iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-104865

UUCD1 version

UUC-RaN-01042

Ensembl Protein ID

ENSRNOP00000009136.3

UniProt Accession

Q8CF97; Q7TNK5; VCIP1_RAT

Genbank Protein ID

BAC44841.2; AAQ14350.1

Protein Name

Deubiquitinating protein VCIP135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135

Genbank Nucleotide ID

AB045378; AF289091

Gene Name

Vcpip1; Vcip135

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000006980.4	ENSRNOT00000009136.4	ENSRNOP00000009136.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.10e-29	102.5	207	359

Active Site

Position(s)	Description	Evidence
215	N/A	{ECO:0000250}
218	Nucleophile	ECO:0000250}
353		{ECO:0000250}

Domain Profile

DUB/OTU

   S: 1    llilktkgDGnCLlrAvsqsllgvfdddslsdalveaLreltseyl....qkesdffsefieek..edekefcqklvepe...akg..e 78
           l++++++gDG+CL++Avs++   ++++++    +++aLre++++++    +++++ f++fi+++  ed+ ++c+ l+ p+        +
   Q: 207  LIPVHVDGDGHCLVHAVSRA---LVGREL----FWHALRENLKQHFqqhlARYQALFHDFIDAAewEDIINECDPLFVPPegvP-LglR 287
           5789****************...******....666666666666544449999*********999************995542.047* PP
   S: 79   eihifaLaqiLsrpiivvdvdsles...kvggillpllfpeek.......lkkpivLlYrsg...HYdaLva 137
           +ihif La++L+rpii++d+ s+++   ++++++lp l+p+ek       l+kpi+++++s+   HY +Lv 
   Q: 288  NIHIFGLANVLHRPIILLDSLSGMRssgDYSATFLPGLIPAEKctgrdghLNKPICIAWSSSgrnHYIPLVG 359
           **********************99999********************************644488*****96 PP

Organism

Rattus norvegicus

Functional Description
(View)

Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MSQPPPPPPL PPPPPPPEAP QTSSSLAAAA TPGGLSKRRD RRILSGSCPD PKCQARLFFP 60
ASGSVSIECT ECGQRHEQQQ LLGVEEVTDP DVVLHNLLRN ALLGVTGAPK KNTELVKVMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGTGCGG AAGCCACGCC TGCGCAGTCT CAGTGAGGGC GTGTATGTCT GTATCTGAGG 60
GAGAGAGCGA GAGTGAGTGA GTGTGAGTGC GGGGTGGGGT GGTGGCCGTT ACGTTCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005795--C:Golgi stack
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016320--P:endoplasmic reticulum membrane fusion
GO:0007030--P:Golgi organization
GO:0090168--P:Golgi reassembly
GO:0007067--P:mitotic nuclear division
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0016567--P:protein ubiquitination

KEGG

rno:286761

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001319	Ailuropoda melanoleuca	96.62	0.00e+00	2259.00
IUUC-Apl-004212	Anas platyrhynchos	83.99	0.00e+00	1961.00
IUUC-Aca-005351	Anolis carolinensis	82.48	0.00e+00	1952.00
IUUC-Ate-010437	Aspergillus terreus	31.17	4.20e-01	28.90
IUUC-Ame-010733	Astyanax mexicanus	73.96	0.00e+00	1328.00
IUUC-Bta-012792	Bos taurus	94.27	0.00e+00	2243.00
IUUC-Cja-019980	Callithrix jacchus	95.62	0.00e+00	2293.00
IUUC-Cfa-020680	Canis familiaris	96.88	0.00e+00	2268.00
IUUC-Cpo-022087	Cavia porcellus	94.68	0.00e+00	2301.00
IUUC-Csa-023550	Chlorocebus sabaeus	95.99	0.00e+00	2288.00
IUUC-Cho-024668	Choloepus hoffmanni	92.34	0.00e+00	2182.00
IUUC-Cin-025548	Ciona intestinalis	44.50	6.00e-155	541.00
IUUC-Csv-026169	Ciona savignyi	46.99	4.00e-45	174.00
IUUC-Cme-027341	Cyanidioschyzon merolae	33.33	5.60e-02	32.30
IUUC-Dre-028151	Danio rerio	71.19	0.00e+00	1536.00
IUUC-Dno-029986	Dasypus novemcinctus	95.32	0.00e+00	2285.00
IUUC-Dor-030555	Dipodomys ordii	89.77	0.00e+00	2066.00
IUUC-Ete-033114	Echinops telfairi	91.93	0.00e+00	2128.00
IUUC-Eca-034153	Equus caballus	96.55	0.00e+00	2261.00
IUUC-Eeu-034681	Erinaceus europaeus	89.71	0.00e+00	804.00
IUUC-Fca-035911	Felis catus	96.64	0.00e+00	2320.00
IUUC-Fal-037214	Ficedula albicollis	84.91	0.00e+00	1971.00
IUUC-Gmo-039664	Gadus morhua	75.70	0.00e+00	1521.00
IUUC-Ggr-039893	Gaeumannomyces graminis	31.71	1.70e+00	28.10
IUUC-Gga-040302	Gallus gallus	84.24	0.00e+00	1974.00
IUUC-Gac-041575	Gasterosteus aculeatus	73.66	0.00e+00	1622.00
IUUC-Ggo-044624	Gorilla gorilla	95.61	0.00e+00	2282.00
IUUC-Hsa-045914	Homo sapiens	95.93	0.00e+00	2286.00
IUUC-Itr-048269	Ictidomys tridecemlineatus	96.57	0.00e+00	2308.00
IUUC-Lch-050083	Latimeria chalumnae	77.50	0.00e+00	1800.00
IUUC-Loc-052258	Lepisosteus oculatus	74.10	0.00e+00	1724.00
IUUC-Laf-054209	Loxodonta africana	96.05	0.00e+00	2311.00
IUUC-Mcc-055670	Macaca mulatta	96.07	0.00e+00	2289.00
IUUC-Meu-056397	Macropus eugenii	96.88	0.00e+00	1035.00
IUUC-Mla-058941	Melampsora laricipopulina	26.49	1.00e-03	37.70
IUUC-Mga-059426	Meleagris gallopavo	84.60	0.00e+00	1938.00
IUUC-Mmr-060911	Microcebus murinus	97.17	0.00e+00	1959.00
IUUC-Mdo-061844	Monodelphis domestica	90.92	0.00e+00	2133.00
IUUC-Mmu-064417	Mus musculus	98.73	0.00e+00	2330.00
IUUC-Mpu-066037	Mustela putorius furo	96.71	0.00e+00	2293.00
IUUC-Mlu-067718	Myotis lucifugus	94.76	0.00e+00	2229.00
IUUC-Nle-069487	Nomascus leucogenys	96.29	0.00e+00	2282.00
IUUC-Opr-070955	Ochotona princeps	91.71	0.00e+00	880.00
IUUC-Ont-071417	Oreochromis niloticus	71.25	0.00e+00	1702.00
IUUC-Oan-072968	Ornithorhynchus anatinus	88.25	0.00e+00	2088.00
IUUC-Ocu-073928	Oryctolagus cuniculus	95.84	0.00e+00	2273.00
IUUC-Olo-080471	Oryza longistaminata	27.55	1.70e-02	33.50
IUUC-Ola-086984	Oryzias latipes	70.98	0.00e+00	1629.00
IUUC-Oga-088277	Otolemur garnettii	95.95	0.00e+00	2223.00
IUUC-Oar-089250	Ovis aries	94.79	0.00e+00	2244.00
IUUC-Ptr-090602	Pan troglodytes	96.29	0.00e+00	2281.00
IUUC-Pan-092319	Papio anubis	96.07	0.00e+00	2289.00
IUUC-Psi-093378	Pelodiscus sinensis	85.36	0.00e+00	1976.00
IUUC-Pma-094476	Petromyzon marinus	52.10	0.00e+00	906.00
IUUC-Pfo-096606	Poecilia formosa	74.28	0.00e+00	1673.00
IUUC-Pab-098367	Pongo abelii	95.36	0.00e+00	2277.00
IUUC-Pca-100395	Procavia capensis	96.81	0.00e+00	2135.00
IUUC-Pva-103143	Pteropus vampyrus	99.32	0.00e+00	1255.00
IUUC-Sha-106910	Sarcophilus harrisii	90.89	0.00e+00	2122.00
IUUC-Sit-109693	Setaria italica	32.76	3.00e-03	37.00
IUUC-Sly-111690	Solanum lycopersicum	42.50	6.70e-02	32.70
IUUC-Stu-112644	Solanum tuberosum	48.48	1.20e-01	31.60
IUUC-Sar-113767	Sorex araneus	92.04	0.00e+00	1114.00
IUUC-Sbi-113844	Sorghum bicolor	32.26	4.00e-04	37.40
IUUC-Ssc-115468	Sus scrofa	97.73	0.00e+00	1748.00
IUUC-Tgu-116788	Taeniopygia guttata	84.74	0.00e+00	1994.00
IUUC-Tru-118008	Takifugu rubripes	72.10	0.00e+00	1622.00
IUUC-Tsy-119457	Tarsius syrichta	96.47	0.00e+00	2291.00
IUUC-Tni-120146	Tetraodon nigroviridis	72.07	0.00e+00	1571.00
IUUC-Tvi-122364	Trichoderma virens	45.45	2.10e-01	31.60
IUUC-Tbe-128060	Tupaia belangeri	98.39	0.00e+00	1585.00
IUUC-Ttr-128257	Tursiops truncatus	91.67	0.00e+00	2140.00
IUUC-Vpa-130661	Vicugna pacos	94.70	0.00e+00	2311.00
IUUC-Xtr-131761	Xenopus tropicalis	77.98	0.00e+00	1836.00
IUUC-Xma-133775	Xiphophorus maculatus	74.55	0.00e+00	1673.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence