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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032219
Ensembl Protein ID FBpp0307723
UniProt Accession A8DZ19; A8DZ19_DROME
Genbank Protein ID ABV53695.2
Protein Name Rho-type guanine nucleotide exchange factor, isoform F
Genbank Nucleotide ID AE014134
Gene Name RtGEF; rtGEF; CG10043; Dmel_CG10043
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0015803 FBtr0336748 FBpp0307724
FBgn0015803 FBtr0336747 FBpp0307723
FBgn0015803 FBtr0112885 FBpp0111798
FBgn0015803 FBtr0081356 FBpp0080888
FBgn0015803 FBtr0336749 FBpp0307725
FBgn0015803 FBtr0302106 FBpp0291316
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDPINA
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 3.30e-15 55.8 6 59
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +vq+ y+++++n+deL ++kGdv++v   + +d+gW++g  +l+ k G fP+n+v++ 
   Q: 6    VVQAEYSFMGSNNDELCFQKGDVITVT--QREDGGWWEG--TLNDKTGWFPSNYVNEC 59
           799***********************7..999*******..8*************985 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MDQPLVVQAE YSFMGSNNDE LCFQKGDVIT VTQREDGGWW EGTLNDKTGW FPSNYVNECK 60
VQLPLTETIR PPEEIQEYRS VVLKDLLDSE RAHVAELQGL LENFLEPMQQ TQILSQDEYA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032219|UBD,SH3|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACACATCTTT AGTTTGGCTG CGGCCGATTG CAGCCCTGGT TTTCTAGGTT TCTATTTTGG 60
TCGAGCGCTG TGTTTTATTT ATGTTTGCCA TGGGAAAAGA GAGTTGCTAA AAGTGCCTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032219|UBD,SH3|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR000219--DH-domain
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
PROSITE

PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF00621--RhoGEF
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0097482--C:muscle cell postsynaptic density
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0032947--F:protein complex scaffold
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035332--P:positive regulation of hippo signaling
GO:0046620--P:regulation of organ growth
GO:0035023--P:regulation of Rho protein signal transduction
GO:0050807--P:regulation of synapse organization
KEGG dme:Dmel_CG10043
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001259 Ailuropoda melanoleuca 45.34 3.00e-103 368.00
IUUC-Apl-003960 Anas platyrhynchos 44.09 5.00e-95 341.00
IUUC-Aca-004591 Anolis carolinensis 44.58 9.00e-102 363.00
IUUC-Afl-008481 Aspergillus flavus 25.10 2.00e-07 50.40
IUUC-Afu-009099 Aspergillus fumigatus 22.29 2.00e-10 60.80
IUUC-Ani-009276 Aspergillus nidulans 24.70 7.00e-12 65.50
IUUC-Ang-009549 Aspergillus niger 26.59 8.00e-13 68.60
IUUC-Aor-010216 Aspergillus oryzae 25.10 2.00e-07 50.40
IUUC-Ate-010338 Aspergillus terreus 24.70 6.00e-10 59.30
IUUC-Ame-011729 Astyanax mexicanus 45.48 4.00e-89 321.00
IUUC-Bta-013328 Bos taurus 45.75 8.00e-104 370.00
IUUC-Cja-018742 Callithrix jacchus 45.09 2.00e-102 365.00
IUUC-Cfa-020756 Canis familiaris 45.09 5.00e-102 364.00
IUUC-Cpo-021284 Cavia porcellus 45.99 6.00e-97 347.00
IUUC-Csa-023162 Chlorocebus sabaeus 45.34 9.00e-103 367.00
IUUC-Cho-024736 Choloepus hoffmanni 51.05 6.00e-42 164.00
IUUC-Cin-025535 Ciona intestinalis 36.20 5.00e-70 257.00
IUUC-Cne-026866 Cryptococcus neoformans 43.14 5.00e-11 63.50
IUUC-Dre-028845 Danio rerio 42.93 3.00e-98 352.00
IUUC-Dno-029461 Dasypus novemcinctus 45.34 3.00e-102 365.00
IUUC-Dor-030623 Dipodomys ordii 39.55 7.00e-80 291.00
IUUC-Ete-032236 Echinops telfairi 39.25 1.00e-84 306.00
IUUC-Eca-034137 Equus caballus 44.94 5.00e-103 368.00
IUUC-Eeu-035269 Erinaceus europaeus 40.86 2.00e-35 143.00
IUUC-Fca-035742 Felis catus 44.84 7.00e-97 347.00
IUUC-Fal-037205 Ficedula albicollis 46.77 8.00e-105 373.00
IUUC-Gmo-039475 Gadus morhua 45.08 5.00e-99 354.00
IUUC-Gga-040539 Gallus gallus 46.35 3.00e-105 375.00
IUUC-Gac-042615 Gasterosteus aculeatus 44.22 2.00e-87 316.00
IUUC-Ggo-044470 Gorilla gorilla 45.59 4.00e-103 368.00
IUUC-Hsa-046398 Homo sapiens 45.59 3.00e-103 368.00
IUUC-Lch-049517 Latimeria chalumnae 44.24 6.00e-99 354.00
IUUC-Lpe-051218 Leersia perrieri 33.33 6.00e-02 28.90
IUUC-Loc-052146 Lepisosteus oculatus 45.48 2.00e-103 369.00
IUUC-Lma-052955 Leptosphaeria maculans 25.50 4.00e-12 66.60
IUUC-Laf-053891 Loxodonta africana 45.09 1.00e-102 366.00
IUUC-Mcc-055483 Macaca mulatta 45.34 9.00e-103 367.00
IUUC-Meu-056285 Macropus eugenii 42.57 4.00e-64 238.00
IUUC-Mga-059410 Meleagris gallopavo 45.59 2.00e-103 369.00
IUUC-Mmr-060758 Microcebus murinus 44.84 2.00e-89 323.00
IUUC-Mdo-061900 Monodelphis domestica 44.84 5.00e-102 364.00
IUUC-Mmu-063849 Mus musculus 46.25 9.00e-98 350.00
IUUC-Mpu-065876 Mustela putorius furo 44.58 5.00e-101 361.00
IUUC-Mlu-067970 Myotis lucifugus 46.25 2.00e-102 366.00
IUUC-Nfi-068331 Neosartorya fischeri 23.79 6.00e-10 59.30
IUUC-Nle-069685 Nomascus leucogenys 45.34 4.00e-103 367.00
IUUC-Opr-071132 Ochotona princeps 38.02 1.00e-64 239.00
IUUC-Ont-071815 Oreochromis niloticus 45.50 3.00e-101 362.00
IUUC-Oan-073057 Ornithorhynchus anatinus 44.96 1.00e-100 359.00
IUUC-Ocu-074852 Oryctolagus cuniculus 42.97 5.00e-97 348.00
IUUC-Ola-086663 Oryzias latipes 44.73 7.00e-100 357.00
IUUC-Oga-088103 Otolemur garnettii 44.89 3.00e-89 322.00
IUUC-Oar-089339 Ovis aries 43.04 8.00e-96 343.00
IUUC-Ptr-091162 Pan troglodytes 45.59 2.00e-103 369.00
IUUC-Pan-092666 Papio anubis 43.72 3.00e-96 345.00
IUUC-Psi-093116 Pelodiscus sinensis 45.41 7.00e-100 357.00
IUUC-Pma-094261 Petromyzon marinus 42.33 2.00e-69 254.00
IUUC-Ppa-095161 Physcomitrella patens 43.75 5.00e-08 51.20
IUUC-Pfo-096736 Poecilia formosa 45.13 3.00e-99 355.00
IUUC-Pab-097641 Pongo abelii 45.34 5.00e-103 367.00
IUUC-Pca-100997 Procavia capensis 37.50 5.00e-75 275.00
IUUC-Pva-102819 Pteropus vampyrus 44.96 4.00e-99 355.00
IUUC-Ptt-103726 Puccinia triticina 41.67 1.00e-09 55.80
IUUC-Pte-104293 Pyrenophora teres 25.81 2.00e-11 64.30
IUUC-Pyt-104722 Pyrenophora triticirepentis 26.21 8.00e-12 65.10
IUUC-Rno-106099 Rattus norvegicus 46.25 1.00e-97 350.00
IUUC-Sha-106845 Sarcophilus harrisii 44.33 2.00e-101 362.00
IUUC-Ssl-108541 Sclerotinia sclerotiorum 24.39 2.00e-10 61.20
IUUC-Sar-113420 Sorex araneus 43.04 2.00e-87 316.00
IUUC-Ssc-116036 Sus scrofa 45.89 9.00e-105 373.00
IUUC-Tgu-117498 Taeniopygia guttata 45.84 2.00e-104 373.00
IUUC-Tru-118278 Takifugu rubripes 44.87 3.00e-101 362.00
IUUC-Tsy-118990 Tarsius syrichta 44.58 6.00e-100 357.00
IUUC-Tni-120852 Tetraodon nigroviridis 43.59 5.00e-97 348.00
IUUC-Tvi-122300 Trichoderma virens 24.70 3.00e-11 63.90
IUUC-Tme-127216 Tuber melanosporum 24.38 7.00e-14 72.00
IUUC-Tbe-127994 Tupaia belangeri 35.60 1.00e-65 243.00
IUUC-Ttr-128922 Tursiops truncatus 44.44 2.00e-94 339.00
IUUC-Vpa-130144 Vicugna pacos 43.78 3.00e-60 226.00
IUUC-Xtr-132012 Xenopus tropicalis 46.13 1.00e-95 343.00
IUUC-Xma-133901 Xiphophorus maculatus 42.82 1.00e-93 337.00
Created Date 25-Jun-2017

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