iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037077

Ensembl Protein ID

ENSFALP00000011473.1

UniProt Accession

U3K8W9; U3K8W9_FICAL

Genbank Protein ID

ENSFALP00000011473

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000059

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000010994.1	ENSFALT00000011519.1	ENSFALP00000011473.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.90e-61	199.3	1145	1181
UBD/Beta-Prp	1.60e-120	401.5	630	887

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H++ v+c+ f ++ tll++G d g i++WD  tg ll
   Q: 1145 HEACVRCCTFsPNnTLLATGDDKGEIRIWDALTGALL 1181
           999********666****************8887766 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h + ++  +fs+d++ +a+ ++d+t++v+++++g  l ++  h++e+ ++ fs dg++ +t+s+D+ +kvw+ +tg+c  ++++h+++v
   Q: 630  HRDAVYHACFSEDRQRIASCGADKTLQVFKAESGERLLEINAHDDEILCCAFSADGEFVATCSSDKKVKVWNSRTGQCKCVYEEHSEQV 718
           45556669********************************************************************************* PP
   S: 98   lslsfsp.sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl......... 175
            +++f+  sg + l++ s+d +i++wdl++++c + t  ghd +vn+ +++p++ +++s+s+D+tv+lW  ++g+ l+           
   Q: 719  NCCQFNNkSGqYLLATCSNDTYIKIWDLNKKYCRN-TMIGHDNSVNHCRFSPNDEYVASCSTDGTVKLWEARSGNELKSIeikdffkna 806
           *******877788999*******************.***********************************999999999999999995 PP
   S: 176  tgghtdsvysls....fdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
             ++ d+v+ l     +++ng+ ++ ++ ++++ l+d++  g   +    h ++++  +f+p de+++++ s+ s+ +W+++s
   Q: 807  D-EQPDDVEVLVkccsWSRNGNMILVAA-KNKLLLFDIEtCGLLTQVIVSHHSTIQYCDFCPGDELVAVALSHCSVELWNIKS 887
           3.47888877777888****97666555.567889****55777788889******************************987 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MGCPQRLLFR SRLESGTVNM DVKSRNYLLM NRQALENDIK TSYIMDRMIS DEVLTLQEEE 60
RVKQQNTRKE RAAMLINIIL TKDNNSYRSF YNALLHEGYR DLAALLQDGI PAVSSGNRKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGCTCCC CCGGAGTGAT GGGGTGCCCC CAAAGGGACC GACTGCCCCC TCCGCTCCCC 60
CGGAGTGATG GGGTGCCCCC AAAGGGACCG ACTGCCCCCT CCGCTCCCCC GGAGTGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	70.69	0.00e+00	1817.00
IUUC-Apl-004201	Anas platyrhynchos	89.52	0.00e+00	2289.00
IUUC-Aca-004638	Anolis carolinensis	70.64	0.00e+00	1866.00
IUUC-Afu-008928	Aspergillus fumigatus	25.46	1.00e-57	218.00
IUUC-Ani-009285	Aspergillus nidulans	26.88	3.00e-66	247.00
IUUC-Ate-010309	Aspergillus terreus	26.23	1.00e-64	241.00
IUUC-Ame-011062	Astyanax mexicanus	54.44	0.00e+00	1363.00
IUUC-Bta-012865	Bos taurus	70.38	0.00e+00	1853.00
IUUC-Cja-018815	Callithrix jacchus	65.39	0.00e+00	1660.00
IUUC-Cfa-020222	Canis familiaris	67.19	0.00e+00	1690.00
IUUC-Cpo-021524	Cavia porcellus	69.90	0.00e+00	1821.00
IUUC-Cre-022868	Chlamydomonas reinhardtii	23.96	1.00e-40	162.00
IUUC-Csa-023861	Chlorocebus sabaeus	70.86	0.00e+00	1833.00
IUUC-Cho-024484	Choloepus hoffmanni	60.21	0.00e+00	911.00
IUUC-Dre-028006	Danio rerio	52.85	0.00e+00	1266.00
IUUC-Dno-029591	Dasypus novemcinctus	71.50	0.00e+00	1866.00
IUUC-Dor-030237	Dipodomys ordii	57.43	0.00e+00	807.00
IUUC-Ete-032620	Echinops telfairi	67.74	0.00e+00	867.00
IUUC-Eca-033569	Equus caballus	70.70	0.00e+00	1830.00
IUUC-Eeu-035354	Erinaceus europaeus	50.52	1.00e-133	470.00
IUUC-Fca-036337	Felis catus	70.16	0.00e+00	1845.00
IUUC-Gmo-039687	Gadus morhua	48.60	0.00e+00	894.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.66	1.00e-43	172.00
IUUC-Gga-040299	Gallus gallus	86.79	0.00e+00	2262.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.03	0.00e+00	1260.00
IUUC-Ggo-045563	Gorilla gorilla	71.10	0.00e+00	1845.00
IUUC-Hsa-046771	Homo sapiens	70.94	0.00e+00	1840.00
IUUC-Lch-050200	Latimeria chalumnae	64.95	0.00e+00	1620.00
IUUC-Loc-052090	Lepisosteus oculatus	59.35	0.00e+00	1533.00
IUUC-Laf-053861	Loxodonta africana	70.24	0.00e+00	1820.00
IUUC-Mcc-055543	Macaca mulatta	70.78	0.00e+00	1830.00
IUUC-Meu-056688	Macropus eugenii	69.74	0.00e+00	1782.00
IUUC-Mga-059243	Meleagris gallopavo	87.34	0.00e+00	2278.00
IUUC-Mmr-061134	Microcebus murinus	67.49	0.00e+00	1573.00
IUUC-Mdo-062913	Monodelphis domestica	68.94	0.00e+00	1790.00
IUUC-Mmu-063811	Mus musculus	69.58	0.00e+00	1835.00
IUUC-Mpu-066780	Mustela putorius furo	70.80	0.00e+00	1808.00
IUUC-Mlu-067276	Myotis lucifugus	70.56	0.00e+00	1848.00
IUUC-Nfi-068459	Neosartorya fischeri	25.81	1.00e-58	222.00
IUUC-Nle-069129	Nomascus leucogenys	70.78	0.00e+00	1831.00
IUUC-Opr-071007	Ochotona princeps	52.22	0.00e+00	852.00
IUUC-Ont-071348	Oreochromis niloticus	54.82	0.00e+00	1398.00
IUUC-Oan-072717	Ornithorhynchus anatinus	72.46	0.00e+00	1887.00
IUUC-Ocu-074286	Oryctolagus cuniculus	70.18	0.00e+00	1546.00
IUUC-Ola-086895	Oryzias latipes	50.33	0.00e+00	1192.00
IUUC-Oga-088678	Otolemur garnettii	70.06	0.00e+00	1820.00
IUUC-Oar-089359	Ovis aries	70.62	0.00e+00	1849.00
IUUC-Ptr-091062	Pan troglodytes	71.18	0.00e+00	1846.00
IUUC-Pan-092528	Papio anubis	75.65	0.00e+00	1137.00
IUUC-Psi-093430	Pelodiscus sinensis	78.74	0.00e+00	2016.00
IUUC-Pma-094690	Petromyzon marinus	36.40	5.00e-143	501.00
IUUC-Pfo-097204	Poecilia formosa	53.70	0.00e+00	1365.00
IUUC-Pab-097690	Pongo abelii	71.10	0.00e+00	1843.00
IUUC-Pca-100778	Procavia capensis	54.45	0.00e+00	888.00
IUUC-Pva-102870	Pteropus vampyrus	68.92	0.00e+00	1652.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	27.03	1.00e-65	244.00
IUUC-Rno-104889	Rattus norvegicus	69.50	0.00e+00	1802.00
IUUC-Sha-107465	Sarcophilus harrisii	70.29	0.00e+00	1843.00
IUUC-Ssl-108421	Sclerotinia sclerotiorum	28.02	1.00e-62	234.00
IUUC-Sar-113268	Sorex araneus	68.66	2.00e-144	507.00
IUUC-Ssc-115654	Sus scrofa	69.98	0.00e+00	1840.00
IUUC-Tgu-117302	Taeniopygia guttata	97.12	0.00e+00	2494.00
IUUC-Tru-118363	Takifugu rubripes	54.26	0.00e+00	1364.00
IUUC-Tsy-119007	Tarsius syrichta	68.86	0.00e+00	1773.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.47	0.00e+00	1310.00
IUUC-Tbe-127413	Tupaia belangeri	60.95	0.00e+00	1099.00
IUUC-Ttr-129213	Tursiops truncatus	65.01	0.00e+00	1658.00
IUUC-Vpa-130146	Vicugna pacos	66.02	0.00e+00	1253.00
IUUC-Xtr-132559	Xenopus tropicalis	60.40	0.00e+00	1559.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence