iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054079

Ensembl Protein ID

ENSLAFP00000025670.1

UniProt Accession

G3UCW2; G3UCW2_LOXAF

Protein Name

Uncharacterized protein

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000013308.3	ENSLAFT00000032022.1	ENSLAFP00000025670.1
ENSLAFG00000013308.3	ENSLAFT00000013309.3	ENSLAFP00000011137.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.80e-24	85.8	462	518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+++ ++d++
   Q: 462  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNVFEDGG 518
           79****************************************************986 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSHQPLSCLT EKGDSLDESP GNGPPNLAHP NLDTFTPEEL LQQMKELLIE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLIAL SHENEKLKEE LGKLKGKAER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCCACC AACCACTCAG CTGCCTGACA GAAAAAGGGG ACAGCCTTGA TGAAAGCCCA 60
GGAAATGGTC CCCCCAATCT GGCTCATCCA AACCTGGACA CGTTCACCCC AGAAGAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	83.11	0.00e+00	799.00
IUUC-Apl-003812	Anas platyrhynchos	56.22	1.00e-145	509.00
IUUC-Aca-004625	Anolis carolinensis	54.73	6.00e-146	510.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.10e-02	33.50
IUUC-Ath-007558	Arabidopsis thaliana	31.37	1.30e+00	26.90
IUUC-Ame-011116	Astyanax mexicanus	47.75	2.00e-54	207.00
IUUC-Bta-013240	Bos taurus	81.97	0.00e+00	898.00
IUUC-Cja-019911	Callithrix jacchus	82.66	0.00e+00	843.00
IUUC-Cfa-020330	Canis familiaris	82.48	0.00e+00	838.00
IUUC-Cpo-021753	Cavia porcellus	78.31	0.00e+00	804.00
IUUC-Csa-023662	Chlorocebus sabaeus	83.00	0.00e+00	844.00
IUUC-Cho-024574	Choloepus hoffmanni	67.93	6.00e-129	453.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.96	6.00e-03	35.40
IUUC-Dre-027720	Danio rerio	39.86	4.00e-90	325.00
IUUC-Dno-029079	Dasypus novemcinctus	78.74	0.00e+00	781.00
IUUC-Dor-030890	Dipodomys ordii	78.08	0.00e+00	815.00
IUUC-Dme-032072	Drosophila melanogaster	26.13	6.00e-03	35.00
IUUC-Ete-032568	Echinops telfairi	79.26	0.00e+00	717.00
IUUC-Eca-033528	Equus caballus	85.11	0.00e+00	860.00
IUUC-Eeu-035219	Erinaceus europaeus	72.25	0.00e+00	768.00
IUUC-Fca-035852	Felis catus	84.52	0.00e+00	855.00
IUUC-Fal-036862	Ficedula albicollis	58.17	6.00e-142	497.00
IUUC-Gmo-038735	Gadus morhua	37.95	5.00e-72	265.00
IUUC-Gga-040939	Gallus gallus	53.72	1.00e-141	496.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.95	1.00e-95	343.00
IUUC-Ggo-045034	Gorilla gorilla	74.83	0.00e+00	759.00
IUUC-Hsa-046624	Homo sapiens	81.99	0.00e+00	839.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	74.62	0.00e+00	789.00
IUUC-Lch-049720	Latimeria chalumnae	47.28	2.00e-80	292.00
IUUC-Loc-052185	Lepisosteus oculatus	43.60	2.00e-101	362.00
IUUC-Mcc-055674	Macaca mulatta	84.18	0.00e+00	843.00
IUUC-Meu-056769	Macropus eugenii	84.62	6.00e-72	265.00
IUUC-Mga-060203	Meleagris gallopavo	55.50	1.00e-132	466.00
IUUC-Mmr-061492	Microcebus murinus	82.48	0.00e+00	820.00
IUUC-Mdo-063051	Monodelphis domestica	73.46	0.00e+00	769.00
IUUC-Mmu-063409	Mus musculus	77.57	0.00e+00	848.00
IUUC-Mpu-065907	Mustela putorius furo	77.78	0.00e+00	824.00
IUUC-Mlu-066957	Myotis lucifugus	81.29	0.00e+00	771.00
IUUC-Ncr-068766	Neurospora crassa	33.33	8.70e-02	32.00
IUUC-Nle-069973	Nomascus leucogenys	82.32	0.00e+00	838.00
IUUC-Opr-071049	Ochotona princeps	75.38	0.00e+00	702.00
IUUC-Ont-071915	Oreochromis niloticus	42.68	4.00e-91	328.00
IUUC-Oan-072965	Ornithorhynchus anatinus	69.54	0.00e+00	736.00
IUUC-Ocu-074029	Oryctolagus cuniculus	74.41	0.00e+00	661.00
IUUC-Ola-087019	Oryzias latipes	40.97	2.00e-87	316.00
IUUC-Oga-088613	Otolemur garnettii	82.69	0.00e+00	846.00
IUUC-Oar-090386	Ovis aries	81.29	0.00e+00	888.00
IUUC-Ptr-091619	Pan troglodytes	81.82	0.00e+00	837.00
IUUC-Pan-092178	Papio anubis	82.24	0.00e+00	827.00
IUUC-Psi-093214	Pelodiscus sinensis	61.49	6.00e-158	550.00
IUUC-Pfo-096901	Poecilia formosa	39.14	2.00e-78	286.00
IUUC-Pab-097560	Pongo abelii	80.14	3.00e-159	555.00
IUUC-Pca-100853	Procavia capensis	74.28	1.00e-123	437.00
IUUC-Pva-102255	Pteropus vampyrus	81.53	0.00e+00	777.00
IUUC-Rno-105812	Rattus norvegicus	79.90	0.00e+00	843.00
IUUC-Sha-107225	Sarcophilus harrisii	77.75	2.00e-149	521.00
IUUC-Sar-113736	Sorex araneus	72.97	2.00e-127	449.00
IUUC-Ssc-115422	Sus scrofa	82.48	0.00e+00	871.00
IUUC-Tgu-116924	Taeniopygia guttata	57.04	2.00e-141	496.00
IUUC-Tru-117695	Takifugu rubripes	39.04	3.00e-87	316.00
IUUC-Tsy-119090	Tarsius syrichta	77.36	2.00e-145	508.00
IUUC-Tni-120645	Tetraodon nigroviridis	41.44	5.00e-89	321.00
IUUC-Tbe-127970	Tupaia belangeri	71.65	5.00e-137	481.00
IUUC-Ttr-129244	Tursiops truncatus	82.03	0.00e+00	815.00
IUUC-Vpa-130313	Vicugna pacos	80.51	0.00e+00	770.00
IUUC-Xtr-132115	Xenopus tropicalis	43.34	3.00e-95	342.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence