iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108097

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable E3 ubiquitin protein ligase C167.07c; HECT-type E3 ubiquitin transferase C167.07c

Genbank Nucleotide ID

CU329670

Gene Name

hul5; SPAC167.07c; SPAC57A7.03c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC167.07c	SPAC167.07c.1	SPAC167.07c.1:pep

Annotation

mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-99	331.5	696	1028

Active Site

Position(s)	Description	Evidence
997	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 5    lkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           lk  ++++fv+     Eeg+d gG+t+efl+ ++k +++ ++glf  se++ + l+pn +++ ++ e+l+++eflG+l+gk++++g  +d
   Q: 696  LKGPIRITFVDehgvvEEGIDGGGLTKEFLTSICKTVFDINYGLF--SETKAHLLYPNTHAYAQDVERLRCYEFLGMLIGKCIYEGIQID 783
           67788999*999999999***************************..77889999*********************************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           + ++++f  + lg++  ++dl ++dp+ly+ l ++k++ + d+e+  ++l+f+v +e++g +++ +L+p+G+ni+VtneN+ +Y++lv +
   Q: 784  AAFASFFVAKWLGHPSYFDDLTSLDPNLYEGLVFLKNY-DGDVEND-MALNFTVVHEEFGVRNVIDLIPNGSNISVTNENRLQYIHLVSN 871
           ***************999******************99.6788885.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y l+ +  +q+ af +Gf+++i++++l++F+e+e+++l+ G+   id++dl+++t y ggy+++sp+i  Fwevl+ef++e+++ f++Fv
   Q: 872  YYLNARLSRQCRAFTNGFTQIIDPHWLAMFHESEIQILVGGDpVPIDIDDLRRHTVYAGGYEPNSPTIVLFWEVLREFEEEDKRSFVKFV 961
           ******************************************999********************************************* PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           T+  r P+ Gf++l+p+ f+ir +++d +rlP+++TC+n+LkLP Ys+k++l++kLl+A++++ gF++
   Q: 962  TSVARPPILGFKALMPS-FCIRVNGEDeTRLPTASTCVNLLKLPMYSTKQTLRDKLLTAVRSGVGFGF 1028
           ***************88.*****77777**************************************97 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MPLSFEGTFK AKRNVNLGGK RVSNDRAQLL RKAAMERKNR EEERKAENNS VAVQSLSRGF 60
LARRKFKQDF RERWIYKYTK SGRTSIRFNT LEDIKCSISL LVLFAEPDID LPFVSQVAHN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTGTTTA CCTAATCATC TCGAAAGTTC TTAAAACGCT ATAATTTACT AAACGGTTAG 60
ATTTTAAACT TTTAATAATT CTATTTTCTC TAAGTCTTTC ATAAAATCTT TGCCTTATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

spo:SPAC167.07c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	35.87	1.00e-83	303.00
IUUC-Aml-001355	Ailuropoda melanoleuca	44.36	5.00e-94	337.00
IUUC-Atr-003017	Amborella trichopoda	37.66	1.00e-95	342.00
IUUC-Apl-003731	Anas platyrhynchos	44.69	1.00e-97	348.00
IUUC-Aca-005248	Anolis carolinensis	44.44	3.00e-97	347.00
IUUC-Aly-005768	Arabidopsis lyrata	36.56	4.00e-99	354.00
IUUC-Ath-006576	Arabidopsis thaliana	36.20	2.00e-98	351.00
IUUC-Ago-007748	Ashbya gossypii	35.93	7.00e-74	270.00
IUUC-Acl-008158	Aspergillus clavatus	38.22	7.00e-93	333.00
IUUC-Afl-008398	Aspergillus flavus	43.43	4.00e-93	334.00
IUUC-Afu-008937	Aspergillus fumigatus	38.64	8.00e-94	337.00
IUUC-Ani-009252	Aspergillus nidulans	44.04	7.00e-102	363.00
IUUC-Ang-009773	Aspergillus niger	38.26	1.00e-92	333.00
IUUC-Aor-009940	Aspergillus oryzae	43.43	4.00e-93	334.00
IUUC-Ate-010395	Aspergillus terreus	42.98	2.00e-91	328.00
IUUC-Ame-010769	Astyanax mexicanus	40.21	2.00e-71	261.00
IUUC-Bgr-012269	Blumeria graminis	41.36	2.00e-83	300.00
IUUC-Bta-012841	Bos taurus	44.36	9.00e-95	339.00
IUUC-Bci-013743	Botrytis cinerea	37.97	7.00e-100	357.00
IUUC-Bdi-014123	Brachypodium distachyon	36.20	2.00e-97	348.00
IUUC-Bol-015390	Brassica oleracea	36.90	2.00e-95	342.00
IUUC-Bra-016853	Brassica rapa	37.41	2.00e-100	358.00
IUUC-Cel-018447	Caenorhabditis elegans	31.94	6.00e-75	274.00
IUUC-Cja-019743	Callithrix jacchus	43.81	4.00e-93	334.00
IUUC-Cfa-021031	Canis familiaris	44.12	3.00e-94	338.00
IUUC-Cpo-022401	Cavia porcellus	43.20	4.00e-94	337.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	37.34	6.00e-75	272.00
IUUC-Csa-024107	Chlorocebus sabaeus	43.63	4.00e-93	334.00
IUUC-Cho-024750	Choloepus hoffmanni	46.59	3.00e-88	318.00
IUUC-Cin-025750	Ciona intestinalis	33.51	2.00e-76	278.00
IUUC-Csv-026016	Ciona savignyi	33.62	2.00e-79	288.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	33.81	3.00e-103	368.00
IUUC-Cne-026841	Cryptococcus neoformans	38.30	8.00e-111	393.00
IUUC-Cme-027265	Cyanidioschyzon merolae	41.09	5.00e-86	310.00
IUUC-Dre-028196	Danio rerio	45.59	7.00e-98	350.00
IUUC-Dno-029024	Dasypus novemcinctus	44.36	3.00e-95	341.00
IUUC-Dor-030938	Dipodomys ordii	40.56	8.00e-81	293.00
IUUC-Dse-031416	Dothistroma septosporum	33.98	4.00e-103	367.00
IUUC-Dme-031946	Drosophila melanogaster	42.08	9.00e-89	320.00
IUUC-Ete-033041	Echinops telfairi	36.54	1.00e-52	199.00
IUUC-Eca-033828	Equus caballus	44.36	5.00e-95	340.00
IUUC-Eeu-035201	Erinaceus europaeus	37.79	3.00e-57	215.00
IUUC-Fca-035907	Felis catus	44.12	2.00e-94	338.00
IUUC-Fal-037389	Ficedula albicollis	44.69	3.00e-97	348.00
IUUC-Fox-037788	Fusarium oxysporum	38.67	2.00e-104	371.00
IUUC-Fso-038088	Fusarium solani	38.52	3.00e-98	351.00
IUUC-Gmo-039412	Gadus morhua	34.10	4.00e-82	297.00
IUUC-Ggr-039941	Gaeumannomyces graminis	36.71	2.00e-97	348.00
IUUC-Gga-040310	Gallus gallus	44.93	2.00e-97	348.00
IUUC-Gac-042088	Gasterosteus aculeatus	34.01	2.00e-82	299.00
IUUC-Gma-042786	Glycine max	36.48	2.00e-88	318.00
IUUC-Ggo-045031	Gorilla gorilla	43.87	1.00e-93	336.00
IUUC-Hsa-045880	Homo sapiens	43.87	1.00e-93	336.00
IUUC-Hvu-047770	Hordeum vulgare	36.56	1.00e-100	358.00
IUUC-Itr-048372	Ictidomys tridecemlineatus	40.31	2.00e-80	291.00
IUUC-Kpa-049307	Komagataella pastoris	32.99	2.00e-67	249.00
IUUC-Lch-050664	Latimeria chalumnae	34.16	2.00e-82	298.00
IUUC-Lpe-051428	Leersia perrieri	34.01	1.00e-90	325.00
IUUC-Loc-052218	Lepisosteus oculatus	43.87	3.00e-95	341.00
IUUC-Lma-053096	Leptosphaeria maculans	41.81	8.00e-91	327.00
IUUC-Laf-053902	Loxodonta africana	33.73	1.00e-83	303.00
IUUC-Mcc-055127	Macaca mulatta	43.87	1.00e-93	336.00
IUUC-Meu-056527	Macropus eugenii	39.42	1.00e-62	233.00
IUUC-Mor-057021	Magnaporthe oryzae	36.02	1.00e-89	323.00
IUUC-Mpo-057570	Magnaporthe poae	42.17	3.00e-94	338.00
IUUC-Mtr-058154	Medicago truncatula	37.39	2.00e-94	338.00
IUUC-Mla-059124	Melampsora laricipopulina	50.00	2.00e-112	397.00
IUUC-Mga-059581	Meleagris gallopavo	44.69	2.00e-97	348.00
IUUC-Mvi-060445	Microbotryum violaceum	43.92	3.00e-131	461.00
IUUC-Mmr-061360	Microcebus murinus	44.12	6.00e-94	337.00
IUUC-Mdo-062194	Monodelphis domestica	44.36	9.00e-96	343.00
IUUC-Mmu-064189	Mus musculus	43.87	5.00e-93	334.00
IUUC-Mac-065275	Musa acuminata	36.99	3.00e-99	354.00
IUUC-Mpu-066439	Mustela putorius furo	44.36	4.00e-95	340.00
IUUC-Mlu-068228	Myotis lucifugus	44.36	4.00e-95	341.00
IUUC-Nfi-068280	Neosartorya fischeri	43.19	1.00e-92	333.00
IUUC-Ncr-068869	Neurospora crassa	38.87	2.00e-100	358.00
IUUC-Nle-069687	Nomascus leucogenys	41.81	1.00e-92	332.00
IUUC-Opr-070554	Ochotona princeps	33.33	6.00e-83	300.00
IUUC-Ont-071836	Oreochromis niloticus	44.85	4.00e-96	344.00
IUUC-Oan-072800	Ornithorhynchus anatinus	44.85	4.00e-97	347.00
IUUC-Ocu-074587	Oryctolagus cuniculus	44.61	8.00e-95	340.00
IUUC-Oba-075006	Oryza barthii	36.67	1.00e-97	349.00
IUUC-Obr-076133	Oryza brachyantha	36.80	6.00e-100	357.00
IUUC-Ogl-077003	Oryza glaberrima	36.67	6.00e-98	350.00
IUUC-Ogu-078947	Oryza glumaepatula	36.49	5.00e-98	350.00
IUUC-Oin-080058	Oryza indica	41.83	3.00e-85	308.00
IUUC-Olo-080475	Oryza longistaminata	36.67	3.00e-98	351.00
IUUC-Ome-081342	Oryza meridionalis	34.72	2.00e-87	315.00
IUUC-Oni-082385	Oryza nivara	36.49	5.00e-98	350.00
IUUC-Opu-083176	Oryza punctata	36.00	6.00e-97	347.00
IUUC-Oru-084554	Oryza rufipogon	34.90	1.00e-87	315.00
IUUC-Osa-085355	Oryza sativa	36.67	3.00e-98	351.00
IUUC-Ola-087209	Oryzias latipes	45.34	9.00e-98	349.00
IUUC-Olu-087699	Ostreococcus lucimarinus	42.23	3.00e-80	290.00
IUUC-Oga-088776	Otolemur garnettii	44.12	9.00e-94	336.00
IUUC-Oar-089441	Ovis aries	44.36	1.00e-94	339.00
IUUC-Ptr-091273	Pan troglodytes	43.87	1.00e-93	336.00
IUUC-Pan-091981	Papio anubis	43.87	1.00e-93	336.00
IUUC-Psi-093251	Pelodiscus sinensis	33.79	1.00e-72	266.00
IUUC-Pma-094738	Petromyzon marinus	43.90	7.00e-94	337.00
IUUC-Pno-095132	Phaeosphaeria nodorum	30.61	3.00e-73	268.00
IUUC-Ppa-095682	Physcomitrella patens	36.96	5.00e-105	373.00
IUUC-Pfo-097511	Poecilia formosa	43.84	5.00e-98	350.00
IUUC-Pab-098570	Pongo abelii	34.07	2.00e-83	302.00
IUUC-Pop-098928	Populus trichocarpa	37.28	1.00e-89	322.00
IUUC-Pca-100987	Procavia capensis	44.95	7.00e-92	330.00
IUUC-Ppe-102040	Prunus persica	35.56	5.00e-89	320.00
IUUC-Pva-103034	Pteropus vampyrus	41.18	9.00e-83	300.00
IUUC-Pgr-103513	Puccinia graminis	42.50	2.00e-121	428.00
IUUC-Ptt-103967	Puccinia triticina	39.76	7.00e-107	379.00
IUUC-Pte-104105	Pyrenophora teres	35.24	8.00e-99	353.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	34.65	2.00e-95	342.00
IUUC-Rno-106028	Rattus norvegicus	31.80	2.00e-67	248.00
IUUC-Sce-106446	Saccharomyces cerevisiae	43.00	2.00e-77	281.00
IUUC-Sha-107108	Sarcophilus harrisii	42.05	2.00e-85	308.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	60.19	0.00e+00	793.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	38.89	2.00e-103	368.00
IUUC-Smo-108853	Selaginella moellendorffii	36.78	1.00e-98	352.00
IUUC-Sit-110457	Setaria italica	36.33	5.00e-91	327.00
IUUC-Sly-111362	Solanum lycopersicum	37.10	6.00e-91	327.00
IUUC-Sbi-113882	Sorghum bicolor	35.71	7.00e-88	317.00
IUUC-Sre-115038	Sporisorium reilianum	49.75	1.00e-110	392.00
IUUC-Ssc-116103	Sus scrofa	34.07	3.00e-83	301.00
IUUC-Tgu-116729	Taeniopygia guttata	45.10	6.00e-98	350.00
IUUC-Tru-118068	Takifugu rubripes	44.85	2.00e-95	341.00
IUUC-Tsy-118942	Tarsius syrichta	47.27	8.00e-69	253.00
IUUC-Tni-120732	Tetraodon nigroviridis	43.63	5.00e-90	323.00
IUUC-Tca-121737	Theobroma cacao	37.74	5.00e-100	357.00
IUUC-Tre-121892	Trichoderma reesei	31.24	5.00e-101	360.00
IUUC-Tvi-122354	Trichoderma virens	31.12	3.00e-97	348.00
IUUC-Tae-125229	Triticum aestivum	36.56	4.00e-101	361.00
IUUC-Tur-126086	Triticum urartu	35.87	1.00e-83	303.00
IUUC-Tme-127102	Tuber melanosporum	34.70	1.00e-114	405.00
IUUC-Tbe-127351	Tupaia belangeri	42.90	3.00e-77	281.00
IUUC-Ttr-129061	Tursiops truncatus	44.95	1.00e-91	329.00
IUUC-Uma-129343	Ustilago maydis	50.50	1.00e-114	406.00
IUUC-Vda-129748	Verticillium dahliae	37.04	1.00e-91	329.00
IUUC-Vvi-131234	Vitis vinifera	37.39	2.00e-90	325.00
IUUC-Xtr-132094	Xenopus tropicalis	43.63	2.00e-93	335.00
IUUC-Xma-133923	Xiphophorus maculatus	43.84	5.00e-98	350.00
IUUC-Yli-134496	Yarrowia lipolytica	36.61	1.00e-94	338.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence