iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068918

Ensembl Protein ID

EAA28350

UniProt Accession

Q7RV01; Q7RV01_NEUCR

Genbank Protein ID

EAA28350.3

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CM002241

Gene Name

NCU03947

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU03947	EAA28350	EAA28350

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-127	423.3	485	816

Active Site

Position(s)	Description	Evidence
785	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           + dlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld+++  ++yk++lg
   Q: 485  ATDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGI-NPEHLNYFKFIGRVVGLAIFHRRFLDAFFIGALYKMVLG 584
           579*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           k +sl d+e vd+++++sl+++++n   di++  ld tfs+++e +g ++ee+L+p+G+ni VtneNk+eYv+l+v++r++++i++q+ af++Gf+e+ip+
   Q: 585  KAVSLADMEGVDADFHRSLQWMLDN---DITDV-LDATFSTEDERFGVITEEDLIPNGRNIAVTNENKKEYVELMVKWRIEKRIEQQFRAFKDGFHELIPQ 681
           ***********************99...9***8.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G +eidv+d+kk+t y+g yte++++iq+Fw+++++++ e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 682  DLINVFDERELELLIGGIAEIDVDDWKKHTDYRG-YTESDEVIQFFWQTVRSWDGEQKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGEITNLPK 781
           ********************************76.*********************************************************9999***** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++TCfn+L+LP+Y+s e l++kL++A+eet gF++
   Q: 782  AHTCFNRLDLPPYKSLEMLQQKLTIAVEETMGFGQ 816
           *********************************96 PP

Organism

Neurospora crassa

Protein Sequence
(Fasta)

MTSSRDSGLP AQPNLRVTII AADGLYKRDV FRFPDPFAVA TINGEQTKTT QVSKRTLNPY 60
WNEHFDFKVN EDSILAVQVF DQKKFKKKDQ GFLGVINVRI GDVIELAPDA EDQMLTRDLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTCGGTCG TTTTCCCTCC CATCCTTTGG CTCATCCGTC GGTTGCAACT TAGTGAAGGT 60
CATTGAGCTC TTCACCTGGA CCTTCTTGGG GTTGGTCCGT CGAACCCAAG CTCACCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ncr:NCU03947

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	47.08	8.00e-154	535.00
IUUC-Apl-003893	Anas platyrhynchos	43.57	2.00e-153	535.00
IUUC-Aca-005338	Anolis carolinensis	45.15	9.00e-155	539.00
IUUC-Ago-007742	Ashbya gossypii	63.24	0.00e+00	984.00
IUUC-Acl-008273	Aspergillus clavatus	71.07	0.00e+00	1100.00
IUUC-Afl-008713	Aspergillus flavus	72.57	0.00e+00	1117.00
IUUC-Afu-009103	Aspergillus fumigatus	71.21	0.00e+00	1104.00
IUUC-Ani-009259	Aspergillus nidulans	70.54	0.00e+00	1126.00
IUUC-Ang-009738	Aspergillus niger	72.17	0.00e+00	1139.00
IUUC-Aor-010053	Aspergillus oryzae	77.93	1.00e-143	499.00
IUUC-Ate-010529	Aspergillus terreus	73.17	0.00e+00	1126.00
IUUC-Ame-010810	Astyanax mexicanus	51.75	5.00e-141	493.00
IUUC-Bgr-012148	Blumeria graminis	74.07	0.00e+00	1154.00
IUUC-Bta-012679	Bos taurus	46.12	2.00e-154	538.00
IUUC-Bci-013785	Botrytis cinerea	77.44	0.00e+00	1231.00
IUUC-Cel-018299	Caenorhabditis elegans	43.91	2.00e-143	501.00
IUUC-Cja-018732	Callithrix jacchus	47.08	3.00e-154	537.00
IUUC-Cfa-021226	Canis familiaris	44.78	3.00e-154	537.00
IUUC-Cpo-021671	Cavia porcellus	47.08	7.00e-154	536.00
IUUC-Csa-023334	Chlorocebus sabaeus	47.66	9.00e-156	542.00
IUUC-Cho-024695	Choloepus hoffmanni	44.41	4.00e-156	543.00
IUUC-Cin-025212	Ciona intestinalis	44.52	1.00e-149	521.00
IUUC-Csv-026256	Ciona savignyi	43.78	2.00e-144	503.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	83.96	0.00e+00	1310.00
IUUC-Cne-026849	Cryptococcus neoformans	61.20	0.00e+00	989.00
IUUC-Dre-027770	Danio rerio	51.75	9.00e-142	496.00
IUUC-Dno-029466	Dasypus novemcinctus	46.91	1.00e-153	535.00
IUUC-Dor-030138	Dipodomys ordii	46.58	6.00e-150	523.00
IUUC-Dse-031241	Dothistroma septosporum	70.90	0.00e+00	1170.00
IUUC-Dme-032041	Drosophila melanogaster	44.61	1.00e-140	492.00
IUUC-Ete-033145	Echinops telfairi	44.24	1.00e-140	491.00
IUUC-Eca-033445	Equus caballus	47.08	8.00e-154	535.00
IUUC-Eeu-035247	Erinaceus europaeus	46.74	3.00e-152	530.00
IUUC-Fca-036384	Felis catus	48.29	1.00e-159	555.00
IUUC-Fal-037547	Ficedula albicollis	45.27	8.00e-152	529.00
IUUC-Fox-037774	Fusarium oxysporum	82.06	0.00e+00	1298.00
IUUC-Fso-038393	Fusarium solani	81.38	0.00e+00	1274.00
IUUC-Gmo-039679	Gadus morhua	46.93	3.00e-151	527.00
IUUC-Ggr-040107	Gaeumannomyces graminis	83.70	0.00e+00	1328.00
IUUC-Gga-040524	Gallus gallus	47.16	9.00e-152	529.00
IUUC-Gac-042020	Gasterosteus aculeatus	45.55	4.00e-150	523.00
IUUC-Ggo-045332	Gorilla gorilla	44.94	1.00e-153	535.00
IUUC-Hsa-045968	Homo sapiens	45.96	6.00e-154	536.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	45.77	5.00e-155	539.00
IUUC-Kpa-049273	Komagataella pastoris	66.83	0.00e+00	1050.00
IUUC-Lch-050443	Latimeria chalumnae	47.40	9.00e-153	532.00
IUUC-Loc-052645	Lepisosteus oculatus	48.19	1.00e-155	541.00
IUUC-Lma-052980	Leptosphaeria maculans	69.64	0.00e+00	672.00
IUUC-Laf-053850	Loxodonta africana	47.08	8.00e-154	535.00
IUUC-Mcc-055821	Macaca mulatta	47.08	8.00e-154	536.00
IUUC-Meu-056436	Macropus eugenii	45.85	3.00e-117	414.00
IUUC-Mor-057097	Magnaporthe oryzae	84.70	0.00e+00	1374.00
IUUC-Mpo-057442	Magnaporthe poae	78.48	0.00e+00	1187.00
IUUC-Mla-058996	Melampsora laricipopulina	61.72	0.00e+00	1001.00
IUUC-Mga-059362	Meleagris gallopavo	46.21	1.00e-151	528.00
IUUC-Mvi-060395	Microbotryum violaceum	79.88	0.00e+00	833.00
IUUC-Mmr-061061	Microcebus murinus	45.63	7.00e-160	556.00
IUUC-Mdo-062173	Monodelphis domestica	42.41	2.00e-149	521.00
IUUC-Mmu-064136	Mus musculus	47.25	2.00e-154	537.00
IUUC-Mpu-066765	Mustela putorius furo	45.96	4.00e-154	537.00
IUUC-Mlu-068148	Myotis lucifugus	47.60	1.00e-158	552.00
IUUC-Nfi-068427	Neosartorya fischeri	79.73	0.00e+00	970.00
IUUC-Nle-069225	Nomascus leucogenys	47.66	2.00e-158	551.00
IUUC-Opr-071044	Ochotona princeps	46.74	4.00e-152	530.00
IUUC-Ont-071664	Oreochromis niloticus	46.50	4.00e-147	513.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.99	7.00e-151	526.00
IUUC-Ocu-074160	Oryctolagus cuniculus	46.67	7.00e-152	529.00
IUUC-Ola-087467	Oryzias latipes	46.15	7.00e-149	519.00
IUUC-Oga-088460	Otolemur garnettii	47.08	9.00e-154	535.00
IUUC-Oar-090198	Ovis aries	45.96	5.00e-154	536.00
IUUC-Ptr-090939	Pan troglodytes	45.96	6.00e-154	536.00
IUUC-Pan-092284	Papio anubis	47.08	5.00e-154	536.00
IUUC-Psi-093645	Pelodiscus sinensis	43.41	6.00e-155	540.00
IUUC-Pma-094364	Petromyzon marinus	51.81	3.00e-144	503.00
IUUC-Pno-095118	Phaeosphaeria nodorum	70.46	0.00e+00	1147.00
IUUC-Pfo-097145	Poecilia formosa	46.74	3.00e-145	507.00
IUUC-Pab-098088	Pongo abelii	45.96	5.00e-154	536.00
IUUC-Pca-100568	Procavia capensis	45.02	1.00e-137	483.00
IUUC-Pva-102354	Pteropus vampyrus	47.08	1.00e-153	535.00
IUUC-Pgr-103620	Puccinia graminis	67.46	0.00e+00	870.00
IUUC-Ptt-103806	Puccinia triticina	78.45	0.00e+00	701.00
IUUC-Pte-104016	Pyrenophora teres	81.69	0.00e+00	982.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	81.69	0.00e+00	982.00
IUUC-Rno-105318	Rattus norvegicus	47.25	3.00e-154	537.00
IUUC-Sce-106289	Saccharomyces cerevisiae	74.28	0.00e+00	910.00
IUUC-Sha-107482	Sarcophilus harrisii	43.70	2.00e-150	524.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	65.26	0.00e+00	1040.00
IUUC-Spo-108171	Schizosaccharomyces pombe	66.50	0.00e+00	1037.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	76.57	0.00e+00	1224.00
IUUC-Sar-113761	Sorex araneus	45.73	1.00e-150	525.00
IUUC-Sre-114929	Sporisorium reilianum	71.65	0.00e+00	883.00
IUUC-Ssc-115368	Sus scrofa	46.04	5.00e-150	523.00
IUUC-Tgu-117474	Taeniopygia guttata	47.67	5.00e-152	530.00
IUUC-Tru-118610	Takifugu rubripes	52.16	3.00e-147	514.00
IUUC-Tsy-119492	Tarsius syrichta	47.75	5.00e-152	530.00
IUUC-Tni-119993	Tetraodon nigroviridis	47.39	2.00e-150	524.00
IUUC-Tre-122203	Trichoderma reesei	80.56	0.00e+00	1239.00
IUUC-Tvi-122595	Trichoderma virens	79.90	0.00e+00	1273.00
IUUC-Tme-126897	Tuber melanosporum	69.05	0.00e+00	1060.00
IUUC-Tbe-127408	Tupaia belangeri	44.54	3.00e-135	474.00
IUUC-Ttr-128235	Tursiops truncatus	51.13	6.00e-143	499.00
IUUC-Uma-129332	Ustilago maydis	71.48	0.00e+00	863.00
IUUC-Vda-129753	Verticillium dahliae	79.95	0.00e+00	1240.00
IUUC-Vpa-130503	Vicugna pacos	47.17	1.00e-146	512.00
IUUC-Xtr-132859	Xenopus tropicalis	45.08	3.00e-154	537.00
IUUC-Xma-133797	Xiphophorus maculatus	45.41	3.00e-151	527.00
IUUC-Yli-134668	Yarrowia lipolytica	74.12	0.00e+00	947.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence