iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004630

UUCD1 version

UUC-AnC-00781

Ensembl Protein ID

ENSACAP00000013672.3

UniProt Accession

G1KPB9; G1KPB9_ANOCA

Protein Name

Nitric oxide synthase-interacting protein

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000013921.3	ENSACAT00000013953.3	ENSACAP00000013672.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.10e-15	55.3	40	89

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.........t 42
           v ++ +C +sl++ +dPvv+p+G+ y++++I +++ +++k         +
   Q: 40   VKDFDCCCLSLQPCKDPVVTPDGYLYEKEAILEYILHQKKeiarqmkayE 89
           567789*****************************999884444443333 PP

Organism

Anolis carolinensis

Functional Description
(View)

Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNVRLSKDAV KDFDCCCLSL QPCKDPVVTP 60
DGYLYEKEAI LEYILHQKKE IARQMKAYEK QKNEKKLEMA ELSKAAKESK VKNFLDKELS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACTTTAGG AGCCCGGCCC TTTTGTTCTC AGCTCTTTGT TTCCTTAGCA ACGGGGATTC 60
TGCAAAGGCT CAAGCCAGAC AGAGACAACA TCAGCGCGCT CCCGGAAGTT ATTCACTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination

KEGG

acs:100561056

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	48.84	5.00e-17	82.40
IUUC-Aml-002069	Ailuropoda melanoleuca	71.75	1.00e-132	465.00
IUUC-Atr-002661	Amborella trichopoda	34.95	4.00e-31	128.00
IUUC-Aly-006316	Arabidopsis lyrata	32.11	4.00e-30	124.00
IUUC-Ath-007000	Arabidopsis thaliana	31.53	4.00e-29	121.00
IUUC-Acl-008175	Aspergillus clavatus	33.04	2.00e-06	46.60
IUUC-Afl-008440	Aspergillus flavus	33.62	1.00e-06	47.00
IUUC-Afu-009012	Aspergillus fumigatus	33.62	4.00e-07	48.90
IUUC-Ani-009153	Aspergillus nidulans	33.06	6.00e-03	35.00
IUUC-Ang-009556	Aspergillus niger	32.74	1.00e-06	47.00
IUUC-Aor-009892	Aspergillus oryzae	33.62	1.00e-06	47.00
IUUC-Ate-010473	Aspergillus terreus	31.09	4.00e-07	50.10
IUUC-Ame-011874	Astyanax mexicanus	65.16	6.00e-108	383.00
IUUC-Bgr-012090	Blumeria graminis	25.52	1.00e-04	40.40
IUUC-Bta-012956	Bos taurus	75.17	4.00e-136	477.00
IUUC-Bci-013897	Botrytis cinerea	40.00	9.00e-10	57.80
IUUC-Bdi-014968	Brachypodium distachyon	35.17	1.00e-35	143.00
IUUC-Bol-015578	Brassica oleracea	32.44	3.00e-34	138.00
IUUC-Bra-017234	Brassica rapa	32.44	3.00e-34	138.00
IUUC-Cel-018637	Caenorhabditis elegans	42.37	7.00e-55	207.00
IUUC-Cja-019632	Callithrix jacchus	75.42	1.00e-136	478.00
IUUC-Cfa-020192	Canis familiaris	74.09	3.00e-135	474.00
IUUC-Cpo-021939	Cavia porcellus	72.82	5.00e-130	456.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	37.24	5.00e-43	167.00
IUUC-Csa-023802	Chlorocebus sabaeus	76.41	3.00e-137	481.00
IUUC-Cho-024637	Choloepus hoffmanni	52.07	3.00e-51	194.00
IUUC-Cin-025180	Ciona intestinalis	56.67	8.00e-89	319.00
IUUC-Csv-026206	Ciona savignyi	48.65	2.00e-44	171.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	32.00	6.00e-12	64.70
IUUC-Cne-026827	Cryptococcus neoformans	28.15	2.00e-09	56.20
IUUC-Dre-028092	Danio rerio	66.12	4.00e-114	404.00
IUUC-Dno-029501	Dasypus novemcinctus	69.87	3.00e-116	411.00
IUUC-Dor-030542	Dipodomys ordii	71.62	8.00e-132	462.00
IUUC-Dse-031188	Dothistroma septosporum	21.35	6.00e-10	58.20
IUUC-Dme-031734	Drosophila melanogaster	46.15	2.00e-80	291.00
IUUC-Eca-033577	Equus caballus	76.08	5.00e-137	479.00
IUUC-Fca-035761	Felis catus	75.75	6.00e-137	479.00
IUUC-Fox-037703	Fusarium oxysporum	25.21	2.00e-12	66.60
IUUC-Fso-038208	Fusarium solani	24.79	2.00e-12	66.20
IUUC-Gmo-038523	Gadus morhua	60.42	1.00e-60	225.00
IUUC-Ggr-040087	Gaeumannomyces graminis	32.84	1.00e-09	57.40
IUUC-Gac-042621	Gasterosteus aculeatus	61.95	5.00e-109	387.00
IUUC-Gma-042698	Glycine max	33.68	2.00e-33	135.00
IUUC-Ggo-045357	Gorilla gorilla	76.08	1.00e-136	478.00
IUUC-Hsa-046195	Homo sapiens	76.08	1.00e-136	478.00
IUUC-Hvu-047174	Hordeum vulgare	34.83	3.00e-36	145.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	74.09	9.00e-134	469.00
IUUC-Lch-050569	Latimeria chalumnae	74.35	1.00e-119	422.00
IUUC-Lpe-050992	Leersia perrieri	39.70	2.00e-24	106.00
IUUC-Loc-052522	Lepisosteus oculatus	72.54	3.00e-117	414.00
IUUC-Lma-053254	Leptosphaeria maculans	37.35	4.00e-10	58.90
IUUC-Laf-053397	Loxodonta africana	75.58	5.00e-136	476.00
IUUC-Mcc-054681	Macaca mulatta	75.75	9.00e-137	479.00
IUUC-Meu-056723	Macropus eugenii	74.58	4.00e-132	463.00
IUUC-Mor-056961	Magnaporthe oryzae	35.14	2.00e-10	60.10
IUUC-Mpo-057359	Magnaporthe poae	25.82	3.00e-08	52.00
IUUC-Mtr-058063	Medicago truncatula	33.91	1.00e-34	139.00
IUUC-Mla-059004	Melampsora laricipopulina	29.94	1.00e-26	113.00
IUUC-Mvi-060460	Microbotryum violaceum	29.97	6.00e-28	117.00
IUUC-Mmr-060847	Microcebus murinus	75.42	4.00e-136	476.00
IUUC-Mdo-062480	Monodelphis domestica	74.09	4.00e-132	463.00
IUUC-Mmu-063809	Mus musculus	72.76	5.00e-131	459.00
IUUC-Mac-064870	Musa acuminata	32.99	1.00e-34	140.00
IUUC-Mpu-066322	Mustela putorius furo	75.25	2.00e-136	478.00
IUUC-Mlu-067556	Myotis lucifugus	72.04	1.00e-130	458.00
IUUC-Nfi-068440	Neosartorya fischeri	33.62	5.00e-07	48.50
IUUC-Ncr-068898	Neurospora crassa	37.18	2.00e-07	49.70
IUUC-Nle-070049	Nomascus leucogenys	76.08	7.00e-137	479.00
IUUC-Opr-070972	Ochotona princeps	71.05	4.00e-128	450.00
IUUC-Ont-071682	Oreochromis niloticus	66.56	6.00e-114	403.00
IUUC-Oan-073296	Ornithorhynchus anatinus	96.61	2.00e-31	127.00
IUUC-Ocu-074218	Oryctolagus cuniculus	71.43	9.00e-113	399.00
IUUC-Oba-075284	Oryza barthii	34.14	1.00e-33	136.00
IUUC-Obr-076651	Oryza brachyantha	33.91	5.00e-36	144.00
IUUC-Ogl-077899	Oryza glaberrima	34.14	1.00e-33	136.00
IUUC-Ogu-078477	Oryza glumaepatula	34.26	1.00e-33	136.00
IUUC-Oin-080011	Oryza indica	33.91	2.00e-33	135.00
IUUC-Olo-080545	Oryza longistaminata	34.65	1.00e-27	117.00
IUUC-Ome-081543	Oryza meridionalis	33.91	2.00e-33	135.00
IUUC-Oni-082955	Oryza nivara	33.91	2.00e-33	135.00
IUUC-Opu-083565	Oryza punctata	33.91	8.00e-34	137.00
IUUC-Oru-084474	Oryza rufipogon	33.91	2.00e-33	135.00
IUUC-Osa-085913	Oryza sativa	33.91	2.00e-33	135.00
IUUC-Ola-086851	Oryzias latipes	67.56	3.00e-118	417.00
IUUC-Olu-087724	Ostreococcus lucimarinus	32.04	3.00e-11	62.40
IUUC-Oga-087970	Otolemur garnettii	75.50	3.00e-134	470.00
IUUC-Oar-089756	Ovis aries	72.85	1.00e-128	451.00
IUUC-Ptr-091485	Pan troglodytes	74.75	9.00e-133	465.00
IUUC-Pan-091832	Papio anubis	76.08	4.00e-137	480.00
IUUC-Pma-094551	Petromyzon marinus	66.45	1.00e-110	392.00
IUUC-Pno-094830	Phaeosphaeria nodorum	27.16	6.00e-07	48.10
IUUC-Ppa-095255	Physcomitrella patens	33.22	5.00e-30	124.00
IUUC-Pfo-096373	Poecilia formosa	67.65	7.00e-120	422.00
IUUC-Pab-098247	Pongo abelii	76.08	1.00e-136	479.00
IUUC-Pop-099186	Populus trichocarpa	34.38	6.00e-33	134.00
IUUC-Pca-100677	Procavia capensis	71.96	4.00e-110	390.00
IUUC-Ppe-101403	Prunus persica	31.83	4.00e-31	128.00
IUUC-Pva-103000	Pteropus vampyrus	76.08	5.00e-137	479.00
IUUC-Pgr-103663	Puccinia graminis	30.34	2.00e-30	126.00
IUUC-Ptt-103712	Puccinia triticina	40.00	1.00e-09	56.20
IUUC-Pte-104287	Pyrenophora teres	25.98	2.00e-14	73.20
IUUC-Pyt-104579	Pyrenophora triticirepentis	24.91	6.00e-13	68.20
IUUC-Rno-106069	Rattus norvegicus	73.09	2.00e-131	461.00
IUUC-Sha-106553	Sarcophilus harrisii	75.42	8.00e-134	469.00
IUUC-Smo-108874	Selaginella moellendorffii	33.11	3.00e-38	151.00
IUUC-Sit-110307	Setaria italica	34.71	1.00e-33	136.00
IUUC-Sly-111094	Solanum lycopersicum	32.87	4.00e-34	138.00
IUUC-Stu-112363	Solanum tuberosum	33.22	6.00e-34	137.00
IUUC-Sar-113480	Sorex araneus	72.52	3.00e-128	450.00
IUUC-Sbi-113939	Sorghum bicolor	34.83	4.00e-34	138.00
IUUC-Ssc-115644	Sus scrofa	76.08	9.00e-138	482.00
IUUC-Tru-118781	Takifugu rubripes	66.99	3.00e-119	421.00
IUUC-Tni-119672	Tetraodon nigroviridis	79.52	4.00e-36	141.00
IUUC-Tca-121795	Theobroma cacao	34.03	6.00e-37	147.00
IUUC-Tre-122037	Trichoderma reesei	33.77	5.00e-08	51.60
IUUC-Tvi-122524	Trichoderma virens	23.59	3.00e-14	72.40
IUUC-Tae-122828	Triticum aestivum	35.17	2.00e-36	145.00
IUUC-Tur-126387	Triticum urartu	34.65	2.00e-29	123.00
IUUC-Tme-127111	Tuber melanosporum	37.50	2.00e-09	56.20
IUUC-Ttr-128227	Tursiops truncatus	75.08	8.00e-135	472.00
IUUC-Vda-129924	Verticillium dahliae	24.71	1.00e-16	80.50
IUUC-Vpa-130802	Vicugna pacos	80.90	4.00e-39	154.00
IUUC-Vvi-131105	Vitis vinifera	34.03	7.00e-34	137.00
IUUC-Xtr-132830	Xenopus tropicalis	73.04	3.00e-132	464.00
IUUC-Xma-133618	Xiphophorus maculatus	67.11	1.00e-112	398.00
IUUC-Zma-135389	Zea mays	34.48	3.00e-33	135.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence