iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108300

Ensembl Protein ID

SPBC800.03.1:pep

UniProt Accession

P56523; CLR3_SCHPO

Genbank Protein ID

AAD05212.1; CAC01518.1

Protein Name

Histone deacetylase clr3; Cryptic loci regulator 3

Genbank Nucleotide ID

AF064207; CU329671

Gene Name

clr3; SPBC800.03

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC800.03	SPBC800.03.1	SPBC800.03.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein 3D Structure
PDB
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/ZnF_UBP	45.36	7.00e-82	303.00	IUUC-Hsa-046904

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).

Protein Sequence
(Fasta)

MLASNSDGAS TSVKPSDDAV NTVTPWSILL TNNKPMSGSE NTLNNESHEM SQILKKSGLC 60
YDPRMRFHAT LSEVDDHPED PRRVLRVFEA IKKAGYVSNV PSPSDVFLRI PAREATLEEL 120

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Nucleotide Sequence
(Fasta)

CCGCGCTTCA AAAAGTGTTT CGACAGTTTT ATGAGGGAGT TGTTTAATAG GAGATTTTTT 60
TATTAATTTA TTAATTGATT GACCTTTTTA AGGGCGATAG AAAACGAATG CTGGCCTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR019154--Arb2_domain
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR017321--Hist_deAcase_II_yeast

Pfam

PF09757--Arb2
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0031934--C:mating-type region heterochromatin
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0030874--C:nucleolar chromatin
GO:0005634--C:nucleus
GO:0033553--C:rDNA heterochromatin
GO:0070824--C:SHREC complex
GO:0004407--F:histone deacetylase activity
GO:0031078--F:histone deacetylase activity (H3-K14 specific)
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030702--P:chromatin silencing at centromere
GO:0000183--P:chromatin silencing at rDNA
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0016575--P:histone deacetylation
GO:0035391--P:maintenance of chromatin silencing at silent mating-type cassette
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016584--P:nucleosome positioning
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPBC800.03

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000749	Aegilops tauschii	46.18	3.00e-69	253.00
IUUC-Aml-002087	Ailuropoda melanoleuca	44.93	9.00e-86	310.00
IUUC-Atr-002745	Amborella trichopoda	37.40	4.00e-74	270.00
IUUC-Apl-003250	Anas platyrhynchos	39.13	1.00e-74	273.00
IUUC-Aca-004303	Anolis carolinensis	44.41	2.00e-87	315.00
IUUC-Aly-006432	Arabidopsis lyrata	40.71	1.00e-70	259.00
IUUC-Ath-007355	Arabidopsis thaliana	42.47	2.00e-73	268.00
IUUC-Ago-007972	Ashbya gossypii	41.41	3.00e-156	543.00
IUUC-Acl-008187	Aspergillus clavatus	46.56	3.00e-169	586.00
IUUC-Afl-008399	Aspergillus flavus	46.29	5.00e-120	422.00
IUUC-Afu-008954	Aspergillus fumigatus	41.04	8.00e-107	379.00
IUUC-Ani-009142	Aspergillus nidulans	46.37	1.00e-158	551.00
IUUC-Ang-009522	Aspergillus niger	39.28	5.00e-118	416.00
IUUC-Aor-010069	Aspergillus oryzae	44.41	4.00e-161	559.00
IUUC-Ate-010291	Aspergillus terreus	42.38	9.00e-148	515.00
IUUC-Ame-010780	Astyanax mexicanus	46.32	1.00e-88	319.00
IUUC-Bta-013052	Bos taurus	42.78	7.00e-81	293.00
IUUC-Bci-013789	Botrytis cinerea	41.40	3.00e-141	493.00
IUUC-Bdi-014007	Brachypodium distachyon	43.71	6.00e-76	276.00
IUUC-Bol-015468	Brassica oleracea	40.47	8.00e-75	272.00
IUUC-Bra-016680	Brassica rapa	40.47	3.00e-75	274.00
IUUC-Cel-018220	Caenorhabditis elegans	40.16	3.00e-73	268.00
IUUC-Cja-019473	Callithrix jacchus	45.48	1.00e-84	306.00
IUUC-Cfa-020263	Canis familiaris	45.21	6.00e-86	310.00
IUUC-Cpo-021691	Cavia porcellus	44.38	3.00e-84	305.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	48.46	3.00e-51	192.00
IUUC-Csa-024223	Chlorocebus sabaeus	45.48	5.00e-84	304.00
IUUC-Csv-026359	Ciona savignyi	42.05	4.00e-59	219.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	43.22	1.00e-133	468.00
IUUC-Cne-026978	Cryptococcus neoformans	37.50	1.00e-132	465.00
IUUC-Dre-028820	Danio rerio	46.43	3.00e-85	308.00
IUUC-Dno-029160	Dasypus novemcinctus	46.79	6.00e-82	297.00
IUUC-Dor-030859	Dipodomys ordii	45.21	9.00e-88	316.00
IUUC-Dse-031186	Dothistroma septosporum	40.24	6.00e-149	519.00
IUUC-Dme-031766	Drosophila melanogaster	39.95	1.00e-76	279.00
IUUC-Ete-032279	Echinops telfairi	38.69	3.00e-66	244.00
IUUC-Eca-033842	Equus caballus	44.66	2.00e-82	299.00
IUUC-Eeu-034487	Erinaceus europaeus	48.10	6.00e-58	217.00
IUUC-Fca-036430	Felis catus	45.48	2.00e-87	315.00
IUUC-Fox-038067	Fusarium oxysporum	43.33	2.00e-129	454.00
IUUC-Fso-038263	Fusarium solani	41.98	2.00e-148	517.00
IUUC-Gmo-038473	Gadus morhua	45.88	7.00e-71	260.00
IUUC-Ggr-040062	Gaeumannomyces graminis	39.91	8.00e-136	475.00
IUUC-Gga-040501	Gallus gallus	39.13	2.00e-74	271.00
IUUC-Gac-042335	Gasterosteus aculeatus	36.97	1.00e-72	266.00
IUUC-Gma-043738	Glycine max	42.56	4.00e-71	260.00
IUUC-Ggo-045022	Gorilla gorilla	45.36	1.00e-83	303.00
IUUC-Hsa-046904	Homo sapiens	45.36	1.00e-83	303.00
IUUC-Hvu-047285	Hordeum vulgare	41.52	3.00e-72	263.00
IUUC-Itr-048484	Ictidomys tridecemlineatus	47.81	5.00e-93	334.00
IUUC-Kpa-049281	Komagataella pastoris	41.16	3.00e-166	577.00
IUUC-Lch-050330	Latimeria chalumnae	45.36	2.00e-76	278.00
IUUC-Lpe-051214	Leersia perrieri	42.47	1.00e-73	269.00
IUUC-Loc-052231	Lepisosteus oculatus	39.32	1.00e-72	266.00
IUUC-Lma-053263	Leptosphaeria maculans	41.60	2.00e-151	528.00
IUUC-Laf-053386	Loxodonta africana	45.65	6.00e-84	303.00
IUUC-Mcc-055530	Macaca mulatta	45.36	4.00e-84	304.00
IUUC-Meu-056442	Macropus eugenii	44.41	7.00e-84	303.00
IUUC-Mor-057095	Magnaporthe oryzae	40.75	1.00e-144	504.00
IUUC-Mpo-057389	Magnaporthe poae	40.97	6.00e-141	492.00
IUUC-Mtr-058463	Medicago truncatula	42.99	6.00e-78	283.00
IUUC-Mla-059143	Melampsora laricipopulina	35.92	1.00e-111	395.00
IUUC-Mmr-060637	Microcebus murinus	44.66	3.00e-78	285.00
IUUC-Mdo-062198	Monodelphis domestica	43.21	1.00e-80	293.00
IUUC-Mmu-063346	Mus musculus	46.30	3.00e-91	328.00
IUUC-Mac-064630	Musa acuminata	42.94	3.00e-73	267.00
IUUC-Mpu-065884	Mustela putorius furo	45.75	1.00e-85	310.00
IUUC-Mlu-068117	Myotis lucifugus	44.66	3.00e-80	291.00
IUUC-Nfi-068404	Neosartorya fischeri	46.08	1.00e-167	581.00
IUUC-Ncr-068672	Neurospora crassa	42.79	2.00e-149	520.00
IUUC-Nle-069868	Nomascus leucogenys	41.62	2.00e-77	281.00
IUUC-Opr-071074	Ochotona princeps	45.05	1.00e-87	315.00
IUUC-Ont-072246	Oreochromis niloticus	40.16	2.00e-88	318.00
IUUC-Oan-073275	Ornithorhynchus anatinus	39.90	3.00e-76	278.00
IUUC-Ocu-074627	Oryctolagus cuniculus	46.03	5.00e-90	324.00
IUUC-Oba-075489	Oryza barthii	43.41	9.00e-75	272.00
IUUC-Obr-076150	Oryza brachyantha	44.88	1.00e-77	282.00
IUUC-Ogl-077437	Oryza glaberrima	43.41	6.00e-75	273.00
IUUC-Ogu-078370	Oryza glumaepatula	43.41	5.00e-75	273.00
IUUC-Oin-079210	Oryza indica	43.41	6.00e-75	273.00
IUUC-Olo-080971	Oryza longistaminata	46.07	2.00e-68	251.00
IUUC-Oni-082031	Oryza nivara	43.41	8.00e-75	273.00
IUUC-Opu-083471	Oryza punctata	43.11	1.00e-74	272.00
IUUC-Oru-084755	Oryza rufipogon	43.41	5.00e-75	273.00
IUUC-Osa-085447	Oryza sativa	43.41	6.00e-75	273.00
IUUC-Ola-087031	Oryzias latipes	37.18	4.00e-69	254.00
IUUC-Oga-089155	Otolemur garnettii	42.93	2.00e-82	298.00
IUUC-Oar-089620	Ovis aries	44.66	1.00e-78	286.00
IUUC-Ptr-090812	Pan troglodytes	40.81	6.00e-76	276.00
IUUC-Pan-092340	Papio anubis	45.48	6.00e-84	304.00
IUUC-Psi-093734	Pelodiscus sinensis	38.46	2.00e-73	269.00
IUUC-Pma-094386	Petromyzon marinus	45.62	1.00e-73	270.00
IUUC-Pno-095131	Phaeosphaeria nodorum	51.75	1.00e-104	371.00
IUUC-Ppa-095550	Physcomitrella patens	43.05	5.00e-79	286.00
IUUC-Pfo-096110	Poecilia formosa	45.31	5.00e-89	320.00
IUUC-Pab-098422	Pongo abelii	41.35	2.00e-77	282.00
IUUC-Pop-099174	Populus trichocarpa	40.64	1.00e-76	278.00
IUUC-Pca-100833	Procavia capensis	44.65	6.00e-78	284.00
IUUC-Ppe-101644	Prunus persica	41.14	1.00e-78	285.00
IUUC-Pva-102410	Pteropus vampyrus	44.59	2.00e-79	289.00
IUUC-Ptt-103841	Puccinia triticina	32.90	1.00e-106	378.00
IUUC-Pte-104383	Pyrenophora teres	42.79	1.00e-156	545.00
IUUC-Pyt-104427	Pyrenophora triticirepentis	43.87	2.00e-145	507.00
IUUC-Rno-105131	Rattus norvegicus	46.99	3.00e-94	338.00
IUUC-Sce-106274	Saccharomyces cerevisiae	40.40	1.00e-152	531.00
IUUC-Sha-106661	Sarcophilus harrisii	46.22	6.00e-79	287.00
IUUC-Sja-107915	Schizosaccharomyces japonicus	62.03	0.00e+00	887.00
IUUC-Smo-109615	Selaginella moellendorffii	43.16	5.00e-77	280.00
IUUC-Sit-110160	Setaria italica	44.28	3.00e-72	264.00
IUUC-Sly-111164	Solanum lycopersicum	38.61	7.00e-76	276.00
IUUC-Stu-112685	Solanum tuberosum	41.19	2.00e-76	277.00
IUUC-Sar-113692	Sorex araneus	38.41	3.00e-61	228.00
IUUC-Sbi-114301	Sorghum bicolor	44.01	1.00e-72	265.00
IUUC-Sre-115013	Sporisorium reilianum	36.23	2.00e-119	421.00
IUUC-Ssc-115724	Sus scrofa	41.48	2.00e-76	278.00
IUUC-Tgu-116605	Taeniopygia guttata	42.64	3.00e-75	274.00
IUUC-Tru-117614	Takifugu rubripes	44.14	3.00e-84	305.00
IUUC-Tsy-118807	Tarsius syrichta	41.92	5.00e-73	267.00
IUUC-Tni-119809	Tetraodon nigroviridis	46.45	3.00e-83	301.00
IUUC-Tca-121312	Theobroma cacao	41.48	4.00e-78	283.00
IUUC-Tre-121930	Trichoderma reesei	42.99	4.00e-154	536.00
IUUC-Tvi-122373	Trichoderma virens	42.97	4.00e-147	513.00
IUUC-Tae-123064	Triticum aestivum	42.90	1.00e-72	264.00
IUUC-Tme-127027	Tuber melanosporum	44.94	4.00e-99	352.00
IUUC-Tbe-127675	Tupaia belangeri	37.50	5.00e-22	98.20
IUUC-Ttr-128411	Tursiops truncatus	46.28	1.00e-79	290.00
IUUC-Uma-129408	Ustilago maydis	34.93	2.00e-106	377.00
IUUC-Vda-129994	Verticillium dahliae	42.19	5.00e-147	512.00
IUUC-Vpa-130525	Vicugna pacos	55.93	4.00e-15	74.70
IUUC-Vvi-131038	Vitis vinifera	41.22	1.00e-79	288.00
IUUC-Xtr-132618	Xenopus tropicalis	44.72	6.00e-87	313.00
IUUC-Xma-133730	Xiphophorus maculatus	44.47	4.00e-87	314.00
IUUC-Yli-134680	Yarrowia lipolytica	41.78	2.00e-161	560.00
IUUC-Zma-135110	Zea mays	43.98	2.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence