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Tag Content
UUCD2 ID IUUC-Ocu-074180
UUCD1 version UUC-OrC-00102
Ensembl Protein ID ENSOCUP00000012982.2
UniProt Accession G1T8R1; G1T8R1_RABIT
Genbank Protein ID ENSOCUP00000012982
Protein Name Platelet-activating factor acetylhydrolase IB subunit alpha; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH alpha
Genbank Nucleotide ID AAGW02049715
Gene Name RAP1GAP2; LIS1; PAFAH1B1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000000200.3 ENSOCUT00000000201.3 ENSOCUP00000000178.3
ENSOCUG00000000200.3 ENSOCUT00000026623.2 ENSOCUP00000024032.2
ENSOCUG00000000200.3 ENSOCUT00000015103.3 ENSOCUP00000012982.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-59 195.7 336 374
UBD/Beta-Prp 4.90e-95 318.2 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH ++v+++ f s+ ++++s++dD+t++vWD++  ++ k
   Q: 336  GHDNWVRGVLFhSGgKFILSCADDKTLRVWDYKNKRCMK 374
           8**********9888****************99998876 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd++++ 
   Q: 283  SWAPESsyssiseatgsetkksgkpgPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372  CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           *****************.99*****************985 PP
   
Organism Oryctolagus cuniculus
Functional Description
(View)

Functional Description


     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
 Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074180|E3,WD_repeat;UBD,Beta-Prp|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGAATGAA CCTTACTTGT TGAATATCTC CTGATTACTG GTTGGATTCA CTTGTAAAAG 60
AATCATTTTC TCCTGTGTGG AAGCCACTTG GTGGCATATT TAATTACAAA TCCAGGGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074180|E3,WD_repeat;UBD,Beta-Prp|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0031965--C:nuclear membrane
GO:0005819--C:spindle
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0016042--P:lipid catabolic process
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport
KEGG ocu:100354130
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 99.75 0.00e+00 834.00
IUUC-Atr-002439 Amborella trichopoda 29.81 2.00e-44 172.00
IUUC-Apl-004024 Anas platyrhynchos 99.02 0.00e+00 851.00
IUUC-Aca-004564 Anolis carolinensis 98.78 0.00e+00 845.00
IUUC-Ath-007308 Arabidopsis thaliana 30.13 2.00e-40 159.00
IUUC-Ago-007862 Ashbya gossypii 27.46 5.00e-39 155.00
IUUC-Acl-008360 Aspergillus clavatus 46.53 9.00e-105 373.00
IUUC-Afl-008502 Aspergillus flavus 45.69 2.00e-94 339.00
IUUC-Afu-008848 Aspergillus fumigatus 47.19 2.00e-106 379.00
IUUC-Ani-009173 Aspergillus nidulans 42.54 1.00e-90 326.00
IUUC-Ang-009873 Aspergillus niger 44.56 2.00e-94 339.00
IUUC-Aor-009973 Aspergillus oryzae 43.94 3.00e-92 332.00
IUUC-Ate-010523 Aspergillus terreus 41.81 2.00e-90 326.00
IUUC-Ame-010969 Astyanax mexicanus 94.63 0.00e+00 821.00
IUUC-Bgr-011972 Blumeria graminis 47.49 2.00e-105 375.00
IUUC-Bta-013106 Bos taurus 99.76 0.00e+00 856.00
IUUC-Bci-013615 Botrytis cinerea 44.58 1.00e-98 353.00
IUUC-Bdi-014263 Brachypodium distachyon 30.94 9.00e-43 167.00
IUUC-Bol-015900 Brassica oleracea 29.07 3.00e-40 158.00
IUUC-Bra-017143 Brassica rapa 28.43 8.00e-40 157.00
IUUC-Cel-018459 Caenorhabditis elegans 57.66 6.00e-149 520.00
IUUC-Cja-018755 Callithrix jacchus 97.32 0.00e+00 836.00
IUUC-Cfa-020749 Canis familiaris 99.76 0.00e+00 856.00
IUUC-Cpo-022371 Cavia porcellus 99.76 0.00e+00 856.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 35.44 4.00e-50 191.00
IUUC-Csa-023524 Chlorocebus sabaeus 99.13 0.00e+00 720.00
IUUC-Cho-024764 Choloepus hoffmanni 89.22 0.00e+00 679.00
IUUC-Cin-025753 Ciona intestinalis 70.80 2.00e-180 625.00
IUUC-Csv-025817 Ciona savignyi 69.27 0.00e+00 634.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 46.81 7.00e-98 350.00
IUUC-Cne-027087 Cryptococcus neoformans 50.39 3.00e-110 391.00
IUUC-Cme-027119 Cyanidioschyzon merolae 26.65 4.00e-32 132.00
IUUC-Dre-028314 Danio rerio 93.66 0.00e+00 816.00
IUUC-Dno-029050 Dasypus novemcinctus 100.00 0.00e+00 857.00
IUUC-Dor-030222 Dipodomys ordii 91.71 0.00e+00 773.00
IUUC-Dse-031164 Dothistroma septosporum 43.58 7.00e-102 364.00
IUUC-Dme-031745 Drosophila melanogaster 69.83 7.00e-172 596.00
IUUC-Ete-032508 Echinops telfairi 82.44 0.00e+00 685.00
IUUC-Eca-034288 Equus caballus 99.25 0.00e+00 830.00
IUUC-Eeu-034984 Erinaceus europaeus 91.46 0.00e+00 769.00
IUUC-Fca-036498 Felis catus 99.76 0.00e+00 856.00
IUUC-Fal-036920 Ficedula albicollis 99.02 0.00e+00 851.00
IUUC-Fox-037996 Fusarium oxysporum 46.41 9.00e-105 373.00
IUUC-Fso-038160 Fusarium solani 44.10 2.00e-99 356.00
IUUC-Gmo-038983 Gadus morhua 93.66 0.00e+00 810.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.11 2.00e-98 352.00
IUUC-Gga-040623 Gallus gallus 99.02 0.00e+00 851.00
IUUC-Gac-041613 Gasterosteus aculeatus 92.68 0.00e+00 807.00
IUUC-Gma-043987 Glycine max 29.15 1.00e-40 159.00
IUUC-Ggo-045410 Gorilla gorilla 88.97 0.00e+00 725.00
IUUC-Hsa-046358 Homo sapiens 99.51 0.00e+00 854.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 99.76 0.00e+00 856.00
IUUC-Kpa-049351 Komagataella pastoris 29.37 2.00e-43 170.00
IUUC-Lch-049936 Latimeria chalumnae 96.59 0.00e+00 832.00
IUUC-Lpe-051082 Leersia perrieri 31.96 2.00e-44 172.00
IUUC-Loc-052476 Lepisosteus oculatus 95.74 0.00e+00 804.00
IUUC-Lma-053170 Leptosphaeria maculans 46.67 3.00e-101 362.00
IUUC-Laf-053713 Loxodonta africana 97.80 0.00e+00 836.00
IUUC-Mcc-054628 Macaca mulatta 99.27 0.00e+00 853.00
IUUC-Meu-055927 Macropus eugenii 85.92 4.00e-140 490.00
IUUC-Mor-056962 Magnaporthe oryzae 45.08 2.00e-98 352.00
IUUC-Mpo-057583 Magnaporthe poae 45.05 2.00e-94 339.00
IUUC-Mtr-057951 Medicago truncatula 29.25 5.00e-39 154.00
IUUC-Mla-058819 Melampsora laricipopulina 48.31 6.00e-119 421.00
IUUC-Mga-059945 Meleagris gallopavo 98.78 0.00e+00 850.00
IUUC-Mvi-060403 Microbotryum violaceum 50.11 5.00e-129 454.00
IUUC-Mmr-061289 Microcebus murinus 99.75 0.00e+00 834.00
IUUC-Mdo-061912 Monodelphis domestica 99.02 0.00e+00 849.00
IUUC-Mmu-063253 Mus musculus 99.76 0.00e+00 856.00
IUUC-Mac-065310 Musa acuminata 31.83 7.00e-44 171.00
IUUC-Mpu-066638 Mustela putorius furo 99.76 0.00e+00 856.00
IUUC-Mlu-067267 Myotis lucifugus 98.04 0.00e+00 838.00
IUUC-Nfi-068571 Neosartorya fischeri 45.57 7.00e-99 353.00
IUUC-Ncr-068895 Neurospora crassa 48.41 7.00e-106 377.00
IUUC-Nle-069087 Nomascus leucogenys 99.40 0.00e+00 697.00
IUUC-Opr-070579 Ochotona princeps 100.00 0.00e+00 857.00
IUUC-Ont-072432 Oreochromis niloticus 94.39 0.00e+00 821.00
IUUC-Oan-073072 Ornithorhynchus anatinus 99.76 0.00e+00 856.00
IUUC-Ogl-077251 Oryza glaberrima 30.25 3.00e-42 165.00
IUUC-Ogu-078882 Oryza glumaepatula 28.06 4.00e-36 145.00
IUUC-Oin-079601 Oryza indica 29.71 1.00e-38 153.00
IUUC-Olo-080976 Oryza longistaminata 31.11 5.00e-37 147.00
IUUC-Ome-081430 Oryza meridionalis 30.43 2.00e-42 166.00
IUUC-Opu-083880 Oryza punctata 30.75 4.00e-43 168.00
IUUC-Osa-085706 Oryza sativa 30.25 3.00e-42 165.00
IUUC-Ola-086772 Oryzias latipes 93.90 0.00e+00 812.00
IUUC-Oga-088219 Otolemur garnettii 97.56 0.00e+00 836.00
IUUC-Oar-090394 Ovis aries 99.76 0.00e+00 856.00
IUUC-Ptr-091517 Pan troglodytes 99.76 0.00e+00 856.00
IUUC-Pan-092421 Papio anubis 99.27 0.00e+00 853.00
IUUC-Psi-093370 Pelodiscus sinensis 99.27 0.00e+00 852.00
IUUC-Pma-094319 Petromyzon marinus 89.11 0.00e+00 643.00
IUUC-Pno-094815 Phaeosphaeria nodorum 47.26 8.00e-105 374.00
IUUC-Ppa-095367 Physcomitrella patens 31.53 2.00e-49 188.00
IUUC-Pfo-097089 Poecilia formosa 93.41 0.00e+00 813.00
IUUC-Pab-098421 Pongo abelii 99.76 0.00e+00 856.00
IUUC-Pop-099778 Populus trichocarpa 28.88 7.00e-40 157.00
IUUC-Pca-100120 Procavia capensis 72.77 5.00e-164 570.00
IUUC-Ppe-101341 Prunus persica 29.55 5.00e-42 164.00
IUUC-Pva-102960 Pteropus vampyrus 99.51 0.00e+00 852.00
IUUC-Pgr-103538 Puccinia graminis 47.43 2.00e-118 419.00
IUUC-Ptt-103990 Puccinia triticina 42.46 1.00e-44 174.00
IUUC-Pte-104261 Pyrenophora teres 47.49 9.00e-105 373.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.73 4.00e-105 375.00
IUUC-Rno-105123 Rattus norvegicus 99.76 0.00e+00 856.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.51 1.00e-36 147.00
IUUC-Sha-107010 Sarcophilus harrisii 98.78 0.00e+00 848.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.34 1.00e-64 239.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 44.71 3.00e-99 355.00
IUUC-Smo-109155 Selaginella moellendorffii 31.09 2.00e-45 176.00
IUUC-Sit-110688 Setaria italica 32.06 2.00e-44 172.00
IUUC-Sly-110891 Solanum lycopersicum 29.97 3.00e-43 168.00
IUUC-Stu-112365 Solanum tuberosum 30.28 2.00e-43 169.00
IUUC-Sar-113309 Sorex araneus 99.00 0.00e+00 825.00
IUUC-Sbi-114284 Sorghum bicolor 32.06 4.00e-44 171.00
IUUC-Sre-115003 Sporisorium reilianum 50.00 1.00e-125 442.00
IUUC-Ssc-116148 Sus scrofa 99.76 0.00e+00 856.00
IUUC-Tgu-117299 Taeniopygia guttata 98.78 0.00e+00 848.00
IUUC-Tru-118179 Takifugu rubripes 91.95 0.00e+00 807.00
IUUC-Tsy-119493 Tarsius syrichta 98.29 0.00e+00 839.00
IUUC-Tni-120355 Tetraodon nigroviridis 92.93 0.00e+00 781.00
IUUC-Tre-121977 Trichoderma reesei 43.22 3.00e-101 362.00
IUUC-Tvi-122661 Trichoderma virens 43.66 5.00e-100 357.00
IUUC-Tae-125819 Triticum aestivum 32.06 7.00e-45 174.00
IUUC-Tme-127031 Tuber melanosporum 48.39 7.00e-104 370.00
IUUC-Tbe-127492 Tupaia belangeri 82.69 1.00e-115 409.00
IUUC-Ttr-128929 Tursiops truncatus 99.51 0.00e+00 853.00
IUUC-Uma-129347 Ustilago maydis 47.72 3.00e-122 431.00
IUUC-Vda-129837 Verticillium dahliae 45.43 1.00e-99 356.00
IUUC-Vpa-130532 Vicugna pacos 85.49 0.00e+00 665.00
IUUC-Vvi-131269 Vitis vinifera 30.15 1.00e-41 163.00
IUUC-Xtr-131985 Xenopus tropicalis 97.80 0.00e+00 843.00
IUUC-Xma-133314 Xiphophorus maculatus 93.90 0.00e+00 815.00
IUUC-Yli-134403 Yarrowia lipolytica 38.12 9.00e-74 270.00
IUUC-Zma-135765 Zea mays 31.43 5.00e-43 167.00
Created Date 25-Jun-2017

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