iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134474

Ensembl Protein ID

CAG83807

UniProt Accession

Q6CHI1; RAD18_YARLI

Genbank Protein ID

CAG83807.1

Protein Name

Postreplication repair E3 ubiquitin-protein ligase RAD18; RING-type E3 ubiquitin transferase RAD18

Genbank Nucleotide ID

CR382127

Gene Name

RAD18; YALI0A08580g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_A08580g	CAG83807	CAG83807

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.90e-10	37.8	23	92
E3 activity/RING/RING	9.10e-09	34.1	28	66
UBD/ZnF/UBZ	1.00e-06	27.3	146	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceen 72
            e ++C I +e ++ P+++ +G+t+   +I+++l +  + cP+++q+ + ++l  n t+  l++++ +++
   Q: 23   DETLRCHICKEFFTAPMITGCGHTFCSLCIQRYLTNTSQRCPTCMQEQQISQLRKNVTVETLVEHFSAQR 92
           5789******************************999999************************999876 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+e f   p++++CgH+f+  C+q++     ++++++rCP+C
   Q: 28   CHICKEFFTA-PMITGCGHTFCSLCIQRY-----LTNTSQRCPTC 66
           99****9999.******************.....8********** PP

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlD 21
           +++CPvCq m++  ++++HlD
   Q: 146  QVECPVCQAMLPGAAINRHLD 166
           69******************9 PP

Organism

Yarrowia lipolytica

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.

Protein Sequence
(Fasta)

MNSDIPDPSD WIDSKLSGLK DVDETLRCHI CKEFFTAPMI TGCGHTFCSL CIQRYLTNTS 60
QRCPTCMQEQ QISQLRKNVT VETLVEHFSA QRATILRVVK EAAKQPIPEV VEPPSSPDLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATAGCG ACATTCCCGA TCCCAGCGAC TGGATCGACT CCAAGCTGAG CGGCCTCAAA 60
GACGTGGACG AGACTCTGCG CTGCCACATC TGCAAGGAGT TCTTCACTGC GCCCATGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING
SM00734--ZnF_Rad18

Gene Ontology

GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003677--F:DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006301--P:postreplication repair
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV

KEGG

yli:YALI0A08580g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	35.92	3.00e-12	65.10
IUUC-Apl-003657	Anas platyrhynchos	27.85	2.00e-14	71.20
IUUC-Aca-005369	Anolis carolinensis	34.43	3.00e-13	65.50
IUUC-Ago-007876	Ashbya gossypii	42.24	2.00e-22	97.80
IUUC-Acl-008246	Aspergillus clavatus	32.34	3.00e-38	150.00
IUUC-Afl-008666	Aspergillus flavus	46.08	5.00e-24	103.00
IUUC-Afu-009052	Aspergillus fumigatus	30.95	9.00e-36	142.00
IUUC-Ani-009488	Aspergillus nidulans	33.23	6.00e-41	159.00
IUUC-Ang-009681	Aspergillus niger	31.14	1.00e-40	158.00
IUUC-Aor-010037	Aspergillus oryzae	32.44	2.00e-41	161.00
IUUC-Ate-010516	Aspergillus terreus	45.10	5.00e-25	105.00
IUUC-Ame-010630	Astyanax mexicanus	27.49	9.00e-15	72.40
IUUC-Bgr-012178	Blumeria graminis	33.33	4.00e-47	179.00
IUUC-Bta-012976	Bos taurus	39.08	6.00e-13	66.60
IUUC-Bci-013680	Botrytis cinerea	33.23	4.00e-44	170.00
IUUC-Cel-018356	Caenorhabditis elegans	43.18	6.00e-09	51.20
IUUC-Cja-019453	Callithrix jacchus	32.10	7.00e-14	70.10
IUUC-Cfa-020856	Canis familiaris	30.06	4.00e-12	64.30
IUUC-Cpo-021950	Cavia porcellus	30.18	2.00e-14	72.00
IUUC-Csa-023997	Chlorocebus sabaeus	31.90	3.00e-13	67.80
IUUC-Cho-024771	Choloepus hoffmanni	39.51	9.00e-12	62.80
IUUC-Cin-025481	Ciona intestinalis	37.04	8.00e-08	50.80
IUUC-Csv-026112	Ciona savignyi	35.80	5.00e-08	51.20
IUUC-Cgl-026668	Colletotrichum gloeosporioides	31.29	2.00e-41	160.00
IUUC-Cme-027202	Cyanidioschyzon merolae	35.48	3.00e-13	67.80
IUUC-Dre-028479	Danio rerio	26.79	2.00e-11	62.00
IUUC-Dno-028943	Dasypus novemcinctus	30.34	1.00e-12	65.90
IUUC-Dor-031046	Dipodomys ordii	28.83	4.00e-10	57.40
IUUC-Dse-031235	Dothistroma septosporum	23.96	4.00e-10	57.00
IUUC-Ete-032503	Echinops telfairi	31.90	3.00e-12	64.30
IUUC-Eca-033725	Equus caballus	37.93	2.00e-12	65.10
IUUC-Eeu-034573	Erinaceus europaeus	41.03	1.00e-11	62.00
IUUC-Fca-036495	Felis catus	29.63	2.00e-12	65.10
IUUC-Fal-036791	Ficedula albicollis	28.49	2.00e-14	72.00
IUUC-Fox-037868	Fusarium oxysporum	30.67	5.00e-36	143.00
IUUC-Fso-038144	Fusarium solani	31.66	3.00e-44	170.00
IUUC-Gmo-039152	Gadus morhua	34.62	3.00e-09	53.90
IUUC-Ggr-039737	Gaeumannomyces graminis	44.90	9.00e-25	105.00
IUUC-Gga-040788	Gallus gallus	41.00	2.00e-15	75.50
IUUC-Gac-041993	Gasterosteus aculeatus	30.64	1.00e-15	75.90
IUUC-Ggo-044889	Gorilla gorilla	32.72	4.00e-14	70.90
IUUC-Hsa-045957	Homo sapiens	31.90	2.00e-13	68.20
IUUC-Itr-048998	Ictidomys tridecemlineatus	36.78	5.00e-12	63.50
IUUC-Kpa-049300	Komagataella pastoris	26.77	3.00e-26	110.00
IUUC-Lch-050381	Latimeria chalumnae	34.62	4.00e-11	60.80
IUUC-Loc-052609	Lepisosteus oculatus	25.49	2.00e-19	88.20
IUUC-Lma-053037	Leptosphaeria maculans	27.08	3.00e-28	117.00
IUUC-Laf-053889	Loxodonta africana	31.14	2.00e-13	68.60
IUUC-Mcc-055853	Macaca mulatta	31.90	3.00e-13	67.80
IUUC-Meu-056866	Macropus eugenii	39.22	3.00e-11	60.50
IUUC-Mor-057071	Magnaporthe oryzae	32.65	5.00e-46	176.00
IUUC-Mpo-057628	Magnaporthe poae	44.57	3.00e-23	100.00
IUUC-Mla-058953	Melampsora laricipopulina	34.51	2.00e-13	68.60
IUUC-Mga-059687	Meleagris gallopavo	29.63	3.00e-12	64.30
IUUC-Mvi-060412	Microbotryum violaceum	44.33	2.00e-17	81.60
IUUC-Mmr-061563	Microcebus murinus	28.22	1.00e-12	65.90
IUUC-Mdo-062655	Monodelphis domestica	41.18	9.00e-14	69.70
IUUC-Mmu-063647	Mus musculus	30.30	5.00e-13	67.00
IUUC-Mac-065427	Musa acuminata	34.67	5.00e-06	42.70
IUUC-Mpu-065778	Mustela putorius furo	37.93	2.00e-12	64.70
IUUC-Mlu-068205	Myotis lucifugus	39.29	2.00e-12	65.10
IUUC-Nfi-068501	Neosartorya fischeri	30.95	1.00e-35	142.00
IUUC-Ncr-068917	Neurospora crassa	28.46	5.00e-38	150.00
IUUC-Nle-068990	Nomascus leucogenys	31.29	2.00e-13	68.20
IUUC-Opr-071146	Ochotona princeps	40.23	5.00e-13	67.00
IUUC-Ont-071835	Oreochromis niloticus	30.18	1.00e-13	68.60
IUUC-Oan-072827	Ornithorhynchus anatinus	33.72	3.00e-11	60.10
IUUC-Ocu-073986	Oryctolagus cuniculus	36.89	6.00e-13	66.60
IUUC-Ola-086997	Oryzias latipes	38.96	1.00e-11	62.00
IUUC-Olu-087771	Ostreococcus lucimarinus	39.74	1.00e-11	62.00
IUUC-Oga-088092	Otolemur garnettii	30.86	2.00e-13	68.90
IUUC-Oar-089651	Ovis aries	39.08	1.00e-12	65.90
IUUC-Ptr-091103	Pan troglodytes	31.90	1.00e-13	69.30
IUUC-Pan-092478	Papio anubis	31.90	3.00e-13	68.20
IUUC-Psi-093356	Pelodiscus sinensis	36.89	2.00e-13	68.60
IUUC-Pma-094218	Petromyzon marinus	46.94	5.00e-08	49.30
IUUC-Pfo-096663	Poecilia formosa	29.19	2.00e-14	72.00
IUUC-Pab-098515	Pongo abelii	31.90	1.00e-13	69.30
IUUC-Pca-100588	Procavia capensis	50.00	6.00e-11	60.10
IUUC-Ppe-101428	Prunus persica	37.66	2.00e-11	61.20
IUUC-Pva-102377	Pteropus vampyrus	30.67	2.00e-12	64.70
IUUC-Pgr-103556	Puccinia graminis	33.33	3.00e-10	58.20
IUUC-Pte-104362	Pyrenophora teres	38.14	5.00e-20	90.10
IUUC-Pyt-104823	Pyrenophora triticirepentis	39.78	6.00e-19	86.70
IUUC-Rno-105866	Rattus norvegicus	30.30	2.00e-13	68.20
IUUC-Sce-106454	Saccharomyces cerevisiae	38.00	2.00e-19	87.80
IUUC-Sha-107515	Sarcophilus harrisii	35.14	4.00e-13	67.00
IUUC-Sja-107689	Schizosaccharomyces japonicus	46.79	8.00e-25	105.00
IUUC-Spo-108248	Schizosaccharomyces pombe	30.88	3.00e-38	150.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	56.47	3.00e-25	107.00
IUUC-Sar-113333	Sorex araneus	37.29	1.00e-07	49.70
IUUC-Sre-115123	Sporisorium reilianum	27.60	5.00e-14	70.10
IUUC-Ssc-115992	Sus scrofa	29.45	2.00e-12	65.10
IUUC-Tgu-117286	Taeniopygia guttata	40.91	5.00e-14	70.10
IUUC-Tru-117959	Takifugu rubripes	28.40	6.00e-14	69.70
IUUC-Tsy-119286	Tarsius syrichta	50.00	1.00e-10	58.90
IUUC-Tni-120570	Tetraodon nigroviridis	28.48	2.00e-13	67.80
IUUC-Tre-121893	Trichoderma reesei	47.67	2.00e-22	98.20
IUUC-Tvi-122405	Trichoderma virens	30.03	4.00e-37	146.00
IUUC-Tbe-127758	Tupaia belangeri	38.89	3.00e-10	57.80
IUUC-Ttr-128841	Tursiops truncatus	36.67	9.00e-13	66.20
IUUC-Uma-129563	Ustilago maydis	33.00	2.00e-12	65.10
IUUC-Vda-130021	Verticillium dahliae	35.92	3.00e-15	73.20
IUUC-Vpa-130169	Vicugna pacos	39.51	2.00e-11	61.60
IUUC-Xtr-132308	Xenopus tropicalis	30.67	2.00e-15	74.30
IUUC-Xma-133868	Xiphophorus maculatus	28.57	1.00e-14	72.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence