iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-13	50.9	477	530

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            ++lydy+a+++ e t+  Gdv++ i  ++ degW++g     g  GlfP+n+ve +
   Q: 477  ARALYDYQAADETEITFDPGDVITHI--DQIDEGWWQG-LGPDGTYGLFPANYVEII 530
           689***********************..9*********.6999***********976 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin (By similarity). Does not seem to be involved in actin-based lamella protrusion during cell migration.

Protein Sequence
(Fasta)

MAVSFEKNRA QIVAAWKDVL DDKSDTNWSL FGYEGQTNEL KVVATGDGGV DELNEDLNSG 60
KIMYAFVRIE DPKTGLNKYL LINWQGEGAP VLRKGTCANH IRDVSNLLSG AHLTINARNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCTCTAGT TTGTTGTTGC AAAAAAAGTG TGTGGGTCGC CGCCAGCGAT CGAATATTTT 60
AAAATTCCAA TCAAATTGGT TAATTGGGGA GTTGCAATTG CTTGAGCGTT AAGTTAAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR002108--ADF-H
IPR029006--ADF-H/Gelsolin-like_dom
IPR001452--SH3_domain

PROSITE

PS51263--ADF_H
PS50002--SH3

Pfam

PF00241--Cofilin_ADF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00102--ADF
SM00326--SH3

Gene Ontology

GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0005856--C:cytoskeleton
GO:0030426--C:growth cone
GO:0031594--C:neuromuscular junction
GO:0061176--C:type Ib terminal bouton
GO:0061177--C:type Is terminal bouton
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786--F:phosphatidylserine binding
GO:0022416--P:chaeta development
GO:0045887--P:positive regulation of synaptic growth at neuromuscular junction
GO:0072553--P:terminal button organization

KEGG

dme:Dmel_CG10083

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007760	Ashbya gossypii	27.34	1.00e-10	60.50
IUUC-Acl-008295	Aspergillus clavatus	34.96	2.00e-17	83.60
IUUC-Afl-008545	Aspergillus flavus	45.28	7.00e-11	62.80
IUUC-Afu-008895	Aspergillus fumigatus	30.32	6.00e-18	85.50
IUUC-Ani-009428	Aspergillus nidulans	44.44	2.00e-10	61.60
IUUC-Ang-009722	Aspergillus niger	40.40	8.00e-18	85.10
IUUC-Aor-010021	Aspergillus oryzae	33.88	5.00e-21	95.50
IUUC-Ate-010587	Aspergillus terreus	39.39	4.00e-17	82.80
IUUC-Ame-011930	Astyanax mexicanus	46.11	3.00e-42	165.00
IUUC-Bci-013690	Botrytis cinerea	41.84	5.00e-20	92.40
IUUC-Cel-018639	Caenorhabditis elegans	29.38	6.00e-25	108.00
IUUC-Cin-025774	Ciona intestinalis	48.24	7.00e-47	180.00
IUUC-Csv-026039	Ciona savignyi	45.10	1.00e-51	196.00
IUUC-Cgl-026571	Colletotrichum gloeosporioides	43.43	3.00e-20	93.20
IUUC-Cne-027017	Cryptococcus neoformans	36.84	3.00e-19	89.70
IUUC-Dre-028279	Danio rerio	43.33	3.00e-50	191.00
IUUC-Dse-031182	Dothistroma septosporum	36.54	4.00e-17	82.80
IUUC-Fox-037778	Fusarium oxysporum	40.23	1.00e-17	84.30
IUUC-Fso-038435	Fusarium solani	40.62	2.00e-18	87.00
IUUC-Gmo-038507	Gadus morhua	44.76	5.00e-42	164.00
IUUC-Ggr-039882	Gaeumannomyces graminis	45.74	6.00e-21	95.50
IUUC-Gac-042596	Gasterosteus aculeatus	45.79	8.00e-52	196.00
IUUC-Lch-050101	Latimeria chalumnae	44.69	1.00e-47	183.00
IUUC-Loc-052422	Lepisosteus oculatus	30.18	4.00e-22	98.60
IUUC-Lma-053035	Leptosphaeria maculans	37.50	1.00e-18	87.80
IUUC-Mor-057105	Magnaporthe oryzae	41.41	1.00e-18	87.40
IUUC-Mpo-057322	Magnaporthe poae	50.91	5.00e-12	66.20
IUUC-Mla-059134	Melampsora laricipopulina	41.61	5.00e-25	108.00
IUUC-Mvi-060304	Microbotryum violaceum	36.36	2.00e-16	80.10
IUUC-Nfi-068448	Neosartorya fischeri	40.40	3.00e-18	86.70
IUUC-Ncr-068730	Neurospora crassa	42.42	3.00e-20	93.20
IUUC-Ont-072094	Oreochromis niloticus	46.96	1.00e-41	163.00
IUUC-Ola-086682	Oryzias latipes	45.86	1.00e-40	159.00
IUUC-Pma-094207	Petromyzon marinus	74.14	4.00e-25	108.00
IUUC-Pno-095096	Phaeosphaeria nodorum	38.46	1.00e-18	87.80
IUUC-Pfo-096770	Poecilia formosa	49.36	2.00e-37	149.00
IUUC-Pgr-103652	Puccinia graminis	38.93	2.00e-26	113.00
IUUC-Pte-104156	Pyrenophora teres	40.38	2.00e-19	90.50
IUUC-Pyt-104742	Pyrenophora triticirepentis	39.42	4.00e-19	89.40
IUUC-Sce-106228	Saccharomyces cerevisiae	48.84	2.00e-06	46.60
IUUC-Sja-107956	Schizosaccharomyces japonicus	38.69	2.00e-22	100.00
IUUC-Spo-108101	Schizosaccharomyces pombe	39.85	2.00e-22	100.00
IUUC-Ssl-108538	Sclerotinia sclerotiorum	43.64	1.00e-10	61.60
IUUC-Sre-115023	Sporisorium reilianum	35.80	4.00e-24	105.00
IUUC-Tru-118773	Takifugu rubripes	46.93	4.00e-42	164.00
IUUC-Tni-120036	Tetraodon nigroviridis	44.69	8.00e-41	160.00
IUUC-Tre-122167	Trichoderma reesei	43.62	3.00e-21	96.70
IUUC-Tvi-122614	Trichoderma virens	43.01	9.00e-21	94.70
IUUC-Tme-127196	Tuber melanosporum	39.36	1.00e-17	84.00
IUUC-Uma-129649	Ustilago maydis	34.48	6.00e-25	108.00
IUUC-Vda-129766	Verticillium dahliae	44.09	6.00e-20	92.00
IUUC-Xtr-132101	Xenopus tropicalis	46.37	8.00e-41	160.00
IUUC-Xma-133290	Xiphophorus maculatus	50.00	9.00e-36	143.00
IUUC-Yli-134511	Yarrowia lipolytica	29.45	1.00e-14	74.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence