iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093382

Ensembl Protein ID

ENSPSIP00000005255.1

UniProt Accession

K7FB45; K7FB45_PELSI

Genbank Protein ID

ENSPSIP00000005255

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01171573

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000004862.1	ENSPSIT00000005285.1	ENSPSIP00000005255.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.40e-06	26.8	948	1037
E3 activity/RING/PHD	2.70e-14	53.1	627	692

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 55   srrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqk 140
            r tpr   r p + + pk+         p p +p p   p    d g  + ++ e+++ ++++l++++l+ + rvc++w++ + +k
   Q: 948  LRSTPRVITRPPPSLSPPKCIQMERHVIRPPPiSPPPDSLPL---DDGAAHVMQREVWMAVFSYLSHSDLCICMRVCKTWNRWCCDK 1031
           4789*******9999999986666666666551344444443...6677788889**************************655559 PP
   S: 141  alwktv 146
           +lw ++
   Q: 1032 RLWTNI 1037
           ***986 PP

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk +     v++elpn+  w+CpkC+++
   Q: 627  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKVKesdgvVNDELPNC--WECPKCNHA 692
           79*********9977765156789*********************************..*******85 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MEAEKDSGRR LRSIGRRRYD ENEDLSDVEE IVCIRSFNLE EKLKSRKYHG DFVRAMEGKD 60
FTFEYVQREA LRFPLLFRSK DGLGIKMPDR DFTVRDVKLL VGSRRIVDVM NVNTQKGIEM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCAG AGAAAGACTC TGGAAGAAGA TTGGTGTGTA GCTGGCTTCT GTCTATTTCC 60
TATTTGTACA TTTTAATTGA TTTTGTTTAA TTATTTGCAA AGGGAGAAAT GCATGTAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	83.46	0.00e+00	2037.00
IUUC-Apl-003787	Anas platyrhynchos	93.64	0.00e+00	2134.00
IUUC-Aca-004247	Anolis carolinensis	80.50	0.00e+00	1877.00
IUUC-Acl-008303	Aspergillus clavatus	42.61	2.00e-63	238.00
IUUC-Afl-008579	Aspergillus flavus	42.55	2.00e-23	104.00
IUUC-Ani-009279	Aspergillus nidulans	45.42	1.00e-62	235.00
IUUC-Aor-010233	Aspergillus oryzae	46.01	1.00e-63	238.00
IUUC-Ate-010345	Aspergillus terreus	45.25	7.00e-65	242.00
IUUC-Ame-011114	Astyanax mexicanus	69.41	7.00e-130	457.00
IUUC-Bta-013531	Bos taurus	83.97	0.00e+00	2045.00
IUUC-Cel-018303	Caenorhabditis elegans	43.83	9.00e-81	295.00
IUUC-Cja-018876	Callithrix jacchus	80.63	0.00e+00	1907.00
IUUC-Cfa-020857	Canis familiaris	83.90	0.00e+00	2041.00
IUUC-Cpo-021967	Cavia porcellus	81.49	0.00e+00	1909.00
IUUC-Csa-023210	Chlorocebus sabaeus	82.67	0.00e+00	1986.00
IUUC-Cme-027118	Cyanidioschyzon merolae	36.16	4.00e-49	189.00
IUUC-Dre-028272	Danio rerio	64.79	0.00e+00	1534.00
IUUC-Dno-030034	Dasypus novemcinctus	83.08	0.00e+00	1990.00
IUUC-Dor-030736	Dipodomys ordii	73.37	0.00e+00	853.00
IUUC-Dse-031402	Dothistroma septosporum	41.18	7.00e-61	229.00
IUUC-Eca-034255	Equus caballus	84.13	0.00e+00	1966.00
IUUC-Eeu-035038	Erinaceus europaeus	84.40	0.00e+00	1041.00
IUUC-Fca-035786	Felis catus	83.98	0.00e+00	1967.00
IUUC-Fal-037589	Ficedula albicollis	92.67	0.00e+00	2245.00
IUUC-Gmo-038932	Gadus morhua	53.53	0.00e+00	710.00
IUUC-Gga-041103	Gallus gallus	93.72	0.00e+00	1227.00
IUUC-Gac-041304	Gasterosteus aculeatus	62.16	0.00e+00	1494.00
IUUC-Ggo-044522	Gorilla gorilla	73.90	0.00e+00	1655.00
IUUC-Hsa-045877	Homo sapiens	83.93	0.00e+00	2008.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	84.55	0.00e+00	1166.00
IUUC-Lch-049950	Latimeria chalumnae	84.71	0.00e+00	2042.00
IUUC-Loc-051972	Lepisosteus oculatus	69.48	0.00e+00	1093.00
IUUC-Lma-053190	Leptosphaeria maculans	43.35	1.00e-60	228.00
IUUC-Laf-053623	Loxodonta africana	82.47	0.00e+00	1966.00
IUUC-Mcc-054943	Macaca mulatta	83.08	0.00e+00	1997.00
IUUC-Meu-056259	Macropus eugenii	84.46	0.00e+00	2000.00
IUUC-Mga-059671	Meleagris gallopavo	90.98	0.00e+00	2167.00
IUUC-Mmr-061003	Microcebus murinus	83.33	0.00e+00	2023.00
IUUC-Mmu-063584	Mus musculus	82.25	0.00e+00	2004.00
IUUC-Mpu-066056	Mustela putorius furo	83.68	0.00e+00	2019.00
IUUC-Mlu-067850	Myotis lucifugus	83.63	0.00e+00	2027.00
IUUC-Nle-069837	Nomascus leucogenys	85.99	0.00e+00	1829.00
IUUC-Opr-070943	Ochotona princeps	80.45	0.00e+00	1874.00
IUUC-Ont-071663	Oreochromis niloticus	65.13	0.00e+00	1576.00
IUUC-Oan-072934	Ornithorhynchus anatinus	78.05	0.00e+00	1303.00
IUUC-Ocu-074706	Oryctolagus cuniculus	83.55	0.00e+00	2019.00
IUUC-Ola-086543	Oryzias latipes	63.17	0.00e+00	1522.00
IUUC-Oga-088671	Otolemur garnettii	75.76	0.00e+00	916.00
IUUC-Oar-089560	Ovis aries	79.77	0.00e+00	1960.00
IUUC-Ptr-090875	Pan troglodytes	83.85	0.00e+00	2026.00
IUUC-Pan-091788	Papio anubis	81.92	0.00e+00	1964.00
IUUC-Pma-094687	Petromyzon marinus	51.40	2.00e-93	336.00
IUUC-Pno-094984	Phaeosphaeria nodorum	44.49	2.00e-61	231.00
IUUC-Ppa-095609	Physcomitrella patens	44.02	3.00e-56	211.00
IUUC-Pfo-096272	Poecilia formosa	66.56	0.00e+00	1519.00
IUUC-Pab-097907	Pongo abelii	79.60	0.00e+00	1859.00
IUUC-Pca-100628	Procavia capensis	75.10	0.00e+00	1634.00
IUUC-Pva-102956	Pteropus vampyrus	77.96	0.00e+00	954.00
IUUC-Ptt-103859	Puccinia triticina	43.81	2.00e-73	270.00
IUUC-Pte-104241	Pyrenophora teres	41.55	6.00e-61	229.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	41.55	3.00e-60	227.00
IUUC-Rno-105722	Rattus norvegicus	83.13	0.00e+00	1617.00
IUUC-Sha-106626	Sarcophilus harrisii	80.05	0.00e+00	1810.00
IUUC-Spo-108120	Schizosaccharomyces pombe	34.45	1.00e-49	191.00
IUUC-Ssc-115918	Sus scrofa	81.87	0.00e+00	1551.00
IUUC-Tgu-117229	Taeniopygia guttata	80.19	0.00e+00	1890.00
IUUC-Tru-118638	Takifugu rubripes	67.83	0.00e+00	969.00
IUUC-Tni-120020	Tetraodon nigroviridis	52.19	0.00e+00	671.00
IUUC-Tme-127054	Tuber melanosporum	41.67	1.00e-51	198.00
IUUC-Tbe-127654	Tupaia belangeri	67.87	0.00e+00	1449.00
IUUC-Ttr-128821	Tursiops truncatus	77.18	0.00e+00	1803.00
IUUC-Xtr-131823	Xenopus tropicalis	75.72	0.00e+00	1792.00
IUUC-Xma-133305	Xiphophorus maculatus	66.37	0.00e+00	997.00
IUUC-Yli-134626	Yarrowia lipolytica	38.53	5.00e-55	208.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence