iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007908

Ensembl Protein ID

AAS52617

UniProt Accession

Q757T0; HUL4_ASHGO

Genbank Protein ID

AAS52617.1

Protein Name

Probable E3 ubiquitin-protein ligase HUL4; HECT ubiquitin ligase 4; HECT-type E3 ubiquitin transferase HUL4

Genbank Nucleotide ID

AE016818

Gene Name

HUL4; AEL068W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AEL068W	AAS52617	AAS52617

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.10e-88	293.4	498	838

Active Site

Position(s)	Description	Evidence
807	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrlldlplsksfy 97
           ++dlkk+l++efv+E g+d+gG+ +e++ ll+++l+np++glf+y ++++ +++   +s+ ++         +l++++G++lg+a++++ +ldl+++++fy
   Q: 498  QKDLKKSLRIEFVNEPGIDAGGLRKEWFLLLTRDLFNPNNGLFVYVPESRLCWFSIMESIEHELlqgegSSSELYYLFGVVLGLAIYNSTILDLKFPRAFY 598
           789*************************************************9999999876559999999****************************** PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafre 195
           k+++g+ ls++d+ e+ pe+  ++ +++e++ +d e++ ++ltf+   ++    ++++ ++L+p+G++  Vt eNk+eY +l +++ l+++i+  +e+fr+
   Q: 599  KKICGEVLSVNDFLELYPETGTNMLKMLEYDGEDFEDI-FALTFEtcfPDRFDESKIHYRQLCPDGSTQAVTRENKHEYFRLWMDFYLNRSIAPGFESFRN 698
           ***********************999999*99999998.8888886677777788899999**************************************** PP
   S: 196  GfneviplellslFteeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdas 294
           Gf  vi+ ++++lF  eele+l+cG+  +++dv++l++ t+y+gg+ ++sp++qwFwe+l+e++  +++++L+FvTgs+r+P+ G+ +++ r+  ir    
   Q: 699  GFFHVIEGNSFRLFGSEELEQLVCGSneQSLDVSMLRSVTRYQGGFDDNSPVVQWFWEILSEMEYPQQRKLLHFVTGSDRVPATGVTTIPFRISRIRS--G 797
           *************************987889***********************************************************66666665..8 PP
   S: 295  ddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            drlP s+TCfn ++L eY+ ke+l++kL++A ee++g+++
   Q: 798  ADRLPLSHTCFNEICLHEYKDKETLRNKLIIALEESQGYGF 838
           8***********************************99875 PP

Organism

Ashbya gossypii

Functional Description
(View)

Probable E3 ubiquitin-protein ligase, component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.

Protein Sequence
(Fasta)

MSFFSRNINS KDRHKIQIIS NSTAPSFEPN NEFVTSSCCC CGTILQHPKN ISKFRCSVCY 60
VTVVLQGTAF TQDKTELFDL DDMRELLSSC NNTYRELDKD EKRLRKHEVF HLLEDYIATR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTTTT TCAGCAGAAA CATAAACAGC AAGGACCGTC ACAAAATACA AATCATATCT 60
AACAGTACAG CTCCGTCTTT CGAGCCGAAC AATGAATTCG TAACATCAAG TTGCTGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0031499--C:TRAMP complex
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ago:AGOS_AEL068W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	34.66	6.00e-83	299.00
IUUC-Atr-003144	Amborella trichopoda	32.39	6.00e-64	235.00
IUUC-Apl-003589	Anas platyrhynchos	34.53	2.00e-77	281.00
IUUC-Aca-004350	Anolis carolinensis	35.58	2.00e-81	295.00
IUUC-Acl-008288	Aspergillus clavatus	33.08	9.00e-99	353.00
IUUC-Afl-008402	Aspergillus flavus	32.88	1.00e-85	308.00
IUUC-Afu-008762	Aspergillus fumigatus	31.42	7.00e-103	366.00
IUUC-Ani-009176	Aspergillus nidulans	33.18	4.00e-92	330.00
IUUC-Ang-009791	Aspergillus niger	32.22	1.00e-92	332.00
IUUC-Aor-009921	Aspergillus oryzae	27.62	5.00e-87	313.00
IUUC-Ate-010295	Aspergillus terreus	32.22	8.00e-96	343.00
IUUC-Ame-011166	Astyanax mexicanus	35.10	4.00e-68	250.00
IUUC-Bgr-011981	Blumeria graminis	30.97	4.00e-93	334.00
IUUC-Bta-012945	Bos taurus	35.43	4.00e-81	293.00
IUUC-Bci-013697	Botrytis cinerea	35.22	1.00e-80	292.00
IUUC-Cel-018150	Caenorhabditis elegans	31.97	5.00e-51	194.00
IUUC-Cja-019263	Callithrix jacchus	35.22	7.00e-81	293.00
IUUC-Cfa-020486	Canis familiaris	34.86	7.00e-83	299.00
IUUC-Cpo-021755	Cavia porcellus	34.86	5.00e-83	300.00
IUUC-Cre-022740	Chlamydomonas reinhardtii	36.83	4.00e-59	219.00
IUUC-Csa-024261	Chlorocebus sabaeus	34.73	1.00e-67	249.00
IUUC-Cho-024325	Choloepus hoffmanni	30.53	2.00e-57	215.00
IUUC-Cin-025643	Ciona intestinalis	35.66	1.00e-63	235.00
IUUC-Csv-026282	Ciona savignyi	36.87	2.00e-58	218.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	38.10	9.00e-87	313.00
IUUC-Cme-027151	Cyanidioschyzon merolae	33.94	8.00e-71	259.00
IUUC-Dre-028551	Danio rerio	37.00	8.00e-84	302.00
IUUC-Dno-029497	Dasypus novemcinctus	35.22	7.00e-81	292.00
IUUC-Dor-030158	Dipodomys ordii	33.92	1.00e-67	249.00
IUUC-Dse-031239	Dothistroma septosporum	30.81	9.00e-91	326.00
IUUC-Dme-032103	Drosophila melanogaster	35.84	4.00e-64	237.00
IUUC-Ete-032902	Echinops telfairi	32.67	1.00e-74	272.00
IUUC-Eca-033678	Equus caballus	34.86	8.00e-83	299.00
IUUC-Eeu-035109	Erinaceus europaeus	33.57	5.00e-57	213.00
IUUC-Fca-035590	Felis catus	34.86	3.00e-83	300.00
IUUC-Fal-036969	Ficedula albicollis	33.13	2.00e-75	275.00
IUUC-Fox-037941	Fusarium oxysporum	30.79	9.00e-94	336.00
IUUC-Fso-038388	Fusarium solani	31.03	4.00e-89	320.00
IUUC-Gmo-039553	Gadus morhua	36.62	4.00e-69	253.00
IUUC-Ggr-040110	Gaeumannomyces graminis	36.06	9.00e-86	310.00
IUUC-Gga-040406	Gallus gallus	34.53	3.00e-82	297.00
IUUC-Gac-042141	Gasterosteus aculeatus	35.80	2.00e-83	301.00
IUUC-Ggo-045504	Gorilla gorilla	35.22	9.00e-81	292.00
IUUC-Hsa-045786	Homo sapiens	34.95	7.00e-81	293.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	34.38	4.00e-63	234.00
IUUC-Kpa-049152	Komagataella pastoris	37.46	3.00e-149	520.00
IUUC-Lch-050197	Latimeria chalumnae	34.86	3.00e-70	258.00
IUUC-Loc-052173	Lepisosteus oculatus	36.20	4.00e-86	310.00
IUUC-Laf-054017	Loxodonta africana	35.43	1.00e-81	295.00
IUUC-Mcc-055713	Macaca mulatta	35.22	6.00e-81	293.00
IUUC-Meu-056061	Macropus eugenii	34.77	3.00e-64	238.00
IUUC-Mor-057045	Magnaporthe oryzae	30.49	3.00e-85	308.00
IUUC-Mla-059187	Melampsora laricipopulina	36.83	4.00e-72	263.00
IUUC-Mga-059884	Meleagris gallopavo	36.34	3.00e-79	287.00
IUUC-Mmr-061344	Microcebus murinus	35.06	5.00e-84	303.00
IUUC-Mdo-062653	Monodelphis domestica	35.64	1.00e-80	292.00
IUUC-Mmu-063775	Mus musculus	35.64	1.00e-81	295.00
IUUC-Mpu-066069	Mustela putorius furo	35.06	1.00e-83	301.00
IUUC-Mlu-067925	Myotis lucifugus	35.43	3.00e-81	294.00
IUUC-Nfi-068439	Neosartorya fischeri	32.89	1.00e-101	362.00
IUUC-Ncr-068903	Neurospora crassa	36.52	2.00e-85	309.00
IUUC-Nle-070046	Nomascus leucogenys	34.46	2.00e-82	298.00
IUUC-Opr-070891	Ochotona princeps	29.84	1.00e-50	192.00
IUUC-Ont-072126	Oreochromis niloticus	35.33	8.00e-84	302.00
IUUC-Oan-072933	Ornithorhynchus anatinus	36.27	3.00e-83	300.00
IUUC-Ocu-073800	Oryctolagus cuniculus	35.22	4.00e-81	293.00
IUUC-Ola-086988	Oryzias latipes	35.33	3.00e-83	300.00
IUUC-Oga-088117	Otolemur garnettii	35.64	3.00e-82	296.00
IUUC-Oar-089371	Ovis aries	35.43	7.00e-81	292.00
IUUC-Ptr-090551	Pan troglodytes	35.43	8.00e-81	292.00
IUUC-Pan-092067	Papio anubis	35.22	6.00e-81	293.00
IUUC-Psi-092963	Pelodiscus sinensis	34.53	2.00e-77	281.00
IUUC-Pma-094113	Petromyzon marinus	32.59	4.00e-69	253.00
IUUC-Ppa-095354	Physcomitrella patens	34.10	6.00e-73	266.00
IUUC-Pfo-096562	Poecilia formosa	34.52	2.00e-83	301.00
IUUC-Pab-098680	Pongo abelii	35.22	6.00e-81	293.00
IUUC-Pca-100869	Procavia capensis	34.05	5.00e-63	233.00
IUUC-Pva-103040	Pteropus vampyrus	37.35	2.00e-58	218.00
IUUC-Pgr-103315	Puccinia graminis	30.27	4.00e-84	303.00
IUUC-Ptt-103736	Puccinia triticina	35.62	1.00e-83	302.00
IUUC-Rno-105270	Rattus norvegicus	35.43	6.00e-81	293.00
IUUC-Sce-106306	Saccharomyces cerevisiae	43.03	0.00e+00	645.00
IUUC-Sha-106819	Sarcophilus harrisii	35.66	2.00e-84	304.00
IUUC-Spo-108271	Schizosaccharomyces pombe	35.94	2.00e-88	317.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	32.49	3.00e-89	321.00
IUUC-Smo-108858	Selaginella moellendorffii	36.38	8.00e-82	295.00
IUUC-Sar-113293	Sorex araneus	34.62	7.00e-65	239.00
IUUC-Ssc-115441	Sus scrofa	35.64	3.00e-81	294.00
IUUC-Tgu-117166	Taeniopygia guttata	35.39	9.00e-79	286.00
IUUC-Tru-117763	Takifugu rubripes	35.25	4.00e-70	257.00
IUUC-Tsy-118898	Tarsius syrichta	31.24	2.00e-61	228.00
IUUC-Tni-120143	Tetraodon nigroviridis	35.34	2.00e-69	255.00
IUUC-Tre-122108	Trichoderma reesei	30.57	6.00e-83	300.00
IUUC-Tvi-122644	Trichoderma virens	31.51	2.00e-86	311.00
IUUC-Tme-127004	Tuber melanosporum	31.87	5.00e-95	340.00
IUUC-Tbe-127640	Tupaia belangeri	31.28	1.00e-57	216.00
IUUC-Ttr-128352	Tursiops truncatus	34.53	2.00e-74	271.00
IUUC-Vda-129969	Verticillium dahliae	37.89	1.00e-86	312.00
IUUC-Vpa-130448	Vicugna pacos	33.40	3.00e-68	251.00
IUUC-Xtr-132881	Xenopus tropicalis	34.86	8.00e-71	259.00
IUUC-Xma-133389	Xiphophorus maculatus	32.58	2.00e-70	258.00
IUUC-Yli-134470	Yarrowia lipolytica	34.91	9.00e-96	342.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence