iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cme-027151

Ensembl Protein ID

CMB070CT

UniProt Accession

M1V6F7; M1V6F7_CYAM1

Genbank Protein ID

BAM78884.1

Protein Name

Ubiquitin protein ligase E3A

Genbank Nucleotide ID

AP006484

Gene Name

CYME_CMB070C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CMB070C	CMB070CT	CMB070CT

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-94	312.9	785	1111

Active Site

Position(s)	Description	Evidence
1080	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           dl k l+vef gE ++d gGv +e++ +l+++l +pd+g+f+y+++ ++ ++ np+s+    e    F ++G l+g+a+++g +l++++++ +yk+llg
   Q: 785  DLLKPLRVEFIGEPAVDEGGVRKEYMMMLMEKLLSPDYGMFQYDAETRYIWF-NPHSF----ESKIEFMLVGLLIGLAVYNGIILEVHFPPILYKRLLG 878
           666789******************************************9988.99998....4567899****************************** PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevi 201
            ++++ dl +  p +++sl+++++++ ++  e  + ltfs++ +  ge+++++L+p+G+nipVt eN++e+v+l++ y l ++++eq++af +Gf+ ++
   Q: 879  MSVDVADLRDAFPRVAQSLQQLLAYEGKEPVEDVFGLTFSIDYNYWGEIRTYDLVPNGRNIPVTRENRQEFVRLYARYLLVDSVREQFDAFAAGFSMML 977
           **************************88888888****************************************************************9 PP
   S: 202  ple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.dr 297
           +    l lF++ ele+++ Ge+e+d+++l++ tky+ggyt++s a++wFw+++  ++++++r+++L FvTgs+r+P+gG+ +l+   fvi+++++d dr
   Q: 978  SRGvALMLFSPDELEIVVRGEPELDFHALERVTKYEGGYTSESLAVRWFWSIVhDNMKEDDRRRLLAFVTGSDRAPVGGLGKLH---FVIQRAGADtDR 1073
           988689***********************************************889****************************...9999966666** PP
   S: 298  lPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           lP+++TCfn+L LP+Yss e+++ +L +Ai++++gF+l
   Q: 1074 LPTAHTCFNVLLLPDYSSREKMRAMLDTAIKNAQGFGL 1111
           ************************************98 PP

Organism

Cyanidioschyzon merolae

Protein Sequence
(Fasta)

MDEKPFLTDP EQRSEGAARK QSSGDESEAA PQGVTEQTTP CLSVSDSEIE RGEASCAATV 60
QWPQTEPLLT HLLVWGAVSL GNVVAVPRLQ PPFSSSTEWA LASIPEPVYA VGGTNFTVVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGAAA AACCTTTCTT GACCGACCCA GAGCAGCGTA GTGAAGGAGC AGCTCGAAAG 60
CAGAGCTCCG GAGACGAGTC GGAAGCGGCC CCGCAGGGCG TTACGGAGCA GACGACGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

cme:CYME_CMB070C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	44.02	3.00e-103	367.00
IUUC-Atr-003144	Amborella trichopoda	43.81	9.00e-111	391.00
IUUC-Apl-003742	Anas platyrhynchos	44.24	1.00e-103	368.00
IUUC-Aca-004873	Anolis carolinensis	44.02	3.00e-103	367.00
IUUC-Ago-007908	Ashbya gossypii	33.94	2.00e-75	274.00
IUUC-Acl-008288	Aspergillus clavatus	35.48	7.00e-78	283.00
IUUC-Afl-008402	Aspergillus flavus	35.06	4.00e-71	260.00
IUUC-Afu-008762	Aspergillus fumigatus	36.84	4.00e-81	294.00
IUUC-Ani-009176	Aspergillus nidulans	37.96	2.00e-81	295.00
IUUC-Ang-009791	Aspergillus niger	37.66	5.00e-77	280.00
IUUC-Aor-009921	Aspergillus oryzae	35.28	7.00e-73	266.00
IUUC-Ate-010295	Aspergillus terreus	36.56	2.00e-81	295.00
IUUC-Ame-011166	Astyanax mexicanus	43.34	9.00e-104	369.00
IUUC-Bgr-011981	Blumeria graminis	36.05	2.00e-81	295.00
IUUC-Bta-013286	Bos taurus	44.02	1.00e-103	368.00
IUUC-Bci-013697	Botrytis cinerea	36.11	7.00e-70	256.00
IUUC-Cel-018150	Caenorhabditis elegans	35.70	6.00e-72	263.00
IUUC-Cja-019707	Callithrix jacchus	44.02	6.00e-103	366.00
IUUC-Cfa-020154	Canis familiaris	44.02	2.00e-103	367.00
IUUC-Cpo-021292	Cavia porcellus	44.75	1.00e-102	365.00
IUUC-Cre-022963	Chlamydomonas reinhardtii	48.44	5.00e-88	315.00
IUUC-Csa-023378	Chlorocebus sabaeus	44.02	3.00e-103	367.00
IUUC-Cho-025059	Choloepus hoffmanni	40.09	9.00e-86	309.00
IUUC-Cin-025643	Ciona intestinalis	41.89	3.00e-94	337.00
IUUC-Csv-026282	Ciona savignyi	41.26	1.00e-86	311.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	37.27	2.00e-84	305.00
IUUC-Dre-027901	Danio rerio	43.12	5.00e-103	366.00
IUUC-Dno-029320	Dasypus novemcinctus	44.02	5.00e-103	366.00
IUUC-Dor-030756	Dipodomys ordii	50.91	1.00e-94	338.00
IUUC-Dse-031239	Dothistroma septosporum	33.47	5.00e-70	257.00
IUUC-Dme-032035	Drosophila melanogaster	40.93	2.00e-94	338.00
IUUC-Ete-032642	Echinops telfairi	36.94	2.00e-69	255.00
IUUC-Eca-033843	Equus caballus	43.79	6.00e-98	349.00
IUUC-Eeu-035109	Erinaceus europaeus	42.89	9.00e-95	338.00
IUUC-Fca-036344	Felis catus	44.02	2.00e-103	367.00
IUUC-Fal-036747	Ficedula albicollis	44.24	9.00e-104	369.00
IUUC-Fox-037941	Fusarium oxysporum	37.80	2.00e-87	315.00
IUUC-Fso-038388	Fusarium solani	38.41	7.00e-85	306.00
IUUC-Gmo-039089	Gadus morhua	41.94	1.00e-96	345.00
IUUC-Ggr-040110	Gaeumannomyces graminis	37.63	3.00e-80	291.00
IUUC-Gga-040399	Gallus gallus	44.24	9.00e-104	369.00
IUUC-Gac-041933	Gasterosteus aculeatus	43.38	2.00e-101	361.00
IUUC-Ggo-044804	Gorilla gorilla	44.02	5.00e-103	366.00
IUUC-Hsa-045727	Homo sapiens	44.02	5.00e-103	366.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	43.61	2.00e-101	361.00
IUUC-Kpa-049152	Komagataella pastoris	35.00	2.00e-64	238.00
IUUC-Lch-050197	Latimeria chalumnae	45.21	2.00e-107	381.00
IUUC-Loc-052743	Lepisosteus oculatus	43.12	2.00e-100	358.00
IUUC-Lma-053245	Leptosphaeria maculans	36.32	4.00e-57	214.00
IUUC-Laf-053615	Loxodonta africana	44.02	5.00e-103	366.00
IUUC-Mcc-054934	Macaca mulatta	44.02	5.00e-103	366.00
IUUC-Meu-056061	Macropus eugenii	44.24	1.00e-101	362.00
IUUC-Mor-057045	Magnaporthe oryzae	36.96	3.00e-81	295.00
IUUC-Mla-059187	Melampsora laricipopulina	39.77	7.00e-72	261.00
IUUC-Mga-059271	Meleagris gallopavo	44.24	1.00e-103	368.00
IUUC-Mmr-061288	Microcebus murinus	44.02	2.00e-103	367.00
IUUC-Mdo-062975	Monodelphis domestica	44.47	3.00e-104	370.00
IUUC-Mmu-063674	Mus musculus	44.52	2.00e-103	367.00
IUUC-Mpu-066568	Mustela putorius furo	44.02	2.00e-103	367.00
IUUC-Mlu-067522	Myotis lucifugus	45.28	1.00e-100	358.00
IUUC-Nfi-068439	Neosartorya fischeri	36.29	3.00e-79	288.00
IUUC-Ncr-068903	Neurospora crassa	37.01	3.00e-79	288.00
IUUC-Nle-069505	Nomascus leucogenys	44.02	5.00e-103	366.00
IUUC-Opr-070570	Ochotona princeps	50.52	2.00e-81	294.00
IUUC-Ont-072087	Oreochromis niloticus	42.79	2.00e-104	370.00
IUUC-Oan-072933	Ornithorhynchus anatinus	40.57	4.00e-90	323.00
IUUC-Ocu-074922	Oryctolagus cuniculus	44.02	3.00e-103	367.00
IUUC-Ola-086833	Oryzias latipes	42.57	4.00e-97	347.00
IUUC-Oga-088261	Otolemur garnettii	44.24	8.00e-104	369.00
IUUC-Oar-090024	Ovis aries	44.02	1.00e-103	368.00
IUUC-Ptr-090455	Pan troglodytes	44.02	5.00e-103	366.00
IUUC-Pan-092067	Papio anubis	40.00	1.00e-88	318.00
IUUC-Psi-092974	Pelodiscus sinensis	44.02	2.00e-103	368.00
IUUC-Pma-094643	Petromyzon marinus	44.70	3.00e-105	374.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.48	8.00e-63	233.00
IUUC-Ppa-095354	Physcomitrella patens	47.77	2.00e-117	415.00
IUUC-Pfo-097021	Poecilia formosa	31.36	3.00e-111	394.00
IUUC-Pab-097840	Pongo abelii	43.79	1.00e-99	355.00
IUUC-Pca-100869	Procavia capensis	43.69	7.00e-101	359.00
IUUC-Pva-103040	Pteropus vampyrus	50.00	6.00e-92	329.00
IUUC-Pgr-103315	Puccinia graminis	37.58	2.00e-81	294.00
IUUC-Ptt-103736	Puccinia triticina	37.90	4.00e-82	297.00
IUUC-Pte-104055	Pyrenophora teres	34.13	8.00e-58	216.00
IUUC-Pyt-104647	Pyrenophora triticirepentis	35.45	9.00e-60	223.00
IUUC-Rno-105453	Rattus norvegicus	44.75	8.00e-104	369.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.13	9.00e-76	276.00
IUUC-Sha-107651	Sarcophilus harrisii	44.47	3.00e-104	370.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.53	6.00e-74	270.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	35.47	5.00e-75	273.00
IUUC-Smo-108858	Selaginella moellendorffii	42.04	6.00e-104	369.00
IUUC-Sar-113293	Sorex araneus	43.79	2.00e-102	364.00
IUUC-Ssc-115979	Sus scrofa	44.02	3.00e-103	367.00
IUUC-Tgu-116901	Taeniopygia guttata	44.24	1.00e-103	368.00
IUUC-Tru-118206	Takifugu rubripes	37.50	2.00e-76	278.00
IUUC-Tsy-119516	Tarsius syrichta	40.05	1.00e-83	302.00
IUUC-Tni-120143	Tetraodon nigroviridis	43.79	3.00e-103	367.00
IUUC-Tre-122108	Trichoderma reesei	38.20	3.00e-77	281.00
IUUC-Tvi-122644	Trichoderma virens	37.85	5.00e-81	293.00
IUUC-Tme-127004	Tuber melanosporum	39.23	4.00e-84	304.00
IUUC-Tbe-127640	Tupaia belangeri	36.81	2.00e-73	268.00
IUUC-Ttr-129078	Tursiops truncatus	43.79	2.00e-101	360.00
IUUC-Vda-129969	Verticillium dahliae	37.77	1.00e-82	299.00
IUUC-Vpa-130589	Vicugna pacos	26.02	7.00e-78	283.00
IUUC-Xtr-132881	Xenopus tropicalis	43.12	9.00e-104	369.00
IUUC-Xma-133389	Xiphophorus maculatus	30.00	6.00e-108	383.00
IUUC-Yli-134470	Yarrowia lipolytica	33.20	2.00e-63	234.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence