iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054568

Ensembl Protein ID

ENSLAFP00000021434.1

UniProt Accession

G3SMC6; G3SMC6_LOXAF

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Gene Name

EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000000772.3	ENSLAFT00000000772.3	ENSLAFP00000000652.3
ENSLAFG00000000772.3	ENSLAFT00000035972.1	ENSLAFP00000021434.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	99.26	7.00e-163	570.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Loxodonta africana

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

MATPPSPTST PPATPSPAPA TEPAPAPAPA PSPAAAPAPA PAPASAPVPA PASAPASSSD 60
PASAAATTSA SAQSSASVQA PAQTSAPPPP GPALPGPFPG GRVVRLHPVI LASIVDSYER 120

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Nucleotide Sequence
(Fasta)

ACCAGCCCTG GCCTAGGTAG ATCCCCTCCC CCCGCCCCCC CGCCACTAGG CACCATAAGA 60
GAGGCCAACA GGCCAGGGCA GCCTCTCCTG CACGCCCCTC ATCCTTTGTA AAGCCATCCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	37.19	5.00e-46	178.00
IUUC-Aml-001527	Ailuropoda melanoleuca	99.25	2.00e-162	565.00
IUUC-Atr-002686	Amborella trichopoda	41.06	6.00e-50	190.00
IUUC-Apl-003977	Anas platyrhynchos	90.62	1.00e-121	428.00
IUUC-Aca-004335	Anolis carolinensis	90.30	1.00e-146	512.00
IUUC-Aly-005945	Arabidopsis lyrata	38.78	3.00e-50	191.00
IUUC-Ath-007045	Arabidopsis thaliana	39.16	3.00e-50	191.00
IUUC-Acl-008365	Aspergillus clavatus	34.80	6.00e-41	160.00
IUUC-Afl-008742	Aspergillus flavus	35.40	5.00e-40	158.00
IUUC-Afu-009030	Aspergillus fumigatus	34.43	1.00e-40	160.00
IUUC-Ani-009212	Aspergillus nidulans	35.40	6.00e-41	160.00
IUUC-Ang-009712	Aspergillus niger	34.31	1.00e-39	156.00
IUUC-Aor-009885	Aspergillus oryzae	35.40	1.00e-41	163.00
IUUC-Ate-010315	Aspergillus terreus	35.53	2.00e-39	155.00
IUUC-Ame-010801	Astyanax mexicanus	54.10	2.00e-66	245.00
IUUC-Bgr-011982	Blumeria graminis	35.64	5.00e-40	158.00
IUUC-Bta-012804	Bos taurus	98.57	6.00e-168	583.00
IUUC-Bci-013891	Botrytis cinerea	34.91	6.00e-35	141.00
IUUC-Bdi-014328	Brachypodium distachyon	39.62	5.00e-48	184.00
IUUC-Bol-015446	Brassica oleracea	39.16	2.00e-51	195.00
IUUC-Bra-016862	Brassica rapa	39.54	7.00e-52	197.00
IUUC-Cel-018171	Caenorhabditis elegans	35.19	9.00e-47	180.00
IUUC-Cja-019335	Callithrix jacchus	99.26	4.00e-165	573.00
IUUC-Cfa-020138	Canis familiaris	98.88	5.00e-162	563.00
IUUC-Cpo-022109	Cavia porcellus	87.27	2.00e-137	481.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	38.81	2.00e-57	215.00
IUUC-Csa-023994	Chlorocebus sabaeus	99.26	3.00e-165	574.00
IUUC-Cho-024351	Choloepus hoffmanni	76.12	8.00e-112	396.00
IUUC-Cin-025801	Ciona intestinalis	56.34	6.00e-88	317.00
IUUC-Csv-025805	Ciona savignyi	55.22	2.00e-85	308.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.50	3.00e-35	142.00
IUUC-Cne-026868	Cryptococcus neoformans	29.15	1.00e-28	119.00
IUUC-Cme-027328	Cyanidioschyzon merolae	27.33	3.00e-22	98.60
IUUC-Dre-028085	Danio rerio	80.15	3.00e-129	454.00
IUUC-Dno-030099	Dasypus novemcinctus	99.63	1.00e-162	565.00
IUUC-Dor-030324	Dipodomys ordii	90.30	2.00e-140	491.00
IUUC-Dse-031314	Dothistroma septosporum	36.26	3.00e-44	172.00
IUUC-Dme-031926	Drosophila melanogaster	49.26	5.00e-77	280.00
IUUC-Ete-032569	Echinops telfairi	92.91	9.00e-146	509.00
IUUC-Eca-033502	Equus caballus	94.03	3.00e-146	511.00
IUUC-Eeu-034883	Erinaceus europaeus	81.62	2.00e-82	297.00
IUUC-Fca-035873	Felis catus	99.25	2.00e-162	564.00
IUUC-Fal-036921	Ficedula albicollis	91.79	6.00e-148	516.00
IUUC-Fox-037765	Fusarium oxysporum	32.25	1.00e-29	123.00
IUUC-Fso-038240	Fusarium solani	32.61	5.00e-32	131.00
IUUC-Gmo-038864	Gadus morhua	78.57	8.00e-129	452.00
IUUC-Ggr-039862	Gaeumannomyces graminis	31.41	5.00e-30	124.00
IUUC-Gga-040952	Gallus gallus	91.79	1.00e-147	515.00
IUUC-Gac-041677	Gasterosteus aculeatus	79.40	8.00e-129	452.00
IUUC-Gma-043061	Glycine max	41.06	6.00e-50	190.00
IUUC-Ggo-045591	Gorilla gorilla	99.26	1.00e-165	575.00
IUUC-Hsa-046860	Homo sapiens	99.26	3.00e-165	574.00
IUUC-Hvu-047410	Hordeum vulgare	31.08	3.00e-20	90.50
IUUC-Itr-048211	Ictidomys tridecemlineatus	98.88	5.00e-162	563.00
IUUC-Lch-049410	Latimeria chalumnae	74.51	5.00e-87	313.00
IUUC-Lpe-051102	Leersia perrieri	40.00	3.00e-47	181.00
IUUC-Loc-052016	Lepisosteus oculatus	72.28	4.00e-113	400.00
IUUC-Lma-053157	Leptosphaeria maculans	34.80	2.00e-42	166.00
IUUC-Mcc-054613	Macaca mulatta	99.26	2.00e-165	574.00
IUUC-Meu-056832	Macropus eugenii	72.38	1.00e-82	298.00
IUUC-Mor-057104	Magnaporthe oryzae	31.21	2.00e-30	126.00
IUUC-Mtr-058445	Medicago truncatula	40.68	2.00e-58	219.00
IUUC-Mla-059038	Melampsora laricipopulina	31.12	2.00e-32	132.00
IUUC-Mga-059548	Meleagris gallopavo	91.53	2.00e-129	454.00
IUUC-Mvi-060520	Microbotryum violaceum	27.95	2.00e-22	99.80
IUUC-Mdo-062376	Monodelphis domestica	94.03	1.00e-150	525.00
IUUC-Mmu-063254	Mus musculus	98.51	4.00e-161	560.00
IUUC-Mac-065635	Musa acuminata	41.09	3.00e-52	198.00
IUUC-Mpu-066314	Mustela putorius furo	99.25	2.00e-162	564.00
IUUC-Mlu-067512	Myotis lucifugus	97.39	2.00e-156	544.00
IUUC-Nfi-068262	Neosartorya fischeri	34.43	1.00e-40	160.00
IUUC-Ncr-068872	Neurospora crassa	32.00	1.00e-32	133.00
IUUC-Nle-070118	Nomascus leucogenys	99.25	2.00e-162	565.00
IUUC-Opr-071228	Ochotona princeps	98.72	2.00e-141	494.00
IUUC-Ont-072600	Oreochromis niloticus	80.52	9.00e-132	462.00
IUUC-Oan-073584	Ornithorhynchus anatinus	93.22	7.00e-133	466.00
IUUC-Ocu-074542	Oryctolagus cuniculus	98.88	1.00e-161	561.00
IUUC-Oba-075923	Oryza barthii	39.54	4.00e-49	187.00
IUUC-Obr-076313	Oryza brachyantha	40.00	1.00e-48	186.00
IUUC-Ogl-076932	Oryza glaberrima	39.54	4.00e-49	187.00
IUUC-Ogu-078152	Oryza glumaepatula	39.54	4.00e-49	187.00
IUUC-Oin-079528	Oryza indica	39.54	4.00e-49	187.00
IUUC-Olo-080401	Oryza longistaminata	39.54	4.00e-49	187.00
IUUC-Ome-081553	Oryza meridionalis	39.16	1.00e-48	186.00
IUUC-Oni-082090	Oryza nivara	39.54	4.00e-49	187.00
IUUC-Opu-083583	Oryza punctata	40.00	4.00e-48	184.00
IUUC-Oru-084492	Oryza rufipogon	39.54	4.00e-49	187.00
IUUC-Osa-085383	Oryza sativa	39.54	4.00e-49	187.00
IUUC-Ola-086835	Oryzias latipes	79.40	1.00e-128	452.00
IUUC-Olu-087716	Ostreococcus lucimarinus	29.70	2.00e-28	119.00
IUUC-Oga-088886	Otolemur garnettii	98.88	2.00e-161	561.00
IUUC-Oar-090079	Ovis aries	98.57	2.00e-168	584.00
IUUC-Ptr-091457	Pan troglodytes	99.26	3.00e-165	574.00
IUUC-Pan-092317	Papio anubis	98.92	5.00e-109	386.00
IUUC-Psi-093129	Pelodiscus sinensis	85.33	2.00e-130	458.00
IUUC-Pma-094488	Petromyzon marinus	76.03	3.00e-123	434.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.80	1.00e-42	166.00
IUUC-Ppa-095341	Physcomitrella patens	41.51	1.00e-63	236.00
IUUC-Pfo-096286	Poecilia formosa	79.03	4.00e-129	453.00
IUUC-Pab-097765	Pongo abelii	99.26	3.00e-165	574.00
IUUC-Pop-099131	Populus trichocarpa	40.68	1.00e-54	206.00
IUUC-Pca-100524	Procavia capensis	82.91	2.00e-108	384.00
IUUC-Ppe-101934	Prunus persica	41.83	2.00e-59	222.00
IUUC-Pva-102577	Pteropus vampyrus	98.51	2.00e-161	561.00
IUUC-Pgr-103521	Puccinia graminis	29.93	3.00e-31	128.00
IUUC-Pte-104304	Pyrenophora teres	35.53	4.00e-43	168.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	35.53	3.00e-43	168.00
IUUC-Rno-105717	Rattus norvegicus	98.88	8.00e-162	562.00
IUUC-Sha-107190	Sarcophilus harrisii	94.25	9.00e-147	512.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	35.74	1.00e-44	172.00
IUUC-Spo-108355	Schizosaccharomyces pombe	36.20	2.00e-46	178.00
IUUC-Smo-109374	Selaginella moellendorffii	44.57	3.00e-68	251.00
IUUC-Sit-110119	Setaria italica	39.54	3.00e-49	188.00
IUUC-Sly-111570	Solanum lycopersicum	37.45	7.00e-46	177.00
IUUC-Stu-112308	Solanum tuberosum	39.66	2.00e-52	198.00
IUUC-Sar-113515	Sorex araneus	96.81	4.00e-52	197.00
IUUC-Sbi-114605	Sorghum bicolor	39.16	2.00e-48	186.00
IUUC-Sre-114906	Sporisorium reilianum	39.78	3.00e-52	198.00
IUUC-Tgu-117087	Taeniopygia guttata	89.83	6.00e-127	446.00
IUUC-Tru-117700	Takifugu rubripes	79.03	9.00e-129	452.00
IUUC-Tni-120470	Tetraodon nigroviridis	79.78	1.00e-129	455.00
IUUC-Tca-121109	Theobroma cacao	39.92	3.00e-48	184.00
IUUC-Tre-122095	Trichoderma reesei	33.57	4.00e-32	131.00
IUUC-Tvi-122580	Trichoderma virens	33.21	2.00e-31	129.00
IUUC-Tae-125129	Triticum aestivum	39.62	1.00e-50	192.00
IUUC-Tur-126658	Triticum urartu	34.94	1.00e-42	166.00
IUUC-Tme-127043	Tuber melanosporum	38.58	1.00e-47	183.00
IUUC-Tbe-127927	Tupaia belangeri	99.25	2.00e-162	564.00
IUUC-Ttr-129231	Tursiops truncatus	98.88	6.00e-162	563.00
IUUC-Uma-129578	Ustilago maydis	39.42	3.00e-51	195.00
IUUC-Vda-129730	Verticillium dahliae	31.88	7.00e-37	147.00
IUUC-Vpa-130677	Vicugna pacos	64.03	4.00e-42	165.00
IUUC-Vvi-130968	Vitis vinifera	41.44	1.00e-53	202.00
IUUC-Xtr-132203	Xenopus tropicalis	85.02	2.00e-136	478.00
IUUC-Xma-133972	Xiphophorus maculatus	78.65	8.00e-129	452.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	5.00e-40	157.00
IUUC-Zma-134941	Zea mays	38.78	1.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence