iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9.

Protein Sequence
(Fasta)

MLQFSFQNCK THTCYMNTSV NEHLDQDESF LRILIDTRKK IRSSYFKPQT FDEFVHCLAR 60
VRAMKRLVSI CSNFDEEDNW NGVWNTLVVD GDSHASAMID YEGLLDKCSL SRNLLELIND 120

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Nucleotide Sequence
(Fasta)

GGTTTGATCA ATTTGTCTTA TCTGATCTGA TAACACCAAT GTTACGTCTT TCACACAAAG 60
AATTAAATTC GATCCACATT AGTATAATAT GCGAAGTATA CCACTAGTTT TTATTATAAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

Pfam

PF13013--F-box-like_2

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0042175--C:nuclear outer membrane-endoplasmic reticulum membrane network
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0034599--P:cellular response to oxidative stress
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0006979--P:response to oxidative stress

KEGG

spo:SPAC13D6.01

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001884	Ailuropoda melanoleuca	60.00	1.00e-02	29.60
IUUC-Aly-005491	Arabidopsis lyrata	50.00	1.30e-01	28.90
IUUC-Ath-007431	Arabidopsis thaliana	22.49	6.00e-04	37.40
IUUC-Aor-010171	Aspergillus oryzae	22.12	2.80e-02	31.20
IUUC-Ame-011699	Astyanax mexicanus	28.97	7.00e-05	41.60
IUUC-Bta-012451	Bos taurus	35.19	2.50e-02	32.00
IUUC-Bra-017664	Brassica rapa	37.50	8.00e-03	32.70
IUUC-Cme-027177	Cyanidioschyzon merolae	25.58	8.00e-04	35.80
IUUC-Eca-034290	Equus caballus	60.00	8.00e-03	30.00
IUUC-Fca-035575	Felis catus	46.67	1.60e-01	28.90
IUUC-Gga-040281	Gallus gallus	26.53	6.40e-02	30.00
IUUC-Ggo-045592	Gorilla gorilla	21.05	8.00e-02	29.30
IUUC-Hsa-046555	Homo sapiens	21.93	5.40e-02	30.00
IUUC-Lch-049874	Latimeria chalumnae	27.19	7.80e-02	30.40
IUUC-Meu-056047	Macropus eugenii	37.68	1.10e-02	33.50
IUUC-Mor-056988	Magnaporthe oryzae	24.10	1.80e-02	32.70
IUUC-Mac-065533	Musa acuminata	34.38	1.30e-01	27.30
IUUC-Mpu-066025	Mustela putorius furo	33.33	9.00e-02	29.60
IUUC-Mlu-068135	Myotis lucifugus	29.00	1.50e-02	32.30
IUUC-Opr-070831	Ochotona princeps	28.44	7.00e-02	30.80
IUUC-Oan-073068	Ornithorhynchus anatinus	32.50	1.20e+00	26.60
IUUC-Ocu-073770	Oryctolagus cuniculus	35.21	4.00e-02	30.40
IUUC-Obr-076419	Oryza brachyantha	50.00	1.30e-02	30.80
IUUC-Oar-090442	Ovis aries	32.61	5.80e-01	27.30
IUUC-Ppe-101496	Prunus persica	39.02	9.00e-03	32.70
IUUC-Pva-102573	Pteropus vampyrus	28.57	5.70e-02	31.60
IUUC-Sha-107313	Sarcophilus harrisii	36.23	2.00e-02	32.30
IUUC-Sja-107770	Schizosaccharomyces japonicus	35.69	8.00e-45	172.00
IUUC-Ssc-116416	Sus scrofa	60.00	7.00e-03	30.40
IUUC-Tgu-116817	Taeniopygia guttata	26.53	5.70e-02	30.00
IUUC-Tni-120700	Tetraodon nigroviridis	32.61	7.00e-03	31.60
IUUC-Tca-121275	Theobroma cacao	37.74	2.40e-01	28.50
IUUC-Tur-126360	Triticum urartu	22.22	3.60e-02	31.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence