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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047017
Ensembl Protein ID ENSP00000232888.6
UniProt Accession O43818; B2R996; Q8IZ30; U3IP2_HUMAN
Genbank Protein ID CAA04687.1; BAG36443.1; EAW65159.1; AAH01113.1; AAH09879.1; AAH10048.1; AAH23662.2
Protein Name U3 small nucleolar RNA-interacting protein 2; RRP9 homolog; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein
Genbank Nucleotide ID AJ001340; AK313696; CH471055; BC001113; BC009879; BC010048; BC023662
Gene Name RRP9; RNU3IP2; U355K
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114767.6 ENST00000232888.6 ENSP00000232888.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.60e-28 97.0 322 356
UBD/Beta-Prp 4.10e-41 142.8 145 406
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgv 34
           gH++s+ c+++ ++ ++vsG+dDg++ +W l++ +
   Q: 322  GHQGSIDCIHLiNEEHMVSGADDGSVALWGLSKKR 356
           8*********9999***************987665 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkl...........lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvht 89
           h+  itc+ ++pd+s ++++ +d +i+ w+v++g +             +  gh++ v ++ +s+dgk+l++g + ++i +w+ ++++ ++t
   Q: 145  HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKlhviprakkgaEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT 236
           6678999****************************9899888888888888888888*********************************** PP
   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           ++gh d v  l+f + ++ l s+shdr ++vw++ +++ +e tl gh+++v  +   + ++++ +G+ D+tvr+W+++ ++ l    g h++
   Q: 237  FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVE-TLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFY-G-HQG 325
           ***************99***********************9.***********************************999988755.6.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght...........dnvksvrfspnderlvsgssDgsiriWdlr 252
           s+ ++ +  + +++vsg++dg+v lw l++++ +  +++              +++sv+++ n++++++gs+   +r+W + 
   Q: 326  SIDCIHLINE-EHMVSGADDGSVALWGLSKKRPLALQREAHglrgepgleqpFWISSVAALLNTDLVATGSHSSCVRLWQCG 406
           ******8886.7*****************999977776655588999999999**************************875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif.
 Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif.
Protein Sequence
(Fasta)
MSATAAARKR GKPASGAGAG AGAGKRRRKA DSAGDRGKSK GGGKMNEEIS SDSESESLAP 60
RKPEEEEEEE LEETAQEKKL RLAKLYLEQL RQQEEEKAEA RAFEEDQVAG RLKEDVLEQR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047017|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCGGCTGG GGAGCTGGGA GGGTTCAGCT GCCACGTGAG TTCTGCGGCC GCTGCTACAC 60
GCCTGGTGGG CAGCATGTCG GCAACAGCGG CTGCTCGTAA GCGGGGAAAG CCGGCCTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047017|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0698--rRNA processing
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0031428--C:box C/D snoRNP complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0032040--C:small-subunit processome
GO:0003723--F:RNA binding
GO:0006364--P:rRNA processing
KEGG hsa:9136
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000586 Aegilops tauschii 33.51 1.00e-54 207.00
IUUC-Aml-002072 Ailuropoda melanoleuca 93.67 0.00e+00 761.00
IUUC-Atr-002824 Amborella trichopoda 37.41 3.00e-70 259.00
IUUC-Apl-003264 Anas platyrhynchos 74.67 8.00e-166 576.00
IUUC-Aca-004898 Anolis carolinensis 78.43 2.00e-180 625.00
IUUC-Aly-005535 Arabidopsis lyrata 38.24 1.00e-66 247.00
IUUC-Ath-007119 Arabidopsis thaliana 36.63 2.00e-71 263.00
IUUC-Ago-007710 Ashbya gossypii 28.74 2.00e-56 213.00
IUUC-Acl-008345 Aspergillus clavatus 34.52 6.00e-56 212.00
IUUC-Afl-008718 Aspergillus flavus 32.12 1.00e-53 204.00
IUUC-Afu-008966 Aspergillus fumigatus 30.43 2.00e-53 203.00
IUUC-Ani-009214 Aspergillus nidulans 31.45 2.00e-56 213.00
IUUC-Ang-009774 Aspergillus niger 34.01 1.00e-57 217.00
IUUC-Aor-009956 Aspergillus oryzae 32.12 1.00e-53 204.00
IUUC-Ate-010449 Aspergillus terreus 30.08 1.00e-54 207.00
IUUC-Ame-011860 Astyanax mexicanus 71.76 5.00e-169 587.00
IUUC-Bgr-012213 Blumeria graminis 30.88 4.00e-62 232.00
IUUC-Bta-012698 Bos taurus 94.86 0.00e+00 724.00
IUUC-Bci-013973 Botrytis cinerea 28.51 2.00e-59 223.00
IUUC-Bdi-014790 Brachypodium distachyon 36.65 4.00e-62 232.00
IUUC-Bol-016068 Brassica oleracea 38.10 4.00e-66 245.00
IUUC-Bra-017410 Brassica rapa 39.15 7.00e-62 231.00
IUUC-Cel-018616 Caenorhabditis elegans 37.01 3.00e-73 269.00
IUUC-Cja-019532 Callithrix jacchus 94.95 0.00e+00 765.00
IUUC-Cfa-020961 Canis familiaris 89.32 0.00e+00 746.00
IUUC-Cpo-021527 Cavia porcellus 91.81 0.00e+00 742.00
IUUC-Csa-023106 Chlorocebus sabaeus 98.41 0.00e+00 792.00
IUUC-Cin-025670 Ciona intestinalis 52.69 1.00e-123 436.00
IUUC-Csv-026172 Ciona savignyi 52.17 2.00e-117 415.00
IUUC-Cgl-026619 Colletotrichum gloeosporioides 33.12 2.00e-63 236.00
IUUC-Cne-027070 Cryptococcus neoformans 30.13 7.00e-48 185.00
IUUC-Cme-027125 Cyanidioschyzon merolae 26.67 8.00e-35 142.00
IUUC-Dre-027919 Danio rerio 68.48 9.00e-161 560.00
IUUC-Dno-029684 Dasypus novemcinctus 94.08 8.00e-169 586.00
IUUC-Dor-030363 Dipodomys ordii 87.19 7.00e-106 377.00
IUUC-Dse-031503 Dothistroma septosporum 31.60 8.00e-60 224.00
IUUC-Dme-031979 Drosophila melanogaster 45.32 8.00e-100 357.00
IUUC-Eca-033735 Equus caballus 95.01 0.00e+00 729.00
IUUC-Fca-036193 Felis catus 93.93 0.00e+00 745.00
IUUC-Fal-037058 Ficedula albicollis 71.08 6.00e-170 590.00
IUUC-Fox-038036 Fusarium oxysporum 32.26 2.00e-64 239.00
IUUC-Fso-038298 Fusarium solani 32.75 6.00e-63 235.00
IUUC-Gmo-038796 Gadus morhua 64.99 2.00e-141 495.00
IUUC-Ggr-040074 Gaeumannomyces graminis 30.75 9.00e-54 204.00
IUUC-Gga-040743 Gallus gallus 77.03 5.00e-137 479.00
IUUC-Gac-042583 Gasterosteus aculeatus 64.54 2.00e-165 575.00
IUUC-Gma-042659 Glycine max 39.29 1.00e-79 290.00
IUUC-Ggo-045543 Gorilla gorilla 99.16 0.00e+00 806.00
IUUC-Hvu-047173 Hordeum vulgare 37.70 7.00e-68 251.00
IUUC-Itr-048062 Ictidomys tridecemlineatus 88.63 0.00e+00 740.00
IUUC-Kpa-049262 Komagataella pastoris 31.50 2.00e-58 220.00
IUUC-Lch-050566 Latimeria chalumnae 72.85 7.00e-155 540.00
IUUC-Lpe-051651 Leersia perrieri 35.14 3.00e-64 239.00
IUUC-Loc-051997 Lepisosteus oculatus 71.47 1.00e-164 573.00
IUUC-Lma-053182 Leptosphaeria maculans 29.90 8.00e-60 224.00
IUUC-Laf-054105 Loxodonta africana 93.59 0.00e+00 728.00
IUUC-Mcc-055215 Macaca mulatta 98.41 0.00e+00 793.00
IUUC-Meu-055943 Macropus eugenii 82.01 0.00e+00 667.00
IUUC-Mor-057069 Magnaporthe oryzae 32.61 1.00e-63 238.00
IUUC-Mpo-057358 Magnaporthe poae 31.16 5.00e-51 196.00
IUUC-Mtr-058209 Medicago truncatula 39.10 7.00e-79 288.00
IUUC-Mla-059043 Melampsora laricipopulina 28.03 5.00e-49 189.00
IUUC-Mga-060024 Meleagris gallopavo 75.69 2.00e-154 538.00
IUUC-Mvi-060371 Microbotryum violaceum 32.02 5.00e-67 248.00
IUUC-Mmr-061403 Microcebus murinus 95.35 0.00e+00 749.00
IUUC-Mdo-063026 Monodelphis domestica 83.80 0.00e+00 669.00
IUUC-Mmu-063646 Mus musculus 94.61 0.00e+00 768.00
IUUC-Mac-064801 Musa acuminata 37.22 6.00e-75 275.00
IUUC-Mpu-065760 Mustela putorius furo 91.58 0.00e+00 764.00
IUUC-Mlu-067963 Myotis lucifugus 94.24 0.00e+00 742.00
IUUC-Nfi-068288 Neosartorya fischeri 32.21 7.00e-57 215.00
IUUC-Ncr-068679 Neurospora crassa 32.76 3.00e-56 213.00
IUUC-Nle-069766 Nomascus leucogenys 90.13 0.00e+00 714.00
IUUC-Opr-070906 Ochotona princeps 93.26 0.00e+00 769.00
IUUC-Ont-071661 Oreochromis niloticus 67.96 3.00e-165 575.00
IUUC-Oan-073465 Ornithorhynchus anatinus 71.04 3.00e-147 515.00
IUUC-Ocu-074263 Oryctolagus cuniculus 93.70 0.00e+00 766.00
IUUC-Oba-075607 Oryza barthii 37.57 2.00e-61 229.00
IUUC-Ogl-077387 Oryza glaberrima 36.77 7.00e-64 238.00
IUUC-Ogu-078323 Oryza glumaepatula 37.60 4.00e-64 238.00
IUUC-Oin-079977 Oryza indica 31.23 9.00e-42 164.00
IUUC-Olo-080857 Oryza longistaminata 37.50 3.00e-64 238.00
IUUC-Ome-081568 Oryza meridionalis 37.24 1.00e-63 237.00
IUUC-Oni-082685 Oryza nivara 37.60 4.00e-67 249.00
IUUC-Opu-084049 Oryza punctata 37.60 5.00e-64 238.00
IUUC-Oru-084348 Oryza rufipogon 37.60 4.00e-67 249.00
IUUC-Osa-086076 Oryza sativa 37.60 4.00e-67 249.00
IUUC-Ola-086991 Oryzias latipes 70.38 1.00e-163 569.00
IUUC-Olu-087891 Ostreococcus lucimarinus 36.41 1.00e-64 239.00
IUUC-Oga-088991 Otolemur garnettii 93.95 0.00e+00 767.00
IUUC-Oar-090430 Ovis aries 93.57 0.00e+00 724.00
IUUC-Ptr-091359 Pan troglodytes 99.32 0.00e+00 800.00
IUUC-Pan-092499 Papio anubis 98.19 0.00e+00 791.00
IUUC-Pma-094447 Petromyzon marinus 61.21 2.00e-127 449.00
IUUC-Pno-095008 Phaeosphaeria nodorum 30.20 2.00e-62 233.00
IUUC-Ppa-095680 Physcomitrella patens 38.89 8.00e-76 278.00
IUUC-Pfo-096430 Poecilia formosa 69.35 6.00e-165 573.00
IUUC-Pab-097649 Pongo abelii 98.87 0.00e+00 795.00
IUUC-Pop-100055 Populus trichocarpa 40.00 1.00e-77 283.00
IUUC-Pca-100317 Procavia capensis 75.83 6.00e-133 467.00
IUUC-Ppe-101999 Prunus persica 37.93 6.00e-78 285.00
IUUC-Pva-103046 Pteropus vampyrus 93.78 0.00e+00 753.00
IUUC-Pgr-103655 Puccinia graminis 30.23 2.00e-53 203.00
IUUC-Ptt-103812 Puccinia triticina 31.32 1.00e-47 184.00
IUUC-Pte-104243 Pyrenophora teres 29.71 8.00e-56 211.00
IUUC-Pyt-104512 Pyrenophora triticirepentis 29.70 5.00e-58 219.00
IUUC-Rno-104973 Rattus norvegicus 95.36 0.00e+00 750.00
IUUC-Sce-106329 Saccharomyces cerevisiae 26.04 4.00e-50 192.00
IUUC-Sha-106941 Sarcophilus harrisii 85.35 0.00e+00 677.00
IUUC-Sja-107821 Schizosaccharomyces japonicus 32.35 1.00e-61 230.00
IUUC-Spo-108329 Schizosaccharomyces pombe 36.78 5.00e-72 265.00
IUUC-Ssl-108552 Sclerotinia sclerotiorum 29.35 3.00e-59 223.00
IUUC-Smo-109198 Selaginella moellendorffii 37.09 9.00e-62 230.00
IUUC-Sit-109694 Setaria italica 36.47 3.00e-71 262.00
IUUC-Sly-111294 Solanum lycopersicum 37.88 1.00e-77 283.00
IUUC-Stu-112747 Solanum tuberosum 38.38 7.00e-79 288.00
IUUC-Sar-113315 Sorex araneus 75.51 4.00e-74 272.00
IUUC-Sbi-114694 Sorghum bicolor 35.93 1.00e-69 257.00
IUUC-Sre-114937 Sporisorium reilianum 29.07 3.00e-65 243.00
IUUC-Ssc-116127 Sus scrofa 94.00 0.00e+00 738.00
IUUC-Tgu-117242 Taeniopygia guttata 70.24 6.00e-107 380.00
IUUC-Tru-118285 Takifugu rubripes 68.02 2.00e-167 582.00
IUUC-Tni-120368 Tetraodon nigroviridis 67.77 5.00e-161 560.00
IUUC-Tca-121724 Theobroma cacao 36.80 6.00e-72 265.00
IUUC-Tre-122106 Trichoderma reesei 33.69 2.00e-68 253.00
IUUC-Tvi-122526 Trichoderma virens 33.13 2.00e-68 253.00
IUUC-Tae-122939 Triticum aestivum 37.17 1.00e-66 247.00
IUUC-Tur-126548 Triticum urartu 37.17 2.00e-66 246.00
IUUC-Tme-126985 Tuber melanosporum 34.35 5.00e-63 235.00
IUUC-Tbe-127923 Tupaia belangeri 95.98 0.00e+00 739.00
IUUC-Ttr-129308 Tursiops truncatus 88.65 0.00e+00 671.00
IUUC-Uma-129472 Ustilago maydis 31.06 5.00e-60 225.00
IUUC-Vda-129910 Verticillium dahliae 31.98 2.00e-63 237.00
IUUC-Vvi-131683 Vitis vinifera 38.76 2.00e-84 306.00
IUUC-Xtr-132118 Xenopus tropicalis 67.64 3.00e-157 548.00
IUUC-Xma-133804 Xiphophorus maculatus 68.84 3.00e-163 568.00
IUUC-Yli-134639 Yarrowia lipolytica 32.78 2.00e-61 230.00
IUUC-Zma-135884 Zea mays 36.58 2.00e-70 260.00
Created Date 25-Jun-2017

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