iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066495

Ensembl Protein ID

ENSMPUP00000004604.1

UniProt Accession

M3XZV3; M3XZV3_MUSPF

Genbank Protein ID

ENSMPUP00000004604

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AEYP01026839

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000004640.1	ENSMPUT00000004684.1	ENSMPUP00000004604.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.30e-26	92.6	1070	1123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1070 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1123
           58********************************.*****99999*******876 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MPVVSAISSR IIKTPRRFIE DEDYDPPIKI ARLESTPNSR FSATSCGSSE KSSAASQHSS 60
QMSSDSSRSS SPSVDTSTDS QASEEIQVLP EERSETPEVH TPLPIAQSPE NDSTERRSRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGAGCAGT TCTTAGGTTT TGGCTCAGAT GAAGAAGTCC GAGTACGAAG TCCCACAAGG 60
TCTCCTTCAG GTATGGCCAG TCAAGTGCAT GGTGCCTTTT GTTTGTTAAG AGACATGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	9.00e-13	68.90
IUUC-Aml-002274	Ailuropoda melanoleuca	97.79	0.00e+00	4294.00
IUUC-Atr-002455	Amborella trichopoda	48.10	9.00e-39	155.00
IUUC-Apl-003478	Anas platyrhynchos	79.11	0.00e+00	2665.00
IUUC-Aca-005086	Anolis carolinensis	68.78	0.00e+00	2018.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	4.00e-39	157.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	5.00e-37	149.00
IUUC-Bta-012974	Bos taurus	94.78	0.00e+00	4047.00
IUUC-Bol-016540	Brassica oleracea	48.05	1.00e-37	151.00
IUUC-Cja-019226	Callithrix jacchus	93.00	0.00e+00	4036.00
IUUC-Cfa-021049	Canis familiaris	96.92	0.00e+00	4209.00
IUUC-Cpo-021459	Cavia porcellus	93.35	0.00e+00	2776.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.00	3.00e-38	155.00
IUUC-Csa-023434	Chlorocebus sabaeus	95.43	0.00e+00	4049.00
IUUC-Cho-024652	Choloepus hoffmanni	93.01	0.00e+00	2568.00
IUUC-Cin-025724	Ciona intestinalis	54.46	2.00e-96	347.00
IUUC-Csv-026268	Ciona savignyi	36.77	1.00e-133	471.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	5.00e-12	67.00
IUUC-Dre-028180	Danio rerio	69.06	0.00e+00	1161.00
IUUC-Dno-029068	Dasypus novemcinctus	90.05	0.00e+00	3831.00
IUUC-Dor-030550	Dipodomys ordii	87.60	0.00e+00	3642.00
IUUC-Ete-032834	Echinops telfairi	84.78	0.00e+00	1420.00
IUUC-Eca-033615	Equus caballus	95.25	0.00e+00	3997.00
IUUC-Eeu-035136	Erinaceus europaeus	83.09	0.00e+00	1191.00
IUUC-Fca-036453	Felis catus	95.25	0.00e+00	1676.00
IUUC-Fal-037256	Ficedula albicollis	78.71	0.00e+00	3455.00
IUUC-Gmo-038641	Gadus morhua	68.24	0.00e+00	1098.00
IUUC-Gga-040828	Gallus gallus	79.77	0.00e+00	3413.00
IUUC-Gac-041452	Gasterosteus aculeatus	71.09	0.00e+00	1167.00
IUUC-Gma-043554	Glycine max	49.02	4.00e-38	153.00
IUUC-Ggo-045124	Gorilla gorilla	90.26	0.00e+00	3765.00
IUUC-Hsa-046143	Homo sapiens	95.55	0.00e+00	4048.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	92.18	0.00e+00	3945.00
IUUC-Lch-049704	Latimeria chalumnae	62.74	0.00e+00	2556.00
IUUC-Loc-052181	Lepisosteus oculatus	79.13	0.00e+00	1316.00
IUUC-Laf-053946	Loxodonta africana	94.22	0.00e+00	3882.00
IUUC-Mcc-055508	Macaca mulatta	95.44	0.00e+00	4052.00
IUUC-Meu-056485	Macropus eugenii	80.69	0.00e+00	1152.00
IUUC-Mtr-058327	Medicago truncatula	41.96	5.00e-39	156.00
IUUC-Mga-059943	Meleagris gallopavo	77.57	0.00e+00	3315.00
IUUC-Mmr-061178	Microcebus murinus	92.61	0.00e+00	3981.00
IUUC-Mdo-063031	Monodelphis domestica	87.23	0.00e+00	2600.00
IUUC-Mmu-063650	Mus musculus	89.40	0.00e+00	2768.00
IUUC-Mlu-068045	Myotis lucifugus	86.77	0.00e+00	3682.00
IUUC-Nle-069064	Nomascus leucogenys	95.51	0.00e+00	4115.00
IUUC-Opr-071043	Ochotona princeps	88.07	0.00e+00	3018.00
IUUC-Ont-072556	Oreochromis niloticus	69.94	0.00e+00	1129.00
IUUC-Oan-073324	Ornithorhynchus anatinus	77.81	0.00e+00	2156.00
IUUC-Ocu-074190	Oryctolagus cuniculus	92.58	0.00e+00	3921.00
IUUC-Oba-075647	Oryza barthii	49.36	3.00e-38	154.00
IUUC-Olo-080577	Oryza longistaminata	47.71	9.00e-36	145.00
IUUC-Ome-081214	Oryza meridionalis	49.36	3.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	49.36	3.00e-38	154.00
IUUC-Opu-083842	Oryza punctata	49.36	3.00e-38	154.00
IUUC-Oru-084361	Oryza rufipogon	49.36	3.00e-38	154.00
IUUC-Olu-087718	Ostreococcus lucimarinus	37.50	2.00e-35	145.00
IUUC-Oga-088208	Otolemur garnettii	93.42	0.00e+00	3905.00
IUUC-Oar-090152	Ovis aries	94.56	0.00e+00	4066.00
IUUC-Ptr-091127	Pan troglodytes	95.55	0.00e+00	4046.00
IUUC-Pan-092679	Papio anubis	95.42	0.00e+00	3338.00
IUUC-Psi-094059	Pelodiscus sinensis	80.67	0.00e+00	3419.00
IUUC-Pma-094258	Petromyzon marinus	60.14	0.00e+00	678.00
IUUC-Pfo-096536	Poecilia formosa	69.21	0.00e+00	1121.00
IUUC-Pab-098262	Pongo abelii	95.55	0.00e+00	4114.00
IUUC-Pca-100358	Procavia capensis	88.66	0.00e+00	3584.00
IUUC-Pva-102522	Pteropus vampyrus	88.28	0.00e+00	3303.00
IUUC-Rno-105200	Rattus norvegicus	89.93	0.00e+00	2730.00
IUUC-Sha-107174	Sarcophilus harrisii	86.15	0.00e+00	3605.00
IUUC-Smo-109164	Selaginella moellendorffii	51.95	2.00e-40	161.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	6.00e-36	146.00
IUUC-Stu-112529	Solanum tuberosum	48.37	2.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	83.23	0.00e+00	1845.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	1.00e-10	62.00
IUUC-Tgu-117047	Taeniopygia guttata	79.37	0.00e+00	3404.00
IUUC-Tsy-118953	Tarsius syrichta	86.98	0.00e+00	1683.00
IUUC-Tni-120837	Tetraodon nigroviridis	65.91	0.00e+00	1140.00
IUUC-Tbe-127950	Tupaia belangeri	90.15	0.00e+00	2174.00
IUUC-Ttr-128643	Tursiops truncatus	92.20	0.00e+00	3897.00
IUUC-Vpa-130660	Vicugna pacos	90.14	0.00e+00	2012.00
IUUC-Vvi-131476	Vitis vinifera	46.75	4.00e-39	157.00
IUUC-Xtr-132869	Xenopus tropicalis	67.49	0.00e+00	2051.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence