iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044939

UUCD1 version

UUC-GoG-01123

Ensembl Protein ID

ENSGGOP00000001523.3

UniProt Accession

G3QGR2; G3QGR2_GORGO

Protein Name

Uncharacterized protein

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000001541.3	ENSGGOT00000001553.3	ENSGGOP00000001523.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-63	215.4	169	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMHELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 256
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 257  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 325
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 326  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 403
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 404  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqtlpstte 492
           ****8888888888888888888888888888888888888888888887777777777777777777777777777777777766555 PP
   S: 268  .........peekqke......................................................................... 274
                    p     +                                                                         
   Q: 493  qqgalsselP-----Stspssvaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 576
           5555555550.....05555555566666666666666666666666666666666666677777777777777777777888888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 577  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 655
           88888888888**************************966556***************99997779************6 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCGTGG AGCAGAACGT GCTGCAGCAG AGCGCGGCGC AGAAGGTGAG GCGAGTCCGC 60
CAGCCGGCGG GCCCCACTTC TCCTTCCGAC GGGCTGTCCT CTCCCGCTGC GGCCGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	95.30	0.00e+00	2020.00
IUUC-Apl-004030	Anas platyrhynchos	84.09	0.00e+00	1848.00
IUUC-Aca-004753	Anolis carolinensis	65.84	0.00e+00	1025.00
IUUC-Ame-010624	Astyanax mexicanus	72.34	0.00e+00	1115.00
IUUC-Bta-013166	Bos taurus	91.89	0.00e+00	1905.00
IUUC-Cel-018346	Caenorhabditis elegans	28.35	7.00e-30	126.00
IUUC-Cja-019150	Callithrix jacchus	94.31	0.00e+00	2016.00
IUUC-Cfa-020649	Canis familiaris	92.18	0.00e+00	1999.00
IUUC-Cpo-021807	Cavia porcellus	94.76	0.00e+00	2094.00
IUUC-Csa-023388	Chlorocebus sabaeus	94.32	0.00e+00	2023.00
IUUC-Cho-024343	Choloepus hoffmanni	77.76	0.00e+00	914.00
IUUC-Cin-025302	Ciona intestinalis	37.50	3.00e-96	345.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	53.19	5.00e-10	60.50
IUUC-Dre-028016	Danio rerio	77.23	0.00e+00	1189.00
IUUC-Dno-029495	Dasypus novemcinctus	89.68	0.00e+00	1975.00
IUUC-Dor-030948	Dipodomys ordii	86.14	0.00e+00	1513.00
IUUC-Fca-035876	Felis catus	92.35	0.00e+00	1929.00
IUUC-Fal-036762	Ficedula albicollis	83.95	0.00e+00	1108.00
IUUC-Gmo-039490	Gadus morhua	73.62	0.00e+00	1564.00
IUUC-Gga-040817	Gallus gallus	80.77	0.00e+00	1825.00
IUUC-Gac-042473	Gasterosteus aculeatus	73.31	0.00e+00	1593.00
IUUC-Hsa-046204	Homo sapiens	95.12	0.00e+00	1959.00
IUUC-Kpa-049349	Komagataella pastoris	28.12	2.00e-10	62.00
IUUC-Lch-049572	Latimeria chalumnae	75.45	0.00e+00	1655.00
IUUC-Loc-052070	Lepisosteus oculatus	74.75	0.00e+00	1636.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	4.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	91.89	0.00e+00	1765.00
IUUC-Mcc-055858	Macaca mulatta	94.49	0.00e+00	2055.00
IUUC-Mga-059808	Meleagris gallopavo	81.22	0.00e+00	1759.00
IUUC-Mmr-060987	Microcebus murinus	92.97	0.00e+00	1990.00
IUUC-Mmu-064245	Mus musculus	89.15	0.00e+00	1925.00
IUUC-Mpu-066304	Mustela putorius furo	91.56	0.00e+00	1964.00
IUUC-Mlu-067139	Myotis lucifugus	91.60	0.00e+00	1939.00
IUUC-Nle-069075	Nomascus leucogenys	94.94	0.00e+00	1954.00
IUUC-Ont-072150	Oreochromis niloticus	70.50	0.00e+00	1592.00
IUUC-Oan-073054	Ornithorhynchus anatinus	81.23	0.00e+00	1726.00
IUUC-Ocu-074102	Oryctolagus cuniculus	90.20	0.00e+00	1984.00
IUUC-Ola-086529	Oryzias latipes	71.12	0.00e+00	1540.00
IUUC-Oga-088939	Otolemur garnettii	91.38	0.00e+00	1927.00
IUUC-Oar-090266	Ovis aries	91.81	0.00e+00	1966.00
IUUC-Ptr-090546	Pan troglodytes	94.94	0.00e+00	1954.00
IUUC-Pan-092311	Papio anubis	94.40	0.00e+00	2054.00
IUUC-Psi-093459	Pelodiscus sinensis	90.87	0.00e+00	1173.00
IUUC-Pfo-096726	Poecilia formosa	69.86	0.00e+00	1586.00
IUUC-Pab-097608	Pongo abelii	97.85	0.00e+00	2015.00
IUUC-Pca-100718	Procavia capensis	86.33	0.00e+00	1412.00
IUUC-Pva-103150	Pteropus vampyrus	93.23	0.00e+00	1475.00
IUUC-Rno-105727	Rattus norvegicus	89.98	0.00e+00	1891.00
IUUC-Sha-107051	Sarcophilus harrisii	85.26	0.00e+00	1793.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	28.85	6.00e-09	57.00
IUUC-Sar-113097	Sorex araneus	86.75	0.00e+00	1823.00
IUUC-Ssc-115877	Sus scrofa	89.95	0.00e+00	1898.00
IUUC-Tgu-117473	Taeniopygia guttata	76.86	0.00e+00	1653.00
IUUC-Tru-118135	Takifugu rubripes	67.19	0.00e+00	1412.00
IUUC-Tsy-119471	Tarsius syrichta	91.29	0.00e+00	1833.00
IUUC-Tni-120139	Tetraodon nigroviridis	64.43	0.00e+00	1290.00
IUUC-Tbe-127549	Tupaia belangeri	89.37	0.00e+00	1837.00
IUUC-Ttr-128896	Tursiops truncatus	91.26	0.00e+00	1931.00
IUUC-Vpa-130500	Vicugna pacos	87.97	0.00e+00	1851.00
IUUC-Xtr-132896	Xenopus tropicalis	77.09	0.00e+00	1661.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence