iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000014439.1	ENSAMET00000015912.1	ENSAMEP00000015277.1
ENSAMEG00000014439.1	ENSAMET00000015917.1	ENSAMEP00000015282.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-64	218.9	168	653

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 168  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 255
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 256  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 324
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    ++++++klP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 325  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTKLPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 402
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 403  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgstpqtlpsateq 491
           ****8888888888888888888888888888888888877777777777777777777777777777777777777777777666655 PP
   S: 268  ........peekqke.......................................................................... 274
                   p     +                                                                          
   Q: 492  qgapsselP-----Stspasiaavssrsvvhkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrti 575
           555555550.....055555555555555666666666666666666666666666666667777777777777777777888888888 PP
   S: 275  ..........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                     ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 576  elmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRENrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 653
           8888888888**************************965556***************99997779************6 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

TVEQNVLQQS AAQKHQQTFL NQLREITGIN DAQILQQALQ DSNGNLELAV AFLTAKNAKT 60
PQQEETTYYQ TALPGNDRYI SVGSQADTNV IDLTGDDKDD LQRAIALSLA ESNRAFRETG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGTGGAGC AGAATGTGCT GCAGCAGAGC GCAGCGCAGA AGGTGAGGCG AGCCCGGGAG 60
CCGGCGCGAC CGGGCCCCGC ACCTCCTTCC GACGTGCTGT TCTCACCCGC CTCGGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004030	Anas platyrhynchos	85.85	0.00e+00	1909.00
IUUC-Aca-004753	Anolis carolinensis	68.27	0.00e+00	1077.00
IUUC-Acl-008164	Aspergillus clavatus	24.88	2.00e-17	85.10
IUUC-Ani-009503	Aspergillus nidulans	32.82	5.00e-12	67.00
IUUC-Ame-010624	Astyanax mexicanus	74.87	0.00e+00	1173.00
IUUC-Bta-013166	Bos taurus	93.54	0.00e+00	1965.00
IUUC-Cel-018346	Caenorhabditis elegans	28.21	3.00e-30	127.00
IUUC-Cja-019150	Callithrix jacchus	94.04	0.00e+00	2042.00
IUUC-Cfa-020649	Canis familiaris	95.81	0.00e+00	2106.00
IUUC-Cpo-021807	Cavia porcellus	96.31	0.00e+00	2159.00
IUUC-Csa-023388	Chlorocebus sabaeus	94.05	0.00e+00	2047.00
IUUC-Cho-024343	Choloepus hoffmanni	81.11	0.00e+00	991.00
IUUC-Cin-025302	Ciona intestinalis	37.73	5.00e-97	348.00
IUUC-Csv-025911	Ciona savignyi	35.28	7.00e-136	478.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.32	1.00e-10	62.80
IUUC-Dre-028016	Danio rerio	77.58	0.00e+00	1199.00
IUUC-Dno-029495	Dasypus novemcinctus	91.57	0.00e+00	2053.00
IUUC-Dor-030948	Dipodomys ordii	85.68	0.00e+00	1527.00
IUUC-Fca-035876	Felis catus	95.89	0.00e+00	2028.00
IUUC-Fal-036762	Ficedula albicollis	83.93	0.00e+00	1119.00
IUUC-Gmo-039490	Gadus morhua	75.39	0.00e+00	1625.00
IUUC-Gga-040817	Gallus gallus	82.62	0.00e+00	1892.00
IUUC-Gac-042473	Gasterosteus aculeatus	74.79	0.00e+00	1645.00
IUUC-Ggo-044939	Gorilla gorilla	95.86	0.00e+00	2024.00
IUUC-Hsa-046204	Homo sapiens	94.57	0.00e+00	1981.00
IUUC-Kpa-049349	Komagataella pastoris	27.75	6.00e-10	60.50
IUUC-Lch-049572	Latimeria chalumnae	76.77	0.00e+00	1702.00
IUUC-Loc-052070	Lepisosteus oculatus	75.90	0.00e+00	1671.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	4.00e-12	67.80
IUUC-Laf-054426	Loxodonta africana	93.99	0.00e+00	1845.00
IUUC-Mcc-055858	Macaca mulatta	94.22	0.00e+00	2074.00
IUUC-Mga-059808	Meleagris gallopavo	83.06	0.00e+00	1826.00
IUUC-Mmr-060987	Microcebus murinus	94.03	0.00e+00	2038.00
IUUC-Mmu-064245	Mus musculus	90.33	0.00e+00	1967.00
IUUC-Mpu-066304	Mustela putorius furo	95.05	0.00e+00	2062.00
IUUC-Mlu-067139	Myotis lucifugus	93.37	0.00e+00	2010.00
IUUC-Nfi-068458	Neosartorya fischeri	23.29	7.00e-17	83.60
IUUC-Nle-069075	Nomascus leucogenys	94.57	0.00e+00	1978.00
IUUC-Ont-072150	Oreochromis niloticus	71.93	0.00e+00	1626.00
IUUC-Oan-073054	Ornithorhynchus anatinus	82.50	0.00e+00	1767.00
IUUC-Ocu-074102	Oryctolagus cuniculus	91.92	0.00e+00	2056.00
IUUC-Ola-086529	Oryzias latipes	72.05	0.00e+00	1571.00
IUUC-Oga-088939	Otolemur garnettii	92.37	0.00e+00	1968.00
IUUC-Oar-090266	Ovis aries	93.24	0.00e+00	2026.00
IUUC-Ptr-090546	Pan troglodytes	94.38	0.00e+00	1977.00
IUUC-Pan-092311	Papio anubis	94.13	0.00e+00	2072.00
IUUC-Psi-093459	Pelodiscus sinensis	90.54	0.00e+00	1181.00
IUUC-Pfo-096726	Poecilia formosa	71.40	0.00e+00	1617.00
IUUC-Pab-097608	Pongo abelii	97.39	0.00e+00	2040.00
IUUC-Pca-100718	Procavia capensis	86.16	0.00e+00	1471.00
IUUC-Pva-103150	Pteropus vampyrus	95.76	0.00e+00	1554.00
IUUC-Rno-105727	Rattus norvegicus	91.34	0.00e+00	1934.00
IUUC-Sha-107051	Sarcophilus harrisii	86.55	0.00e+00	1859.00
IUUC-Sar-113097	Sorex araneus	88.42	0.00e+00	1889.00
IUUC-Sre-115145	Sporisorium reilianum	30.77	2.00e-08	55.80
IUUC-Ssc-115877	Sus scrofa	92.05	0.00e+00	1953.00
IUUC-Tgu-117473	Taeniopygia guttata	79.28	0.00e+00	1722.00
IUUC-Tru-118135	Takifugu rubripes	68.38	0.00e+00	1429.00
IUUC-Tsy-119471	Tarsius syrichta	92.89	0.00e+00	1887.00
IUUC-Tni-120139	Tetraodon nigroviridis	64.64	0.00e+00	1301.00
IUUC-Tbe-127549	Tupaia belangeri	90.94	0.00e+00	1910.00
IUUC-Ttr-128896	Tursiops truncatus	93.64	0.00e+00	1994.00
IUUC-Vda-129742	Verticillium dahliae	24.19	2.00e-12	68.90
IUUC-Vpa-130500	Vicugna pacos	89.83	0.00e+00	1906.00
IUUC-Xtr-132896	Xenopus tropicalis	78.55	0.00e+00	1714.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence