419.00
IUUC-Uma-129395 Ustilago maydis 22.26 7.00e-03 36.60
IUUC-Vpa-130111 Vicugna pacos 78.69 0.00e+00 1168.00
IUUC-Vvi-131490 Vitis vinifera 25.11 2.00e-39 157.00
IUUC-Xtr-132380 Xenopus tropicalis 69.07 0.00e+00 1059.00
IUUC-Xma-133597 Xiphophorus maculatus 64.82 0.00e+00 921.00
IUUC-Yli-134609 Yarrowia lipolytica 22.11 2.00e-14 74.30
Created Date 25-Jun-2017

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