iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021226

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03000117

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000116.4	ENSCAFT00000000200.3	ENSCAFP00000000179.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-135	451.3	627	958

Active Site

Position(s)	Description	Evidence
928	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 627  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 715
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 716  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 799
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 800  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 888
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+d+lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 889  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 958
           *********************************************************************8 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

QQGESRILRV KVVSGIDLAK KDIFGASDPY VKLSLYVADE NRELALVQTK TIKKTLNPKW 60
NEEFYFRVNP SNHRLLFEVF DENRLTRDDF LGQVDIPLSH LPTEDPTMER PYTFKDFLLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACAGGGAG AGTCACGTAT TCTCAGAGTG AAGGTTGTTT CTGGAATTGA TCTCGCCAAA 60
AAGGACATCT TTGGGGCCAG GTATGTTTGT TTAGTTTTTG TTTTTGTTTT GTTTTGTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	96.50	0.00e+00	1706.00
IUUC-Apl-003893	Anas platyrhynchos	93.95	0.00e+00	1707.00
IUUC-Aca-004744	Anolis carolinensis	90.20	0.00e+00	1645.00
IUUC-Ago-007742	Ashbya gossypii	49.08	2.00e-161	563.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	2.00e-163	569.00
IUUC-Afl-008713	Aspergillus flavus	46.68	3.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	2.00e-163	569.00
IUUC-Ani-009259	Aspergillus nidulans	48.53	1.00e-161	563.00
IUUC-Ang-009738	Aspergillus niger	49.33	7.00e-162	564.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.42	3.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	71.87	0.00e+00	1250.00
IUUC-Bta-012679	Bos taurus	97.72	0.00e+00	1595.00
IUUC-Cel-018564	Caenorhabditis elegans	52.69	0.00e+00	634.00
IUUC-Cja-018732	Callithrix jacchus	97.71	0.00e+00	1798.00
IUUC-Cpo-021671	Cavia porcellus	96.15	0.00e+00	1746.00
IUUC-Csa-023344	Chlorocebus sabaeus	95.91	0.00e+00	1783.00
IUUC-Cho-024832	Choloepus hoffmanni	99.72	0.00e+00	741.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.66	2.00e-155	543.00
IUUC-Cne-026849	Cryptococcus neoformans	47.37	3.00e-158	552.00
IUUC-Dre-027770	Danio rerio	79.10	0.00e+00	1419.00
IUUC-Dno-029466	Dasypus novemcinctus	97.71	0.00e+00	1798.00
IUUC-Dor-030138	Dipodomys ordii	91.97	0.00e+00	1623.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	9.00e-160	557.00
IUUC-Ete-033145	Echinops telfairi	88.37	0.00e+00	1269.00
IUUC-Eca-033445	Equus caballus	98.63	0.00e+00	1601.00
IUUC-Eeu-035247	Erinaceus europaeus	89.22	0.00e+00	1498.00
IUUC-Fca-035489	Felis catus	95.59	0.00e+00	1539.00
IUUC-Fal-037604	Ficedula albicollis	91.53	0.00e+00	1715.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	1.00e-158	553.00
IUUC-Fso-038393	Fusarium solani	47.41	1.00e-153	537.00
IUUC-Gmo-039674	Gadus morhua	77.61	0.00e+00	1386.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	5.00e-156	545.00
IUUC-Gga-040703	Gallus gallus	93.55	0.00e+00	1741.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.35	0.00e+00	1420.00
IUUC-Ggo-045332	Gorilla gorilla	95.73	0.00e+00	1722.00
IUUC-Hsa-045968	Homo sapiens	97.71	0.00e+00	1797.00
IUUC-Kpa-049273	Komagataella pastoris	49.16	6.00e-162	564.00
IUUC-Lch-050443	Latimeria chalumnae	86.59	0.00e+00	1437.00
IUUC-Loc-052662	Lepisosteus oculatus	80.89	0.00e+00	1439.00
IUUC-Laf-053850	Loxodonta africana	96.67	0.00e+00	1786.00
IUUC-Mcc-055821	Macaca mulatta	97.70	0.00e+00	1789.00
IUUC-Meu-056712	Macropus eugenii	81.58	0.00e+00	776.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	8.00e-157	547.00
IUUC-Mpo-057442	Magnaporthe poae	52.16	1.00e-145	510.00
IUUC-Mmr-060798	Microcebus murinus	93.87	0.00e+00	1666.00
IUUC-Mdo-062173	Monodelphis domestica	94.79	0.00e+00	1798.00
IUUC-Mmu-064136	Mus musculus	96.99	0.00e+00	1759.00
IUUC-Mpu-066765	Mustela putorius furo	99.06	0.00e+00	1782.00
IUUC-Mlu-067565	Myotis lucifugus	95.45	0.00e+00	1572.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	1.00e-163	570.00
IUUC-Ncr-068918	Neurospora crassa	47.40	3.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	93.76	0.00e+00	1697.00
IUUC-Opr-071044	Ochotona princeps	96.12	0.00e+00	1196.00
IUUC-Ont-072044	Oreochromis niloticus	78.05	0.00e+00	1453.00
IUUC-Oan-073032	Ornithorhynchus anatinus	92.76	0.00e+00	1443.00
IUUC-Ocu-074160	Oryctolagus cuniculus	94.59	0.00e+00	1716.00
IUUC-Ola-087467	Oryzias latipes	79.53	0.00e+00	1441.00
IUUC-Oga-088460	Otolemur garnettii	93.16	0.00e+00	1565.00
IUUC-Oar-090198	Ovis aries	97.50	0.00e+00	1759.00
IUUC-Ptr-090939	Pan troglodytes	97.71	0.00e+00	1797.00
IUUC-Pan-092284	Papio anubis	97.71	0.00e+00	1795.00
IUUC-Psi-093645	Pelodiscus sinensis	93.75	0.00e+00	1735.00
IUUC-Pma-094364	Petromyzon marinus	82.44	0.00e+00	860.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.01	1.00e-163	570.00
IUUC-Pfo-096768	Poecilia formosa	91.16	0.00e+00	963.00
IUUC-Pab-098088	Pongo abelii	97.81	0.00e+00	1795.00
IUUC-Pca-100714	Procavia capensis	75.16	0.00e+00	1310.00
IUUC-Pva-102354	Pteropus vampyrus	96.25	0.00e+00	1694.00
IUUC-Pgr-103620	Puccinia graminis	53.53	9.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	1.00e-122	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	2.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	2.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	96.36	0.00e+00	1739.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	8.00e-164	570.00
IUUC-Sha-107482	Sarcophilus harrisii	96.25	0.00e+00	1612.00
IUUC-Ssc-115950	Sus scrofa	71.11	0.00e+00	1176.00
IUUC-Tgu-117130	Taeniopygia guttata	94.17	0.00e+00	1746.00
IUUC-Tru-118610	Takifugu rubripes	80.41	0.00e+00	1462.00
IUUC-Tsy-119492	Tarsius syrichta	91.94	0.00e+00	1635.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.21	0.00e+00	1359.00
IUUC-Tme-126897	Tuber melanosporum	52.69	1.00e-147	516.00
IUUC-Tbe-127441	Tupaia belangeri	91.17	0.00e+00	797.00
IUUC-Ttr-128235	Tursiops truncatus	88.43	0.00e+00	1519.00
IUUC-Vda-129753	Verticillium dahliae	47.85	5.00e-157	548.00
IUUC-Xtr-132859	Xenopus tropicalis	90.05	0.00e+00	1664.00
IUUC-Xma-133797	Xiphophorus maculatus	80.96	0.00e+00	1457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence