iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037126

Ensembl Protein ID

ENSFALP00000013077.1

UniProt Accession

U3KDH3; U3KDH3_FICAL

Genbank Protein ID

ENSFALP00000013077

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGTO01001505

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000012533.1	ENSFALT00000013131.1	ENSFALP00000013077.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-136	453.3	545	877

Active Site

Position(s)	Description	Evidence
846	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 545  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 632
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k + l+dle+vdpe+y+sl ++ken   diee+gl++ fsv++eilge+k+++Lkp+G+ni Vt+eNke+Y++lv+e
   Q: 633  GFSLPFYKRILNKAVGLKDLESVDPEFYNSLIWVKEN---DIEECGLEMFFSVDKEILGEIKSHDLKPNGSNILVTEENKEDYIRLVAE 718
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 719  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSRQIVWFWQFVKEIDNEKRMRLLQFV 806
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+++e+lkekLl+Aieet+gF++
   Q: 807  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKNYEQLKEKLLFAIEETEGFGQ 877
           *********************************************************************96 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MAGSGSRLGP ASGLSMKSQL QITVISAKLK EKNKWFGPSP YVEVSVDGQS KKTEKCNNTN 60
SPKWKQHLTV IVTPVSKLNF RVWSHQTLKS DVLLGSAALD IHETLKSNSM KLEQVVVTLH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCAAGATC CAGCCCATAT TATGGCTGGC AGTGGGTCCA GATTAGGACC AGCCAGTGGG 60
TTGTCCATGA AATCGCAGCT TCAGATCACT GGTGAGCCTT CTGAAATTAT CTGTCTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

KEGG

fab:101813986

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	84.22	0.00e+00	1441.00
IUUC-Apl-003752	Anas platyrhynchos	94.59	0.00e+00	1608.00
IUUC-Aca-005338	Anolis carolinensis	86.58	0.00e+00	1491.00
IUUC-Ago-007742	Ashbya gossypii	48.88	1.00e-161	563.00
IUUC-Ame-010601	Astyanax mexicanus	86.63	0.00e+00	1120.00
IUUC-Bta-012782	Bos taurus	96.34	0.00e+00	1189.00
IUUC-Cja-018899	Callithrix jacchus	95.40	0.00e+00	1198.00
IUUC-Cfa-020648	Canis familiaris	83.12	0.00e+00	1407.00
IUUC-Cpo-022073	Cavia porcellus	82.63	0.00e+00	1461.00
IUUC-Csa-023252	Chlorocebus sabaeus	81.95	0.00e+00	1446.00
IUUC-Cho-024695	Choloepus hoffmanni	77.66	0.00e+00	1418.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.37	5.00e-155	541.00
IUUC-Cne-026849	Cryptococcus neoformans	46.68	8.00e-161	560.00
IUUC-Dre-028451	Danio rerio	74.55	0.00e+00	1307.00
IUUC-Dno-029884	Dasypus novemcinctus	82.09	0.00e+00	1467.00
IUUC-Dse-031241	Dothistroma septosporum	47.80	7.00e-156	544.00
IUUC-Eca-033793	Equus caballus	83.45	0.00e+00	1450.00
IUUC-Eeu-034716	Erinaceus europaeus	90.39	0.00e+00	874.00
IUUC-Fca-035605	Felis catus	83.29	0.00e+00	1462.00
IUUC-Fox-037774	Fusarium oxysporum	47.04	2.00e-154	539.00
IUUC-Fso-038393	Fusarium solani	47.04	4.00e-153	535.00
IUUC-Gmo-038596	Gadus morhua	80.55	0.00e+00	1012.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.60	9.00e-154	537.00
IUUC-Gga-040832	Gallus gallus	94.76	0.00e+00	1625.00
IUUC-Gac-041658	Gasterosteus aculeatus	86.94	0.00e+00	1117.00
IUUC-Ggo-044535	Gorilla gorilla	80.25	0.00e+00	1411.00
IUUC-Hsa-046564	Homo sapiens	78.42	0.00e+00	1432.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	94.72	0.00e+00	1196.00
IUUC-Kpa-049273	Komagataella pastoris	49.31	1.00e-162	566.00
IUUC-Lch-050454	Latimeria chalumnae	76.31	0.00e+00	1392.00
IUUC-Loc-052647	Lepisosteus oculatus	72.96	0.00e+00	1345.00
IUUC-Laf-054383	Loxodonta africana	82.86	0.00e+00	1460.00
IUUC-Mcc-055532	Macaca mulatta	81.73	0.00e+00	1443.00
IUUC-Mor-057097	Magnaporthe oryzae	47.53	8.00e-155	540.00
IUUC-Mpo-057442	Magnaporthe poae	51.55	1.00e-144	507.00
IUUC-Mla-058996	Melampsora laricipopulina	52.49	2.00e-149	522.00
IUUC-Mga-059661	Meleagris gallopavo	94.65	0.00e+00	1600.00
IUUC-Mvi-060395	Microbotryum violaceum	51.45	8.00e-149	520.00
IUUC-Mmr-061135	Microcebus murinus	83.43	0.00e+00	1470.00
IUUC-Mdo-062505	Monodelphis domestica	86.74	0.00e+00	1491.00
IUUC-Mmu-063375	Mus musculus	95.91	0.00e+00	1209.00
IUUC-Mpu-066203	Mustela putorius furo	84.68	0.00e+00	1446.00
IUUC-Mlu-067837	Myotis lucifugus	83.90	0.00e+00	1455.00
IUUC-Nle-069244	Nomascus leucogenys	82.97	0.00e+00	1440.00
IUUC-Opr-070585	Ochotona princeps	79.61	0.00e+00	1422.00
IUUC-Ont-071798	Oreochromis niloticus	89.55	0.00e+00	1137.00
IUUC-Ocu-074298	Oryctolagus cuniculus	95.91	0.00e+00	1211.00
IUUC-Ola-086526	Oryzias latipes	85.98	0.00e+00	1112.00
IUUC-Oga-088167	Otolemur garnettii	76.77	0.00e+00	1337.00
IUUC-Oar-090316	Ovis aries	73.78	0.00e+00	842.00
IUUC-Ptr-090819	Pan troglodytes	77.85	0.00e+00	1393.00
IUUC-Pan-092454	Papio anubis	81.73	0.00e+00	1443.00
IUUC-Psi-093319	Pelodiscus sinensis	88.66	0.00e+00	1505.00
IUUC-Pfo-097346	Poecilia formosa	85.21	0.00e+00	1102.00
IUUC-Pab-097580	Pongo abelii	73.10	0.00e+00	1280.00
IUUC-Pop-099613	Populus trichocarpa	44.50	5.00e-93	337.00
IUUC-Pca-100923	Procavia capensis	69.16	0.00e+00	1202.00
IUUC-Pva-103209	Pteropus vampyrus	81.84	0.00e+00	1393.00
IUUC-Pgr-103620	Puccinia graminis	52.49	2.00e-148	519.00
IUUC-Rno-104924	Rattus norvegicus	95.91	0.00e+00	1211.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.48	1.00e-162	566.00
IUUC-Sha-107175	Sarcophilus harrisii	86.04	0.00e+00	1476.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	50.09	6.00e-159	554.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.71	3.00e-162	565.00
IUUC-Sar-113761	Sorex araneus	95.99	0.00e+00	1183.00
IUUC-Tgu-116632	Taeniopygia guttata	90.39	0.00e+00	1469.00
IUUC-Tru-118442	Takifugu rubripes	88.91	0.00e+00	1123.00
IUUC-Tsy-119198	Tarsius syrichta	75.80	0.00e+00	1330.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.99	0.00e+00	1060.00
IUUC-Tbe-127756	Tupaia belangeri	65.84	0.00e+00	1118.00
IUUC-Ttr-128504	Tursiops truncatus	75.45	0.00e+00	1011.00
IUUC-Vda-129753	Verticillium dahliae	47.36	8.00e-154	537.00
IUUC-Vpa-130103	Vicugna pacos	69.91	0.00e+00	1200.00
IUUC-Xtr-132885	Xenopus tropicalis	74.21	0.00e+00	1381.00
IUUC-Xma-133987	Xiphophorus maculatus	88.81	0.00e+00	1124.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence