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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018173
Ensembl Protein ID F08G12.4
UniProt Accession Q19213; VHL_CAEEL
Genbank Protein ID CAA91456.1
Protein Name Von Hippel-Lindau tumor suppressor homolog
Genbank Nucleotide ID Z66561
Gene Name vhl-1; F08G12.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00006922 F08G12.4 F08G12.4
Annotation
mRNA Expression
GEO
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 23.33 7.00e-05 43.90 IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 31.87 2.00e-03 39.70 IUUC-Hsa-046547
E3 adaptor/Cullin RING/SCF/F-box 29.79 1.20e-01 30.80 IUUC-Sce-106336
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%) (PubMed:11595184). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size (PubMed:12686697, PubMed:19372390, PubMed:22396654). Mediates resistance to enteropathogenic E.coli (PubMed:16091039). Mediates susceptibility to B.thuringiensis pore-forming toxins (PubMed:20011506). Not involved in P.aeruginosa susceptibility (PubMed:20865124).
 Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%) (PubMed:11595184). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size (PubMed:12686697, PubMed:19372390, PubMed:22396654). Mediates resistance to enteropathogenic E.coli (PubMed:16091039). Mediates susceptibility to B.thuringiensis pore-forming toxins (PubMed:20011506). Not involved in P.aeruginosa susceptibility (PubMed:20865124).
Protein Sequence
(Fasta)
MSDGSMDDDG RLFPDLGSST HDNREIRVRF LNRCAYPVDV FWLNPSKQPT KYGTLAQKKY 60
LDIKTFKDHP WVARRSFDGC KVLVNEKEVF WPEPAPRMNL IVRNHCVITM KVQSLREIAG 120
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Protein Fasta Sequence


>IUUC-Cel-018173|E3,SOCS;E3,F-box|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAAGAAAAA TGTCAGACGG TTCGATGGAT GATGATGGAA GGTTATTTCC TGACTTGGGC 60
TCATCAACAC ATGACAATCG AGAGATACGT GTTCGTTTCC TAAACAGATG TGCTTACCCC 120
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Nucleotide Fasta Sequence


>IUUC-Cel-018173|E3,SOCS;E3,F-box|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR002714--VHL
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom
Pfam

PF01847--VHL
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination
GO:0001666--P:response to hypoxia
KEGG cel:CELE_F08G12.4
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002327 Ailuropoda melanoleuca 30.30 1.50e-01 28.10
IUUC-Aca-004492 Anolis carolinensis 27.47 1.70e-02 30.80
IUUC-Ame-011818 Astyanax mexicanus 34.44 9.00e-08 48.90
IUUC-Bta-013459 Bos taurus 31.82 5.00e-06 42.70
IUUC-Cja-019826 Callithrix jacchus 31.82 8.00e-06 42.40
IUUC-Cfa-021280 Canis familiaris 31.87 4.00e-05 40.00
IUUC-Cpo-022544 Cavia porcellus 31.82 1.00e-05 41.60
IUUC-Cre-022809 Chlamydomonas reinhardtii 30.77 4.40e-02 31.20
IUUC-Csa-023644 Chlorocebus sabaeus 31.48 1.00e-05 41.60
IUUC-Cin-025505 Ciona intestinalis 26.67 9.60e-02 28.10
IUUC-Cme-027232 Cyanidioschyzon merolae 29.85 1.90e-02 31.20
IUUC-Dre-028350 Danio rerio 29.41 5.00e-04 35.80
IUUC-Dme-031988 Drosophila melanogaster 25.74 5.00e-06 42.40
IUUC-Fca-036350 Felis catus 33.33 2.00e-04 38.10
IUUC-Fal-037192 Ficedula albicollis 30.65 1.00e-04 37.70
IUUC-Gmo-038921 Gadus morhua 27.66 5.00e-06 42.70
IUUC-Gga-041016 Gallus gallus 25.60 6.00e-03 32.30
IUUC-Gac-042560 Gasterosteus aculeatus 27.83 1.00e-05 41.60
IUUC-Ggo-045419 Gorilla gorilla 31.87 7.00e-05 39.30
IUUC-Hsa-046547 Homo sapiens 31.87 7.00e-05 39.30
IUUC-Itr-048225 Ictidomys tridecemlineatus 30.91 4.00e-05 39.30
IUUC-Lch-050463 Latimeria chalumnae 30.00 1.00e-04 38.50
IUUC-Loc-052053 Lepisosteus oculatus 25.19 3.00e-04 36.60
IUUC-Laf-053893 Loxodonta africana 31.87 1.00e-04 38.50
IUUC-Mdo-062031 Monodelphis domestica 32.14 3.00e-06 42.00
IUUC-Mmu-064366 Mus musculus 29.29 1.00e-04 37.70
IUUC-Mpu-066593 Mustela putorius furo 31.87 8.00e-05 39.30
IUUC-Mlu-066926 Myotis lucifugus 30.77 2.00e-04 37.70
IUUC-Nle-069724 Nomascus leucogenys 31.87 6.00e-05 39.30
IUUC-Opr-070679 Ochotona princeps 31.30 3.00e-04 37.00
IUUC-Ont-071332 Oreochromis niloticus 29.31 2.00e-08 50.40
IUUC-Ola-086869 Oryzias latipes 33.33 1.00e-07 48.50
IUUC-Oga-089124 Otolemur garnettii 32.94 6.00e-05 39.30
IUUC-Pan-092150 Papio anubis 31.87 4.00e-05 40.00
IUUC-Pma-094129 Petromyzon marinus 28.15 7.00e-08 48.90
IUUC-Pfo-096892 Poecilia formosa 29.79 3.00e-07 46.60
IUUC-Pab-097822 Pongo abelii 31.87 6.00e-05 39.30
IUUC-Pca-101058 Procavia capensis 30.37 1.00e-05 42.00
IUUC-Pva-102932 Pteropus vampyrus 31.87 6.00e-05 39.30
IUUC-Rno-105050 Rattus norvegicus 30.91 2.00e-05 40.40
IUUC-Sce-106336 Saccharomyces cerevisiae 29.79 4.50e-02 31.60
IUUC-Sha-106738 Sarcophilus harrisii 32.65 9.60e-02 26.90
IUUC-Ssc-115973 Sus scrofa 31.48 3.00e-05 40.40
IUUC-Tru-118654 Takifugu rubripes 30.17 6.00e-05 38.90
IUUC-Ttr-128418 Tursiops truncatus 31.87 3.00e-05 40.40
IUUC-Vpa-130268 Vicugna pacos 31.34 4.00e-03 33.10
IUUC-Xtr-132506 Xenopus tropicalis 29.29 1.00e-06 44.70
Created Date 25-Jun-2017

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