iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108333

Ensembl Protein ID

SPBC1734.08.1:pep

UniProt Accession

O74749; HSE1_SCHPO

Genbank Protein ID

CAA21302.1

Protein Name

Class E vacuolar protein-sorting machinery protein hse1

Genbank Nucleotide ID

CU329671

Gene Name

hse1; SPBC1734.08

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC1734.08	SPBC1734.08.1	SPBC1734.08.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	12055639; 17079730; 17543868

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/DUIM	0.0027	15.9	165	180
UBD/SH3	1.80e-16	58.0	219	272

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/DUIM

   S: 2    EdeeLqlAlalSlqEe 17
           E+eeLq AlalSl+E 
   Q: 165  EEEELQYALALSLSES 180
           9*************97 PP

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++lyd+ a++++eL++kkGd++lv+  e+  ++W+kg    ++  G+fP n+v+++
   Q: 219  RVRALYDFAATEQGELSFKKGDIILVL--ESVYKDWWKG--SCKNAVGIFPVNYVQRV 272
           799************************..999*******..8**************98 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).

Protein Sequence
(Fasta)

MFRGKPNSIE TLILQATDEK NTKEKWDVIM DACDQLSSTS GDVGRNSIKF LNKRLDTANA 60
NIQLLALTLT DAIVKNCKTS IVREISSRTF TDSLLKIASD STTHNRVRSR IAVLVNEWAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAAATACA ACTCGGTAGT GAAACTGTCT TTTTATTCTA AAAGGAACCC AAGCTTAACC 60
CAAAAAGTAT AAATATTACT GAATATTTAA AAATTGACTC GTATTTTTGA ACCAAGAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom

PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS

Pfam

PF00018--SH3_1
PF00790--VHS

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3
SM00288--VHS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0033565--C:ESCRT-0 complex
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0005628--C:prospore membrane
GO:0005774--C:vacuolar membrane
GO:0031321--P:ascospore-type prospore assembly
GO:0045324--P:late endosome to vacuole transport
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

spo:SPBC1734.08

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002079	Ailuropoda melanoleuca	29.67	6.00e-31	126.00
IUUC-Apl-003548	Anas platyrhynchos	32.57	2.00e-31	127.00
IUUC-Aca-004991	Anolis carolinensis	33.83	4.00e-33	134.00
IUUC-Ago-007874	Ashbya gossypii	33.33	1.00e-51	195.00
IUUC-Acl-008046	Aspergillus clavatus	39.57	4.00e-74	270.00
IUUC-Afl-008621	Aspergillus flavus	42.27	2.00e-77	281.00
IUUC-Afu-008826	Aspergillus fumigatus	38.67	2.00e-67	248.00
IUUC-Ani-009419	Aspergillus nidulans	39.95	2.00e-75	274.00
IUUC-Ang-009580	Aspergillus niger	39.84	1.00e-75	275.00
IUUC-Ate-010532	Aspergillus terreus	41.36	9.00e-80	288.00
IUUC-Ame-011220	Astyanax mexicanus	26.15	9.00e-30	122.00
IUUC-Bgr-012113	Blumeria graminis	40.26	1.00e-70	258.00
IUUC-Bta-013368	Bos taurus	26.48	5.00e-29	120.00
IUUC-Bci-013955	Botrytis cinerea	39.89	3.00e-71	260.00
IUUC-Bol-016437	Brassica oleracea	31.13	3.00e-08	51.60
IUUC-Bra-018053	Brassica rapa	30.19	2.00e-04	38.90
IUUC-Cel-018461	Caenorhabditis elegans	24.91	4.00e-18	84.00
IUUC-Cja-018846	Callithrix jacchus	27.16	4.00e-34	137.00
IUUC-Cfa-020589	Canis familiaris	29.63	2.00e-30	124.00
IUUC-Cpo-021460	Cavia porcellus	28.76	2.00e-32	131.00
IUUC-Csa-023912	Chlorocebus sabaeus	26.13	3.00e-31	127.00
IUUC-Cho-024297	Choloepus hoffmanni	27.81	6.00e-30	123.00
IUUC-Cin-025766	Ciona intestinalis	31.75	2.00e-16	77.00
IUUC-Csv-026035	Ciona savignyi	30.95	1.00e-12	65.10
IUUC-Cgl-026648	Colletotrichum gloeosporioides	40.11	2.00e-72	265.00
IUUC-Cne-027007	Cryptococcus neoformans	39.13	1.00e-31	129.00
IUUC-Dre-027454	Danio rerio	27.27	1.00e-29	122.00
IUUC-Dno-029182	Dasypus novemcinctus	32.58	1.00e-31	129.00
IUUC-Dor-030515	Dipodomys ordii	25.14	1.00e-23	102.00
IUUC-Dse-031527	Dothistroma septosporum	39.34	2.00e-70	258.00
IUUC-Dme-031987	Drosophila melanogaster	28.06	9.00e-23	99.80
IUUC-Ete-032804	Echinops telfairi	27.64	3.00e-26	111.00
IUUC-Eca-033520	Equus caballus	26.93	2.00e-29	121.00
IUUC-Fca-035958	Felis catus	29.50	1.00e-30	125.00
IUUC-Fal-037193	Ficedula albicollis	32.35	5.00e-32	130.00
IUUC-Fox-037748	Fusarium oxysporum	36.49	3.00e-59	220.00
IUUC-Fso-038126	Fusarium solani	40.32	1.00e-75	275.00
IUUC-Gmo-039440	Gadus morhua	28.98	1.00e-30	124.00
IUUC-Ggr-040048	Gaeumannomyces graminis	38.93	1.00e-72	265.00
IUUC-Gga-041158	Gallus gallus	28.96	1.00e-32	132.00
IUUC-Gac-042301	Gasterosteus aculeatus	27.25	2.00e-32	131.00
IUUC-Ggo-044661	Gorilla gorilla	32.21	9.00e-33	132.00
IUUC-Hsa-046959	Homo sapiens	26.38	1.00e-31	129.00
IUUC-Itr-048399	Ictidomys tridecemlineatus	27.61	2.00e-30	124.00
IUUC-Kpa-049200	Komagataella pastoris	32.70	9.00e-60	222.00
IUUC-Lch-050505	Latimeria chalumnae	32.13	3.00e-33	134.00
IUUC-Loc-052761	Lepisosteus oculatus	26.74	1.00e-27	115.00
IUUC-Lma-053287	Leptosphaeria maculans	41.49	2.00e-75	275.00
IUUC-Laf-053943	Loxodonta africana	26.92	4.00e-31	127.00
IUUC-Mcc-055609	Macaca mulatta	26.13	3.00e-31	127.00
IUUC-Meu-056575	Macropus eugenii	54.90	4.00e-14	70.90
IUUC-Mor-056972	Magnaporthe oryzae	38.29	4.00e-68	250.00
IUUC-Mpo-057476	Magnaporthe poae	39.34	2.00e-73	268.00
IUUC-Mla-059162	Melampsora laricipopulina	44.87	1.00e-36	145.00
IUUC-Mga-059462	Meleagris gallopavo	28.88	3.00e-31	127.00
IUUC-Mvi-060560	Microbotryum violaceum	30.93	2.00e-38	152.00
IUUC-Mmr-061413	Microcebus murinus	26.22	1.00e-28	119.00
IUUC-Mdo-062314	Monodelphis domestica	29.61	8.00e-34	136.00
IUUC-Mmu-064020	Mus musculus	27.46	6.00e-30	123.00
IUUC-Mpu-066320	Mustela putorius furo	28.24	3.00e-25	107.00
IUUC-Mlu-067472	Myotis lucifugus	30.11	2.00e-31	128.00
IUUC-Nfi-068568	Neosartorya fischeri	39.57	6.00e-74	270.00
IUUC-Ncr-068765	Neurospora crassa	39.14	5.00e-74	270.00
IUUC-Nle-070035	Nomascus leucogenys	28.12	1.00e-31	128.00
IUUC-Ont-072419	Oreochromis niloticus	27.20	2.00e-32	131.00
IUUC-Oan-072727	Ornithorhynchus anatinus	30.47	2.00e-29	121.00
IUUC-Ocu-074576	Oryctolagus cuniculus	29.86	3.00e-32	131.00
IUUC-Ola-087487	Oryzias latipes	27.18	1.00e-31	129.00
IUUC-Oga-089079	Otolemur garnettii	31.40	6.00e-31	126.00
IUUC-Oar-089306	Ovis aries	27.49	3.00e-30	124.00
IUUC-Ptr-090536	Pan troglodytes	27.37	2.00e-31	128.00
IUUC-Pan-092172	Papio anubis	26.13	2.00e-32	131.00
IUUC-Psi-092953	Pelodiscus sinensis	25.90	3.00e-28	117.00
IUUC-Pma-094312	Petromyzon marinus	28.95	3.00e-26	110.00
IUUC-Pno-094911	Phaeosphaeria nodorum	40.46	8.00e-70	255.00
IUUC-Pfo-096200	Poecilia formosa	26.72	1.00e-32	132.00
IUUC-Pab-098151	Pongo abelii	26.65	1.00e-31	129.00
IUUC-Pva-103093	Pteropus vampyrus	31.58	2.00e-31	128.00
IUUC-Pgr-103679	Puccinia graminis	44.44	3.00e-34	138.00
IUUC-Ptt-103709	Puccinia triticina	39.75	6.00e-28	117.00
IUUC-Pte-104251	Pyrenophora teres	41.38	5.00e-76	276.00
IUUC-Pyt-104694	Pyrenophora triticirepentis	41.05	4.00e-76	277.00
IUUC-Rno-105275	Rattus norvegicus	32.20	2.00e-29	121.00
IUUC-Sce-106209	Saccharomyces cerevisiae	35.15	5.00e-50	189.00
IUUC-Sha-107090	Sarcophilus harrisii	28.02	2.00e-32	131.00
IUUC-Sja-107859	Schizosaccharomyces japonicus	45.73	1.00e-89	321.00
IUUC-Ssl-108525	Sclerotinia sclerotiorum	40.16	2.00e-71	261.00
IUUC-Smo-109609	Selaginella moellendorffii	31.90	1.00e-11	61.60
IUUC-Sar-113125	Sorex araneus	31.39	3.00e-16	78.20
IUUC-Sre-115010	Sporisorium reilianum	42.28	4.00e-34	137.00
IUUC-Ssc-116366	Sus scrofa	29.78	8.00e-32	129.00
IUUC-Tgu-117414	Taeniopygia guttata	28.39	7.00e-32	129.00
IUUC-Tru-118646	Takifugu rubripes	25.58	9.00e-29	119.00
IUUC-Tsy-119199	Tarsius syrichta	31.00	3.00e-30	124.00
IUUC-Tni-120765	Tetraodon nigroviridis	27.97	2.00e-31	128.00
IUUC-Tca-121260	Theobroma cacao	33.68	5.00e-12	63.90
IUUC-Tre-122061	Trichoderma reesei	40.50	1.00e-69	255.00
IUUC-Tvi-122365	Trichoderma virens	40.37	1.00e-73	268.00
IUUC-Tme-127104	Tuber melanosporum	42.13	2.00e-79	287.00
IUUC-Tbe-127233	Tupaia belangeri	24.83	2.00e-20	92.00
IUUC-Ttr-128960	Tursiops truncatus	29.50	2.00e-30	124.00
IUUC-Uma-129613	Ustilago maydis	43.83	3.00e-39	154.00
IUUC-Vda-129759	Verticillium dahliae	40.29	3.00e-62	231.00
IUUC-Vpa-130600	Vicugna pacos	30.74	2.00e-31	128.00
IUUC-Xtr-132472	Xenopus tropicalis	28.17	2.00e-30	125.00
IUUC-Xma-133716	Xiphophorus maculatus	26.84	1.00e-29	122.00
IUUC-Yli-134599	Yarrowia lipolytica	39.56	2.00e-69	255.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence