iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006773

UUCD1 version

UUC-ArT-01086

Ensembl Protein ID

AT3G16090.1

UniProt Accession

Q9LW77; HRD1A_ARATH

Genbank Protein ID

AAY57599.1; BAB02675.1; AEE75770.1; BAC41836.1

Protein Name

ERAD-associated E3 ubiquitin-protein ligase HRD1A; RING-type E3 ubiquitin transferase HRD1A

Genbank Nucleotide ID

DQ059113; AB012247; CP002686; AK117158

Gene Name

HRD1A; At3g16090; MSL1.13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G16090	AT3G16090.1	AT3G16090.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.00e-08	33.8	292	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e++ +  + l CgH+fh +Cl  w        ++++CP+Cr
   Q: 292  CIICREEMTN-AKKLICGHLFHVHCLRSW------LERQQTCPTCR 330
           ********99.99999*************......**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3B.

Protein Sequence
(Fasta)

MIRLRTYAGL SFMATLAVIY HAFSSRGQFY PATVYLSTSK ISLVLLLNMC LVLMLSLWHL 60
VKFVFLGSLR EAEVERLNEQ AWRELMEILF AITIFRQDFS SGFLPLVVTL LLIKALHWLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAATGTT GTCAAGGGTA TAATTGGAAC TTTCAAAATA GTCGGAGAAC TAAAAGTTTG 60
GTCTTAATCG GAAAAACATA GAAACACCGT TTCCTCCTCC GCTTCTTCGT CTTTCCGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

ath:AT3G16090

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000344	Aegilops tauschii	56.53	4.00e-121	427.00
IUUC-Aml-001539	Ailuropoda melanoleuca	44.11	2.00e-77	282.00
IUUC-Atr-002892	Amborella trichopoda	67.40	8.00e-169	586.00
IUUC-Aca-004799	Anolis carolinensis	45.16	2.00e-76	279.00
IUUC-Aly-006352	Arabidopsis lyrata	93.60	0.00e+00	844.00
IUUC-Ago-007894	Ashbya gossypii	21.33	3.00e-17	82.80
IUUC-Acl-008041	Aspergillus clavatus	32.41	2.00e-63	236.00
IUUC-Afl-008427	Aspergillus flavus	33.61	5.00e-55	208.00
IUUC-Afu-009023	Aspergillus fumigatus	32.14	6.00e-64	238.00
IUUC-Ani-009133	Aspergillus nidulans	33.00	3.00e-65	242.00
IUUC-Ang-009612	Aspergillus niger	37.21	4.00e-62	231.00
IUUC-Aor-010045	Aspergillus oryzae	34.15	1.00e-65	244.00
IUUC-Ate-010533	Aspergillus terreus	33.33	3.00e-63	235.00
IUUC-Ame-011083	Astyanax mexicanus	44.69	7.00e-76	277.00
IUUC-Bgr-012122	Blumeria graminis	38.42	8.00e-34	138.00
IUUC-Bta-013375	Bos taurus	44.41	2.00e-77	282.00
IUUC-Bdi-015070	Brachypodium distachyon	75.14	6.00e-150	523.00
IUUC-Bol-015674	Brassica oleracea	83.53	0.00e+00	756.00
IUUC-Cja-019779	Callithrix jacchus	43.20	6.00e-72	264.00
IUUC-Cfa-020189	Canis familiaris	44.41	2.00e-78	286.00
IUUC-Cpo-022209	Cavia porcellus	44.41	6.00e-78	284.00
IUUC-Cre-022743	Chlamydomonas reinhardtii	52.68	1.00e-96	345.00
IUUC-Csa-023571	Chlorocebus sabaeus	44.41	9.00e-78	283.00
IUUC-Csv-026160	Ciona savignyi	38.46	5.00e-64	238.00
IUUC-Dre-027999	Danio rerio	43.81	3.00e-76	278.00
IUUC-Dno-029250	Dasypus novemcinctus	44.41	1.00e-77	283.00
IUUC-Dor-030718	Dipodomys ordii	43.20	2.00e-72	266.00
IUUC-Dse-031498	Dothistroma septosporum	41.61	7.00e-34	138.00
IUUC-Dme-031969	Drosophila melanogaster	41.25	8.00e-74	270.00
IUUC-Eca-033258	Equus caballus	44.41	1.00e-77	283.00
IUUC-Fca-035980	Felis catus	44.41	2.00e-78	286.00
IUUC-Fso-038418	Fusarium solani	30.17	4.00e-43	169.00
IUUC-Gmo-039288	Gadus morhua	42.86	2.00e-76	278.00
IUUC-Gac-042347	Gasterosteus aculeatus	44.44	6.00e-78	284.00
IUUC-Gma-044123	Glycine max	78.40	7.00e-177	613.00
IUUC-Ggo-044858	Gorilla gorilla	44.41	1.00e-77	283.00
IUUC-Hsa-046412	Homo sapiens	44.41	1.00e-77	283.00
IUUC-Hvu-047279	Hordeum vulgare	68.30	5.00e-153	533.00
IUUC-Itr-048924	Ictidomys tridecemlineatus	44.41	2.00e-77	282.00
IUUC-Lpe-051229	Leersia perrieri	59.29	1.00e-88	319.00
IUUC-Loc-052843	Lepisosteus oculatus	45.37	1.00e-49	188.00
IUUC-Laf-053482	Loxodonta africana	44.41	2.00e-77	282.00
IUUC-Mcc-055075	Macaca mulatta	44.41	1.00e-77	283.00
IUUC-Meu-056683	Macropus eugenii	45.17	6.00e-60	224.00
IUUC-Mor-057082	Magnaporthe oryzae	44.30	9.00e-35	141.00
IUUC-Mpo-057573	Magnaporthe poae	32.00	5.00e-48	185.00
IUUC-Mtr-058601	Medicago truncatula	74.64	0.00e+00	635.00
IUUC-Mvi-060515	Microbotryum violaceum	39.12	7.00e-62	231.00
IUUC-Mmr-060922	Microcebus murinus	44.41	6.00e-78	284.00
IUUC-Mdo-062491	Monodelphis domestica	44.11	2.00e-74	273.00
IUUC-Mmu-063770	Mus musculus	44.41	1.00e-77	283.00
IUUC-Mac-064789	Musa acuminata	72.33	2.00e-175	607.00
IUUC-Mpu-066107	Mustela putorius furo	44.41	3.00e-77	282.00
IUUC-Mlu-067918	Myotis lucifugus	44.52	6.00e-73	267.00
IUUC-Nfi-068389	Neosartorya fischeri	32.65	8.00e-62	231.00
IUUC-Ncr-068742	Neurospora crassa	32.66	5.00e-47	182.00
IUUC-Nle-069139	Nomascus leucogenys	44.41	1.00e-77	283.00
IUUC-Opr-070898	Ochotona princeps	47.45	8.00e-49	187.00
IUUC-Ont-071991	Oreochromis niloticus	43.93	6.00e-78	284.00
IUUC-Ocu-074065	Oryctolagus cuniculus	44.11	9.00e-77	280.00
IUUC-Oba-075221	Oryza barthii	59.92	2.00e-156	545.00
IUUC-Obr-076914	Oryza brachyantha	69.52	1.00e-140	492.00
IUUC-Ogu-078124	Oryza glumaepatula	59.92	2.00e-156	544.00
IUUC-Oin-080013	Oryza indica	63.96	4.00e-148	517.00
IUUC-Olo-080247	Oryza longistaminata	62.73	9.00e-140	489.00
IUUC-Ome-081769	Oryza meridionalis	60.31	2.00e-159	554.00
IUUC-Oni-082946	Oryza nivara	59.92	2.00e-156	545.00
IUUC-Opu-083268	Oryza punctata	52.17	2.00e-120	425.00
IUUC-Oru-085114	Oryza rufipogon	59.92	2.00e-156	544.00
IUUC-Osa-085829	Oryza sativa	59.72	3.00e-156	544.00
IUUC-Ola-087449	Oryzias latipes	44.05	3.00e-76	278.00
IUUC-Olu-087894	Ostreococcus lucimarinus	52.92	3.00e-95	340.00
IUUC-Oga-089036	Otolemur garnettii	44.41	1.00e-77	283.00
IUUC-Oar-089715	Ovis aries	44.41	1.00e-77	283.00
IUUC-Ptr-091000	Pan troglodytes	44.41	2.00e-77	282.00
IUUC-Pan-092187	Papio anubis	44.41	7.00e-78	284.00
IUUC-Psi-093377	Pelodiscus sinensis	44.52	9.00e-72	263.00
IUUC-Pno-094883	Phaeosphaeria nodorum	33.24	1.00e-58	220.00
IUUC-Ppa-095684	Physcomitrella patens	70.64	2.00e-124	438.00
IUUC-Pfo-096861	Poecilia formosa	43.50	2.00e-74	273.00
IUUC-Pab-098030	Pongo abelii	44.41	1.00e-77	283.00
IUUC-Pop-099245	Populus trichocarpa	63.20	0.00e+00	662.00
IUUC-Pca-100191	Procavia capensis	43.20	5.00e-73	268.00
IUUC-Ppe-101829	Prunus persica	64.53	0.00e+00	637.00
IUUC-Pva-102689	Pteropus vampyrus	44.11	3.00e-77	282.00
IUUC-Pte-104372	Pyrenophora teres	34.17	5.00e-64	238.00
IUUC-Pyt-104456	Pyrenophora triticirepentis	33.67	1.00e-61	230.00
IUUC-Rno-105723	Rattus norvegicus	44.41	2.00e-77	283.00
IUUC-Sha-107300	Sarcophilus harrisii	44.83	1.00e-60	226.00
IUUC-Spo-108308	Schizosaccharomyces pombe	30.50	3.00e-49	189.00
IUUC-Smo-109123	Selaginella moellendorffii	61.11	8.00e-133	466.00
IUUC-Sit-110276	Setaria italica	70.02	7.00e-159	553.00
IUUC-Sly-111819	Solanum lycopersicum	62.83	3.00e-162	564.00
IUUC-Stu-112048	Solanum tuberosum	73.48	2.00e-171	594.00
IUUC-Sbi-114027	Sorghum bicolor	70.27	3.00e-170	590.00
IUUC-Ssc-116323	Sus scrofa	44.11	2.00e-76	279.00
IUUC-Tru-118045	Takifugu rubripes	43.81	2.00e-79	289.00
IUUC-Tni-120106	Tetraodon nigroviridis	46.00	3.00e-55	208.00
IUUC-Tca-121462	Theobroma cacao	78.88	0.00e+00	643.00
IUUC-Tre-122204	Trichoderma reesei	46.15	4.00e-34	139.00
IUUC-Tvi-122550	Trichoderma virens	45.45	3.00e-34	139.00
IUUC-Tae-125239	Triticum aestivum	59.52	2.00e-155	541.00
IUUC-Tur-126538	Triticum urartu	53.39	5.00e-113	401.00
IUUC-Tbe-127385	Tupaia belangeri	39.27	3.00e-66	245.00
IUUC-Ttr-128795	Tursiops truncatus	44.41	1.00e-77	283.00
IUUC-Vda-129968	Verticillium dahliae	31.85	7.00e-54	204.00
IUUC-Vvi-130944	Vitis vinifera	71.22	0.00e+00	634.00
IUUC-Xtr-131884	Xenopus tropicalis	43.03	6.00e-76	278.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence