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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-106009
UUCD1 version UUC-RaN-00678
Ensembl Protein ID ENSRNOP00000021998.4
UniProt Accession Q7TSL3; FBX11_RAT
Genbank Protein ID AAP42075.1
Protein Name F-box only protein 11
Genbank Nucleotide ID AY274810
Gene Name Fbxo11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000016396.4 ENSRNOT00000021998.4 ENSRNOP00000021998.4
Annotation
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 8.00e-07 29.6 65 116
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 93   tpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktvt 147
           +p    ++ l+++lp+e++++i+++l +++l+raa+vc+r++ela+++ lwk+++
   Q: 65   APA---EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLY 116
           443...467889***************************************9876 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.
Protein Sequence
(Fasta)
MVAEESGPGA QNSPYQLRRK TLLPKRTACP TKNSMEGAST STTENFGHRA KRARVSGKSQ 60
DLSAAPAEQY LQEKLPDEVV LKIFSYLLEQ DLCRAACVCK RFSELANDPI LWKRLYMEVF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-106009|E3,F-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATGATGTTC CTGCAGATAT GGTTGCAGAA GAATCAGGTC CTGGTGCACA AAACAGTCCA 60
TACCAGCTTC GTAGAAAAAC TCTTTTGCCA AAAAGAACAG CGTGTCCTAC AAAGAACAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-106009|E3,F-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006633--Carb-bd_sugar_hydrolysis-dom
IPR001810--F-box_dom
IPR029799--FBX11/DRE-1
IPR022441--Para_beta_helix_rpt-2
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence
IPR003126--Znf_UBR
PROSITE

PS50181--FBOX
PS51157--ZF_UBR
Pfam

PF12937--F-box-like
PF02207--zf-UBR
SMART

SM00722--CASH
SM00256--FBOX
SM00710--PbH1
SM00396--ZnF_UBR1
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0000151--C:ubiquitin ligase complex
GO:0016274--F:protein-arginine N-methyltransferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007605--P:sensory perception of sound
KEGG rno:301674
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002291 Ailuropoda melanoleuca 99.64 0.00e+00 1754.00
IUUC-Apl-003412 Anas platyrhynchos 99.53 0.00e+00 1752.00
IUUC-Aca-004842 Anolis carolinensis 99.17 0.00e+00 1742.00
IUUC-Ate-010540 Aspergillus terreus 27.27 6.00e-06 45.40
IUUC-Ame-011539 Astyanax mexicanus 98.70 0.00e+00 1741.00
IUUC-Bta-013526 Bos taurus 99.35 0.00e+00 1271.00
IUUC-Bci-013908 Botrytis cinerea 43.90 2.00e-04 41.20
IUUC-Cel-018135 Caenorhabditis elegans 59.18 0.00e+00 950.00
IUUC-Cja-019156 Callithrix jacchus 99.88 0.00e+00 1759.00
IUUC-Cfa-020503 Canis familiaris 99.88 0.00e+00 1759.00
IUUC-Cpo-022148 Cavia porcellus 99.64 0.00e+00 1755.00
IUUC-Csa-023799 Chlorocebus sabaeus 99.88 0.00e+00 1759.00
IUUC-Cho-024925 Choloepus hoffmanni 91.93 0.00e+00 1565.00
IUUC-Cin-025649 Ciona intestinalis 69.23 0.00e+00 1229.00
IUUC-Csv-026010 Ciona savignyi 74.10 0.00e+00 1199.00
IUUC-Cgl-026674 Colletotrichum gloeosporioides 35.37 5.00e-07 49.70
IUUC-Cne-027052 Cryptococcus neoformans 33.90 2.00e-05 44.70
IUUC-Dre-027855 Danio rerio 98.46 0.00e+00 1736.00
IUUC-Dno-029555 Dasypus novemcinctus 99.41 0.00e+00 1746.00
IUUC-Dor-030610 Dipodomys ordii 88.31 0.00e+00 1508.00
IUUC-Dme-031852 Drosophila melanogaster 69.09 0.00e+00 1115.00
IUUC-Ete-032999 Echinops telfairi 94.78 0.00e+00 1643.00
IUUC-Eca-033942 Equus caballus 99.76 0.00e+00 1756.00
IUUC-Eeu-034872 Erinaceus europaeus 99.76 0.00e+00 1753.00
IUUC-Fca-035904 Felis catus 98.46 0.00e+00 1722.00
IUUC-Fal-036742 Ficedula albicollis 99.53 0.00e+00 1753.00
IUUC-Gmo-039082 Gadus morhua 96.44 0.00e+00 1704.00
IUUC-Gga-040292 Gallus gallus 99.52 0.00e+00 1746.00
IUUC-Gac-042106 Gasterosteus aculeatus 97.75 0.00e+00 1714.00
IUUC-Ggo-045283 Gorilla gorilla 99.88 0.00e+00 1759.00
IUUC-Hsa-046244 Homo sapiens 99.88 0.00e+00 1759.00
IUUC-Itr-047990 Ictidomys tridecemlineatus 99.76 0.00e+00 1758.00
IUUC-Lch-049831 Latimeria chalumnae 97.86 0.00e+00 1725.00
IUUC-Loc-051875 Lepisosteus oculatus 99.05 0.00e+00 1744.00
IUUC-Laf-053642 Loxodonta africana 99.64 0.00e+00 1751.00
IUUC-Mcc-055761 Macaca mulatta 99.88 0.00e+00 1758.00
IUUC-Meu-056886 Macropus eugenii 99.81 0.00e+00 1088.00
IUUC-Mga-059470 Meleagris gallopavo 99.53 0.00e+00 1752.00
IUUC-Mmr-060959 Microcebus murinus 99.76 0.00e+00 1758.00
IUUC-Mdo-062165 Monodelphis domestica 99.76 0.00e+00 1758.00
IUUC-Mmu-063590 Mus musculus 99.88 0.00e+00 1758.00
IUUC-Mpu-066702 Mustela putorius furo 99.88 0.00e+00 1759.00
IUUC-Mlu-067906 Myotis lucifugus 99.06 0.00e+00 1744.00
IUUC-Nle-069878 Nomascus leucogenys 99.88 0.00e+00 1759.00
IUUC-Opr-070211 Ochotona princeps 92.67 0.00e+00 746.00
IUUC-Ont-072305 Oreochromis niloticus 97.05 0.00e+00 1709.00
IUUC-Oan-073077 Ornithorhynchus anatinus 93.03 0.00e+00 1283.00
IUUC-Ocu-074419 Oryctolagus cuniculus 99.88 0.00e+00 1754.00
IUUC-Ola-087393 Oryzias latipes 97.03 0.00e+00 1704.00
IUUC-Oga-088010 Otolemur garnettii 99.87 0.00e+00 1629.00
IUUC-Oar-089660 Ovis aries 99.76 0.00e+00 1754.00
IUUC-Ptr-091220 Pan troglodytes 99.88 0.00e+00 1759.00
IUUC-Pan-092606 Papio anubis 99.69 0.00e+00 1347.00
IUUC-Psi-093950 Pelodiscus sinensis 99.41 0.00e+00 1749.00
IUUC-Pma-094248 Petromyzon marinus 86.47 0.00e+00 1522.00
IUUC-Pfo-097361 Poecilia formosa 97.27 0.00e+00 1707.00
IUUC-Pab-097736 Pongo abelii 99.88 0.00e+00 1759.00
IUUC-Pca-100204 Procavia capensis 93.86 0.00e+00 1601.00
IUUC-Pva-102248 Pteropus vampyrus 95.11 0.00e+00 1362.00
IUUC-Pgr-103283 Puccinia graminis 41.82 6.00e-07 49.30
IUUC-Sha-107330 Sarcophilus harrisii 99.76 0.00e+00 1758.00
IUUC-Stu-111936 Solanum tuberosum 43.48 7.00e-06 43.10
IUUC-Sar-112927 Sorex araneus 100.00 0.00e+00 688.00
IUUC-Sre-115181 Sporisorium reilianum 45.45 6.00e-08 52.80
IUUC-Ssc-115330 Sus scrofa 99.29 0.00e+00 1743.00
IUUC-Tgu-116883 Taeniopygia guttata 99.53 0.00e+00 1753.00
IUUC-Tru-118225 Takifugu rubripes 96.58 0.00e+00 1702.00
IUUC-Tsy-119194 Tarsius syrichta 95.68 0.00e+00 1367.00
IUUC-Tni-119690 Tetraodon nigroviridis 95.64 0.00e+00 1677.00
IUUC-Tvi-122264 Trichoderma virens 32.61 1.00e-06 48.50
IUUC-Tae-123166 Triticum aestivum 38.03 3.00e-06 46.20
IUUC-Tme-127013 Tuber melanosporum 38.98 8.00e-05 42.40
IUUC-Tbe-127560 Tupaia belangeri 100.00 2.00e-158 553.00
IUUC-Ttr-129186 Tursiops truncatus 96.21 0.00e+00 1681.00
IUUC-Uma-129621 Ustilago maydis 41.07 4.00e-07 50.40
IUUC-Vda-129883 Verticillium dahliae 34.18 3.00e-06 47.00
IUUC-Vpa-130098 Vicugna pacos 97.27 0.00e+00 1694.00
IUUC-Xtr-132162 Xenopus tropicalis 97.98 0.00e+00 1729.00
Created Date 25-Jun-2017

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