iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046363

UUCD1 version

UUC-HoS-00218

Ensembl Protein ID

ENSP00000369299.3

UniProt Accession

Q8IYM9; Q05CQ0; Q15521; TRI22_HUMAN

Genbank Protein ID

CAA57684.1; AAH22281.1; AAH35582.1

Protein Name

E3 ubiquitin-protein ligase TRIM22; 50 kDa-stimulated trans-acting factor; RING finger protein 94; RING-type E3 ubiquitin transferase TRIM22; Staf-50; Tripartite motif-containing protein 22

Genbank Nucleotide ID

X82200; BC022281; BC035582

Gene Name

TRIM22; RNF94; STAF50

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132274.15	ENST00000379965.7	ENSP00000369299.3
ENSG00000132274.15	ENST00000454828.5	ENSP00000393250.1
ENSG00000132274.15	ENST00000414897.5	ENSP00000388994.1
ENSG00000132274.15	ENST00000450670.5	ENSP00000406412.1
ENSG00000132274.15	ENST00000429063.5	ENSP00000409991.1
ENSG00000132274.15	ENST00000444844.1	ENSP00000404204.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19218198; 18656448; 19218198

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	6.50e-07	31.0	9	79
E3 activity/RING/RING	5.00e-09	38.2	15	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrliq 66
           + +e  CpI lel ++P  l +G+++ +++I   +      ++g+++cPv+++++++ +l Pn  l ++++
   Q: 9    IEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIkesviiSRGESSCPVCQTRFQPGNLRPNRHLANIVE 79
           567899*************************999955555566666******************9988776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ C+  k++ +   s++e +CP+C+
   Q: 15   CPICLELLTE-PLSLDCGHSFCQACItAKIKESVIISRGESSCPVCQ 60
           ********99.***************7555899999**********7 PP

Organism

Homo sapiens

Functional Description
(View)

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

Protein Sequence
(Fasta)

MDFSVKVDIE KEVTCPICLE LLTEPLSLDC GHSFCQACIT AKIKESVIIS RGESSCPVCQ 60
TRFQPGNLRP NRHLANIVER VKEVKMSPQE GQKRDVCEHH GKKLQIFCKE DGKVICWVCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGTTTAT TGTTATGTAA GTTCTTGTTC AGCTTCCTTT GTTTTCTTTC ACTTCTGAGA 60
ATTTAACTTT CGTTTCTCAC TCAGCTCCTG TGGGGAAACT CATTTGTGGA GACCAGCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0015030--C:Cajal body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030674--F:protein binding, bridging
GO:0019901--F:protein kinase binding
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0006955--P:immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206--P:protein trimerization
GO:0016567--P:protein ubiquitination
GO:0032880--P:regulation of protein localization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009615--P:response to virus
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:10346

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002371	Ailuropoda melanoleuca	68.07	0.00e+00	706.00
IUUC-Acl-008013	Aspergillus clavatus	58.82	3.00e-06	47.80
IUUC-Ani-009293	Aspergillus nidulans	60.61	6.00e-06	46.60
IUUC-Cfa-021080	Canis familiaris	66.47	0.00e+00	679.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	33.75	1.00e-09	57.40
IUUC-Csa-023785	Chlorocebus sabaeus	89.96	0.00e+00	906.00
IUUC-Ggo-044550	Gorilla gorilla	98.59	0.00e+00	960.00
IUUC-Laf-053647	Loxodonta africana	65.86	0.00e+00	642.00
IUUC-Mcc-054743	Macaca mulatta	91.57	0.00e+00	927.00
IUUC-Mpu-066674	Mustela putorius furo	65.86	0.00e+00	685.00
IUUC-Nle-068980	Nomascus leucogenys	97.59	0.00e+00	983.00
IUUC-Ptr-091300	Pan troglodytes	99.00	0.00e+00	993.00
IUUC-Pan-092605	Papio anubis	81.93	0.00e+00	794.00
IUUC-Pab-098535	Pongo abelii	99.20	0.00e+00	999.00
IUUC-Tsy-119330	Tarsius syrichta	76.51	0.00e+00	738.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence