iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.80e-08	33.4	178	217

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg.plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C++Cled ++  p++++CgHvf++ C+++         +   CPlC
   Q: 178  CPVCLEDVREKlPVSTNCGHVFCKACIKRA------VDTGRVCPLC 217
           ********5555***************998......999999**** PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MGDSSDSDSS TEWEQNTRVI SLPFSRNRSH LSSRLSYLVG LQMENFRTSN NSGVSQRIHN 60
TGPTPVLAPS GLRSRLLSGS SERNPNEYYG DSDSSSSSRS IDRTPFLLEY SSDSESSSSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCAAGGAA ACGGGTTCAA CTGAATTTGT AAAAAGTTGT AAGTTCCAAG GCAGAATTCA 60
TTGGTAGTAT TAAAACTGCA AAAACAGGTG CGATTTCAAA TGGGTGATTC CAGCGACTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG15150

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cfa-020058	Canis familiaris	51.06	1.00e-06	50.40
IUUC-Cre-022730	Chlamydomonas reinhardtii	38.89	7.00e-05	40.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence