iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072087

Ensembl Protein ID

ENSONIP00000024350.1

UniProt Accession

I3KTA4; I3KTA4_ORENI

Genbank Protein ID

ENSONIP00000024350

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01011547

Gene Name

ube3a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000019346.1	ENSONIT00000024371.1	ENSONIP00000024350.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.20e-106	354.6	506	832

Active Site

Position(s)	Description	Evidence
801	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +sdlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+++ k  ++ n++s     e +  ++++G++lg+a++++ +ld+
   Q: 506  PSDLKKQLYVEFEGEQGVDEGGVSKEFFQLVLEEIFNPDIGMFTYDNDTKLFWF-NSSSL----ETEAQYTLIGIVLGLAIYNNCILDV 589
           799****************************************99998888877.55554....6899********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slk ++e+   ++ee  + +tf+  +++++g+   ++Lk++G++ipVt+eN++e+v+l++
   Q: 590  HFPMVVYRKLMGKKGTYLDLSDSHPVLYQSLKGVLEYM-GNVEED-MMMTFQiSHTDLFGNPVIYDLKEQGDQIPVTKENRQEFVDLYA 676
           *************************************4.567664.8888884456679****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++af++Gf  v +++ l  lF++ee+ellicG++++d+e+l+k+t+y+ggy++ds+ i+ Fwev+++f +e+++ fLq
   Q: 677  DYILNKSVERQFKAFKKGFLMVTNESpLKYLFRPEEVELLICGSRKLDFEALEKTTEYDGGYSKDSQIIKDFWEVVHSFGEEQKRLFLQ 765
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++sd drlP+s+TCfn L LPeYsske+l+e+Ll Ai+++kgF++
   Q: 766  FTTGTDRAPVGGLGKLK---MIIAKNGSDtDRLPTSHTCFNALLLPEYSSKEKLRERLLKAITYAKGFGM 832
           *****************...8899978777**************************************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MNRATAKLLI ERYFRQLTEG CGNGNCTNEF CASCCDFQPL DNNSAAAKAL ELFKINAKLC 60
DYHPSITASA DGSTQEDSKM SDKDPGFTKE DFSEVHHLTE NTICTILSFC EEEGDYSALV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGCCTGCG CTGTCTGGAA GAAAGCAGGC GGAGAAGAAG AGCGTATATG GCGCCGTTGT 60
TTACAGGCTG TTAGAGGAAA TAAATTCGCT GTGACTCAAC AAACTAAAAT CATTTGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003144	Amborella trichopoda	44.39	2.00e-94	339.00
IUUC-Cin-025643	Ciona intestinalis	44.46	0.00e+00	689.00
IUUC-Cme-027151	Cyanidioschyzon merolae	42.79	3.00e-99	357.00
IUUC-Gmo-038840	Gadus morhua	69.01	0.00e+00	1177.00
IUUC-Gac-042293	Gasterosteus aculeatus	78.77	0.00e+00	1339.00
IUUC-Ola-086833	Oryzias latipes	82.75	0.00e+00	1336.00
IUUC-Pfo-096868	Poecilia formosa	82.80	0.00e+00	1360.00
IUUC-Smo-108858	Selaginella moellendorffii	49.07	1.00e-112	400.00
IUUC-Tru-117763	Takifugu rubripes	74.97	0.00e+00	1272.00
IUUC-Tni-120640	Tetraodon nigroviridis	72.54	0.00e+00	1173.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence