iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004638

UUCD1 version

UUC-AnC-00757

Ensembl Protein ID

ENSACAP00000012965.3

UniProt Accession

G1KNE2; G1KNE2_ANOCA

Protein Name

Apoptotic protease-activating factor 1

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000013012.3	ENSACAT00000013224.3	ENSACAP00000012965.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-63	206.9	656	692
UBD/Beta-Prp	7.40e-124	412.7	942	1166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           H d+v c++f  +d++++++s D+++kvW+ rtg ++
   Q: 656  HDDEVLCCSFsaDDRFVATCSADKKVKVWNSRTGQPV 692
           9**********777*******************9886 PP

UBD/Beta-Prp

   S: 29   srdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshd 115
             ++++++ +  tg+++   +++++ + ++++s+d+k+ + g + +t+kv +l++g ++ + +gh + v  ++f  +g++l+s s+d
   Q: 942  DSSKRLQLISGYTGNTIYLTKEQDSLICCCCLSHDRKVAAFGENNGTVKVLSLQNGNTLNSRTGHREAVQHCQFTSDGKTLISSSDD 1028
           33445555555555555555666666************************************************************* PP
   S: 116  rtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldg 202
           +ti+vw++++++c+  +l+gh++ v    + + ++ l s s D+tv+lW++ tg++ ++    h++++ s +++++ + + + s d+
   Q: 1029 STIQVWNWQSEECI--LLKGHNERVKKFLLLK-DSRLLSWSFDGTVKLWNIVTGEIEKDVIC-HENAILSCAISPDATMFSTTSSDK 1111
           **************..5*********999998.778899*********************98.************************ PP
   S: 203  tvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdll 257
           t k+w+++t++++++ln h++ v++ +fs n+e+l++g + + ir+Wd+  g+ll
   Q: 1112 TAKIWSFETSSMLHKLNSHESCVRCCAFSLNNELLATGDDNREIRVWDVSRGELL 1166
           *************************************************999887 PP

Organism

Anolis carolinensis

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDLTARSHLL QNREALERDI KTSYVIDHMI ADGALTPQEE AEVKAVTTQR DRAAKLIKTI 60
LKKDDHAYIS FYNALVHEGY KDLAALLQDG IPIISPRNGN KSTDGVTSYV KTILCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTACCTCAT ATTGCAATTC ACTAAGAAAG AAAGTTTAAA CGACAATGGA TTTGACCGCT 60
CGAAGTCACT TGCTTCAGAA TCGGGAGGCT CTGGAAAGAG ATATTAAGAC TTCCTATGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

KEGG

acs:100556318

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	69.51	0.00e+00	1803.00
IUUC-Apl-004201	Anas platyrhynchos	71.12	0.00e+00	1865.00
IUUC-Ani-009285	Aspergillus nidulans	26.23	2.00e-64	241.00
IUUC-Ate-010309	Aspergillus terreus	26.71	6.00e-66	246.00
IUUC-Ame-011062	Astyanax mexicanus	54.24	0.00e+00	1380.00
IUUC-Bta-012865	Bos taurus	69.43	0.00e+00	1845.00
IUUC-Cja-018815	Callithrix jacchus	63.97	0.00e+00	1620.00
IUUC-Cfa-020222	Canis familiaris	66.22	0.00e+00	1684.00
IUUC-Cpo-021524	Cavia porcellus	68.24	0.00e+00	1801.00
IUUC-Csa-023861	Chlorocebus sabaeus	69.11	0.00e+00	1809.00
IUUC-Cho-024484	Choloepus hoffmanni	58.44	0.00e+00	897.00
IUUC-Dre-028006	Danio rerio	52.61	0.00e+00	1277.00
IUUC-Dno-029591	Dasypus novemcinctus	69.59	0.00e+00	1846.00
IUUC-Dor-030237	Dipodomys ordii	54.85	0.00e+00	790.00
IUUC-Ete-032620	Echinops telfairi	65.06	0.00e+00	832.00
IUUC-Eca-033569	Equus caballus	69.11	0.00e+00	1813.00
IUUC-Eeu-035354	Erinaceus europaeus	49.38	1.00e-130	460.00
IUUC-Fca-036337	Felis catus	68.90	0.00e+00	1833.00
IUUC-Fal-037077	Ficedula albicollis	70.64	0.00e+00	1848.00
IUUC-Gmo-039687	Gadus morhua	49.76	0.00e+00	941.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.44	2.00e-42	168.00
IUUC-Gga-040299	Gallus gallus	70.24	0.00e+00	1871.00
IUUC-Gac-041762	Gasterosteus aculeatus	51.74	0.00e+00	1295.00
IUUC-Ggo-045563	Gorilla gorilla	68.95	0.00e+00	1811.00
IUUC-Hsa-046771	Homo sapiens	68.95	0.00e+00	1813.00
IUUC-Lch-050200	Latimeria chalumnae	63.58	0.00e+00	1620.00
IUUC-Loc-052090	Lepisosteus oculatus	57.46	0.00e+00	1518.00
IUUC-Laf-053861	Loxodonta africana	68.50	0.00e+00	1817.00
IUUC-Mcc-055543	Macaca mulatta	69.19	0.00e+00	1811.00
IUUC-Meu-056688	Macropus eugenii	67.52	0.00e+00	1748.00
IUUC-Mga-059243	Meleagris gallopavo	70.02	0.00e+00	1872.00
IUUC-Mmr-061134	Microcebus murinus	65.03	0.00e+00	1530.00
IUUC-Mdo-062913	Monodelphis domestica	67.04	0.00e+00	1752.00
IUUC-Mmu-063811	Mus musculus	67.44	0.00e+00	1795.00
IUUC-Mpu-066780	Mustela putorius furo	69.46	0.00e+00	1788.00
IUUC-Mlu-067276	Myotis lucifugus	69.14	0.00e+00	1837.00
IUUC-Nfi-068459	Neosartorya fischeri	25.00	3.00e-57	217.00
IUUC-Nle-069129	Nomascus leucogenys	68.56	0.00e+00	1797.00
IUUC-Opr-071007	Ochotona princeps	50.52	0.00e+00	818.00
IUUC-Ont-071348	Oreochromis niloticus	54.82	0.00e+00	1406.00
IUUC-Oan-072717	Ornithorhynchus anatinus	70.63	0.00e+00	1875.00
IUUC-Ocu-074286	Oryctolagus cuniculus	67.96	0.00e+00	1517.00
IUUC-Ola-086895	Oryzias latipes	49.59	0.00e+00	1182.00
IUUC-Oga-088678	Otolemur garnettii	67.92	0.00e+00	1796.00
IUUC-Oar-089359	Ovis aries	69.03	0.00e+00	1822.00
IUUC-Ptr-091062	Pan troglodytes	69.03	0.00e+00	1813.00
IUUC-Pan-092528	Papio anubis	73.76	0.00e+00	1121.00
IUUC-Psi-093430	Pelodiscus sinensis	74.42	0.00e+00	1966.00
IUUC-Pma-094690	Petromyzon marinus	39.16	1.00e-154	540.00
IUUC-Pfo-097204	Poecilia formosa	53.86	0.00e+00	1374.00
IUUC-Pab-097690	Pongo abelii	69.03	0.00e+00	1811.00
IUUC-Pca-100778	Procavia capensis	54.08	0.00e+00	903.00
IUUC-Pva-102870	Pteropus vampyrus	66.84	0.00e+00	1633.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	26.94	2.00e-64	241.00
IUUC-Rno-104889	Rattus norvegicus	67.76	0.00e+00	1773.00
IUUC-Sha-107465	Sarcophilus harrisii	67.75	0.00e+00	1799.00
IUUC-Sar-113268	Sorex araneus	65.06	9.00e-140	491.00
IUUC-Ssc-115654	Sus scrofa	69.11	0.00e+00	1838.00
IUUC-Tgu-117302	Taeniopygia guttata	70.88	0.00e+00	1863.00
IUUC-Tru-118363	Takifugu rubripes	53.78	0.00e+00	1377.00
IUUC-Tsy-119007	Tarsius syrichta	66.56	0.00e+00	1738.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.30	0.00e+00	1321.00
IUUC-Tbe-127413	Tupaia belangeri	59.15	0.00e+00	1085.00
IUUC-Ttr-129213	Tursiops truncatus	64.09	0.00e+00	1649.00
IUUC-Vpa-130146	Vicugna pacos	63.70	0.00e+00	1234.00
IUUC-Xtr-132559	Xenopus tropicalis	59.06	0.00e+00	1550.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence