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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063952
Ensembl Protein ID ENSMUSP00000026900.7
UniProt Accession Q99LI8; Q61691; Q8BQW3; HGS_MOUSE
Genbank Protein ID BAA08768.1; BAC32676.1; AAH03239.1
Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate
Genbank Nucleotide ID D50050; AK046299; BC003239
Gene Name Hgs; Hrs
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025793.15 ENSMUST00000140862.6 ENSMUSP00000119396.1
ENSMUSG00000025793.15 ENSMUST00000106205.7 ENSMUSP00000101811.1
ENSMUSG00000025793.15 ENSMUST00000106203.7 ENSMUSP00000101809.1
ENSMUSG00000025793.15 ENSMUST00000135231.1 ENSMUSP00000115037.1
ENSMUSG00000025793.15 ENSMUST00000026900.13 ENSMUSP00000026900.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 11988743; 12230472; 12551915
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 4.90e-51 173.3 15 143
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel+ellk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
 Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Protein Sequence
(Fasta)
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063952|UBD,UIM;UBD,VHS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCAGAAAA AGAAAGGCGG AAGCGGAAGT TGGGGGGCGC GTCAGCTCCG AAAGAGGGAG 60
CGACTGCAGC GTCGGTCCGG AGTGGGGTCG CCATGGGGCG AGGCAGCGGC ACCTTCGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063952|UBD,UIM;UBD,VHS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS
SMART

SM00064--FYVE
SM00288--VHS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005764--C:lysosome
GO:0032585--C:multivesicular body membrane
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0043130--F:ubiquitin binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity
KEGG mmu:15239
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001518 Ailuropoda melanoleuca 87.24 0.00e+00 1008.00
IUUC-Apl-003662 Anas platyrhynchos 81.07 0.00e+00 990.00
IUUC-Aca-004940 Anolis carolinensis 83.83 0.00e+00 1150.00
IUUC-Ago-007931 Ashbya gossypii 30.33 5.00e-27 115.00
IUUC-Acl-008274 Aspergillus clavatus 31.41 1.00e-39 158.00
IUUC-Afl-008521 Aspergillus flavus 34.66 2.00e-41 164.00
IUUC-Afu-008774 Aspergillus fumigatus 32.59 1.00e-40 161.00
IUUC-Ani-009445 Aspergillus nidulans 32.96 2.00e-41 164.00
IUUC-Ang-009863 Aspergillus niger 33.21 2.00e-42 167.00
IUUC-Ate-010444 Aspergillus terreus 35.56 1.00e-42 167.00
IUUC-Ame-011111 Astyanax mexicanus 78.60 0.00e+00 954.00
IUUC-Bgr-012087 Blumeria graminis 33.93 2.00e-43 171.00
IUUC-Bta-012506 Bos taurus 91.35 0.00e+00 1168.00
IUUC-Bci-013782 Botrytis cinerea 31.16 3.00e-42 166.00
IUUC-Cel-018493 Caenorhabditis elegans 52.61 4.00e-68 253.00
IUUC-Cja-019998 Callithrix jacchus 90.23 0.00e+00 1109.00
IUUC-Cfa-020615 Canis familiaris 88.49 0.00e+00 1083.00
IUUC-Cpo-022019 Cavia porcellus 92.82 0.00e+00 1248.00
IUUC-Csa-023596 Chlorocebus sabaeus 92.02 0.00e+00 1113.00
IUUC-Cin-025488 Ciona intestinalis 47.76 3.00e-128 452.00
IUUC-Csv-025802 Ciona savignyi 50.18 3.00e-115 409.00
IUUC-Cgl-026560 Colletotrichum gloeosporioides 35.42 9.00e-41 161.00
IUUC-Cne-026847 Cryptococcus neoformans 35.09 4.00e-38 153.00
IUUC-Dre-028353 Danio rerio 76.41 0.00e+00 928.00
IUUC-Dno-029005 Dasypus novemcinctus 87.11 0.00e+00 1153.00
IUUC-Dor-030280 Dipodomys ordii 92.02 0.00e+00 1181.00
IUUC-Dse-031238 Dothistroma septosporum 38.71 5.00e-43 169.00
IUUC-Dme-031952 Drosophila melanogaster 47.65 9.00e-79 288.00
IUUC-Ete-032235 Echinops telfairi 97.27 2.00e-133 469.00
IUUC-Eca-033873 Equus caballus 92.58 0.00e+00 1168.00
IUUC-Eeu-034652 Erinaceus europaeus 96.65 1.00e-105 377.00
IUUC-Fca-036563 Felis catus 90.12 0.00e+00 1134.00
IUUC-Fal-036649 Ficedula albicollis 83.87 0.00e+00 1039.00
IUUC-Fox-037962 Fusarium oxysporum 33.46 8.00e-40 159.00
IUUC-Fso-038396 Fusarium solani 33.70 4.00e-40 159.00
IUUC-Gmo-039510 Gadus morhua 74.27 0.00e+00 946.00
IUUC-Ggr-039938 Gaeumannomyces graminis 32.15 3.00e-38 153.00
IUUC-Gga-040201 Gallus gallus 82.82 0.00e+00 1127.00
IUUC-Gac-041459 Gasterosteus aculeatus 73.96 0.00e+00 955.00
IUUC-Ggo-044573 Gorilla gorilla 93.31 0.00e+00 1206.00
IUUC-Hsa-046009 Homo sapiens 93.44 0.00e+00 1250.00
IUUC-Itr-049065 Ictidomys tridecemlineatus 94.72 0.00e+00 1277.00
IUUC-Kpa-049327 Komagataella pastoris 30.13 2.00e-33 137.00
IUUC-Lch-049944 Latimeria chalumnae 76.01 1.00e-156 546.00
IUUC-Loc-051850 Lepisosteus oculatus 79.89 0.00e+00 1035.00
IUUC-Lma-053252 Leptosphaeria maculans 35.65 2.00e-41 164.00
IUUC-Laf-053346 Loxodonta africana 83.57 0.00e+00 1041.00
IUUC-Mcc-055789 Macaca mulatta 92.42 0.00e+00 1175.00
IUUC-Meu-056329 Macropus eugenii 71.15 2.00e-157 549.00
IUUC-Mor-057205 Magnaporthe oryzae 33.90 5.00e-39 155.00
IUUC-Mpo-057295 Magnaporthe poae 32.48 1.00e-39 158.00
IUUC-Mla-058849 Melampsora laricipopulina 32.90 1.00e-32 134.00
IUUC-Mga-059361 Meleagris gallopavo 82.57 0.00e+00 1064.00
IUUC-Mvi-060561 Microbotryum violaceum 38.56 8.00e-40 158.00
IUUC-Mmr-061122 Microcebus murinus 94.89 0.00e+00 1044.00
IUUC-Mdo-062171 Monodelphis domestica 89.17 0.00e+00 1187.00
IUUC-Mpu-065852 Mustela putorius furo 90.00 0.00e+00 1094.00
IUUC-Mlu-066996 Myotis lucifugus 82.88 7.00e-146 510.00
IUUC-Nfi-068539 Neosartorya fischeri 32.59 9.00e-41 162.00
IUUC-Ncr-068726 Neurospora crassa 39.19 5.00e-40 159.00
IUUC-Nle-070148 Nomascus leucogenys 87.77 0.00e+00 1079.00
IUUC-Opr-070833 Ochotona princeps 72.94 0.00e+00 803.00
IUUC-Ont-071261 Oreochromis niloticus 77.81 0.00e+00 965.00
IUUC-Oan-073684 Ornithorhynchus anatinus 72.11 4.00e-162 564.00
IUUC-Ola-087570 Oryzias latipes 75.03 0.00e+00 969.00
IUUC-Oga-089087 Otolemur garnettii 87.66 0.00e+00 1092.00
IUUC-Oar-089534 Ovis aries 91.22 0.00e+00 1168.00
IUUC-Ptr-091654 Pan troglodytes 88.16 0.00e+00 1098.00
IUUC-Pan-092652 Papio anubis 92.15 0.00e+00 1182.00
IUUC-Pno-095125 Phaeosphaeria nodorum 38.53 2.00e-42 167.00
IUUC-Pfo-096757 Poecilia formosa 76.35 0.00e+00 938.00
IUUC-Pab-097788 Pongo abelii 94.86 0.00e+00 839.00
IUUC-Pca-100145 Procavia capensis 78.22 0.00e+00 909.00
IUUC-Pva-102965 Pteropus vampyrus 87.06 0.00e+00 1111.00
IUUC-Pgr-103609 Puccinia graminis 34.69 8.00e-34 138.00
IUUC-Ptt-103865 Puccinia triticina 35.71 1.00e-34 142.00
IUUC-Pte-104095 Pyrenophora teres 35.24 4.00e-42 166.00
IUUC-Pyt-104668 Pyrenophora triticirepentis 35.87 1.00e-41 164.00
IUUC-Rno-105125 Rattus norvegicus 97.70 0.00e+00 1267.00
IUUC-Sce-106192 Saccharomyces cerevisiae 28.00 7.00e-27 115.00
IUUC-Sha-107066 Sarcophilus harrisii 89.90 0.00e+00 1147.00
IUUC-Sja-107931 Schizosaccharomyces japonicus 33.43 8.00e-42 165.00
IUUC-Spo-108220 Schizosaccharomyces pombe 36.24 5.00e-37 149.00
IUUC-Stu-112464 Solanum tuberosum 45.90 2.00e-13 71.60
IUUC-Sar-113393 Sorex araneus 92.11 8.00e-107 381.00
IUUC-Sre-114986 Sporisorium reilianum 38.12 2.00e-42 167.00
IUUC-Tgu-117505 Taeniopygia guttata 81.89 0.00e+00 1051.00
IUUC-Tru-118494 Takifugu rubripes 76.81 0.00e+00 995.00
IUUC-Tsy-119626 Tarsius syrichta 98.97 8.00e-54 204.00
IUUC-Tni-120174 Tetraodon nigroviridis 73.09 0.00e+00 995.00
IUUC-Tre-122191 Trichoderma reesei 33.82 9.00e-41 162.00
IUUC-Tvi-122318 Trichoderma virens 32.87 9.00e-42 165.00
IUUC-Tme-126914 Tuber melanosporum 34.75 2.00e-44 174.00
IUUC-Ttr-129095 Tursiops truncatus 91.90 0.00e+00 1206.00
IUUC-Uma-129475 Ustilago maydis 36.61 3.00e-39 157.00
IUUC-Vda-129908 Verticillium dahliae 32.87 6.00e-36 145.00
IUUC-Xtr-131900 Xenopus tropicalis 75.63 0.00e+00 1039.00
IUUC-Xma-133124 Xiphophorus maculatus 76.69 0.00e+00 977.00
IUUC-Yli-134682 Yarrowia lipolytica 35.71 5.00e-33 135.00
Created Date 25-Jun-2017

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