iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105129

Ensembl Protein ID

ENSRNOP00000025559.3

UniProt Accession

Q9ESS9; Q9ESS9_RAT

Genbank Protein ID

AAH61849.1; BAB16047.1; EDL87344.1

Protein Name

Homocysteine-inducible ER protein with ubiquitin-like domain 1; Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, isoform CRA_a; SUP

Genbank Nucleotide ID

AABR07042824; AB033771; CH474006

Gene Name

Herpud1; SUP; rCG_39087

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000018796.5	ENSRNOT00000025559.5	ENSRNOP00000025559.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	12826399

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.10e-13	51.4	10	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgke..felevseddtveelKekiakesgvp....peqqkLIyaGkiLkDdttLselgikdg..svvhlv 70
           ++l vk +++++  +el++++ ++v++lK++++++  +p    pe+q+LIy+Gk L D+++L++l  k++  +v+hlv
   Q: 10   VTLLVKSPNQRHrdLELSGDRGWSVSRLKAHLSRV--YPerprPEDQRLIYSGKLLLDHQCLQDLLPKQEkrHVLHLV 85
           6899********9999*******************..777778*********************95544322566666 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MEPEPQPEPV TLLVKSPNQR HRDLELSGDR GWSVSRLKAH LSRVYPERPR PEDQRLIYSG 60
KLLLDHQCLQ DLLPKQEKRH VLHLVCNVRS PSKKPEASTK GAESTEQPDN TSQAQYPGDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGACACCAA GTGTCGTTGT GGGGTCGCAG ACGGCTGCGT CGCCGCCCGT TCGGCATCCC 60
TGAGCGCAGT CGAGCCTCCA GCGCCGCAGA CATGGAGCCC GAGCCACAGC CCGAGCCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0034704--C:calcium channel complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:1990037--C:Lewy body core
GO:0044325--F:ion channel binding
GO:0006874--P:cellular calcium ion homeostasis
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:0031396--P:regulation of protein ubiquitination
GO:0034976--P:response to endoplasmic reticulum stress
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:85430

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001647	Ailuropoda melanoleuca	87.40	1.00e-156	545.00
IUUC-Atr-002574	Amborella trichopoda	26.80	5.00e-03	33.50
IUUC-Apl-004142	Anas platyrhynchos	55.14	8.00e-78	283.00
IUUC-Acl-008367	Aspergillus clavatus	36.47	2.00e-04	40.80
IUUC-Afl-008623	Aspergillus flavus	43.64	4.00e-04	40.00
IUUC-Ani-009402	Aspergillus nidulans	33.71	9.00e-05	42.00
IUUC-Ang-009511	Aspergillus niger	36.59	2.00e-05	44.30
IUUC-Aor-010022	Aspergillus oryzae	43.64	4.00e-04	40.00
IUUC-Ate-010527	Aspergillus terreus	45.45	6.00e-06	45.40
IUUC-Ame-011187	Astyanax mexicanus	31.89	7.00e-48	184.00
IUUC-Bta-013339	Bos taurus	86.34	1.00e-150	526.00
IUUC-Cja-018806	Callithrix jacchus	85.71	2.00e-142	498.00
IUUC-Cfa-020141	Canis familiaris	87.66	1.00e-142	499.00
IUUC-Cpo-021802	Cavia porcellus	87.47	5.00e-165	573.00
IUUC-Csa-023973	Chlorocebus sabaeus	86.19	1.00e-154	538.00
IUUC-Cho-024463	Choloepus hoffmanni	81.68	8.00e-138	483.00
IUUC-Cin-025601	Ciona intestinalis	35.67	7.00e-14	71.20
IUUC-Csv-025997	Ciona savignyi	37.50	9.00e-11	58.50
IUUC-Cme-027117	Cyanidioschyzon merolae	35.29	6.00e-05	42.70
IUUC-Dno-029118	Dasypus novemcinctus	82.86	1.00e-158	552.00
IUUC-Dor-030815	Dipodomys ordii	82.20	5.00e-150	523.00
IUUC-Ete-033054	Echinops telfairi	67.11	2.00e-99	355.00
IUUC-Eca-033245	Equus caballus	83.69	5.00e-149	520.00
IUUC-Eeu-034795	Erinaceus europaeus	87.76	4.00e-161	560.00
IUUC-Fca-036200	Felis catus	88.71	6.00e-159	553.00
IUUC-Fal-036890	Ficedula albicollis	52.06	1.00e-77	283.00
IUUC-Fox-037920	Fusarium oxysporum	48.00	2.20e-01	29.60
IUUC-Gmo-038670	Gadus morhua	44.69	2.00e-32	133.00
IUUC-Gga-040151	Gallus gallus	53.78	2.00e-71	262.00
IUUC-Gac-041925	Gasterosteus aculeatus	36.47	4.00e-54	205.00
IUUC-Gma-043968	Glycine max	28.00	8.30e-02	32.70
IUUC-Ggo-045103	Gorilla gorilla	87.06	2.00e-145	508.00
IUUC-Hsa-046226	Homo sapiens	87.21	5.00e-158	550.00
IUUC-Itr-048589	Ictidomys tridecemlineatus	88.48	4.00e-165	574.00
IUUC-Lch-050254	Latimeria chalumnae	50.13	7.00e-65	240.00
IUUC-Loc-052154	Lepisosteus oculatus	51.63	4.00e-42	165.00
IUUC-Laf-053533	Loxodonta africana	85.86	2.00e-165	575.00
IUUC-Mcc-055840	Macaca mulatta	86.96	2.00e-156	545.00
IUUC-Meu-056691	Macropus eugenii	81.48	2.00e-106	378.00
IUUC-Mtr-058097	Medicago truncatula	37.50	1.40e-01	30.80
IUUC-Mga-060042	Meleagris gallopavo	55.69	1.00e-75	276.00
IUUC-Mmr-060875	Microcebus murinus	89.27	4.00e-171	594.00
IUUC-Mdo-062924	Monodelphis domestica	76.76	6.00e-126	443.00
IUUC-Mmu-063831	Mus musculus	94.88	0.00e+00	630.00
IUUC-Mpu-066883	Mustela putorius furo	87.66	4.00e-155	540.00
IUUC-Mlu-067783	Myotis lucifugus	85.67	8.00e-136	476.00
IUUC-Nle-069005	Nomascus leucogenys	86.70	2.00e-156	545.00
IUUC-Opr-070231	Ochotona princeps	85.86	4.00e-160	557.00
IUUC-Ont-072578	Oreochromis niloticus	36.15	1.00e-38	153.00
IUUC-Oan-073354	Ornithorhynchus anatinus	69.27	6.00e-119	421.00
IUUC-Ocu-074495	Oryctolagus cuniculus	88.22	2.00e-158	552.00
IUUC-Oin-080191	Oryza indica	36.21	6.60e-02	31.20
IUUC-Ome-081116	Oryza meridionalis	41.67	3.90e-01	29.30
IUUC-Ola-087167	Oryzias latipes	34.79	8.00e-56	211.00
IUUC-Oga-088825	Otolemur garnettii	88.49	9.00e-158	549.00
IUUC-Oar-089616	Ovis aries	86.13	3.00e-147	514.00
IUUC-Ptr-090458	Pan troglodytes	86.96	4.00e-156	543.00
IUUC-Pan-091940	Papio anubis	86.51	6.00e-155	540.00
IUUC-Psi-093972	Pelodiscus sinensis	55.63	8.00e-57	213.00
IUUC-Pfo-096041	Poecilia formosa	40.52	3.00e-45	176.00
IUUC-Pab-097734	Pongo abelii	86.70	2.00e-166	578.00
IUUC-Pca-100301	Procavia capensis	76.89	2.00e-81	295.00
IUUC-Pva-102349	Pteropus vampyrus	87.76	1.00e-166	578.00
IUUC-Sha-107280	Sarcophilus harrisii	76.88	3.00e-136	478.00
IUUC-Sar-113496	Sorex araneus	78.33	2.00e-140	491.00
IUUC-Ssc-115558	Sus scrofa	89.32	7.00e-93	332.00
IUUC-Tgu-117337	Taeniopygia guttata	52.71	5.00e-86	311.00
IUUC-Tru-117847	Takifugu rubripes	39.22	1.00e-43	170.00
IUUC-Tsy-119527	Tarsius syrichta	88.97	4.00e-125	440.00
IUUC-Tni-119885	Tetraodon nigroviridis	34.62	2.00e-49	189.00
IUUC-Tre-121914	Trichoderma reesei	33.33	8.90e-02	32.30
IUUC-Tae-123106	Triticum aestivum	31.52	4.50e-02	32.00
IUUC-Tur-126441	Triticum urartu	48.15	5.00e-01	28.90
IUUC-Tbe-127599	Tupaia belangeri	84.16	2.00e-84	305.00
IUUC-Ttr-128320	Tursiops truncatus	79.53	2.00e-132	465.00
IUUC-Vpa-130608	Vicugna pacos	87.92	1.00e-158	552.00
IUUC-Xtr-131896	Xenopus tropicalis	44.22	1.00e-52	200.00
IUUC-Xma-133006	Xiphophorus maculatus	42.44	1.00e-66	247.00
IUUC-Zma-135954	Zea mays	32.84	9.40e-02	31.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence