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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046980
UUCD1 version UUC-HoS-00366
Ensembl Protein ID ENSP00000251547.5
UniProt Accession Q9H4M3; B3KNZ2; B7Z743; Q5TGX2; Q5TGX4; Q5TGX5; Q68DJ9; Q8WWY2; FBX44_HUMAN
Genbank Protein ID AAG09623.1; AAK77940.1; BAH13479.1; BAG51504.1; CAH18221.1; CAI20210.1; CAI20211.1; CAI20212.1; CAI20213.1; EAW71690.1; EAW71691.1; AAH07832.1
Protein Name F-box only protein 44; F-box protein FBX30; F-box/G-domain protein 3
Genbank Nucleotide ID AY007380; AY040878; AK301418; AK055344; CR749368; AL031731; AL031731; AL031731; AL031731; CH471130; CH471130; BC007832
Gene Name FBXO44; FBG3; FBX30; FBX44; FBX6A; FBXO6A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000132879.13 ENST00000251546.8 ENSP00000251546.4
ENSG00000132879.13 ENST00000376768.5 ENSP00000365959.1
ENSG00000132879.13 ENST00000251547.9 ENSP00000251547.5
ENSG00000132879.13 ENST00000475435.5 ENSP00000473420.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWAS CentralOMIM
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 20057081; 20682791; 14701835
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.0046 18.7 5 49
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 102  lldrlpeeilveilklldkee.llraarvcrrwqelasqkalwkt 145
           ++++lpe+il+e ++++++++ ll++++vc  w+ l++  +lwk+
   Q: 5    NINELPENILLELFTHVPARQlLLNCRLVCSLWRDLIDLVTLWKR 49
           6789*************999989***********99998999986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
 Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
Protein Sequence
(Fasta)
MAVGNINELP ENILLELFTH VPARQLLLNC RLVCSLWRDL IDLVTLWKRK CLREGFITED 60
WDQPVADWKI FYFLRSLHRN LLHNPCAEEG FEFWSLDVNG GDEWKVEDLS RDQRKEFPND 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046980|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGCTGCGG GCTGCGCGAG TCCCGGGGCG GCGAGTCCCG GCGCTGTCCG CGTCTGTGTC 60
GGTCCCGGCG ACCGCGCCTC TTAAAGGCCC CCGACCCGAC CCGCCCCGCC CCGCCTCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046980|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like
PROSITE

PS51114--FBA
PS50181--FBOX
Pfam

PF12937--F-box-like
PF04300--FBA
SMART

SM01198--FBA
SM00256--FBOX
Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
KEGG hsa:93611
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Afl-008683 Aspergillus flavus 29.23 2.10e-02 33.90
IUUC-Aor-009983 Aspergillus oryzae 29.23 1.70e-02 34.30
IUUC-Bta-013435 Bos taurus 98.04 2.00e-141 494.00
IUUC-Cpo-022098 Cavia porcellus 94.51 3.00e-145 507.00
IUUC-Cre-022851 Chlamydomonas reinhardtii 33.33 4.00e-01 29.60
IUUC-Dre-027973 Danio rerio 45.78 1.00e-64 239.00
IUUC-Dno-029141 Dasypus novemcinctus 95.72 9.00e-106 375.00
IUUC-Fca-035783 Felis catus 98.82 6.00e-142 496.00
IUUC-Ggo-044871 Gorilla gorilla 100.00 4.00e-144 503.00
IUUC-Itr-048981 Ictidomys tridecemlineatus 97.65 3.00e-141 493.00
IUUC-Laf-054093 Loxodonta africana 96.86 2.00e-139 488.00
IUUC-Mdo-062841 Monodelphis domestica 83.12 3.00e-118 417.00
IUUC-Mmu-063279 Mus musculus 96.47 4.00e-138 483.00
IUUC-Mpu-066829 Mustela putorius furo 98.82 2.00e-142 498.00
IUUC-Mlu-067889 Myotis lucifugus 98.02 7.00e-140 489.00
IUUC-Oan-073142 Ornithorhynchus anatinus 82.13 8.00e-117 412.00
IUUC-Oga-089060 Otolemur garnettii 96.46 1.00e-147 514.00
IUUC-Oar-090113 Ovis aries 98.43 3.00e-142 497.00
IUUC-Ptr-090986 Pan troglodytes 99.61 4.00e-143 500.00
IUUC-Pma-094635 Petromyzon marinus 42.68 2.00e-31 128.00
IUUC-Ppe-101983 Prunus persica 32.35 7.20e-02 31.20
IUUC-Pgr-103356 Puccinia graminis 26.25 1.20e-01 30.80
IUUC-Rno-105253 Rattus norvegicus 96.08 9.00e-139 485.00
IUUC-Sce-106428 Saccharomyces cerevisiae 25.23 5.00e-03 38.10
IUUC-Sha-107296 Sarcophilus harrisii 82.21 4.00e-125 440.00
IUUC-Sit-109886 Setaria italica 27.85 1.10e-01 31.20
IUUC-Ssc-115419 Sus scrofa 98.82 6.00e-142 496.00
Created Date 25-Jun-2017

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