iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061955

UUCD1 version

UUC-MoD-01150

Ensembl Protein ID

ENSMODP00000017739.3

UniProt Accession

F6U6L7; F6U6L7_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000014180.3	ENSMODT00000018067.3	ENSMODP00000017739.3
ENSMODG00000014180.3	ENSMODT00000018056.3	ENSMODP00000017728.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-56	192.5	162	641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L++++e+r+l+l      +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 162  VGLKNVGNTCWFSAVIQSLFQLSEFRRLVLGyslpqNILENCRSH-TEKRNIVFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 248
           6******************************96665455555443.478888*******************************99998. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
              +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +  +++   +e+f +++
   Q: 249  ADEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNSPRNKSENPMVQLFYGTFLTEGVHE--GKTFCNNETFGQYP 317
           789********************22..................23467899****************999985..45556699****** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e e+e    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 318  LQVNGYR-----NLDECLEGAMVEGEIE----MLPPD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 395
           *******.....9*****9998888888....44444..3455678889**************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ s                                                                                    
   Q: 396  RYMYSskelirtkrehirklkeevkvlqqkleryvkygsgparfplpdmlqyvlefastkpateappsvhcpisdlttkksiraeeysc 484
           *9999777777777777777777777766666666666666666666666666666666666666666666666665555555555555 PP
   S: 268  peekqke.................................................................................. 274
           +     +                                                                                  
   Q: 485  Q-----Vevplsslekdnllqtdlinkpftssrhsvkmpehpaprtiteeemnfvktclqrwrseieqdiqdlkncianttqtieqmys 568
           0.....05555555555556666666666666666666667777777777777777788888888888888888888888899999999 PP
   S: 275  .....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 569  dpllhQVPYRLHAVLVHEGQANAGHYWAYIYNRPRNiWLKYNDISVTESSWEELERDSYgglrnVSAYCLMYI 641
           99999***************************88888*******************8879************6 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MTAELQQEDA ASAAESHGSS CQMLLNQLRE ITGIQDPSFL HEALKASNGD ITQAVSLLTD 60
ERVKEPSQDT IAAEPSEGEG SAANKVVPTK VIDPTHDNKD DLQAAIALSL LESPKIQTDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGTGTCGGC GAAGGGGTGG GCCCGCCCGG GGCGCGCGCG CGCCCAGGTT AAGGGAGGGC 60
GAGCTAAGGG GGCGGGGCTG GAACCGAACC CAGGAGGGGG GGTTGTGAGG CGGAGGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009361--RZZ-complex_Zw10
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF06248--Zw10

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:1990423--C:RZZ complex
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0007067--P:mitotic nuclear division
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	84.68	0.00e+00	1296.00
IUUC-Apl-004010	Anas platyrhynchos	65.38	0.00e+00	1371.00
IUUC-Aca-004741	Anolis carolinensis	61.66	0.00e+00	1273.00
IUUC-Acl-008164	Aspergillus clavatus	25.25	2.00e-17	85.50
IUUC-Afl-008717	Aspergillus flavus	25.42	9.00e-10	59.70
IUUC-Afu-008871	Aspergillus fumigatus	26.82	2.00e-10	62.00
IUUC-Ani-009503	Aspergillus nidulans	38.68	1.00e-12	68.90
IUUC-Ang-009577	Aspergillus niger	37.37	2.00e-12	68.90
IUUC-Ate-010275	Aspergillus terreus	21.45	1.00e-16	82.40
IUUC-Ame-011910	Astyanax mexicanus	46.18	0.00e+00	1361.00
IUUC-Bta-013377	Bos taurus	78.86	0.00e+00	1669.00
IUUC-Cel-018346	Caenorhabditis elegans	29.51	6.00e-25	110.00
IUUC-Cja-019977	Callithrix jacchus	81.36	0.00e+00	1718.00
IUUC-Cfa-020378	Canis familiaris	86.12	0.00e+00	1828.00
IUUC-Cpo-021817	Cavia porcellus	78.41	0.00e+00	1654.00
IUUC-Csa-023446	Chlorocebus sabaeus	86.40	0.00e+00	1856.00
IUUC-Cho-024717	Choloepus hoffmanni	68.40	0.00e+00	987.00
IUUC-Cin-025302	Ciona intestinalis	36.11	2.00e-89	323.00
IUUC-Csv-025911	Ciona savignyi	38.46	3.00e-98	352.00
IUUC-Cme-027167	Cyanidioschyzon merolae	30.88	1.00e-13	72.40
IUUC-Dre-028105	Danio rerio	57.33	0.00e+00	722.00
IUUC-Dno-029495	Dasypus novemcinctus	49.56	0.00e+00	1024.00
IUUC-Dor-030955	Dipodomys ordii	78.31	0.00e+00	1662.00
IUUC-Ete-032828	Echinops telfairi	77.67	0.00e+00	730.00
IUUC-Eca-034300	Equus caballus	81.10	0.00e+00	1674.00
IUUC-Eeu-034458	Erinaceus europaeus	80.90	0.00e+00	1186.00
IUUC-Fca-035753	Felis catus	81.46	0.00e+00	1734.00
IUUC-Fal-037062	Ficedula albicollis	67.16	0.00e+00	1364.00
IUUC-Fox-037752	Fusarium oxysporum	25.25	3.00e-18	87.80
IUUC-Gmo-039490	Gadus morhua	54.44	0.00e+00	711.00
IUUC-Gga-040817	Gallus gallus	51.89	0.00e+00	1064.00
IUUC-Gac-041867	Gasterosteus aculeatus	54.93	0.00e+00	1083.00
IUUC-Ggo-045384	Gorilla gorilla	81.18	0.00e+00	1709.00
IUUC-Hsa-046277	Homo sapiens	81.34	0.00e+00	1716.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	76.72	5.00e-157	547.00
IUUC-Kpa-049349	Komagataella pastoris	34.78	5.00e-09	57.40
IUUC-Lch-049692	Latimeria chalumnae	61.05	0.00e+00	1251.00
IUUC-Loc-052636	Lepisosteus oculatus	61.60	0.00e+00	1301.00
IUUC-Laf-053808	Loxodonta africana	81.81	0.00e+00	1195.00
IUUC-Mcc-055473	Macaca mulatta	86.40	0.00e+00	1855.00
IUUC-Meu-056416	Macropus eugenii	80.85	0.00e+00	1662.00
IUUC-Mla-058944	Melampsora laricipopulina	22.75	3.00e-12	67.80
IUUC-Mga-060011	Meleagris gallopavo	63.47	0.00e+00	1291.00
IUUC-Mmr-060720	Microcebus murinus	79.03	0.00e+00	1617.00
IUUC-Mmu-063870	Mus musculus	81.19	0.00e+00	1257.00
IUUC-Mpu-066454	Mustela putorius furo	84.71	0.00e+00	1736.00
IUUC-Mlu-067487	Myotis lucifugus	76.17	0.00e+00	1595.00
IUUC-Nfi-068458	Neosartorya fischeri	23.69	8.00e-15	76.60
IUUC-Nle-070044	Nomascus leucogenys	81.25	0.00e+00	1712.00
IUUC-Opr-070888	Ochotona princeps	84.39	3.00e-139	489.00
IUUC-Ont-072150	Oreochromis niloticus	49.91	0.00e+00	1020.00
IUUC-Oan-073054	Ornithorhynchus anatinus	51.53	0.00e+00	664.00
IUUC-Ocu-074523	Oryctolagus cuniculus	78.97	0.00e+00	1661.00
IUUC-Ola-086393	Oryzias latipes	52.28	0.00e+00	1050.00
IUUC-Oga-088618	Otolemur garnettii	79.23	0.00e+00	1659.00
IUUC-Oar-089848	Ovis aries	84.16	0.00e+00	1758.00
IUUC-Ptr-091630	Pan troglodytes	78.44	0.00e+00	1250.00
IUUC-Pan-092882	Papio anubis	83.98	0.00e+00	1314.00
IUUC-Psi-093422	Pelodiscus sinensis	73.26	0.00e+00	1554.00
IUUC-Pma-094250	Petromyzon marinus	50.17	1.00e-77	283.00
IUUC-Pno-095093	Phaeosphaeria nodorum	31.86	5.00e-13	70.50
IUUC-Pfo-096466	Poecilia formosa	56.85	0.00e+00	783.00
IUUC-Pab-098337	Pongo abelii	81.34	0.00e+00	1711.00
IUUC-Pca-100718	Procavia capensis	55.17	0.00e+00	642.00
IUUC-Pva-102226	Pteropus vampyrus	74.85	0.00e+00	1457.00
IUUC-Rno-105735	Rattus norvegicus	83.58	0.00e+00	1801.00
IUUC-Sce-106441	Saccharomyces cerevisiae	26.22	1.00e-10	62.80
IUUC-Sha-107489	Sarcophilus harrisii	91.35	0.00e+00	1946.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	34.57	1.00e-09	59.70
IUUC-Sar-112977	Sorex araneus	68.61	0.00e+00	753.00
IUUC-Ssc-115463	Sus scrofa	81.70	0.00e+00	1005.00
IUUC-Tgu-116609	Taeniopygia guttata	64.17	0.00e+00	1295.00
IUUC-Tru-117807	Takifugu rubripes	50.33	0.00e+00	955.00
IUUC-Tsy-119471	Tarsius syrichta	49.29	2.00e-180	626.00
IUUC-Tni-119983	Tetraodon nigroviridis	57.21	0.00e+00	733.00
IUUC-Tme-126928	Tuber melanosporum	25.69	3.00e-20	94.40
IUUC-Tbe-127549	Tupaia belangeri	49.02	0.00e+00	656.00
IUUC-Ttr-128887	Tursiops truncatus	75.28	0.00e+00	1564.00
IUUC-Uma-129338	Ustilago maydis	22.81	3.00e-10	61.60
IUUC-Vpa-130614	Vicugna pacos	77.53	0.00e+00	1237.00
IUUC-Xtr-132436	Xenopus tropicalis	58.76	0.00e+00	1128.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence