iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013474

Ensembl Protein ID

ENSBTAP00000042073.3

UniProt Accession

Q2TA06; AURKA_BOVIN

Genbank Protein ID

ABC61056.1; AAI11182.1

Protein Name

Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A

Genbank Nucleotide ID

DQ334808; BC111181

Gene Name

AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013009.5	ENSBTAT00000044590.3	ENSBTAP00000042073.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	88.83	0.00e+00	731.00	IUUC-Hsa-046968

Active Site

Position(s)	Description	Evidence
256	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027}

Organism

Bos taurus

Functional Description
(View)

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Necessary for proper cilia disassembly prior to mitosis (By similarity). Interacts with SIRT2 (By similarity).

Protein Sequence
(Fasta)

MDRCKENCIS GPKTAVPLSD GPKRVPVAQQ FPSQNPVSVN SGQAQRVLCP TNSSQRVPSQ 60
AQKLVSIQKP VQTLKQKPPQ AASAPRPVTR PPSNTQKSKQ PQPPAPGNNP EKEVASKQKN 120

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Nucleotide Sequence
(Fasta)

AACTTCCGGT AGGGATGAGT ACTAGGAAGT GGGCTAGTTT GAATAGACTA GCCAGGAAAG 60
GCCCTTGTCC GGGCAGCATG GATGAGTGGG TGAATAAATA AACCTGGAAG CCAGTGTTTC 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR030616--Aur
IPR030611--AURKA
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0043203--C:axon hillock
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0005929--C:cilium
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0070938--C:contractile ring
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0042585--C:germinal vesicle
GO:0072687--C:meiotic spindle
GO:0072686--C:mitotic spindle
GO:0048471--C:perinuclear region of cytoplasm
GO:0045120--C:pronucleus
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0000922--C:spindle pole
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0009948--P:anterior/posterior axis specification
GO:0051301--P:cell division
GO:0051642--P:centrosome localization
GO:0097421--P:liver regeneration
GO:0007100--P:mitotic centrosome separation
GO:0007052--P:mitotic spindle organization
GO:0043066--P:negative regulation of apoptotic process
GO:0032091--P:negative regulation of protein binding
GO:1990138--P:neuron projection extension
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071539--P:protein localization to centrosome
GO:0032465--P:regulation of cytokinesis
GO:0031647--P:regulation of protein stability
GO:0009611--P:response to wounding
GO:0007057--P:spindle assembly involved in female meiosis I

KEGG

bta:504437

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	63.80	2.00e-104	371.00
IUUC-Aml-001426	Ailuropoda melanoleuca	90.44	0.00e+00	722.00
IUUC-Atr-002453	Amborella trichopoda	64.38	3.00e-109	387.00
IUUC-Apl-003626	Anas platyrhynchos	72.47	1.00e-153	536.00
IUUC-Aca-004602	Anolis carolinensis	69.43	6.00e-149	520.00
IUUC-Aly-005878	Arabidopsis lyrata	63.27	4.00e-105	374.00
IUUC-Ath-007117	Arabidopsis thaliana	65.07	2.00e-106	378.00
IUUC-Acl-008199	Aspergillus clavatus	57.66	2.00e-88	319.00
IUUC-Afl-008419	Aspergillus flavus	56.93	4.00e-87	315.00
IUUC-Afu-008751	Aspergillus fumigatus	57.66	3.00e-88	318.00
IUUC-Ani-009181	Aspergillus nidulans	51.58	6.00e-92	330.00
IUUC-Ang-009787	Aspergillus niger	58.03	1.00e-88	320.00
IUUC-Aor-009980	Aspergillus oryzae	56.93	4.00e-87	315.00
IUUC-Ate-010286	Aspergillus terreus	55.24	4.00e-87	315.00
IUUC-Ame-010849	Astyanax mexicanus	60.97	1.00e-129	456.00
IUUC-Bgr-012110	Blumeria graminis	58.72	1.00e-88	320.00
IUUC-Bci-013756	Botrytis cinerea	59.78	1.00e-94	340.00
IUUC-Bdi-014257	Brachypodium distachyon	62.33	5.00e-106	377.00
IUUC-Bol-016310	Brassica oleracea	61.38	2.00e-104	371.00
IUUC-Bra-017438	Brassica rapa	62.86	2.00e-105	375.00
IUUC-Cel-018157	Caenorhabditis elegans	61.35	8.00e-103	366.00
IUUC-Cja-019282	Callithrix jacchus	88.59	0.00e+00	707.00
IUUC-Cfa-020162	Canis familiaris	88.89	0.00e+00	717.00
IUUC-Cpo-021764	Cavia porcellus	83.05	0.00e+00	650.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	67.16	2.00e-108	384.00
IUUC-Csa-023694	Chlorocebus sabaeus	88.83	0.00e+00	680.00
IUUC-Cho-024350	Choloepus hoffmanni	95.92	1.00e-111	395.00
IUUC-Cin-025542	Ciona intestinalis	73.00	3.00e-118	417.00
IUUC-Csv-025873	Ciona savignyi	66.55	2.00e-118	418.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	50.00	2.00e-81	295.00
IUUC-Cne-026928	Cryptococcus neoformans	61.48	2.00e-94	339.00
IUUC-Cme-027336	Cyanidioschyzon merolae	72.83	2.00e-119	422.00
IUUC-Dre-028198	Danio rerio	62.21	2.00e-132	464.00
IUUC-Dno-029928	Dasypus novemcinctus	86.05	0.00e+00	650.00
IUUC-Dor-030238	Dipodomys ordii	80.49	0.00e+00	639.00
IUUC-Dse-031266	Dothistroma septosporum	53.06	1.00e-94	339.00
IUUC-Dme-032007	Drosophila melanogaster	60.84	4.00e-100	358.00
IUUC-Ete-032911	Echinops telfairi	67.72	4.00e-133	467.00
IUUC-Eca-033749	Equus caballus	90.96	0.00e+00	721.00
IUUC-Eeu-035170	Erinaceus europaeus	85.93	0.00e+00	702.00
IUUC-Fca-035498	Felis catus	89.77	0.00e+00	721.00
IUUC-Fal-037397	Ficedula albicollis	68.69	1.00e-150	525.00
IUUC-Fox-037747	Fusarium oxysporum	51.48	1.00e-92	333.00
IUUC-Fso-038429	Fusarium solani	54.14	5.00e-91	327.00
IUUC-Gmo-039378	Gadus morhua	61.35	9.00e-129	453.00
IUUC-Ggr-039939	Gaeumannomyces graminis	58.82	2.00e-95	342.00
IUUC-Gga-040187	Gallus gallus	70.79	2.00e-152	531.00
IUUC-Gac-042223	Gasterosteus aculeatus	60.80	7.00e-134	470.00
IUUC-Gma-042870	Glycine max	63.83	1.00e-100	359.00
IUUC-Ggo-045617	Gorilla gorilla	88.59	0.00e+00	728.00
IUUC-Hsa-046968	Homo sapiens	88.83	0.00e+00	731.00
IUUC-Hvu-047072	Hordeum vulgare	54.18	4.00e-83	301.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	75.68	2.00e-171	595.00
IUUC-Kpa-049093	Komagataella pastoris	55.94	5.00e-77	281.00
IUUC-Lch-050346	Latimeria chalumnae	66.26	1.00e-146	512.00
IUUC-Lpe-051466	Leersia perrieri	66.05	2.00e-106	378.00
IUUC-Lma-053006	Leptosphaeria maculans	58.74	3.00e-90	325.00
IUUC-Laf-053422	Loxodonta africana	86.14	0.00e+00	707.00
IUUC-Mcc-055245	Macaca mulatta	88.13	0.00e+00	664.00
IUUC-Mor-056952	Magnaporthe oryzae	59.70	3.00e-91	328.00
IUUC-Mpo-057605	Magnaporthe poae	58.08	3.00e-96	345.00
IUUC-Mtr-057726	Medicago truncatula	63.73	8.00e-107	379.00
IUUC-Mla-059174	Melampsora laricipopulina	61.36	3.00e-97	348.00
IUUC-Mga-059562	Meleagris gallopavo	61.56	4.00e-118	417.00
IUUC-Mvi-060305	Microbotryum violaceum	59.93	2.00e-94	339.00
IUUC-Mmr-061588	Microcebus murinus	86.57	0.00e+00	715.00
IUUC-Mdo-061914	Monodelphis domestica	79.12	9.00e-180	622.00
IUUC-Mmu-063288	Mus musculus	82.22	0.00e+00	644.00
IUUC-Mac-064969	Musa acuminata	63.45	1.00e-107	382.00
IUUC-Mpu-066855	Mustela putorius furo	89.15	0.00e+00	714.00
IUUC-Mlu-068046	Myotis lucifugus	87.86	0.00e+00	697.00
IUUC-Nfi-068527	Neosartorya fischeri	57.66	1.00e-87	316.00
IUUC-Ncr-068678	Neurospora crassa	60.98	3.00e-93	335.00
IUUC-Nle-069848	Nomascus leucogenys	87.84	0.00e+00	721.00
IUUC-Opr-070589	Ochotona princeps	83.37	0.00e+00	646.00
IUUC-Ont-071733	Oreochromis niloticus	61.78	6.00e-126	444.00
IUUC-Oan-073399	Ornithorhynchus anatinus	83.71	2.00e-152	531.00
IUUC-Ocu-074063	Oryctolagus cuniculus	87.38	0.00e+00	717.00
IUUC-Oba-075264	Oryza barthii	62.76	1.00e-105	375.00
IUUC-Obr-076048	Oryza brachyantha	64.84	4.00e-105	374.00
IUUC-Ogl-077637	Oryza glaberrima	65.68	4.00e-105	374.00
IUUC-Ogu-078830	Oryza glumaepatula	62.76	9.00e-106	376.00
IUUC-Oin-079150	Oryza indica	62.76	7.00e-106	376.00
IUUC-Olo-080398	Oryza longistaminata	58.40	8.00e-83	300.00
IUUC-Ome-081544	Oryza meridionalis	56.13	3.00e-91	328.00
IUUC-Oni-082250	Oryza nivara	62.76	7.00e-106	376.00
IUUC-Opu-083638	Oryza punctata	64.34	5.00e-106	377.00
IUUC-Oru-084981	Oryza rufipogon	62.76	5.00e-106	377.00
IUUC-Osa-085961	Oryza sativa	62.76	5.00e-106	377.00
IUUC-Olu-087880	Ostreococcus lucimarinus	68.54	1.00e-111	395.00
IUUC-Oga-088891	Otolemur garnettii	87.56	0.00e+00	691.00
IUUC-Oar-090021	Ovis aries	99.25	0.00e+00	789.00
IUUC-Ptr-091458	Pan troglodytes	89.08	0.00e+00	731.00
IUUC-Pan-092546	Papio anubis	88.59	0.00e+00	677.00
IUUC-Psi-093280	Pelodiscus sinensis	75.27	1.00e-162	565.00
IUUC-Pma-094298	Petromyzon marinus	77.65	4.00e-121	427.00
IUUC-Pno-094847	Phaeosphaeria nodorum	59.19	7.00e-91	327.00
IUUC-Ppa-095855	Physcomitrella patens	62.37	1.00e-108	385.00
IUUC-Pfo-096428	Poecilia formosa	61.52	6.00e-131	460.00
IUUC-Pab-098696	Pongo abelii	87.87	0.00e+00	712.00
IUUC-Pop-099405	Populus trichocarpa	62.28	5.00e-107	380.00
IUUC-Pca-100740	Procavia capensis	80.69	0.00e+00	663.00
IUUC-Ppe-101854	Prunus persica	62.67	1.00e-107	382.00
IUUC-Pva-103212	Pteropus vampyrus	88.89	0.00e+00	702.00
IUUC-Pgr-103474	Puccinia graminis	59.36	8.00e-99	353.00
IUUC-Ptt-103933	Puccinia triticina	48.48	5.00e-62	231.00
IUUC-Pte-104089	Pyrenophora teres	50.73	8.00e-91	327.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	50.73	7.00e-91	327.00
IUUC-Rno-105057	Rattus norvegicus	83.95	0.00e+00	663.00
IUUC-Sha-107137	Sarcophilus harrisii	79.59	0.00e+00	626.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	59.34	2.00e-98	352.00
IUUC-Spo-108078	Schizosaccharomyces pombe	60.58	4.00e-102	364.00
IUUC-Smo-109288	Selaginella moellendorffii	67.04	2.00e-108	385.00
IUUC-Sit-110246	Setaria italica	64.54	5.00e-106	377.00
IUUC-Sly-111379	Solanum lycopersicum	65.12	2.00e-108	385.00
IUUC-Stu-112777	Solanum tuberosum	61.64	1.00e-107	382.00
IUUC-Sbi-114325	Sorghum bicolor	64.18	7.00e-106	376.00
IUUC-Sre-115203	Sporisorium reilianum	57.25	3.00e-81	295.00
IUUC-Ssc-115361	Sus scrofa	90.52	0.00e+00	750.00
IUUC-Tgu-116967	Taeniopygia guttata	72.80	3.00e-149	521.00
IUUC-Tru-117570	Takifugu rubripes	61.00	1.00e-134	472.00
IUUC-Tsy-119280	Tarsius syrichta	92.99	2.00e-117	416.00
IUUC-Tni-120721	Tetraodon nigroviridis	63.04	7.00e-136	476.00
IUUC-Tca-121494	Theobroma cacao	61.94	1.00e-106	379.00
IUUC-Tre-121869	Trichoderma reesei	54.33	1.00e-93	336.00
IUUC-Tvi-122510	Trichoderma virens	57.24	2.00e-92	332.00
IUUC-Tae-123071	Triticum aestivum	63.80	2.00e-104	371.00
IUUC-Tur-126240	Triticum urartu	63.80	8.00e-104	369.00
IUUC-Tme-126921	Tuber melanosporum	62.26	1.00e-96	346.00
IUUC-Tbe-127872	Tupaia belangeri	81.59	0.00e+00	630.00
IUUC-Ttr-129134	Tursiops truncatus	93.28	0.00e+00	716.00
IUUC-Uma-129412	Ustilago maydis	45.50	2.00e-79	290.00
IUUC-Vda-130003	Verticillium dahliae	53.77	1.00e-91	329.00
IUUC-Vvi-131272	Vitis vinifera	62.29	2.00e-107	382.00
IUUC-Xtr-132019	Xenopus tropicalis	67.74	8.00e-153	533.00
IUUC-Xma-134203	Xiphophorus maculatus	61.54	8.00e-137	479.00
IUUC-Yli-134503	Yarrowia lipolytica	47.65	2.00e-86	312.00
IUUC-Zma-135232	Zea mays	65.11	1.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence